Jason Trubiano
@trubianojason.bsky.social
Prof/Director of Infectious Diseases & Immunology @austin_health. UoM Research Fellow @ID_austin @CAAR_Aus @TheDohertyInst @UniMelbMDHS #AMS #AMR #penicillinallergy #drugallergy #TID
Pinned
Jason Trubiano
@trubianojason.bsky.social
· Nov 12
My Top 5 Antibiotic Allergy Papers - #5
▶️Gadde et al. JAMA 1993; 270 (20)
▶️ A paper before its time. Skin testing for #penicillinallergy in patients with ID indication!
▶️ 7.1% + ; PPL & MDM utilisation; safety (1/128+ required adrenaline); Allergy LOSS WITH TIME.
jamanetwork.com/journals/jam...
▶️Gadde et al. JAMA 1993; 270 (20)
▶️ A paper before its time. Skin testing for #penicillinallergy in patients with ID indication!
▶️ 7.1% + ; PPL & MDM utilisation; safety (1/128+ required adrenaline); Allergy LOSS WITH TIME.
jamanetwork.com/journals/jam...
Clinical Experience With Penicillin Skin Testing in a Large Inner-City STD Clinic
Objective.
—To establish (1) the prevalence of positive penicillin skin tests among outpatients with well-defined but variable history of penicillin allergy and (2) the reproducibility, safety, a...
jamanetwork.com
Reposted by Jason Trubiano
In high-income countries, up to 11.5% of adults report a penicillin allergy, and in high-risk groups prevalence can reach 35%. However, more than 90% of these labels are inaccurate, resulting in substantial clinical and public health consequences in hospitals and communities #idsky
🆕🔥State-of-the-Art Review with 🌟s @trubianojason.bsky.social : Antibiotic Allergy—A Multidisciplinary Approach to Delabeling #idsky
url: academic.oup.com/cid/article/...
url: academic.oup.com/cid/article/...
November 7, 2025 at 2:37 PM
In high-income countries, up to 11.5% of adults report a penicillin allergy, and in high-risk groups prevalence can reach 35%. However, more than 90% of these labels are inaccurate, resulting in substantial clinical and public health consequences in hospitals and communities #idsky
Reposted by Jason Trubiano
🆕🔥State-of-the-Art Review with 🌟s @trubianojason.bsky.social : Antibiotic Allergy—A Multidisciplinary Approach to Delabeling #idsky
url: academic.oup.com/cid/article/...
url: academic.oup.com/cid/article/...
November 6, 2025 at 8:09 PM
🆕🔥State-of-the-Art Review with 🌟s @trubianojason.bsky.social : Antibiotic Allergy—A Multidisciplinary Approach to Delabeling #idsky
url: academic.oup.com/cid/article/...
url: academic.oup.com/cid/article/...
Congratulations Elise Mitri from NACE, Austin Health & The Peter Doherty Institute presenting the iNAAN Trial results - > 5000 pts & 1500 inpatient #penicillinallergy DOC performed. Safe irrespective of stakeholder with significant prescribing gains. Largest inpatient penicillin allergy study 👏🎉
August 29, 2025 at 8:17 AM
Congratulations Elise Mitri from NACE, Austin Health & The Peter Doherty Institute presenting the iNAAN Trial results - > 5000 pts & 1500 inpatient #penicillinallergy DOC performed. Safe irrespective of stakeholder with significant prescribing gains. Largest inpatient penicillin allergy study 👏🎉
Is one dose enough?! Great talk from Dr Rose for the #PROSPECTOR #penicillinallergy #RCT at #EAACI HK Summer School. 6.7% increase in immune mediated reactions with prolonged oral challenge. Looking forward to #PROSPECTOR2 definitive phase III study to change practice!
August 28, 2025 at 1:54 PM
Is one dose enough?! Great talk from Dr Rose for the #PROSPECTOR #penicillinallergy #RCT at #EAACI HK Summer School. 6.7% increase in immune mediated reactions with prolonged oral challenge. Looking forward to #PROSPECTOR2 definitive phase III study to change practice!
Excited to be at EAACI Hong Kong School 2025 Hosted by Prof Li. Can’t wait for Elise Mitri from The Peter Doherty Institute to present the #iNAAN Results - #PenicillinAllergy #delabing Global Implementation! Dr Rose will present #PROSPECTOR1 - is one dose enough to delabel penicillin allergy?!? ‼️👀
August 27, 2025 at 2:02 AM
Excited to be at EAACI Hong Kong School 2025 Hosted by Prof Li. Can’t wait for Elise Mitri from The Peter Doherty Institute to present the #iNAAN Results - #PenicillinAllergy #delabing Global Implementation! Dr Rose will present #PROSPECTOR1 - is one dose enough to delabel penicillin allergy?!? ‼️👀
Thank you @eurekaprizes.bsky.social for the opportunity and my research team Austin Health & Doherty Institute for driving the research in #antibioticallergy #EurekaPrizes
Professor @trubianojason.bsky.social is a finalist in the Eureka Prize for Emerging Leader in Science.
Learn more: youtu.be/qaPw-YsXix4
#EurekaPrizes
Learn more: youtu.be/qaPw-YsXix4
#EurekaPrizes
July 31, 2025 at 10:09 PM
Thank you @eurekaprizes.bsky.social for the opportunity and my research team Austin Health & Doherty Institute for driving the research in #antibioticallergy #EurekaPrizes
#ESCMIDGlobal #FOMO…. Watching online the amazing @elisemitri.bsky.social and thanks to @cmicomms.bsky.social for publishing this work! Not missing another #ESCMIDGlobal!!
Congrats to @elisemitri.bsky.social, @trubianojason.bsky.social et al for their great work on safely delabeling patients with #penicillinallergy. Elise presenting their prospective, pharmacist-led program live at #ESCMIDGlobal
#IDSky #PharmSky #openacess
www.cmi-comms.com/article/S295...
#IDSky #PharmSky #openacess
www.cmi-comms.com/article/S295...
April 13, 2025 at 12:11 PM
#ESCMIDGlobal #FOMO…. Watching online the amazing @elisemitri.bsky.social and thanks to @cmicomms.bsky.social for publishing this work! Not missing another #ESCMIDGlobal!!
Hopefully can get a # going for the conference - #ASID2025 ? Get some of the proffered papers and new research out from #EMCR #IDResearch #Infectiousdiseases
April 4, 2025 at 12:37 AM
Hopefully can get a # going for the conference - #ASID2025 ? Get some of the proffered papers and new research out from #EMCR #IDResearch #Infectiousdiseases
Reposted by Jason Trubiano
ASID Annual Scientific Meeting kicked off yesterday in Canberra. The pre-conference workshop hosted by Therapeutic Guidelines Australia attracted over 120 attendees and was a very engaging and informative session. The formal program commences tomorrow in what will be one of the largest ASM’s.
April 2, 2025 at 11:22 PM
ASID Annual Scientific Meeting kicked off yesterday in Canberra. The pre-conference workshop hosted by Therapeutic Guidelines Australia attracted over 120 attendees and was a very engaging and informative session. The formal program commences tomorrow in what will be one of the largest ASM’s.
Well done team 👏 Perioperative Penicillin and Cephalosporin Antibiotic Allergy Assessment and Testing: The PREPARE Randomized Clinical Trial jamanetwork.com/journals/jam...
Perioperative Penicillin and Cephalosporin Antibiotic Allergy Assessment and Testing
This pilot randomized clinical trial assesses the feasibility and safety of using a smartphone application for antibiotic allergy assessment and delabeling in anesthesiologist-led clinics among patien...
jamanetwork.com
March 27, 2025 at 10:36 AM
Well done team 👏 Perioperative Penicillin and Cephalosporin Antibiotic Allergy Assessment and Testing: The PREPARE Randomized Clinical Trial jamanetwork.com/journals/jam...
We randomised our first patients yesterday into the #PROSPECTOR2 ⛏️ study - international superioty trail of 1 dose versus day challenge for #penicillinallergy. “Is one dose ever enough….”
March 26, 2025 at 8:50 PM
We randomised our first patients yesterday into the #PROSPECTOR2 ⛏️ study - international superioty trail of 1 dose versus day challenge for #penicillinallergy. “Is one dose ever enough….”
February 28, 2025 at 3:19 PM
www.sciencedirect.com/science/arti... - nice review and global prevalence number!
The Global Prevalence of Reported Penicillin Allergy: A Systematic Review and Meta-Analysis
Patients labelled with penicillin allergy (PenA) often receive broader spectrum antibiotics, associated with antimicrobial resistance and poorer outco…
www.sciencedirect.com
January 29, 2025 at 1:25 AM
www.sciencedirect.com/science/arti... - nice review and global prevalence number!
Reposted by Jason Trubiano
Very proud of this hard work & team effort from all involved! Limited benefit of adjuvanted flu 💉 & 2 vs 1 dose in pts w/ MM, CLL or NHL. @ncicancer.bsky.social @petermaccc.bsky.social @benwteh.bsky.social @trubianojason.bsky.social @michyong.bsky.social @nejm.org www.nejm.org/doi/full/10....
Influenza Vaccination Strategies in Patients with Hematologic Cancer | NEJM
In this trial involving patients with hematologic cancers, the immune responses that
were elicited were similar for adjuvanted-dose and standard-dose influenza vaccines.
www.nejm.org
January 16, 2025 at 10:10 PM
Very proud of this hard work & team effort from all involved! Limited benefit of adjuvanted flu 💉 & 2 vs 1 dose in pts w/ MM, CLL or NHL. @ncicancer.bsky.social @petermaccc.bsky.social @benwteh.bsky.social @trubianojason.bsky.social @michyong.bsky.social @nejm.org www.nejm.org/doi/full/10....
Reposted by Jason Trubiano
📣 @elisemitri.bsky.social et al prospectively assessed 477 inpatients with #penicillin allergy. 166 were low-risk & underwent oral challenge: 158 (95%) delabeled. 111 (type A allergy) delabeled without challenge.
➡️ No SAE
#IDSky #MedSky
@trubianojason.bsky.social
www.cmi-comms.com/article/S295...
➡️ No SAE
#IDSky #MedSky
@trubianojason.bsky.social
www.cmi-comms.com/article/S295...
The long-term sustainability of a pharmacist-led antimicrobial stewardship penicillin allergy delabelling ward round: A prospective cohort study.
Inpatient penicillin allergy is associated with inappropriate antibiotic prescribing and adverse patient outcomes. We reviewed the long-term effectiveness, safety and antimicrobial stewardship impacts of a pharmacist-led penicillin allergy delabelling ward round.
www.cmi-comms.com
January 7, 2025 at 12:14 PM
📣 @elisemitri.bsky.social et al prospectively assessed 477 inpatients with #penicillin allergy. 166 were low-risk & underwent oral challenge: 158 (95%) delabeled. 111 (type A allergy) delabeled without challenge.
➡️ No SAE
#IDSky #MedSky
@trubianojason.bsky.social
www.cmi-comms.com/article/S295...
➡️ No SAE
#IDSky #MedSky
@trubianojason.bsky.social
www.cmi-comms.com/article/S295...
Reposted by Jason Trubiano
🆕💫Prospective cohort study
The long-term sustainability of a pharmacist-led antimicrobial stewardship penicillin allergy delabelling ward round with 🌟 @trubianojason.bsky.social @cmicomms.bsky.social #idsky
www.sciencedirect.com/science/arti...
The long-term sustainability of a pharmacist-led antimicrobial stewardship penicillin allergy delabelling ward round with 🌟 @trubianojason.bsky.social @cmicomms.bsky.social #idsky
www.sciencedirect.com/science/arti...
The long-term sustainability of a pharmacist-led antimicrobial stewardship penicillin allergy delabelling ward round: A prospective cohort study.
Inpatient penicillin allergy is associated with inappropriate antibiotic prescribing and adverse patient outcomes. We reviewed the long-term effective…
www.sciencedirect.com
December 20, 2024 at 11:40 AM
🆕💫Prospective cohort study
The long-term sustainability of a pharmacist-led antimicrobial stewardship penicillin allergy delabelling ward round with 🌟 @trubianojason.bsky.social @cmicomms.bsky.social #idsky
www.sciencedirect.com/science/arti...
The long-term sustainability of a pharmacist-led antimicrobial stewardship penicillin allergy delabelling ward round with 🌟 @trubianojason.bsky.social @cmicomms.bsky.social #idsky
www.sciencedirect.com/science/arti...
1000 direct oral #penicillinallergy challenges in the prospective iNAAN study 🎉- 39 hospitals and 7 countries 😳. The largest adult penicillin challenge study! Well done @elisemitri.bsky.social 👏👏 and all collaborators! @escmid.bsky.social data coming hopefully to #ESCMIDglobal 2025!
November 23, 2024 at 4:25 AM
1000 direct oral #penicillinallergy challenges in the prospective iNAAN study 🎉- 39 hospitals and 7 countries 😳. The largest adult penicillin challenge study! Well done @elisemitri.bsky.social 👏👏 and all collaborators! @escmid.bsky.social data coming hopefully to #ESCMIDglobal 2025!
Reposted by Jason Trubiano
🚨 Delighted to share our paper defining a new role for IL-6 in TB. 🚨
We used genetic variation to show *reduced* IL-6 signalling is causally associated with *lower* risk of TB.
Lead author @gushamilton.bsky.social
#TBSky #IDSky #ImmunoSky www.thelancet.com/journals/lan...
Thread 👇 (1/8)
We used genetic variation to show *reduced* IL-6 signalling is causally associated with *lower* risk of TB.
Lead author @gushamilton.bsky.social
#TBSky #IDSky #ImmunoSky www.thelancet.com/journals/lan...
Thread 👇 (1/8)
Altered IL-6 signalling and risk of tuberculosis: a multi-ancestry mendelian randomisation study
Our findings propose a causal relationship between reduced IL-6 signalling and lower
risk of tuberculosis, akin to the effect seen in other IL-6 mediated diseases. This
study suggests that IL-6 antago...
www.thelancet.com
November 21, 2024 at 10:30 AM
🚨 Delighted to share our paper defining a new role for IL-6 in TB. 🚨
We used genetic variation to show *reduced* IL-6 signalling is causally associated with *lower* risk of TB.
Lead author @gushamilton.bsky.social
#TBSky #IDSky #ImmunoSky www.thelancet.com/journals/lan...
Thread 👇 (1/8)
We used genetic variation to show *reduced* IL-6 signalling is causally associated with *lower* risk of TB.
Lead author @gushamilton.bsky.social
#TBSky #IDSky #ImmunoSky www.thelancet.com/journals/lan...
Thread 👇 (1/8)
Reposted by Jason Trubiano
The incredibly impressive Ouli Xie is presenting his PhD completion seminar on Monday Nov 25 at 12.30pm AEDT.
"The clinical, epidemiological, and evolutionary intersection between Streptococcus dysgalactiae subspecies equisimilis and Streptococcus pyogenes"
unimelb.zoom.us/j/8944229688...?
"The clinical, epidemiological, and evolutionary intersection between Streptococcus dysgalactiae subspecies equisimilis and Streptococcus pyogenes"
unimelb.zoom.us/j/8944229688...?
Join our Cloud HD Video Meeting
Zoom is the leader in modern enterprise video communications, with an easy, reliable cloud platform for video and audio conferencing, chat, and webinars across mobile, desktop, and room systems. Zoom ...
unimelb.zoom.us
November 22, 2024 at 3:52 AM
The incredibly impressive Ouli Xie is presenting his PhD completion seminar on Monday Nov 25 at 12.30pm AEDT.
"The clinical, epidemiological, and evolutionary intersection between Streptococcus dysgalactiae subspecies equisimilis and Streptococcus pyogenes"
unimelb.zoom.us/j/8944229688...?
"The clinical, epidemiological, and evolutionary intersection between Streptococcus dysgalactiae subspecies equisimilis and Streptococcus pyogenes"
unimelb.zoom.us/j/8944229688...?
Reposted by Jason Trubiano
Feels right that my 1st post here should be to share this incredible RCT, led by my PhD supervisor Nick Daneman:
www.nejm.org/doi/full/10....
Main takeaway: 7-days of abx should be the standard of care for patients with uncomplicated non-S. aureus BSI.
A deep dive 🧵:
#IDsky
www.nejm.org/doi/full/10....
Main takeaway: 7-days of abx should be the standard of care for patients with uncomplicated non-S. aureus BSI.
A deep dive 🧵:
#IDsky
Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections | NEJM
Bloodstream infections are associated with substantial morbidity and mortality. Early, appropriate antibiotic therapy is important, but the duration of treatment is uncertain. In a multicenter, non...
www.nejm.org
November 21, 2024 at 6:56 AM
Feels right that my 1st post here should be to share this incredible RCT, led by my PhD supervisor Nick Daneman:
www.nejm.org/doi/full/10....
Main takeaway: 7-days of abx should be the standard of care for patients with uncomplicated non-S. aureus BSI.
A deep dive 🧵:
#IDsky
www.nejm.org/doi/full/10....
Main takeaway: 7-days of abx should be the standard of care for patients with uncomplicated non-S. aureus BSI.
A deep dive 🧵:
#IDsky
Reposted by Jason Trubiano
Hi #IDSky! I’m putting together my usual top 10 ID papers of this year list again (this time will post here not in the other world).
Please tell me your candidate papers - practice changing paradigm shifting or dogma challenging!
Please tell me your candidate papers - practice changing paradigm shifting or dogma challenging!
November 21, 2024 at 8:45 PM
Hi #IDSky! I’m putting together my usual top 10 ID papers of this year list again (this time will post here not in the other world).
Please tell me your candidate papers - practice changing paradigm shifting or dogma challenging!
Please tell me your candidate papers - practice changing paradigm shifting or dogma challenging!
Thought worth a share on #WAAW @ncas.bsky.social day today. A practical guide to #penicillinallergy into inpatient #AMS programs. A partner to implementation! #IDSky #MedSky
pubmed.ncbi.nlm.nih.gov/39444148/
pubmed.ncbi.nlm.nih.gov/39444148/
Adult penicillin allergy programmes in Australian hospitals: a practical guide from the National Antibiotic Allergy Network - PubMed
Penicillin allergy is a significant burden on patient, prescribing and hospital outcomes. There has been increasing interest in the incorporation of penicillin allergy testing (i.e. delabelling) into ...
pubmed.ncbi.nlm.nih.gov
November 22, 2024 at 12:04 AM
Thought worth a share on #WAAW @ncas.bsky.social day today. A practical guide to #penicillinallergy into inpatient #AMS programs. A partner to implementation! #IDSky #MedSky
pubmed.ncbi.nlm.nih.gov/39444148/
pubmed.ncbi.nlm.nih.gov/39444148/
#WAAW kicking off at @ncas.bsky.social symposium today 🇦🇺. Looking forward to a great program and a lot of representation from team #AustinHealth #AMS #DrugAllergy
November 21, 2024 at 8:30 PM
#WAAW kicking off at @ncas.bsky.social symposium today 🇦🇺. Looking forward to a great program and a lot of representation from team #AustinHealth #AMS #DrugAllergy
