Andy Webb
@ajwpharm.bsky.social
Neurocritical Care Clinical Pharmacist MGH NeuroICU | BCCCP | Alum OHSU, Mayo, URI Pharmacy | #rstats | He/him | http://neurowiserx.com | #SkyRx | #MedSky | #PharmSky
Reposted by Andy Webb
www.nephjc.com/news/...
Check out the excellent #NephJC summary by @msocomd.bsky.social and @sejalplakhani.bsky.social
Check out the excellent #NephJC summary by @msocomd.bsky.social and @sejalplakhani.bsky.social
Dialyze Less, Recover More? AKI’s Chance to Get LIBERATE-D — NephJC
This week, we will discuss whether less is more when it comes to
discontinuing dialysis in patients with AKI and a chance to recover.
www.nephjc.com
December 17, 2025 at 2:04 AM
www.nephjc.com/news/...
Check out the excellent #NephJC summary by @msocomd.bsky.social and @sejalplakhani.bsky.social
Check out the excellent #NephJC summary by @msocomd.bsky.social and @sejalplakhani.bsky.social
AAN guidelines for functional seizure/PNES were just published, which covers a small group who end up in the unit
Key takeaways:
1️⃣ Median time to dx is 7-8 YEARS!
2️⃣ Pts can have both PNES & epilepsy
3️⃣ Psych/therapy can reduce PNES freq
4️⃣ Meds don't work for PNES
www.neurology.org/doi/10.1212/...
Key takeaways:
1️⃣ Median time to dx is 7-8 YEARS!
2️⃣ Pts can have both PNES & epilepsy
3️⃣ Psych/therapy can reduce PNES freq
4️⃣ Meds don't work for PNES
www.neurology.org/doi/10.1212/...
December 17, 2025 at 2:22 AM
AAN guidelines for functional seizure/PNES were just published, which covers a small group who end up in the unit
Key takeaways:
1️⃣ Median time to dx is 7-8 YEARS!
2️⃣ Pts can have both PNES & epilepsy
3️⃣ Psych/therapy can reduce PNES freq
4️⃣ Meds don't work for PNES
www.neurology.org/doi/10.1212/...
Key takeaways:
1️⃣ Median time to dx is 7-8 YEARS!
2️⃣ Pts can have both PNES & epilepsy
3️⃣ Psych/therapy can reduce PNES freq
4️⃣ Meds don't work for PNES
www.neurology.org/doi/10.1212/...
Reposted by Andy Webb
Thanks for at least serving as conference pro-con debate fodder for almost 10 years
Andexanet alfa, 2018-2025
Andexanet alfa, 2018-2025
December 11, 2025 at 2:12 PM
Thanks for at least serving as conference pro-con debate fodder for almost 10 years
Andexanet alfa, 2018-2025
Andexanet alfa, 2018-2025
End of an era, you will not be missed
December 11, 2025 at 1:49 AM
End of an era, you will not be missed
Reposted by Andy Webb
In a randomized trial involving critically ill patients undergoing intubation in EDs or ICUs, the use of ketamine for the induction of anesthesia did not lead to significantly lower in-hospital mortality than etomidate. Full trial results: nej.md/44EOlxB
@criticalcarereviews.com
@criticalcarereviews.com
December 10, 2025 at 12:20 AM
In a randomized trial involving critically ill patients undergoing intubation in EDs or ICUs, the use of ketamine for the induction of anesthesia did not lead to significantly lower in-hospital mortality than etomidate. Full trial results: nej.md/44EOlxB
@criticalcarereviews.com
@criticalcarereviews.com
Looking to learn more about aSAH care and get some CE credit? Tune in to my webinar today at 1pm or 8pm EST on nimodipine in aSAH
For my pharmacist friends - this is accredited for med safety! Tis the season to get your CEs
www.pharmacytimes.org/courses/unde...
For my pharmacist friends - this is accredited for med safety! Tis the season to get your CEs
www.pharmacytimes.org/courses/unde...
Pharmacy Times Continuing Education - PTCE
Free Continuing Education By Pharmacists For Pharmacists
www.pharmacytimes.org
December 4, 2025 at 1:51 PM
Looking to learn more about aSAH care and get some CE credit? Tune in to my webinar today at 1pm or 8pm EST on nimodipine in aSAH
For my pharmacist friends - this is accredited for med safety! Tis the season to get your CEs
www.pharmacytimes.org/courses/unde...
For my pharmacist friends - this is accredited for med safety! Tis the season to get your CEs
www.pharmacytimes.org/courses/unde...
Found on the same MAR
Which one will win!
Which one will win!
November 24, 2025 at 1:52 PM
Found on the same MAR
Which one will win!
Which one will win!
Petition to ban the phrase "maxed out on pressors"
There is not a max dose of any pressor
Sign below 👇🏼
There is not a max dose of any pressor
Sign below 👇🏼
November 20, 2025 at 2:24 PM
Petition to ban the phrase "maxed out on pressors"
There is not a max dose of any pressor
Sign below 👇🏼
There is not a max dose of any pressor
Sign below 👇🏼
Putting together a presentation on aSAH and I am always amazed re-reading the nimodipine trials just how different aSAH care is from how it was then
Mean time to azm clipping in British Aneurysm Trial was ~11 DAYS and they simply stopped tx if no azm was found
Best data we have 🤷
Mean time to azm clipping in British Aneurysm Trial was ~11 DAYS and they simply stopped tx if no azm was found
Best data we have 🤷
November 18, 2025 at 12:31 PM
Putting together a presentation on aSAH and I am always amazed re-reading the nimodipine trials just how different aSAH care is from how it was then
Mean time to azm clipping in British Aneurysm Trial was ~11 DAYS and they simply stopped tx if no azm was found
Best data we have 🤷
Mean time to azm clipping in British Aneurysm Trial was ~11 DAYS and they simply stopped tx if no azm was found
Best data we have 🤷
Excited to share our newest work on free VPA: improving ability to predict levels with the Fraser equation. We reveal that the orig eq. is modestly accurate in an external cohort and make improvements to the eq, but confirm measurement remains ideal
@cbthepharmd.bsky.social
doi.org/10.1002/phar...
@cbthepharmd.bsky.social
doi.org/10.1002/phar...
November 17, 2025 at 11:27 AM
Excited to share our newest work on free VPA: improving ability to predict levels with the Fraser equation. We reveal that the orig eq. is modestly accurate in an external cohort and make improvements to the eq, but confirm measurement remains ideal
@cbthepharmd.bsky.social
doi.org/10.1002/phar...
@cbthepharmd.bsky.social
doi.org/10.1002/phar...
Kicking off SOCHIMI 2025 in beautiful Pucon, Chile listening to Jason Roberts discuss PK/PD of antibiotics in the ICU
November 12, 2025 at 12:25 PM
Kicking off SOCHIMI 2025 in beautiful Pucon, Chile listening to Jason Roberts discuss PK/PD of antibiotics in the ICU
Reposted by Andy Webb
Augmented renal clearance (ARC) is so important, we all need to think about this more. 👌👌
ARC most commonly comes into play regarding antibiotics, but it can be relevant for any renally cleared drug.
ARC most commonly comes into play regarding antibiotics, but it can be relevant for any renally cleared drug.
1/ 👋 there #neurotwitter #neurosky #neurocritcare, as part of my @neurocritcarej #SoMeAmbassador role, today we will be breaking down the following article: link.springer.com/ar...
October 29, 2025 at 8:27 PM
Augmented renal clearance (ARC) is so important, we all need to think about this more. 👌👌
ARC most commonly comes into play regarding antibiotics, but it can be relevant for any renally cleared drug.
ARC most commonly comes into play regarding antibiotics, but it can be relevant for any renally cleared drug.
Do you use vasopression for MAP augmentation in your SCI patients?
In our newly published series, we describe significant hyponatremia frequently develops when used just to push up the MAP - quite literally induced SIADH
pubmed.ncbi.nlm.nih.gov/41051384/
In our newly published series, we describe significant hyponatremia frequently develops when used just to push up the MAP - quite literally induced SIADH
pubmed.ncbi.nlm.nih.gov/41051384/
October 7, 2025 at 6:42 PM
Do you use vasopression for MAP augmentation in your SCI patients?
In our newly published series, we describe significant hyponatremia frequently develops when used just to push up the MAP - quite literally induced SIADH
pubmed.ncbi.nlm.nih.gov/41051384/
In our newly published series, we describe significant hyponatremia frequently develops when used just to push up the MAP - quite literally induced SIADH
pubmed.ncbi.nlm.nih.gov/41051384/
Excited for #NCS2025! If you're attending, be sure to participate in the @neurocritical.bsky.social Social Media Contest to potential win some great prizes - see more below
www.neurocriticalcare.org/Events/Annua...
www.neurocriticalcare.org/Events/Annua...
September 16, 2025 at 12:49 PM
Excited for #NCS2025! If you're attending, be sure to participate in the @neurocritical.bsky.social Social Media Contest to potential win some great prizes - see more below
www.neurocriticalcare.org/Events/Annua...
www.neurocriticalcare.org/Events/Annua...
Have you seen the new package insert tenecteplase dosing for stroke? It uses broad-stroke dose rounding that we think may put patients at risk of harm - a 40 kg patient will get a dose 50% higher than intended! See our editorial published today in Cerebrovascular Diseases
karger.com/ced/article/...
karger.com/ced/article/...
August 28, 2025 at 7:03 PM
Have you seen the new package insert tenecteplase dosing for stroke? It uses broad-stroke dose rounding that we think may put patients at risk of harm - a 40 kg patient will get a dose 50% higher than intended! See our editorial published today in Cerebrovascular Diseases
karger.com/ced/article/...
karger.com/ced/article/...
Reposted by Andy Webb
Real-🌎 data in Veterans with fXaI-related ICH treated w/ andexanet alfa (AA; n=129) or 4F-PCC ( n=221)
🔷Propensity matched
🔷No difference in 90-day mortality
🔷⬆️30-day thrombotic events w/ AA (11.4 % vs. 2.4 %, p < 0.01)
Free 👉https://www.sciencedirect.com/science/article/pii/S073567572500498X
🔷Propensity matched
🔷No difference in 90-day mortality
🔷⬆️30-day thrombotic events w/ AA (11.4 % vs. 2.4 %, p < 0.01)
Free 👉https://www.sciencedirect.com/science/article/pii/S073567572500498X
Andexanet alfa increases 30-day thrombotic events relative to four-factor prothrombin complex concentrate for factor Xa inhibitors-related intracerebral hemorrhage in veterans
Two hemostatic agents are commonly used to reverse factor Xa (fXa) inhibitor-related intracranial hemorrhage (ICH): andexanet alfa (AA) or 4-factor pr…
www.sciencedirect.com
July 23, 2025 at 3:16 PM
Real-🌎 data in Veterans with fXaI-related ICH treated w/ andexanet alfa (AA; n=129) or 4F-PCC ( n=221)
🔷Propensity matched
🔷No difference in 90-day mortality
🔷⬆️30-day thrombotic events w/ AA (11.4 % vs. 2.4 %, p < 0.01)
Free 👉https://www.sciencedirect.com/science/article/pii/S073567572500498X
🔷Propensity matched
🔷No difference in 90-day mortality
🔷⬆️30-day thrombotic events w/ AA (11.4 % vs. 2.4 %, p < 0.01)
Free 👉https://www.sciencedirect.com/science/article/pii/S073567572500498X
Reposted by Andy Webb
🔥🔥Just published 🔥🔥
ATS CAP guidelines 2025
Diagnosis and Management of Community-acquired Pneumonia. An Official American Thoracic Society Clinical Practice Guideline
Free access pdf #IDsky#EMIMCC
www.atsjournals.org/doi/10.1164/...
ATS CAP guidelines 2025
Diagnosis and Management of Community-acquired Pneumonia. An Official American Thoracic Society Clinical Practice Guideline
Free access pdf #IDsky#EMIMCC
www.atsjournals.org/doi/10.1164/...
Diagnosis and Management of Community-acquired Pneumonia. An Official American Thoracic Society Clinical Practice Guideline | American Journal of Respiratory and Critical Care Medicine | Articles in P...
www.atsjournals.org
July 20, 2025 at 6:45 AM
🔥🔥Just published 🔥🔥
ATS CAP guidelines 2025
Diagnosis and Management of Community-acquired Pneumonia. An Official American Thoracic Society Clinical Practice Guideline
Free access pdf #IDsky#EMIMCC
www.atsjournals.org/doi/10.1164/...
ATS CAP guidelines 2025
Diagnosis and Management of Community-acquired Pneumonia. An Official American Thoracic Society Clinical Practice Guideline
Free access pdf #IDsky#EMIMCC
www.atsjournals.org/doi/10.1164/...
Ah nothing quite as useless as a clonidine patch being ordered for acute agitation
June 21, 2025 at 11:40 AM
Ah nothing quite as useless as a clonidine patch being ordered for acute agitation
Reposted by Andy Webb
Webb et al: Clinical Consequences of Disproportionate Free Valproate Elevation in Critically Ill Adult Patients: A Multicenter Retrospective Cohort Study
Link: link.springer.com/ar...
@neurocritical #neurocritcare
@AJWPharm
Link: link.springer.com/ar...
@neurocritical #neurocritcare
@AJWPharm
June 12, 2025 at 12:00 PM
Webb et al: Clinical Consequences of Disproportionate Free Valproate Elevation in Critically Ill Adult Patients: A Multicenter Retrospective Cohort Study
Link: link.springer.com/ar...
@neurocritical #neurocritcare
@AJWPharm
Link: link.springer.com/ar...
@neurocritical #neurocritcare
@AJWPharm
Excited to be speaking for @neurocritical.bsky.social on the treatment of SE with some phenomenal co-presenters. The Masterclass will have an interactive portion where participants can ask questions and join in discussion about treatment controversies!
www.neurocriticalcare.org/NCS-Learning...
www.neurocriticalcare.org/NCS-Learning...
June 11, 2025 at 4:09 PM
Excited to be speaking for @neurocritical.bsky.social on the treatment of SE with some phenomenal co-presenters. The Masterclass will have an interactive portion where participants can ask questions and join in discussion about treatment controversies!
www.neurocriticalcare.org/NCS-Learning...
www.neurocriticalcare.org/NCS-Learning...
Results of an important study
June 8, 2025 at 2:44 PM
Results of an important study
Reposted by Andy Webb
Reposted by Andy Webb
May 14, 2025 at 9:59 PM
Our team is expanding! One of our cardiology pharmacists is moving to a clinic position full time so are recruiting an additional full FTE inpatient cardiology pharmacist.
massgeneralbrigham.wd1.myworkdayjobs.com/en-US/MGBExt...
massgeneralbrigham.wd1.myworkdayjobs.com/en-US/MGBExt...
Clinical Pharmacist, Cardiology
Site: The General Hospital Corporation Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to adva...
massgeneralbrigham.wd1.myworkdayjobs.com
May 14, 2025 at 6:57 PM
Our team is expanding! One of our cardiology pharmacists is moving to a clinic position full time so are recruiting an additional full FTE inpatient cardiology pharmacist.
massgeneralbrigham.wd1.myworkdayjobs.com/en-US/MGBExt...
massgeneralbrigham.wd1.myworkdayjobs.com/en-US/MGBExt...