pedrojimenezb.bsky.social
@pedrojimenezb.bsky.social
Reposted
⚠️The right mutations at these sites can, on paper, significantly increase h-h transmission. That's why there needs to be immediate focus on this sample. It's somewhat unclear if the mutations occurred in this patient or prior to their infection.
November 16, 2024 at 7:25 PM
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Ok, this is actually concerning. The sequence of the hospitalized teen with H5N1 has been released. Both of these mutation sites are known to impact α2,6 binding that is needed for human to human transmissibility.

Need top experts on H5N1 to immediately to look into this.
Excellent summary thread here by @scottehensley.bsky.social. To add a few more important notes, the sequence (GISAID EPI_ISL_19548836) is ambiguous at *both* site Q226 (as Scott mentions above) and site E190 (H3 numbering)

Both these sites play an important role in sialic acid binding specificity
November 16, 2024 at 5:01 PM
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⚠️ BREAKING:

Oregon reports its first human case of H5N1 bird flu, according to the Oregon Health Authority.

The person was infected at a commercial poultry operation in Clackamas County.

55 cases have been reported nationwide this year.
November 15, 2024 at 8:58 PM
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Can't wait till they let Bird flu "rip" through the US with a massive mortality rate.
November 16, 2024 at 3:11 PM
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So how well do you think the Trump admin will handle bird flu if it goes fully human to human.
November 15, 2024 at 7:16 PM
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glad to know the bird flu epidemic will be in such capable hands
November 14, 2024 at 8:58 PM
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just ... absolute collapse of every source of countervailing power, and he hasn't even taken office yet
November 16, 2024 at 8:31 PM
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Flashback to the time Matt Gaetz tried to enter literal Chinese state propaganda into the record during a House hearing and was instantly called out for it
November 16, 2024 at 3:04 PM
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Today in Columbus, Ohio.
November 16, 2024 at 8:11 PM