Nature Synthesis
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A synthesis-oriented chemistry & materials science journal from
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@natureportfolio.nature.com. Posts by the editors @peterseavill.bsky.social @alexrgroves.bsky.social @jetsinglee.bsky.social
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Now online:
Article by Yu Zhao, Ming Joo Koh & co-workers
Divergent synthesis of N heterocycles from carbocycles enabled by electrochemical nitrogen atom insertion
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Article by Yu Zhao, Ming Joo Koh & co-workers
Divergent synthesis of N heterocycles from carbocycles enabled by electrochemical nitrogen atom insertion
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Divergent synthesis of N heterocycles from carbocycles enabled by electrochemical nitrogen atom insertion - Nature Synthesis
A divergent electrochemical nitrogen atom insertion into saturated carbocycles is reported, enabling selective access to either functionalized quinolines or N-alkylated saturated N heterocycles. This ...
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December 18, 2025 at 1:46 PM
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Article by Yu Zhao, Ming Joo Koh & co-workers
Divergent synthesis of N heterocycles from carbocycles enabled by electrochemical nitrogen atom insertion
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Article by Yu Zhao, Ming Joo Koh & co-workers
Divergent synthesis of N heterocycles from carbocycles enabled by electrochemical nitrogen atom insertion
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I’m here at #Pacifichem2025, looking forward to meeting peeps and talking about all things synthetic @natsynth.nature.com
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December 15, 2025 at 9:17 PM
I’m here at #Pacifichem2025, looking forward to meeting peeps and talking about all things synthetic @natsynth.nature.com
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Now online and open access:
Article by Pavel K. Mykhailiuk, Peng Liu, K. Barry Sharpless, Keary M. Engle & co-workers
Alkyl sulfonyl fluorides as ambiphiles in the stereoselective palladium(II)-catalysed cyclopropanation of unactivated alkenes
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Article by Pavel K. Mykhailiuk, Peng Liu, K. Barry Sharpless, Keary M. Engle & co-workers
Alkyl sulfonyl fluorides as ambiphiles in the stereoselective palladium(II)-catalysed cyclopropanation of unactivated alkenes
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Alkyl sulfonyl fluorides as ambiphiles in the stereoselective palladium(II)-catalysed cyclopropanation of unactivated alkenes - Nature Synthesis
The ambiphilic reactivity of alkyl sulfonyl fluorides in stereoselective cyclopropanation under Pd(II) catalysis is reported. The method provides convenient access to cis-disubstituted cyclopropanes t...
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December 16, 2025 at 1:51 PM
Now online and open access:
Article by Pavel K. Mykhailiuk, Peng Liu, K. Barry Sharpless, Keary M. Engle & co-workers
Alkyl sulfonyl fluorides as ambiphiles in the stereoselective palladium(II)-catalysed cyclopropanation of unactivated alkenes
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Article by Pavel K. Mykhailiuk, Peng Liu, K. Barry Sharpless, Keary M. Engle & co-workers
Alkyl sulfonyl fluorides as ambiphiles in the stereoselective palladium(II)-catalysed cyclopropanation of unactivated alkenes
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December 15, 2025 at 10:37 AM
Research Highlight now online:
Heck-type reactions with bismuth photocatalysts by Eric Piechota
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Highlighting the Nature Catalysis Article by Josep Cornella & co-workers
Heck-type reactions with bismuth photocatalysts by Eric Piechota
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Highlighting the Nature Catalysis Article by Josep Cornella & co-workers
Heck-type reactions with bismuth photocatalysts - Nature Synthesis
Nature Synthesis - Heck-type reactions with bismuth photocatalysts
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December 15, 2025 at 10:34 AM
Research Highlight now online:
Heck-type reactions with bismuth photocatalysts by Eric Piechota
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Highlighting the Nature Catalysis Article by Josep Cornella & co-workers
Heck-type reactions with bismuth photocatalysts by Eric Piechota
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Highlighting the Nature Catalysis Article by Josep Cornella & co-workers
Now online:
Article by Jianwei Nai, Lin Guo, Hua Wang & co-workers
Scalable ultrathin sodium metal anodes
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Article by Jianwei Nai, Lin Guo, Hua Wang & co-workers
Scalable ultrathin sodium metal anodes
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Scalable ultrathin sodium metal anodes - Nature Synthesis
Sodium metal is of interest for high-energy-density batteries, but the lack of large-area ultrathin sodium metal foils hinders research. Here a metre-length, ultrathin (≤50 μm), mechanically strengthe...
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December 15, 2025 at 10:29 AM
Now online:
Article by Jianwei Nai, Lin Guo, Hua Wang & co-workers
Scalable ultrathin sodium metal anodes
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Article by Jianwei Nai, Lin Guo, Hua Wang & co-workers
Scalable ultrathin sodium metal anodes
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Now online and open access:
Article by Roly J. Armstrong, Erli Lu, Koji Kubota, Hajime Ito & co-workers
Mechanochemical synthesis of organosodium compounds through direct sodiation of organic halides
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Article by Roly J. Armstrong, Erli Lu, Koji Kubota, Hajime Ito & co-workers
Mechanochemical synthesis of organosodium compounds through direct sodiation of organic halides
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Mechanochemical synthesis of organosodium compounds through direct sodiation of organic halides - Nature Synthesis
A mechanochemical protocol for the direct synthesis of organosodium compounds is developed using cheap and shelf-stable sodium lumps and readily available organic halides under bulk, solvent-free cond...
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December 15, 2025 at 10:25 AM
Now online and open access:
Article by Roly J. Armstrong, Erli Lu, Koji Kubota, Hajime Ito & co-workers
Mechanochemical synthesis of organosodium compounds through direct sodiation of organic halides
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Article by Roly J. Armstrong, Erli Lu, Koji Kubota, Hajime Ito & co-workers
Mechanochemical synthesis of organosodium compounds through direct sodiation of organic halides
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Now online:
Review article by Weihua Guo, Zihao Li, Libei Huang, Ma Qian, James M. Tour & Ruquan Ye
Laser-assisted materials engineering at the atomic and nanoscales
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Review article by Weihua Guo, Zihao Li, Libei Huang, Ma Qian, James M. Tour & Ruquan Ye
Laser-assisted materials engineering at the atomic and nanoscales
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Laser-assisted materials engineering at the atomic and nanoscales - Nature Synthesis
Laser technology offers high energy, precise spatial resolution and seamless automation for materials synthesis and device fabrication. This Review highlights laser-assisted materials engineering at t...
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December 5, 2025 at 3:42 PM
Now online:
Review article by Weihua Guo, Zihao Li, Libei Huang, Ma Qian, James M. Tour & Ruquan Ye
Laser-assisted materials engineering at the atomic and nanoscales
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Review article by Weihua Guo, Zihao Li, Libei Huang, Ma Qian, James M. Tour & Ruquan Ye
Laser-assisted materials engineering at the atomic and nanoscales
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Now online:
Article by Min Ye, Xue Qiao, Menghao Cai & co-workers
Biosynthesis of plant vitexin-derived flavonoid glycosides in yeast
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Article by Min Ye, Xue Qiao, Menghao Cai & co-workers
Biosynthesis of plant vitexin-derived flavonoid glycosides in yeast
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Biosynthesis of plant vitexin-derived flavonoid glycosides in yeast - Nature Synthesis
Microbial biosynthesis is a promising alternative to plant extraction to obtain post-modified flavonoids, but current de novo biosynthesis is limited to milligrams per litre. Now the production of pla...
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December 5, 2025 at 3:37 PM
Now online:
Article by Min Ye, Xue Qiao, Menghao Cai & co-workers
Biosynthesis of plant vitexin-derived flavonoid glycosides in yeast
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Article by Min Ye, Xue Qiao, Menghao Cai & co-workers
Biosynthesis of plant vitexin-derived flavonoid glycosides in yeast
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Now online:
Article by Dmitri V. Talapin & co-workers
Molecular organohalides as general precursors for direct synthesis of two-dimensional transition metal carbide MXenes
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Article by Dmitri V. Talapin & co-workers
Molecular organohalides as general precursors for direct synthesis of two-dimensional transition metal carbide MXenes
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Molecular organohalides as general precursors for direct synthesis of two-dimensional transition metal carbide MXenes - Nature Synthesis
Ti-, Zr- and Nb-based MXenes with Cl, Br or mixed terminations can be synthesized by a bottom-up, atom-economic route directly from metals and molecular organohalides. The reactivity of organohalide p...
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December 3, 2025 at 5:16 PM
Now online:
Article by Dmitri V. Talapin & co-workers
Molecular organohalides as general precursors for direct synthesis of two-dimensional transition metal carbide MXenes
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Article by Dmitri V. Talapin & co-workers
Molecular organohalides as general precursors for direct synthesis of two-dimensional transition metal carbide MXenes
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Now online:
News & Views by @jetsinglee.bsky.social to mark the 2025 Nobel Prize in Chemistry
Medal for metal–organic frameworks
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News & Views by @jetsinglee.bsky.social to mark the 2025 Nobel Prize in Chemistry
Medal for metal–organic frameworks
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Medal for metal–organic frameworks - Nature Synthesis
Building space into solids is the focus of the 2025 Nobel Prize in Chemistry, which has been awarded to Susumu Kitagawa (Kyoto University), Richard Robson (University of Melbourne) and Omar M. Yaghi (...
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December 1, 2025 at 3:26 PM
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News & Views by @jetsinglee.bsky.social to mark the 2025 Nobel Prize in Chemistry
Medal for metal–organic frameworks
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News & Views by @jetsinglee.bsky.social to mark the 2025 Nobel Prize in Chemistry
Medal for metal–organic frameworks
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Now online:
News & Views on the Article by Yan Liu, Yong Cui & co-workers
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Helically ordered polymers under metal–organic framework confinement by Natalia M. Padial & Carlos Martí-Gastaldo
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News & Views on the Article by Yan Liu, Yong Cui & co-workers
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Helically ordered polymers under metal–organic framework confinement by Natalia M. Padial & Carlos Martí-Gastaldo
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Helically ordered polymers under metal–organic framework confinement - Nature Synthesis
Confining conjugated polymers within chiral metal–organic frameworks enables direct visualization of helical order and enhances their charge transport and spin selectivity properties.
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December 1, 2025 at 3:22 PM
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News & Views on the Article by Yan Liu, Yong Cui & co-workers
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Helically ordered polymers under metal–organic framework confinement by Natalia M. Padial & Carlos Martí-Gastaldo
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News & Views on the Article by Yan Liu, Yong Cui & co-workers
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Helically ordered polymers under metal–organic framework confinement by Natalia M. Padial & Carlos Martí-Gastaldo
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Now online:
Article by Qi Yang, Sanzhong Luo & co-workers
Heuristic data-driven approach for synergistic cobalt(IV)–enamine catalysis
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Article by Qi Yang, Sanzhong Luo & co-workers
Heuristic data-driven approach for synergistic cobalt(IV)–enamine catalysis
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Heuristic data-driven approach for synergistic cobalt(IV)–enamine catalysis - Nature Synthesis
Discovering new chemical reactions is often a slow process. Now a data-driven strategy that integrates expert intuition with artificial intelligence-guided exploration enables the rapid identification...
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December 1, 2025 at 3:19 PM
Now online:
Article by Qi Yang, Sanzhong Luo & co-workers
Heuristic data-driven approach for synergistic cobalt(IV)–enamine catalysis
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Article by Qi Yang, Sanzhong Luo & co-workers
Heuristic data-driven approach for synergistic cobalt(IV)–enamine catalysis
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Reposted by Nature Synthesis
I am attending the #F25MRS this week in Boston. Send me an email is you would like to meet up to discuss potential submissions or learn more about the journal! @materials-mrs.bsky.social
November 30, 2025 at 4:08 PM
I am attending the #F25MRS this week in Boston. Send me an email is you would like to meet up to discuss potential submissions or learn more about the journal! @materials-mrs.bsky.social
Now online:
News & Views on the Article by Tehshik P. Yoon & co-workers
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Skeletal editing of C(sp3)–C(sp3) bonds via photoinduced oxidative oxygen migration by Ajay H. Bansode & Marvin Parasram
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News & Views on the Article by Tehshik P. Yoon & co-workers
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Skeletal editing of C(sp3)–C(sp3) bonds via photoinduced oxidative oxygen migration by Ajay H. Bansode & Marvin Parasram
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Skeletal editing of C(sp3)–C(sp3) bonds via photoinduced oxidative oxygen migration - Nature Synthesis
Photochemical oxygen atom migration into carbon–carbon bonds enables the efficient synthesis of ethers from alcohol motifs.
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November 27, 2025 at 6:26 PM
Now online:
News & Views on the Article by Tehshik P. Yoon & co-workers
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Skeletal editing of C(sp3)–C(sp3) bonds via photoinduced oxidative oxygen migration by Ajay H. Bansode & Marvin Parasram
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News & Views on the Article by Tehshik P. Yoon & co-workers
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Skeletal editing of C(sp3)–C(sp3) bonds via photoinduced oxidative oxygen migration by Ajay H. Bansode & Marvin Parasram
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Now online:
Article by Chunsen Li, Wei-Hui Fang, Jian Zhang & co-workers
Precise synthesis of spherical aluminium oxo clusters for accurate surface guest recognition
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Article by Chunsen Li, Wei-Hui Fang, Jian Zhang & co-workers
Precise synthesis of spherical aluminium oxo clusters for accurate surface guest recognition
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Precise synthesis of spherical aluminium oxo clusters for accurate surface guest recognition - Nature Synthesis
Nanoclusters have precise structures and therefore offer a molecular-level approach for studying surface adsorption phenomena. Here, spherical aluminium oxo clusters are synthesized via a co-encapsula...
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November 27, 2025 at 6:22 PM
Now online:
Article by Chunsen Li, Wei-Hui Fang, Jian Zhang & co-workers
Precise synthesis of spherical aluminium oxo clusters for accurate surface guest recognition
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Article by Chunsen Li, Wei-Hui Fang, Jian Zhang & co-workers
Precise synthesis of spherical aluminium oxo clusters for accurate surface guest recognition
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Now online and open access:
Article by Zichao Rong, Mario Boley, Laurent El Ghaoui, Omar M. Yaghi & co-workers
Algorithmic iterative reticular synthesis of zeolitic imidazolate framework crystals
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Article by Zichao Rong, Mario Boley, Laurent El Ghaoui, Omar M. Yaghi & co-workers
Algorithmic iterative reticular synthesis of zeolitic imidazolate framework crystals
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Algorithmic iterative reticular synthesis of zeolitic imidazolate framework crystals - Nature Synthesis
AIRES (algorithmic iterative reticular synthesis) is an integrated cycle combining automated synthesis, image recognition, single-crystal X-ray diffraction and algorithmic decision-making to maximize ...
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November 25, 2025 at 5:56 PM
Now online and open access:
Article by Zichao Rong, Mario Boley, Laurent El Ghaoui, Omar M. Yaghi & co-workers
Algorithmic iterative reticular synthesis of zeolitic imidazolate framework crystals
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Article by Zichao Rong, Mario Boley, Laurent El Ghaoui, Omar M. Yaghi & co-workers
Algorithmic iterative reticular synthesis of zeolitic imidazolate framework crystals
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Research Highlight now online:
Deaminative aromatic functionalization by Joel Cejas-Sánchez
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Highlighting the @nature.com article by Xiaosong Xue, Xiaheng Zhang and co-workers
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Deaminative aromatic functionalization by Joel Cejas-Sánchez
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Highlighting the @nature.com article by Xiaosong Xue, Xiaheng Zhang and co-workers
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Deaminative aromatic functionalization - Nature Synthesis
Nature Synthesis - Deaminative aromatic functionalization
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November 24, 2025 at 3:35 PM
Research Highlight now online:
Deaminative aromatic functionalization by Joel Cejas-Sánchez
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Highlighting the @nature.com article by Xiaosong Xue, Xiaheng Zhang and co-workers
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Deaminative aromatic functionalization by Joel Cejas-Sánchez
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Highlighting the @nature.com article by Xiaosong Xue, Xiaheng Zhang and co-workers
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Now online:
News & Views on the Article by Raffaella Buonsanti & co-workers
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Liquid metal nanoreactors forge dynamic and stable nanocatalysts by Yangwoo Lee & Hyung-Jun Koo
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News & Views on the Article by Raffaella Buonsanti & co-workers
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Liquid metal nanoreactors forge dynamic and stable nanocatalysts by Yangwoo Lee & Hyung-Jun Koo
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Liquid metal nanoreactors forge dynamic and stable nanocatalysts - Nature Synthesis
Liquid gallium is employed as a reaction medium to synthesize uniquely structured solid–liquid–solid core–shell–shell nanoparticles, enabling the fabrication of diverse metallic nanostructures with ex...
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November 24, 2025 at 3:30 PM
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News & Views on the Article by Raffaella Buonsanti & co-workers
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Liquid metal nanoreactors forge dynamic and stable nanocatalysts by Yangwoo Lee & Hyung-Jun Koo
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News & Views on the Article by Raffaella Buonsanti & co-workers
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Liquid metal nanoreactors forge dynamic and stable nanocatalysts by Yangwoo Lee & Hyung-Jun Koo
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Now online:
News & Views on the Article by Yuting Zhou, Zhenchuang Xu & Jeffrey S. Moore
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Electrochemical upcycling of polyolefins into adaptable networks by Rhys W. Hughes & Brent S. Sumerlin
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News & Views on the Article by Yuting Zhou, Zhenchuang Xu & Jeffrey S. Moore
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Electrochemical upcycling of polyolefins into adaptable networks by Rhys W. Hughes & Brent S. Sumerlin
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Electrochemical upcycling of polyolefins into adaptable networks - Nature Synthesis
Electrolysis enables selective dual C–H functionalization for transforming inert polyolefin deconstruction products into dynamic recyclable networks.
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November 24, 2025 at 3:26 PM
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News & Views on the Article by Yuting Zhou, Zhenchuang Xu & Jeffrey S. Moore
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Electrochemical upcycling of polyolefins into adaptable networks by Rhys W. Hughes & Brent S. Sumerlin
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News & Views on the Article by Yuting Zhou, Zhenchuang Xu & Jeffrey S. Moore
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Electrochemical upcycling of polyolefins into adaptable networks by Rhys W. Hughes & Brent S. Sumerlin
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Now online:
Article by Wenping Hu, Kian Ping Loh & co-workers
Two-dimensional mixed tetrahedral–octahedral hybrid perovskites with coexisting ferroelectricity and intralayer antiferromagnetism
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Article by Wenping Hu, Kian Ping Loh & co-workers
Two-dimensional mixed tetrahedral–octahedral hybrid perovskites with coexisting ferroelectricity and intralayer antiferromagnetism
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Two-dimensional mixed tetrahedral–octahedral hybrid perovskites with coexisting ferroelectricity and intralayer antiferromagnetism - Nature Synthesis
A family of 2D hybrid perovskites engineered with bulky organic ligands in a copper halide lattice is synthesized, demonstrating mixed tetrahedral–octahedral connectivity. These materials undergo stra...
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November 20, 2025 at 12:35 PM
Now online:
Article by Wenping Hu, Kian Ping Loh & co-workers
Two-dimensional mixed tetrahedral–octahedral hybrid perovskites with coexisting ferroelectricity and intralayer antiferromagnetism
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Article by Wenping Hu, Kian Ping Loh & co-workers
Two-dimensional mixed tetrahedral–octahedral hybrid perovskites with coexisting ferroelectricity and intralayer antiferromagnetism
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Now online:
Article by Xile Hu & co-workers @xilehu-epfl.bsky.social
Construction of dual-cofactor artificial metalloenzymes for synergistic and enantiodivergent catalysis of Michael addition reactions
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Article by Xile Hu & co-workers @xilehu-epfl.bsky.social
Construction of dual-cofactor artificial metalloenzymes for synergistic and enantiodivergent catalysis of Michael addition reactions
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Construction of dual-cofactor artificial metalloenzymes for synergistic and enantiodivergent catalysis of Michael addition reactions - Nature Synthesis
A dual-cofactor artificial metalloenzyme is developed, incorporating a biotinylated nickel complex and a Strep-tagged peptide catalyst in adjacent streptavidin-binding sites. This synergistic artifici...
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November 20, 2025 at 12:33 PM
Now online:
Article by Xile Hu & co-workers @xilehu-epfl.bsky.social
Construction of dual-cofactor artificial metalloenzymes for synergistic and enantiodivergent catalysis of Michael addition reactions
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Article by Xile Hu & co-workers @xilehu-epfl.bsky.social
Construction of dual-cofactor artificial metalloenzymes for synergistic and enantiodivergent catalysis of Michael addition reactions
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Now online:
Article by Pengfei Wei, Guoxiong Wang & co-workers
Copper–palladium hydride interfaces promote electrochemical ammonia synthesis
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Article by Pengfei Wei, Guoxiong Wang & co-workers
Copper–palladium hydride interfaces promote electrochemical ammonia synthesis
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Copper–palladium hydride interfaces promote electrochemical ammonia synthesis - Nature Synthesis
Electrochemical nitrate reduction is a promising method for greener ammonia synthesis. Here, a CuPd bimetallic catalyst with abundant Cu–PdHx interfaces is synthesized, enabling efficient electrocatal...
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November 19, 2025 at 1:06 PM
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Article by Pengfei Wei, Guoxiong Wang & co-workers
Copper–palladium hydride interfaces promote electrochemical ammonia synthesis
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Article by Pengfei Wei, Guoxiong Wang & co-workers
Copper–palladium hydride interfaces promote electrochemical ammonia synthesis
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Article by Marco Gobbi & co-workers @cfmdonostia.bsky.social
Galvanic intercalation of molecular cations into van der Waals materials and heterostructures
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Article by Marco Gobbi & co-workers @cfmdonostia.bsky.social
Galvanic intercalation of molecular cations into van der Waals materials and heterostructures
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Galvanic intercalation of molecular cations into van der Waals materials and heterostructures - Nature Synthesis
A galvanic strategy enables the intercalation of diverse molecular cations into bulk and few-layer van der Waals crystals under mild conditions, yielding 50 organic–inorganic superlattices. This metho...
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November 19, 2025 at 1:05 PM
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Article by Marco Gobbi & co-workers @cfmdonostia.bsky.social
Galvanic intercalation of molecular cations into van der Waals materials and heterostructures
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Article by Marco Gobbi & co-workers @cfmdonostia.bsky.social
Galvanic intercalation of molecular cations into van der Waals materials and heterostructures
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Now online:
Article by Su Huang, Daming Zeng, Ming Wang & Xuefeng Jiang
Ligand-controlled divergent sulfuration and disulfuration via Ni-catalysed reductive cross-coupling involving thiourea dioxide
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Article by Su Huang, Daming Zeng, Ming Wang & Xuefeng Jiang
Ligand-controlled divergent sulfuration and disulfuration via Ni-catalysed reductive cross-coupling involving thiourea dioxide
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Ligand-controlled divergent sulfuration and disulfuration via Ni-catalysed reductive cross-coupling involving thiourea dioxide - Nature Synthesis
Ni-catalysed multicomponent reductive cross-coupling of aziridines, thiourea dioxide and alkyl halides enables the ligand-controlled synthesis of β-amino sulfides and disulfides. A planar ligand facil...
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November 19, 2025 at 1:02 PM
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Article by Su Huang, Daming Zeng, Ming Wang & Xuefeng Jiang
Ligand-controlled divergent sulfuration and disulfuration via Ni-catalysed reductive cross-coupling involving thiourea dioxide
www.nature.com/articles/s44... ($)
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Article by Su Huang, Daming Zeng, Ming Wang & Xuefeng Jiang
Ligand-controlled divergent sulfuration and disulfuration via Ni-catalysed reductive cross-coupling involving thiourea dioxide
www.nature.com/articles/s44... ($)
#Chemsky