Mark Fortner
@markfortner.bsky.social
CEO @ https://aspen.bio, bioinformatics, cheminformatics, cancer research, AI in Drug Discovery, Research Project & Portfolio Management, FAIR data, semantic web, web components, java, groovy, genomics, proteomics, DEL, TPDs, Pancreatic Cancer
Pinned
Digital Transformation with Robot Monkeys
YouTube video by Aspen Biosciences
youtu.be
Does your #DrugDiscovery strategy feel like... AI-fueled robot monkeys hammering away and hoping for a miracle? 🐒🤖
The race for funding is real, but chaos isn't a plan. It's time to swap the monkeys for a real #DigitalTransformation roadmap.
youtu.be/R0n__5HOOe8?...
The race for funding is real, but chaos isn't a plan. It's time to swap the monkeys for a real #DigitalTransformation roadmap.
youtu.be/R0n__5HOOe8?...
New #AI framework can uncover space physics equations in raw data
New AI framework can uncover space physics equations in raw data
Artificial intelligence (AI) systems, particularly artificial neural networks, have proved to be highly promising tools for uncovering patterns in large amounts of data that would otherwise be difficu...
phys.org
November 10, 2025 at 8:31 PM
New #AI framework can uncover space physics equations in raw data
Reposted by Mark Fortner
PyrMol: A Knowledge-Structured Pyramid Graph Framework forGeneralizable Molecular Property Prediction https://www.biorxiv.org/content/10.1101/2025.11.09.686426v1
November 10, 2025 at 2:47 PM
PyrMol: A Knowledge-Structured Pyramid Graph Framework forGeneralizable Molecular Property Prediction https://www.biorxiv.org/content/10.1101/2025.11.09.686426v1
Reposted by Mark Fortner
An experimental gene-editing treatment shows promise for permanently lowering levels of cholesterol and triglycerides, possibly helping cut the risk for heart disease. n.pr/4hPhrQp
CRISPR gene-editing works to reduce high cholesterol in a new study
An experimental gene-editing treatment shows promise for permanently lowering levels of cholesterol and triglycerides, possibly helping cut the risk for heart disease.
n.pr
November 8, 2025 at 3:51 PM
An experimental gene-editing treatment shows promise for permanently lowering levels of cholesterol and triglycerides, possibly helping cut the risk for heart disease. n.pr/4hPhrQp
Reposted by Mark Fortner
After several days of dry, balmy weather and temperatures reaching into the 90s, California is expected to see a dramatic change in the weather this week, likely beginning on Wednesday when a storm system will usher in lower temperatures and heavy rain and snow.
Heavy Rain Expected in California After Spell of Unusually Warm Weather
Areas across the state could record anywhere from one to five or more inches of rain. The Sierra will get some snow.
nyti.ms
November 8, 2025 at 10:44 PM
After several days of dry, balmy weather and temperatures reaching into the 90s, California is expected to see a dramatic change in the weather this week, likely beginning on Wednesday when a storm system will usher in lower temperatures and heavy rain and snow.
Reposted by Mark Fortner
Roman theatre at Amman, Jordan. It is a 6,000-seat, 2nd-century Roman theatre when the city was known as Philadelphia. A Greek inscription on one of the pillars indicates that this theater was built in honour of Emperor Antoninus Pius (AD 138–161). #RomanSiteSaturday
November 8, 2025 at 4:58 AM
Roman theatre at Amman, Jordan. It is a 6,000-seat, 2nd-century Roman theatre when the city was known as Philadelphia. A Greek inscription on one of the pillars indicates that this theater was built in honour of Emperor Antoninus Pius (AD 138–161). #RomanSiteSaturday
I sometimes wonder when I see articles like this. | #cancer #genetics #heritability #syndrones #LynchSyndrome
A woman's cancer seemed incurable. Identifying a rare genetic condition saved her life.
Chemo and surgery failed to treat Diane Davis' advanced cancer. Things seemed hopeless until genetic testing found an unlikely culprit.
www.cbsnews.com
November 8, 2025 at 8:43 PM
I sometimes wonder when I see articles like this. | #cancer #genetics #heritability #syndrones #LynchSyndrome
Reposted by Mark Fortner
James Watson has died. www.nytimes.com/2025/11/07/s...
James Watson, Co-Discoverer of the Structure of DNA, Is Dead at 97
www.nytimes.com
November 7, 2025 at 7:43 PM
James Watson has died. www.nytimes.com/2025/11/07/s...
Reposted by Mark Fortner
On the event of James Watson's death, I highly recommend this 2023 commentary from @matthewcobb.bsky.social and Nathaniel Comfort with crucial new insights into the discovery of the double helix. (And also check out Cobb's brand new biography of Francis Crick) www.nature.com/articles/d41...
What Rosalind Franklin truly contributed to the discovery of DNA’s structure
Franklin was no victim in how the DNA double helix was solved. An overlooked letter and an unpublished news article, both written in 1953, reveal that she was an equal player.
www.nature.com
November 7, 2025 at 9:25 PM
On the event of James Watson's death, I highly recommend this 2023 commentary from @matthewcobb.bsky.social and Nathaniel Comfort with crucial new insights into the discovery of the double helix. (And also check out Cobb's brand new biography of Francis Crick) www.nature.com/articles/d41...
Reposted by Mark Fortner
Identification of Therapeutic Gene Targets in Triple-Negative Breast Cancer: A Hybrid Approach Integrating Semidefinite Programming, Boolean Simulation, and Druggability Analysis https://www.biorxiv.org/content/10.1101/2025.11.05.686831v1
November 7, 2025 at 3:47 AM
Identification of Therapeutic Gene Targets in Triple-Negative Breast Cancer: A Hybrid Approach Integrating Semidefinite Programming, Boolean Simulation, and Druggability Analysis https://www.biorxiv.org/content/10.1101/2025.11.05.686831v1
Reposted by Mark Fortner
Insurance companies aren’t just players in the fight with doctors over money; they’re also the referees.
They produce their own guidelines on when to pay claims. If a doctor appeals a denial, insurers make all the initial decisions.
(Published April)
By @tchristianmiller.bsky.social
They produce their own guidelines on when to pay claims. If a doctor appeals a denial, insurers make all the initial decisions.
(Published April)
By @tchristianmiller.bsky.social
“Slow Pay, Low Pay or No Pay”: Trial Reveals How Insurers Try to Wield Power Over Doctors
Blue Cross authorized mastectomies and breast reconstructions for women with cancer but refused to pay the full doctors’ bills. A jury called it fraud and awarded the practice $421 million.
www.propublica.org
November 7, 2025 at 4:00 AM
Insurance companies aren’t just players in the fight with doctors over money; they’re also the referees.
They produce their own guidelines on when to pay claims. If a doctor appeals a denial, insurers make all the initial decisions.
(Published April)
By @tchristianmiller.bsky.social
They produce their own guidelines on when to pay claims. If a doctor appeals a denial, insurers make all the initial decisions.
(Published April)
By @tchristianmiller.bsky.social
Reposted by Mark Fortner
Over the past decade, there has been a rush of scholars moving across the Pacific to China, drawn by Beijing’s drive to become a scientific superpower.
But President Trump’s return to the White House has turbocharged this effort.
But President Trump’s return to the White House has turbocharged this effort.
Why Trump’s cuts to scientific research are a big win for China
China is attracting American scientific talent, especially in STEM fields, partly due to funding cuts and immigration restrictions under President Donald Trump.
www.washingtonpost.com
November 7, 2025 at 4:00 AM
Over the past decade, there has been a rush of scholars moving across the Pacific to China, drawn by Beijing’s drive to become a scientific superpower.
But President Trump’s return to the White House has turbocharged this effort.
But President Trump’s return to the White House has turbocharged this effort.
Reposted by Mark Fortner
BChemXtract - a ChemDraw parser and structure extractor - is our first open source software project and is available on @github:
🔗 https://github.com/Beilstein-Institut/BChemXtract
#openscience #opensource #fairdata #fairchemistry #Cheminformatics #github #beilsteincheminfolabs #bchemxtract
🔗 https://github.com/Beilstein-Institut/BChemXtract
#openscience #opensource #fairdata #fairchemistry #Cheminformatics #github #beilsteincheminfolabs #bchemxtract
November 5, 2025 at 2:00 PM
BChemXtract - a ChemDraw parser and structure extractor - is our first open source software project and is available on @github:
🔗 https://github.com/Beilstein-Institut/BChemXtract
#openscience #opensource #fairdata #fairchemistry #Cheminformatics #github #beilsteincheminfolabs #bchemxtract
🔗 https://github.com/Beilstein-Institut/BChemXtract
#openscience #opensource #fairdata #fairchemistry #Cheminformatics #github #beilsteincheminfolabs #bchemxtract
Reposted by Mark Fortner
BChemXtract, the new @BeilsteinInstitut ChemDraw parser and structure extractor, uses CDK 2.11
2.11
https://hessen.social/@BeilsteinInstitut/115497448450303612
#Cheminformatics #chemistry #openscience
https://hessen.social/@BeilsteinInstitut/115497448450303612
#Cheminformatics #chemistry #openscience
Beilstein-Institut (@BeilsteinInstitut@hessen.social)
Angehängt: 1 Bild BChemXtract - a ChemDraw parser and structure extractor - is our first open source software project and is available on @github@hachyderm.io: 🔗 https://github.com/Beilstein-Institut/BChemXtract #openscience #opensource #FAIRdata #FAIRchemistry #cheminformatics #GitHub #BeilsteinCheminfoLabs #BChemXtract
hessen.social
November 7, 2025 at 4:55 AM
BChemXtract, the new @BeilsteinInstitut ChemDraw parser and structure extractor, uses CDK 2.11
2.11
https://hessen.social/@BeilsteinInstitut/115497448450303612
#Cheminformatics #chemistry #openscience
https://hessen.social/@BeilsteinInstitut/115497448450303612
#Cheminformatics #chemistry #openscience
Reposted by Mark Fortner
No idea why people keep saying this is socialism.
When Trump says "us" he isn't talking about Novo Nordisk giving a piece of the company to the US government, he's talking about them giving a piece of the company to him and his crooked ass sons.
When Trump says "us" he isn't talking about Novo Nordisk giving a piece of the company to the US government, he's talking about them giving a piece of the company to him and his crooked ass sons.
Trump to the Novo Nordisk CEO: "Maybe you should give us a piece of the company like I've been asking for."
November 6, 2025 at 10:05 PM
No idea why people keep saying this is socialism.
When Trump says "us" he isn't talking about Novo Nordisk giving a piece of the company to the US government, he's talking about them giving a piece of the company to him and his crooked ass sons.
When Trump says "us" he isn't talking about Novo Nordisk giving a piece of the company to the US government, he's talking about them giving a piece of the company to him and his crooked ass sons.
Reposted by Mark Fortner
On the same day world leaders arrived at the COP30 summit in Brazil to push for more action on climate change, Greece announced it will start drilling for fossil fuels in the Mediterranean Sea — with US help.
As UN decries fossil fuel expansion, Greece starts drilling for gas in Mediterranean
U.S. oil giant ExxonMobil will lead the project, to the delight of Donald Trump’s energy czar.
www.politico.eu
November 6, 2025 at 6:04 PM
On the same day world leaders arrived at the COP30 summit in Brazil to push for more action on climate change, Greece announced it will start drilling for fossil fuels in the Mediterranean Sea — with US help.
Reposted by Mark Fortner
Reposted by Mark Fortner
Melanoma, pancreatic cancer, and triple-negative breast cancer (TNBC) are each serious clinical challenges due to how common or aggressive they are and how poorly they often respond to treatment. Which is why researchers are determined to develop an effective treatment for all of them.
November 5, 2025 at 5:03 PM
Melanoma, pancreatic cancer, and triple-negative breast cancer (TNBC) are each serious clinical challenges due to how common or aggressive they are and how poorly they often respond to treatment. Which is why researchers are determined to develop an effective treatment for all of them.
Reposted by Mark Fortner
a form developed from tumor lysate -inactive cancer cells from actual tumors- to mimic the complex mixture of proteins in human cancers. The vaccine was shown to protect against a number of different types: 88% of mice from pancreatic cancer, 75% from breast cancer, and 69% from melanoma. The
November 5, 2025 at 5:13 PM
a form developed from tumor lysate -inactive cancer cells from actual tumors- to mimic the complex mixture of proteins in human cancers. The vaccine was shown to protect against a number of different types: 88% of mice from pancreatic cancer, 75% from breast cancer, and 69% from melanoma. The
Reposted by Mark Fortner
Something that was conserved between pig and human systems. This is particularly useful in the context of anti-pancreatic cancer effects of statins as shown in a recent article: www.cell.com/cell-stem-ce... /3
A pancreatic cancer organoid biobank links multi-omics signatures to therapeutic response and clinical evaluation of statin combination therapy
Gao and colleagues identify new therapeutic opportunities for pancreatic cancer via
integrated pharmacogenomic analysis of organoid models, highlighting statins as effective
agents to overcome chemore...
www.cell.com
November 5, 2025 at 7:50 PM
Something that was conserved between pig and human systems. This is particularly useful in the context of anti-pancreatic cancer effects of statins as shown in a recent article: www.cell.com/cell-stem-ce... /3
Reposted by Mark Fortner
GOOD NEWS! Researchers have developed a cancer vaccine that has shown STUNNING results, PREVENTING up to 88% of MULTIPLE aggressive cancers by harnessing dual-pathway nanoparticles that train the immune system to recognize and destroy tumor cells. In some cases, it COMPLETELY prevented metastasis.
November 5, 2025 at 5:00 PM
GOOD NEWS! Researchers have developed a cancer vaccine that has shown STUNNING results, PREVENTING up to 88% of MULTIPLE aggressive cancers by harnessing dual-pathway nanoparticles that train the immune system to recognize and destroy tumor cells. In some cases, it COMPLETELY prevented metastasis.
Reposted by Mark Fortner
A new treatment in Stage 3 trials for pancreatic cancer with amazing promis
www.yahoo.com/news/article...
www.yahoo.com/news/article...
A pill is raising hope for one of the deadliest cancers. The question is how fast patients should get it.
At 69 years old, Debby Orcutt was diagnosed last year with pancreatic cancer, a condition so dire that her doctor refused to tell her how long she had to live. With few good options, she enrolled in a...
www.yahoo.com
November 5, 2025 at 8:43 PM
A new treatment in Stage 3 trials for pancreatic cancer with amazing promis
www.yahoo.com/news/article...
www.yahoo.com/news/article...
Reposted by Mark Fortner
Daraxonrasib was given to 83 patients with pancreatic cancer that had spread after treatment. Over more than 16 months, 90% of them saw no tumor growth.
Next steps: The pill will undergo a new, fast-track review process approved by the FDA.
Next steps: The pill will undergo a new, fast-track review process approved by the FDA.
November 5, 2025 at 9:41 PM
Daraxonrasib was given to 83 patients with pancreatic cancer that had spread after treatment. Over more than 16 months, 90% of them saw no tumor growth.
Next steps: The pill will undergo a new, fast-track review process approved by the FDA.
Next steps: The pill will undergo a new, fast-track review process approved by the FDA.
Reposted by Mark Fortner
Cell populations in human breast cancers are molecularly and biologically distinct with age
"how age affects cells in the breast tumor microenvironment or how they contribute to age-related pathology."
www.nature.com/articles/s43...
"how age affects cells in the breast tumor microenvironment or how they contribute to age-related pathology."
www.nature.com/articles/s43...
Cell populations in human breast cancers are molecularly and biologically distinct with age - Nature Aging
Parsons and colleagues characterize age-associated changes in the tumor microenvironment of triple-negative and estrogen receptor-positive breast cancer using computational analysis of transcriptomic ...
www.nature.com
November 5, 2025 at 10:40 AM
Cell populations in human breast cancers are molecularly and biologically distinct with age
"how age affects cells in the breast tumor microenvironment or how they contribute to age-related pathology."
www.nature.com/articles/s43...
"how age affects cells in the breast tumor microenvironment or how they contribute to age-related pathology."
www.nature.com/articles/s43...
Reposted by Mark Fortner
