Osvaldo Chara
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osvaldo-chara.bsky.social
Osvaldo Chara
@osvaldo-chara.bsky.social
Biophysicist/Modeller playing with tissues in Development and Regeneration
School of Biosciences, University of Nottingham
Pinned
Our ForSys method to infer the mechanical state of a tissue in space and time is published now in @cp-iscience.bsky.social !
www.cell.com/iscience/ful...

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Thrilled to have contributed to this @nature.com study on ethylene and cell wall mechanics in root compaction responses!! — Featuring Jiao Zhang, Lucas Peralta Ogorek, @borgesaugust.bsky.social , Bipin Pandey, Staffan Persson, Wanqi Zhang, Malcolm Bennett & more!!

www.nature.com/articles/s41...
Ethylene modulates cell wall mechanics for root responses to compaction - Nature
Soil compaction traps ethylene around roots, which causes transcriptional upregulation of Auxin Response Factor1, resulting in decreased root cortical cell wall thickness and thereby promoting root ra...
www.nature.com
November 26, 2025 at 9:18 PM
Reposted by Osvaldo Chara
Looking forward to my visit to Fac Biologicas @ucm.es (biologicas.ucm.es) in #Madrid, my alma mater, where I studied (and dreamt) 50 years ago!
November 20, 2025 at 2:24 PM
Reposted by Osvaldo Chara
Are you a postdoc or Asst. Prof on the job market? Check out our listing and consider applying! The search is very broad and it’s in a great department, location, university! Even with the crazy schedule that comes with being a PI- I love my job @ucdavis.bsky.social @ucdavisvetmed.bsky.social!
Our department @ucdavisvetmed.bsky.social @ucdavis.bsky.social is hiring! We welcome research that diversifies or complements existing strengths in gastrointestinal, neuroimmune, musculoskeletal, cardiorespiratory
systems and/or developmental biology. @socdevbio.bsky.social @ascbiology.bsky.social
November 12, 2025 at 6:54 PM
Reposted by Osvaldo Chara
We have a new lab photo. Busy times in the Delas Lab!

Last month Maria and Shaun joined us to start their PhDs.

Learn more about our research and our team: delaslab.com

We will be recruiting another postdoc next year so have a look through our recent work and get in touch if you are interested.
November 12, 2025 at 2:04 PM
Reposted by Osvaldo Chara
About stress inference
bsky.app/profile/epim...
Mechanical forces can affect the way tissue grows. Ideally, we want to characterize them without interfering with the processes we are studying. Is there a way to achieve this?

I am @borgesaugust.bsky.social
Welcome to my stress inference tutorial!
#EpithelialMechanics
November 8, 2025 at 7:59 AM
Reposted by Osvaldo Chara
📚 Welcome to the Epithelial Mechanics Fan Club! 🌟

We're all about sharing research papers and threads. If you'd like to contribute, please send DM us! 💬

Our goal is to build a community that fosters knowledge sharing.

Explore our previous 🧵 here 👇
November 21, 2024 at 10:40 PM
Reposted by Osvaldo Chara
We are looking for: PhD Student (starting as Research Assistant) and Postdoctoral Researcher in Stem Cell Biology and Mechanobiology. Please RT💕
🔗 About our lab: renew.science/principal_in...
🎓 PhD position: jobportal.ku.dk/phd/?show=15...
🧪 Postdoc position: jobportal.ku.dk/videnskabeli...
November 3, 2025 at 7:05 PM
Reposted by Osvaldo Chara
We're advertising a PhD at the intersection of mathematical ecology, metallobiology, and microbiology to study the impact of metals on microbial communities with @thecopperdoctor.bsky.social @kateduncan.bsky.social and Denis Patterson. Come join us in lovely Durham!

iapetus.ac.uk/studentships...
When nutrients turn toxic: how metals shape microbial coexistence
iapetus.ac.uk
October 28, 2025 at 9:48 AM
Reposted by Osvaldo Chara
Help us to promote this DevBiol course (in Spanish)
¡Nuevo curso gratuito de Biología del Desarrollo (en español)!
Aprende sobre los procesos que dan origen a la vida
Cupos limitados → forms.gle/sfSV1GTae2nC...
Detalles y programa: drive.google.com/file/d/1-9dd...
#BiologíaDelDesarrollo
Registro "Biología del Desarrollo Sintética: Diseñando la Vida"
Curso Electivo de Verano, dirigido a estudiantes de pregrado Programa: Link Fechas: 5 al 15 de Enero de 2026 Lugar: Santiago de Chile, clases presenciales (Campus Manuel Montt, U. Mayor) Para estudian...
forms.gle
October 26, 2025 at 2:16 PM
Reposted by Osvaldo Chara
Speaking of time, @osvaldo-chara.bsky.social 's lab recently developed a new method, ForSys, that uses all available dynamic information. It also tracks the elements of the tissue over time and uses their movement to further inform the stress inference algorithm.

bsky.app/profile/epim...
October 25, 2025 at 7:03 AM
Reposted by Osvaldo Chara
Mechanical forces can affect the way tissue grows. Ideally, we want to characterize them without interfering with the processes we are studying. Is there a way to achieve this?

I am @borgesaugust.bsky.social
Welcome to my stress inference tutorial!
#EpithelialMechanics
October 25, 2025 at 7:03 AM
Reposted by Osvaldo Chara
Borges, A., Miranda-Rodriguez, J. R., Ceccarelli, A., Ventura, G., Sedzinski, J., Lopez-Schier, H., & Chara, O. (2025). ForSys: non-invasive stress inference from time-lapse microscopy. iScience, 28, 113685. #EpithelialMechanics
buff.ly/jQ96TCK
October 24, 2025 at 7:02 AM
Reposted by Osvaldo Chara
Register for your place at this exciting @embo.org workshop in China now! Places are filling up fast! @biologists.bsky.social
October 21, 2025 at 2:29 PM
Reposted by Osvaldo Chara
Excited to take part on this @embo.org workshop - register now and see you in Haining! Thanks @yanlanmao.bsky.social for putting together such an interdisciplinary programme! 🧪
October 21, 2025 at 4:37 PM
Are you, like me, fascinated by the interface between biophysical and molecular mechanisms of animal homeostasis and repair? Join us at this amazing @embo.org workshop in Haining, China!
Register for your place at this exciting @embo.org workshop in China now! Places are filling up fast! @biologists.bsky.social
Our interdisciplinary @embo.org @biologists.bsky.social workshop on Biophysical and Molecular Mechanisms of Animal Homeostasis and Repair will take place in beautiful Haining, China, 6-10 April 2026. Exciting line up of international speakers! Register now: meetings.embo.org/event/26-hom...
October 21, 2025 at 4:41 PM
Postdoc or PhD position to unveil the amazing problem of limb regeneration!!! Come to work with the great @canaztekin.bsky.social and myself!!
🔬 Limb regeneration depends on regenerative signaling center cells — but how do these cells influence others to proliferate, migrate, or differentiate?
We’re recruiting PhD or Postdoc candidates to explore this with our collaborator @osvaldo-chara.bsky.social !
October 21, 2025 at 7:10 AM
Our ForSys method to infer the mechanical state of a tissue in space and time is published now in @cp-iscience.bsky.social !
www.cell.com/iscience/ful...

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October 20, 2025 at 1:03 PM
Reposted by Osvaldo Chara
Borges, A., & Chara, O. (2024). Peeking into the future: inferring mechanics in dynamical tissues. Biochemical Society transactions, 52(6), 2579–2592. #EpithelialMechanicsReview
buff.ly/sntsjqb
October 16, 2025 at 7:01 AM
Looking for an interesting interdisciplinary PhD on spinal cord regeneration? Join us to explore how tissues rebuild after injury — combining biology, physics, and computational approaches!
PIs: Karel Dorey, @ramandas.bsky.social, and @osvaldo-chara.bsky.social.

👉: www.findaphd.com/phds/project...
(Bicentenary) Applying a multidisciplinary approach to uncover the mechanisms underpinning successful regeneration of the spinal cord after injury at The University of Manchester on FindAPhD.com
PhD Project - (Bicentenary) Applying a multidisciplinary approach to uncover the mechanisms underpinning successful regeneration of the spinal cord after injury at The University of Manchester, listed...
www.findaphd.com
October 15, 2025 at 1:28 PM
Reposted by Osvaldo Chara
New article out now!

Our researchers @sumrubayin.bsky.social, @bensteventon.bsky.social, and @storerlab.bsky.social share key takeaways from a workshop on complex tissue regeneration, highlighting the need for more collaboration and interdisciplinary work.

➡️ journals.biologists.com/dev/article/...
Building and rebuilding complex tissues: strategic visions from a research-led workshop
ABSTRACT. How complex tissues develop and regenerate post-injury is one of the most fascinating and important processes in biology. Recent technical advances that enable the generation of a quantitati...
journals.biologists.com
September 4, 2025 at 2:10 PM
Reposted by Osvaldo Chara
These are great - and could support your attendance to the 2025 CBIAS napari workshop for example! www.crick.ac.uk/whats-on/cbi...
August 28, 2025 at 10:01 AM
Reposted by Osvaldo Chara
Summer break prevented me from properly advertising this serie of reviews on the function of cell death during development that I edited. There is still a lot to dig in regarding regulation of apoptosis in vivo ad I hope we managed to illustrate this well
www.sciencedirect.com/special-issu...
Seminars in Cell & Developmental Biology | Novel functions of programmed cell death in development: current status and future challenges | ScienceDirect.com by Elsevier
While the core regulators of programmed cell death have been relatively well characterised, our understanding of the regulation and role of programmed cell death in tissue during embryonic development...
www.sciencedirect.com
August 28, 2025 at 10:58 AM
Reposted by Osvaldo Chara
Spread the word - we at @stanford-chemh.bsky.social are searching to fill a new junior faculty at the interface of molecular and computational science. See link below!
Open faculty position!
We're seeking applicants for a tenure-track faculty position at the junior level (Assistant or untenured Associate Professor) with research programs that exist at the interface between molecular science and computation. Apply here: stanford.io/45MF3Qa
August 27, 2025 at 3:27 AM
Reposted by Osvaldo Chara
Thrilled to share the first story from my postdoc! 🎉 A wonderful experiment + simulations collaboration. In the Drosophila wing, we find that 3D cell shapes affect signalling range and fine-tune developmental patterning www.biorxiv.org/content/10.1... Thread below ⬇️
August 11, 2025 at 1:18 PM
Reposted by Osvaldo Chara
An exciting new paper from the lab! Check it out:
Thrilled to share the first story from my postdoc! 🎉 A wonderful experiment + simulations collaboration. In the Drosophila wing, we find that 3D cell shapes affect signalling range and fine-tune developmental patterning www.biorxiv.org/content/10.1... Thread below ⬇️
August 12, 2025 at 6:23 AM