This is super exciting. JAK1 inhibitor turns out to be a very effective treatment for TEN/SJS

www.nature.com/articles/s41...

Hi #IDSky! I’m putting together my usual top 10 ID papers of this year list again (this time will post here not in the other world).

Please tell me your candidate papers - practice changing paradigm shifting or dogma challenging!

New paper from my colleagues at UCLH

Nearly 70% (!!!) resistance to Cefiderocol in NDM positive bacteria.

Cefiderocol...we hardly knew ye...

Perfect timing for World Antimicrobial Awareness Week #waaw24 #IDSky

academic.oup.com/jac/advance-...

Incredible graphic - the myriad of ways that bacteria defend themselves against antibiotics.

14 resistance mechanisms, summarised by Idan Yelin & Roy Kishony in Cell

www.sciencedirect.com/science/arti...

Morning #IDSky what is your preferred rounding structure for teaching services? Would love to know why in comments 👇

1️⃣ <a href="https://poll.blue/p/b0UxKV/1" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">AM team rounds
2️⃣ <a href="https://poll.blue/p/b0UxKV/2" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">PM team rounds
3️⃣ <a href="https://poll.blue/p/b0UxKV/3" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">BID team rounds
4️⃣ <a href="https://poll.blue/p/b0UxKV/4" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">Keep it flexible

📊 Show results

ID Connections #2
Same game as the NYT Connections but with ID content and unlimited guesses.
connections.swellgarfo.com/game/-OBYIEo...

Interesting! SubQ meropenem.

“Subcutaneous meropenem appears to be well tolerated and has a favourable pharmacokinetic profile. Either 1.5 g twice daily or 3 g as a 24 h subcutaneous infusion could be considered for future evaluation.”

academic.oup.com/jac/advance-...

Can we treat patients with low-risk BSI discharged from the ED with a fully-oral course of antibiotics?

[Spoiler: Yes!]

🆓🔓Our recent article on #OralIsTheNewIV! 👉🏻 journals.asm.org/doi/10.1128/...

Food for thought for #AMSsky #IDSky

My Top 5 Antibiotic Allergy Papers - #5
▶️Gadde et al. JAMA 1993; 270 (20)
▶️ A paper before its time. Skin testing for #penicillinallergy in patients with ID indication!
▶️ 7.1% + ; PPL & MDM utilisation; safety (1/128+ required adrenaline); Allergy LOSS WITH TIME.
jamanetwork.com/journals/jam...

To get hopefully some #peniicillinallergy #drugallergy folk over to 🦋 from X I am going to list my top 5 #antibioticallergy papers of all time - starting tomorrow! Stay tuned 👀

Very happy to report that @sidpharm.bsky.social and @mad-id.bsky.social is here. Waiting on SHEA...

I'm advertising a PhD studentship (open to international students) working on long read pangenome / assembly algorithms in bacteria. Would suit someone with maths/compsci/coding background. Aptitude + interest more important than experience.
Details here:
www.findaphd.com/phds/project...

Hello #IDSky #MedSky #PharmSky!

We are MAD-ID, striving to educate 🎓 and promote 🏆 infectious diseases and antimicrobial stewardship clinicians and researchers!

Looking forward to the bright future of our ID community on this platform 🦋

Here’s pack 2! Still in progress - will update more tomorrow.

It’s been a fun day. Love seeing our community rebuild here! Goodnight Bluesky. 🦋💤

Along the lines of what others have started, here's a #SkyRx starter pack - if I'm missing you let me know!

go.bsky.app/DTkEEWG

IDSky continues to grow rapidly

We are now >300 users, which means we are on a third Starter Pack

IDSky Starter Pack 1 go.bsky.app/LnAQjdq
IDSky Starter Pack 2 go.bsky.app/JNfSvQT
ID Starter Pack 3 go.bsky.app/FeogT7o

Check back on the most recent one often as it is updated frequently

Hi friends on #IDSky. Hoping we re-create what we once had on twixter.

So here's another old favorite, guaranteed to get your Sunday off to a happy start.

(Grrrr ... still mad about this one.)
blogs.jwatch.org/hiv-id-obser...

PSA: If you’re ever reversing anticoagulation & someone asks if the patient has had a vasectomy, they’re not being a weirdo.

Protamine is made from salmon sperm & post vasectomy patients may have anti sperm antibodies that cross react causing life threatening anaphylaxis!

🔍👁️🍄 “Based on available evidence, and high risk of morbidity of eye involvement, continued ophthalmological screens seem prudent, but a definitive consensus was found to be challenging given a lack of outcome data...”

academic.oup.com/ofid/advance... #IDbluesky

Fun ID Pharm Q today
Pt on mero 2q8 for ESBL infx and has adenovirus viremia.

Starting cidofovor + probenecid = mero dose adjustment

1989 study to the rescue! Mero AUC ⬆️ 55%. T1/2 ⬆️ from 0.9 hr to 1.3 hr.

➡️ 2 Q12 x 48 hrs based on probenecid t1/2 of 5-15 hrs

pubmed.ncbi.nlm.nih.gov/2808215/

Looking to build/join the ID peeps

I make ID themed games. Obsessed with beta-lactam side chains. New fan of topical estrogen for rUTIs.

connections.swellgarfo.com/game/-NuSggy...