Pat Sharp
@patsharp.bsky.social
Drug developer | Co-founder of Gate Bio | Fmr Big Pharma | Inventing small molecule medicines | Artist | Polymath
When are all the US scientists moving to Australia?
I don’t know who needs to hear this but the CDC is being eviscerated right now. America is not going to have any kind of outbreak response capacity after tonight. Americans’ health data is no longer secure. Say goodbye to federal public health in any capacity. It’s a disaster. We won’t recover.
October 11, 2025 at 10:54 AM
When are all the US scientists moving to Australia?
That new name…Genetix…wow
Bye Bye Bluebird: Gene Therapy Biotech Emerges From Private Buyout With Rebrand | #biotech #BiotechNews
Bye Bye Bluebird: Gene Therapy Biotech Emerges From Private Buyout With Rebrand
Bluebird bio has re-emerged after a private equity buyout as Genetix Biotherapeutics, marking a return to its roots and a new path forward for manufacturing.
www.biospace.com
September 21, 2025 at 7:21 AM
That new name…Genetix…wow
If someone argues that living “in nature” is inherently healthier, cats and dogs provide a counterexample: they clearly live longer, on average, when removed from “natural” conditions.
September 14, 2025 at 8:37 PM
If someone argues that living “in nature” is inherently healthier, cats and dogs provide a counterexample: they clearly live longer, on average, when removed from “natural” conditions.
You’ve got to be kidding - I’m good thanks
As modern warfare weaponizes the very air we breathe, chemists should leverage their skills and knowledge to detect, neutralize, and reclaim toxic atmospheres in the world’s most devastated conflict zones. cen.acs.org/environment/... #chemsky 🧪
A new role for chemists: Tackling toxic air in conflict zones
As modern warfare weaponizes the very air we breathe, chemists should leverage their skills and knowledge to detect, neutralize, and reclaim toxic atmospheres in the world’s most devastated conflict z...
cen.acs.org
August 12, 2025 at 5:20 AM
You’ve got to be kidding - I’m good thanks
Everyone wants to meet on Zoom again, rather than in person.
Has the promise of the return to office in-person productivity and relationship building failed to deliver?
Has the promise of the return to office in-person productivity and relationship building failed to deliver?
June 19, 2025 at 5:22 AM
Everyone wants to meet on Zoom again, rather than in person.
Has the promise of the return to office in-person productivity and relationship building failed to deliver?
Has the promise of the return to office in-person productivity and relationship building failed to deliver?
The origin from chirality - from amino acids to pasta 🍝
I made a survey over at Mastodon and found that Fusilli are mostly right-handed spirals, but about a third of the brands is left-handed.
So far there seems to be no racemic Fusilli brand. Pasta producerst have achieved a degree of enantiomeric purity chemists can only dream of.
🧪
#chemsky
So far there seems to be no racemic Fusilli brand. Pasta producerst have achieved a degree of enantiomeric purity chemists can only dream of.
🧪
#chemsky
What about pasta salad? Are Fusilli enantiomerically pure? And if so, are there brands which sell D-Fusilli and others that sell L-Fusilli? Has anyone ever researched that?
#chemsky
🧪
#chemsky
🧪
May 31, 2025 at 11:49 AM
The origin from chirality - from amino acids to pasta 🍝
The Shine Dome - home of the Australian Academy of Science - Canberra ACT.
It’s my favourite building in Australia.
I’d love to give a seminar here one day.
#chemsky #australia #science #architecture
It’s my favourite building in Australia.
I’d love to give a seminar here one day.
#chemsky #australia #science #architecture
April 28, 2025 at 4:00 AM
The Shine Dome - home of the Australian Academy of Science - Canberra ACT.
It’s my favourite building in Australia.
I’d love to give a seminar here one day.
#chemsky #australia #science #architecture
It’s my favourite building in Australia.
I’d love to give a seminar here one day.
#chemsky #australia #science #architecture
Chat getting better at organic molecules.
Asked for alprazolam. Got the chlorine atom. Almost got the benzodiazepine and almost got the triazole.
How many months until it starts to nail it?
Asked for alprazolam. Got the chlorine atom. Almost got the benzodiazepine and almost got the triazole.
How many months until it starts to nail it?
April 16, 2025 at 9:32 PM
Chat getting better at organic molecules.
Asked for alprazolam. Got the chlorine atom. Almost got the benzodiazepine and almost got the triazole.
How many months until it starts to nail it?
Asked for alprazolam. Got the chlorine atom. Almost got the benzodiazepine and almost got the triazole.
How many months until it starts to nail it?
I was thinking about how we draw organic molecules — those 2D skeletal structures we all know — and I stumbled into an old mathematical idea that made me stop in my tracks.
Turns out, the number of continuous lines you need to draw any molecule can be predicted.
Turns out, the number of continuous lines you need to draw any molecule can be predicted.
April 16, 2025 at 4:08 PM
I was thinking about how we draw organic molecules — those 2D skeletal structures we all know — and I stumbled into an old mathematical idea that made me stop in my tracks.
Turns out, the number of continuous lines you need to draw any molecule can be predicted.
Turns out, the number of continuous lines you need to draw any molecule can be predicted.
50g ATP processed in a few SECONDS…gone…let that sink in.
Muscles
Muscles
April 7, 2025 at 5:44 AM
50g ATP processed in a few SECONDS…gone…let that sink in.
Muscles
Muscles
Reposted by Pat Sharp
One thing you can count on from me is to share great synthesis. While we may be competitors, I’ll highlight this review of #MerckChemistry innovations in #JOCasap from my respected industry colleague and friend @drlcsquare.bsky.social The work here is inspiring and drives us to our best #ChemSky
From Cortisone to Enlicitide: A Journey of Synthetic Chemistry Innovations at Merck
Necessity is the mother of invention. Most synthetic chemistry innovations are driven by our desire to make molecules. In the first half of the 20th century, much of this work was inspired by natural ...
pubs.acs.org
April 1, 2025 at 10:42 PM
One thing you can count on from me is to share great synthesis. While we may be competitors, I’ll highlight this review of #MerckChemistry innovations in #JOCasap from my respected industry colleague and friend @drlcsquare.bsky.social The work here is inspiring and drives us to our best #ChemSky
Any progress on new approaches to pain are welcomed.
Here I like that chemical modification affecting the distribution is a key design principle.
www.nature.com/articles/s41...
Here I like that chemical modification affecting the distribution is a key design principle.
www.nature.com/articles/s41...
March 15, 2025 at 1:03 AM
Any progress on new approaches to pain are welcomed.
Here I like that chemical modification affecting the distribution is a key design principle.
www.nature.com/articles/s41...
Here I like that chemical modification affecting the distribution is a key design principle.
www.nature.com/articles/s41...
Pretty impressive. Would be useful for organizing competitive patent data.
Chemistry is changed by AI at a super rapid pace! Check our data miner for chemical reactions, MERMaid!
@accelerationc.bsky.social @thematterlab.bsky.social @shixuanleong.bsky.social #chemsky #compchemski #ai #vlm #llm #aiforscience Please follow @thematterlab.bsky.social
@accelerationc.bsky.social @thematterlab.bsky.social @shixuanleong.bsky.social #chemsky #compchemski #ai #vlm #llm #aiforscience Please follow @thematterlab.bsky.social
Now out on ChemRxiv: doi.org/10.26434/che...
Authors: @shixuanleong.bsky.social, Sergio Pablo-García, Brandon Wong, @aspuru.bsky.social
Authors: @shixuanleong.bsky.social, Sergio Pablo-García, Brandon Wong, @aspuru.bsky.social
March 15, 2025 at 12:59 AM
Pretty impressive. Would be useful for organizing competitive patent data.
Reposted by Pat Sharp
The story of Taxol another NIH gift that saved millions of lives - In the 1960 the National Cancer Institute led a search for plant based medicines that could help fight cancer - that was when four botanists collecting samples from plants native to the US west coast came across Western Yew tree 🧵
March 13, 2025 at 12:01 PM
The story of Taxol another NIH gift that saved millions of lives - In the 1960 the National Cancer Institute led a search for plant based medicines that could help fight cancer - that was when four botanists collecting samples from plants native to the US west coast came across Western Yew tree 🧵
Don’t want to overhype this. But it’s certainly interesting.
“Notably, we demonstrated the relevance of this FABP5-mTORC1 signaling pathway in vivo by feeding animals a diet enriched for safflower oil that promoted TNBC tumor growth.”
“Notably, we demonstrated the relevance of this FABP5-mTORC1 signaling pathway in vivo by feeding animals a diet enriched for safflower oil that promoted TNBC tumor growth.”
How a fat in our diet (omega-6 linoleic acid)—a dietary long-chain polyunsaturated fatty acid) has the potential to promote tumor growth www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
@science.org
www.science.org/doi/10.1126/...
@science.org
March 14, 2025 at 12:24 AM
Don’t want to overhype this. But it’s certainly interesting.
“Notably, we demonstrated the relevance of this FABP5-mTORC1 signaling pathway in vivo by feeding animals a diet enriched for safflower oil that promoted TNBC tumor growth.”
“Notably, we demonstrated the relevance of this FABP5-mTORC1 signaling pathway in vivo by feeding animals a diet enriched for safflower oil that promoted TNBC tumor growth.”
Psychedelics might be a good starting point for this project.
Someone needs to invent a pharmaceutical drug that treats greed, which I consider to be a mental illness.
Prove God wrong.
Prove God wrong.
March 14, 2025 at 12:09 AM
Psychedelics might be a good starting point for this project.
Looks like the residue in the bottom of the flask during my PhD
Now online:
Article by Zi-Yuan Wang, Yi-Ze Xu, Zhanpeng Cui, Luo Zhang, Jia-Yu Lu, Yu-Qing Zheng & Rong Zhu
Chain-growth synthesis of extensively cross-conjugated polyenes
www.nature.com/articles/s44...
#ChemSky
Article by Zi-Yuan Wang, Yi-Ze Xu, Zhanpeng Cui, Luo Zhang, Jia-Yu Lu, Yu-Qing Zheng & Rong Zhu
Chain-growth synthesis of extensively cross-conjugated polyenes
www.nature.com/articles/s44...
#ChemSky
Chain-growth synthesis of extensively cross-conjugated polyenes - Nature Synthesis
The synthesis of long dendralene skeletons is made possible by a copper-mediated chain-growth polymerization of strained [3]cumulenes. These extensively cross-conjugated molecules enable visible-range...
www.nature.com
March 12, 2025 at 9:17 AM
Looks like the residue in the bottom of the flask during my PhD