Paul Watton
@paulwatton.bsky.social
I was "TheGodofPleasure" on Twitter.
I've had M.E. most of my adult life and am still trying to find a way out of it.
I believe that Prof. Bhupesh Prusty is close to providing the answers.
I've had M.E. most of my adult life and am still trying to find a way out of it.
I believe that Prof. Bhupesh Prusty is close to providing the answers.
Reposted by Paul Watton
It is sad to see @bmj.com platforming quack therapies in 2025
The mind-over-matter approach to #MECFS has been debunked for years, but a cadre of psych devotees in the UK persist in peddling evidence-free miracle cures
Pure and utter pseudoscience
#pwME #LongCovid @georgemonbiot.bsky.social
The mind-over-matter approach to #MECFS has been debunked for years, but a cadre of psych devotees in the UK persist in peddling evidence-free miracle cures
Pure and utter pseudoscience
#pwME #LongCovid @georgemonbiot.bsky.social
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) affects around 250 000 people in the UK.
Reframing beliefs about illness, along with specialist rehabilitation, can help recovery in people with severe ME/CFS, @paulgarnerwoof.bsky.social and colleagues
www.bmj.com/content/389/...
Reframing beliefs about illness, along with specialist rehabilitation, can help recovery in people with severe ME/CFS, @paulgarnerwoof.bsky.social and colleagues
www.bmj.com/content/389/...
May 14, 2025 at 4:32 PM
It is sad to see @bmj.com platforming quack therapies in 2025
The mind-over-matter approach to #MECFS has been debunked for years, but a cadre of psych devotees in the UK persist in peddling evidence-free miracle cures
Pure and utter pseudoscience
#pwME #LongCovid @georgemonbiot.bsky.social
The mind-over-matter approach to #MECFS has been debunked for years, but a cadre of psych devotees in the UK persist in peddling evidence-free miracle cures
Pure and utter pseudoscience
#pwME #LongCovid @georgemonbiot.bsky.social
Reposted by Paul Watton
#MECFSAwarenessMonth – Day 13
2015: A landmark report in the US reviews 9,000+ studies and concludes ME/CFS is a “serious, chronic, complex” disease — not psychiatric. It identifies post-exertional malaise as a key diagnostic feature and helps shift understanding.
2015: A landmark report in the US reviews 9,000+ studies and concludes ME/CFS is a “serious, chronic, complex” disease — not psychiatric. It identifies post-exertional malaise as a key diagnostic feature and helps shift understanding.
May 13, 2025 at 7:09 AM
#MECFSAwarenessMonth – Day 13
2015: A landmark report in the US reviews 9,000+ studies and concludes ME/CFS is a “serious, chronic, complex” disease — not psychiatric. It identifies post-exertional malaise as a key diagnostic feature and helps shift understanding.
2015: A landmark report in the US reviews 9,000+ studies and concludes ME/CFS is a “serious, chronic, complex” disease — not psychiatric. It identifies post-exertional malaise as a key diagnostic feature and helps shift understanding.
Reposted by Paul Watton
#MECFSAwarenessMonth – Day 12
2011: Ian Gibson MP highlights a high-level block on biomedical #MECFS research. A study also reveals nurses’ frustration delivering psychological treatments — one supervisor reported a feeling of, “the bastards don’t want to get better.”
2011: Ian Gibson MP highlights a high-level block on biomedical #MECFS research. A study also reveals nurses’ frustration delivering psychological treatments — one supervisor reported a feeling of, “the bastards don’t want to get better.”
May 12, 2025 at 6:12 AM
#MECFSAwarenessMonth – Day 12
2011: Ian Gibson MP highlights a high-level block on biomedical #MECFS research. A study also reveals nurses’ frustration delivering psychological treatments — one supervisor reported a feeling of, “the bastards don’t want to get better.”
2011: Ian Gibson MP highlights a high-level block on biomedical #MECFS research. A study also reveals nurses’ frustration delivering psychological treatments — one supervisor reported a feeling of, “the bastards don’t want to get better.”
Reposted by Paul Watton
#MECFSAwarenessMonth – Day 11
The Science Media Centre, which has strong ties to Wessely, launches a media campaign portraying #MECFS patients as dangerous activists who threaten researchers - it discredits patients and diverts attention from valid concerns about research.
The Science Media Centre, which has strong ties to Wessely, launches a media campaign portraying #MECFS patients as dangerous activists who threaten researchers - it discredits patients and diverts attention from valid concerns about research.
May 11, 2025 at 6:44 AM
#MECFSAwarenessMonth – Day 11
The Science Media Centre, which has strong ties to Wessely, launches a media campaign portraying #MECFS patients as dangerous activists who threaten researchers - it discredits patients and diverts attention from valid concerns about research.
The Science Media Centre, which has strong ties to Wessely, launches a media campaign portraying #MECFS patients as dangerous activists who threaten researchers - it discredits patients and diverts attention from valid concerns about research.
Reposted by Paul Watton
The problem we have about health is that it’s marketed as this personal thing & conceptualised as the result of what you do to yourself or what individually happens to you -your bad luck-
But health is largely a collective expression of our environment & circumstances. This requires societal action.
But health is largely a collective expression of our environment & circumstances. This requires societal action.
May 6, 2025 at 2:22 PM
The problem we have about health is that it’s marketed as this personal thing & conceptualised as the result of what you do to yourself or what individually happens to you -your bad luck-
But health is largely a collective expression of our environment & circumstances. This requires societal action.
But health is largely a collective expression of our environment & circumstances. This requires societal action.
Reposted by Paul Watton
#MECFSAwarenessMonth – Day 6
1993-96: Wessely lobbied the UK government to reject ME as a neurological disorder and led an influential report that downplayed biomedical causes, pushed psychological treatments, and resulted in the virtual disappearance of ME for the next decade.
1993-96: Wessely lobbied the UK government to reject ME as a neurological disorder and led an influential report that downplayed biomedical causes, pushed psychological treatments, and resulted in the virtual disappearance of ME for the next decade.
May 6, 2025 at 6:09 AM
#MECFSAwarenessMonth – Day 6
1993-96: Wessely lobbied the UK government to reject ME as a neurological disorder and led an influential report that downplayed biomedical causes, pushed psychological treatments, and resulted in the virtual disappearance of ME for the next decade.
1993-96: Wessely lobbied the UK government to reject ME as a neurological disorder and led an influential report that downplayed biomedical causes, pushed psychological treatments, and resulted in the virtual disappearance of ME for the next decade.
Zhu et al. (2025) highlights declining levels of Plasma Fibronectin in the progression of #Parkinsons
Its findings complement & reinforce the broader point made by @BhupeshPrusty regarding the biological significance of circulating Fn in chronic neuroimmune diseases.
www.nature.com/articles/s41...
Its findings complement & reinforce the broader point made by @BhupeshPrusty regarding the biological significance of circulating Fn in chronic neuroimmune diseases.
www.nature.com/articles/s41...
Plasma fibronectin is a prognostic biomarker of disability in Parkinson’s disease: a prospective, multicenter cohort study - npj Parkinson's Disease
npj Parkinson's Disease - Plasma fibronectin is a prognostic biomarker of disability in Parkinson’s disease: a prospective, multicenter cohort study
www.nature.com
May 5, 2025 at 11:23 AM
Zhu et al. (2025) highlights declining levels of Plasma Fibronectin in the progression of #Parkinsons
Its findings complement & reinforce the broader point made by @BhupeshPrusty regarding the biological significance of circulating Fn in chronic neuroimmune diseases.
www.nature.com/articles/s41...
Its findings complement & reinforce the broader point made by @BhupeshPrusty regarding the biological significance of circulating Fn in chronic neuroimmune diseases.
www.nature.com/articles/s41...
Reposted by Paul Watton
I’d counter by having pensioners sent to classes on climate change, trade economics and the histories of slavery and colonialism. Two can play at this game.
May 4, 2025 at 8:39 AM
I’d counter by having pensioners sent to classes on climate change, trade economics and the histories of slavery and colonialism. Two can play at this game.
Reposted by Paul Watton
Why might Epstein-Barr virus infection lead to ME/CFS in some people and not in others?
30% of ME/CFS cases associated with an infection are thought to be due to Epstein–Barr virus (EBV) – but not everyone who has an EBV infection develops ME/CFS.
Researchers
www.meresearch.org.uk/why-might-ep...
30% of ME/CFS cases associated with an infection are thought to be due to Epstein–Barr virus (EBV) – but not everyone who has an EBV infection develops ME/CFS.
Researchers
www.meresearch.org.uk/why-might-ep...
Why might Epstein-Barr virus infection lead to ME/CFS in some people and not in others?
www.meresearch.org.uk
April 24, 2025 at 2:47 PM
Why might Epstein-Barr virus infection lead to ME/CFS in some people and not in others?
30% of ME/CFS cases associated with an infection are thought to be due to Epstein–Barr virus (EBV) – but not everyone who has an EBV infection develops ME/CFS.
Researchers
www.meresearch.org.uk/why-might-ep...
30% of ME/CFS cases associated with an infection are thought to be due to Epstein–Barr virus (EBV) – but not everyone who has an EBV infection develops ME/CFS.
Researchers
www.meresearch.org.uk/why-might-ep...
Too often #Psychiatry is a menace to good science.
Too frequently, they're the shoddy "First Colonisers" of the knowledge void.
Too easily, they fill it with Patient-blaming crap, which takes too long to debunk.
Only then can the groundbreaking work of competent scientists take root.
bit.ly/4lBoKwB
Too frequently, they're the shoddy "First Colonisers" of the knowledge void.
Too easily, they fill it with Patient-blaming crap, which takes too long to debunk.
Only then can the groundbreaking work of competent scientists take root.
bit.ly/4lBoKwB
Dissecting the genetic complexity of myalgic encephalomyelitis/chronic fatigue syndrome via deep learning-powered genome analysis
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex, heterogeneous, and systemic disease defined by a suite of symptoms, including unexplained persistent fatigue, post-exertional ...
bit.ly
April 18, 2025 at 8:18 AM
Too often #Psychiatry is a menace to good science.
Too frequently, they're the shoddy "First Colonisers" of the knowledge void.
Too easily, they fill it with Patient-blaming crap, which takes too long to debunk.
Only then can the groundbreaking work of competent scientists take root.
bit.ly/4lBoKwB
Too frequently, they're the shoddy "First Colonisers" of the knowledge void.
Too easily, they fill it with Patient-blaming crap, which takes too long to debunk.
Only then can the groundbreaking work of competent scientists take root.
bit.ly/4lBoKwB
This is the story of how the Pumpkin-headed buffoon in the Whitehouse, was completely outmanoeuvred and consequently forced to rescind his bullying imposition of trade #Tariffs
I guarantee that it will make you smile. 😇
#dumbfuck #Capitulation #Humiliation
deanblundell.substack.com/p/carneys-ch...
I guarantee that it will make you smile. 😇
#dumbfuck #Capitulation #Humiliation
deanblundell.substack.com/p/carneys-ch...
Carney’s Checkmate: How Canada's Quiet Bond Play Forced Trump to Drop Tariffs
Carney, Japan And The EU proved America's Idiot Emperor Has No Clothes
deanblundell.substack.com
April 13, 2025 at 6:59 AM
This is the story of how the Pumpkin-headed buffoon in the Whitehouse, was completely outmanoeuvred and consequently forced to rescind his bullying imposition of trade #Tariffs
I guarantee that it will make you smile. 😇
#dumbfuck #Capitulation #Humiliation
deanblundell.substack.com/p/carneys-ch...
I guarantee that it will make you smile. 😇
#dumbfuck #Capitulation #Humiliation
deanblundell.substack.com/p/carneys-ch...
Reposted by Paul Watton
Import Chinese battery: 145% tariff
Import Chinese battery inside Chinese laptop: 20% tariff
Import Chinese battery inside Vietnamese laptop: 0% tariff
Fuckin brilliant. A+ work here team. I am so glad there are such smart people working on our trade policy.
Import Chinese battery inside Chinese laptop: 20% tariff
Import Chinese battery inside Vietnamese laptop: 0% tariff
Fuckin brilliant. A+ work here team. I am so glad there are such smart people working on our trade policy.
April 12, 2025 at 3:11 PM
Import Chinese battery: 145% tariff
Import Chinese battery inside Chinese laptop: 20% tariff
Import Chinese battery inside Vietnamese laptop: 0% tariff
Fuckin brilliant. A+ work here team. I am so glad there are such smart people working on our trade policy.
Import Chinese battery inside Chinese laptop: 20% tariff
Import Chinese battery inside Vietnamese laptop: 0% tariff
Fuckin brilliant. A+ work here team. I am so glad there are such smart people working on our trade policy.
Reposted by Paul Watton
In addition to discovering and reproducing detailed long COVID genetic associations for the first time, PrecisionLife researchers were also the first to identify genetic risk factors for ME/CFS.
To learn more about our research into long COVID and ME/CFS, visit precisionlife.com/longcovid-me
To learn more about our research into long COVID and ME/CFS, visit precisionlife.com/longcovid-me
Unraveling the Biological Drivers of ME and Long COVID | PrecisionLife
We have identified different genetic mechanisms causing ME/CFS and Long COVID and used this to stratify patients. Learn more about our research.
precisionlife.com
February 28, 2025 at 11:52 AM
In addition to discovering and reproducing detailed long COVID genetic associations for the first time, PrecisionLife researchers were also the first to identify genetic risk factors for ME/CFS.
To learn more about our research into long COVID and ME/CFS, visit precisionlife.com/longcovid-me
To learn more about our research into long COVID and ME/CFS, visit precisionlife.com/longcovid-me
Reposted by Paul Watton
Last week we shared a significant advancement in our understanding of long COVID and its implications for precision medicine.
This breakthrough exemplifies our commitment to driving precision medicine in complex chronic diseases, offering hope to billions affected worldwide.
#PrecisionMedicine
This breakthrough exemplifies our commitment to driving precision medicine in complex chronic diseases, offering hope to billions affected worldwide.
#PrecisionMedicine
March 7, 2025 at 11:04 AM
Last week we shared a significant advancement in our understanding of long COVID and its implications for precision medicine.
This breakthrough exemplifies our commitment to driving precision medicine in complex chronic diseases, offering hope to billions affected worldwide.
#PrecisionMedicine
This breakthrough exemplifies our commitment to driving precision medicine in complex chronic diseases, offering hope to billions affected worldwide.
#PrecisionMedicine
Epigenetic "reprogramming" of immune cells by Epstein Barr Virus is probably what initiates the cascade of events which culminates in the disease known as #MEcfs
Even after decades of neglecting Patients, the Medical Profession are far too slow to wake up to this reality
app.box.com/s/a0ya16d5h8...
Even after decades of neglecting Patients, the Medical Profession are far too slow to wake up to this reality
app.box.com/s/a0ya16d5h8...
Epigenetic alteration of cells of the immune system by Epstein Barr Virus infection.docx | Powered by Box
app.box.com
April 4, 2025 at 3:23 PM
Epigenetic "reprogramming" of immune cells by Epstein Barr Virus is probably what initiates the cascade of events which culminates in the disease known as #MEcfs
Even after decades of neglecting Patients, the Medical Profession are far too slow to wake up to this reality
app.box.com/s/a0ya16d5h8...
Even after decades of neglecting Patients, the Medical Profession are far too slow to wake up to this reality
app.box.com/s/a0ya16d5h8...
Reposted by Paul Watton
The involvement of microRNAs in the pathogenesis of #MEcfs cannot be ignored.
The altered expression of these Non-coding RNAs in ME/cfs patients has a profound impact on several bodily systems via their regulatory pathways.
Here's my take on what we currently know:
app.box.com/s/engwwo7me9...
The altered expression of these Non-coding RNAs in ME/cfs patients has a profound impact on several bodily systems via their regulatory pathways.
Here's my take on what we currently know:
app.box.com/s/engwwo7me9...
The Evidence for the Role of Non-Coding RNAs in the Pathogenesis of MEcfs.docx | Powered by Box
app.box.com
April 1, 2025 at 6:45 AM
The involvement of microRNAs in the pathogenesis of #MEcfs cannot be ignored.
The altered expression of these Non-coding RNAs in ME/cfs patients has a profound impact on several bodily systems via their regulatory pathways.
Here's my take on what we currently know:
app.box.com/s/engwwo7me9...
The altered expression of these Non-coding RNAs in ME/cfs patients has a profound impact on several bodily systems via their regulatory pathways.
Here's my take on what we currently know:
app.box.com/s/engwwo7me9...
Reposted by Paul Watton
Registration for online participation in the @mecfsresearch.bsky.social International ME/CFS Conference 2025 on 12-13 May 2025 is now open
events.mecfs-research.org/en/events/co...
Image is from the latest Science for ME weekly update
#MEcfs #LongCovid
events.mecfs-research.org/en/events/co...
Image is from the latest Science for ME weekly update
#MEcfs #LongCovid
March 31, 2025 at 1:15 AM
Registration for online participation in the @mecfsresearch.bsky.social International ME/CFS Conference 2025 on 12-13 May 2025 is now open
events.mecfs-research.org/en/events/co...
Image is from the latest Science for ME weekly update
#MEcfs #LongCovid
events.mecfs-research.org/en/events/co...
Image is from the latest Science for ME weekly update
#MEcfs #LongCovid
For decades, I've been (wrongly) led to believe that latent Herpes virus infections and Gilbert's Syndrome are both benign.
It now transpires that both are potentially contributory factors in the pathogenesis of #MEcfs
Here's my hypothesis:
app.box.com/s/korv1z60yy...
It now needs to be tested.
It now transpires that both are potentially contributory factors in the pathogenesis of #MEcfs
Here's my hypothesis:
app.box.com/s/korv1z60yy...
It now needs to be tested.
March 28, 2025 at 5:15 AM
For decades, I've been (wrongly) led to believe that latent Herpes virus infections and Gilbert's Syndrome are both benign.
It now transpires that both are potentially contributory factors in the pathogenesis of #MEcfs
Here's my hypothesis:
app.box.com/s/korv1z60yy...
It now needs to be tested.
It now transpires that both are potentially contributory factors in the pathogenesis of #MEcfs
Here's my hypothesis:
app.box.com/s/korv1z60yy...
It now needs to be tested.
Reposted by Paul Watton
An important assertion in this statement is that the flight to Louisiana occurred on Wednesday morning. The district court ordered that she not to be moved out of Massachusetts on Tuesday.
New from Rumeysa Ozturk's lawyer:
Rumeysa hasn't been accused of any crime & "DHS has not produced any evidence" that she did anything unlawful.
Rumeysa wasn't able to speak to her lawyer for 24+ hours & not until after she was in Louisiana — despite a court order that she not be moved from Mass.
Rumeysa hasn't been accused of any crime & "DHS has not produced any evidence" that she did anything unlawful.
Rumeysa wasn't able to speak to her lawyer for 24+ hours & not until after she was in Louisiana — despite a court order that she not be moved from Mass.
March 28, 2025 at 3:10 AM
An important assertion in this statement is that the flight to Louisiana occurred on Wednesday morning. The district court ordered that she not to be moved out of Massachusetts on Tuesday.
Reposted by Paul Watton
Reposted by Paul Watton
I’m finding it very hard to understand the stance of the Royal Society here. Science is part of society, not separate from it, existing in some strange metaphysical bubble. I look across the Atlantic, aghast at the damage being done to science and scientists.
www.theguardian.com/technology/2...
www.theguardian.com/technology/2...
Royal Society decides not to take disciplinary action against Elon Musk
Exclusive: Fellows argue Musk has violated code of conduct but council believes investigation ‘could do more harm than good’
www.theguardian.com
March 26, 2025 at 8:44 AM
I’m finding it very hard to understand the stance of the Royal Society here. Science is part of society, not separate from it, existing in some strange metaphysical bubble. I look across the Atlantic, aghast at the damage being done to science and scientists.
www.theguardian.com/technology/2...
www.theguardian.com/technology/2...
The question must be asked by Congress:
"What did he know and when did he know it."
apnews.com/article/trum...
"What did he know and when did he know it."
apnews.com/article/trum...
Trump downplays national security team texting military operation plan on Signal as a minor 'glitch'
President Donald Trump told NBC News that the lapse “turned out not to be a serious one," and expressed his continued support for national security adviser Mike Waltz.
apnews.com
March 26, 2025 at 12:51 PM
The question must be asked by Congress:
"What did he know and when did he know it."
apnews.com/article/trum...
"What did he know and when did he know it."
apnews.com/article/trum...
For 30+ years, #MEcfs has been largely ignored, because researchers haven't had the tools to enable them to understand it.
With the advent of VISOR-CyTOF, the full extent of the consequences of Herpesvirus infection on the cells of the immune system can now be explored.
www.cell.com/cell-reports...
With the advent of VISOR-CyTOF, the full extent of the consequences of Herpesvirus infection on the cells of the immune system can now be explored.
www.cell.com/cell-reports...
March 24, 2025 at 8:13 AM
For 30+ years, #MEcfs has been largely ignored, because researchers haven't had the tools to enable them to understand it.
With the advent of VISOR-CyTOF, the full extent of the consequences of Herpesvirus infection on the cells of the immune system can now be explored.
www.cell.com/cell-reports...
With the advent of VISOR-CyTOF, the full extent of the consequences of Herpesvirus infection on the cells of the immune system can now be explored.
www.cell.com/cell-reports...
Reposted by Paul Watton
This is what anti-Palestinian racism and dehumanization looks like.
March 21, 2025 at 4:11 AM
This is what anti-Palestinian racism and dehumanization looks like.