Pat Sharp
@patsharp.bsky.social
Drug developer | Co-founder of Gate Bio | Fmr Big Pharma | Inventing small molecule medicines | Artist | Polymath
The Shine Dome - home of the Australian Academy of Science - Canberra ACT.
It’s my favourite building in Australia.
I’d love to give a seminar here one day.
#chemsky #australia #science #architecture
It’s my favourite building in Australia.
I’d love to give a seminar here one day.
#chemsky #australia #science #architecture
April 28, 2025 at 4:00 AM
The Shine Dome - home of the Australian Academy of Science - Canberra ACT.
It’s my favourite building in Australia.
I’d love to give a seminar here one day.
#chemsky #australia #science #architecture
It’s my favourite building in Australia.
I’d love to give a seminar here one day.
#chemsky #australia #science #architecture
Chat getting better at organic molecules.
Asked for alprazolam. Got the chlorine atom. Almost got the benzodiazepine and almost got the triazole.
How many months until it starts to nail it?
Asked for alprazolam. Got the chlorine atom. Almost got the benzodiazepine and almost got the triazole.
How many months until it starts to nail it?
April 16, 2025 at 9:32 PM
Chat getting better at organic molecules.
Asked for alprazolam. Got the chlorine atom. Almost got the benzodiazepine and almost got the triazole.
How many months until it starts to nail it?
Asked for alprazolam. Got the chlorine atom. Almost got the benzodiazepine and almost got the triazole.
How many months until it starts to nail it?
50g ATP processed in a few SECONDS…gone…let that sink in.
Muscles
Muscles
April 7, 2025 at 5:44 AM
50g ATP processed in a few SECONDS…gone…let that sink in.
Muscles
Muscles
Any progress on new approaches to pain are welcomed.
Here I like that chemical modification affecting the distribution is a key design principle.
www.nature.com/articles/s41...
Here I like that chemical modification affecting the distribution is a key design principle.
www.nature.com/articles/s41...
March 15, 2025 at 1:03 AM
Any progress on new approaches to pain are welcomed.
Here I like that chemical modification affecting the distribution is a key design principle.
www.nature.com/articles/s41...
Here I like that chemical modification affecting the distribution is a key design principle.
www.nature.com/articles/s41...
March 10, 2025 at 1:54 AM
chatGPT spat this out. Still trying to verify it. Looks reasonable enough by an eyeball test, although THF looks high (higher than thiazole?).
March 10, 2025 at 1:47 AM
chatGPT spat this out. Still trying to verify it. Looks reasonable enough by an eyeball test, although THF looks high (higher than thiazole?).
VLE (Volume Ligand Efficiency)? It’s a little known metric in drug design that helps predict low human dose compounds by balancing potency and unbound exposure. It refines drug selection early-ish in lead op.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
March 7, 2025 at 3:35 AM
VLE (Volume Ligand Efficiency)? It’s a little known metric in drug design that helps predict low human dose compounds by balancing potency and unbound exposure. It refines drug selection early-ish in lead op.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
We need better pain meds and I don’t think VX-548 is going to be efficacious enough to displace opioids. That’s why this paper caught my attention
February 19, 2025 at 10:52 PM
We need better pain meds and I don’t think VX-548 is going to be efficacious enough to displace opioids. That’s why this paper caught my attention
Correction: Breast cancer
January 21, 2025 at 7:00 PM
Correction: Breast cancer
Anyone with pharma experience who is over US politics.
Very welcome in Australia.
We need experienced pharma/biotech operators. People who have made drugs before.
In Aus the research infrastructure and research biology is the some of the best in the world.
We also have the best beaches.
Very welcome in Australia.
We need experienced pharma/biotech operators. People who have made drugs before.
In Aus the research infrastructure and research biology is the some of the best in the world.
We also have the best beaches.
January 20, 2025 at 5:34 AM
Anyone with pharma experience who is over US politics.
Very welcome in Australia.
We need experienced pharma/biotech operators. People who have made drugs before.
In Aus the research infrastructure and research biology is the some of the best in the world.
We also have the best beaches.
Very welcome in Australia.
We need experienced pharma/biotech operators. People who have made drugs before.
In Aus the research infrastructure and research biology is the some of the best in the world.
We also have the best beaches.
Molecular Gates rendered by DallE. Which one do you like the most?
December 22, 2024 at 9:38 AM
Molecular Gates rendered by DallE. Which one do you like the most?