William Wade
@oralmolecol.bsky.social
Professor of Oral Microbiology, King’s College London. Microbiome.
Reposted by William Wade
Still reeling from the Stanford report on Brexit. Reduced GDP by up to 8% and investment by as much as 18%. The UK Treasury would have £40 billion more each year if Britain had remained in the EU. Devastating self-immolation.
The Economic Impact of Brexit
Other
siepr.stanford.edu
November 24, 2025 at 11:02 AM
Still reeling from the Stanford report on Brexit. Reduced GDP by up to 8% and investment by as much as 18%. The UK Treasury would have £40 billion more each year if Britain had remained in the EU. Devastating self-immolation.
Reposted by William Wade
Our latest paper is out with @adiop.bsky.social and @gmdouglas.bsky.social. We analyzed the extent of homologous recombination between bacterial species (introgression) and how it affects species borders (it can vary a lot depending on the approach used to classify species!). rdcu.be/eQAMf
Introgression impacts the evolution of bacteria, but species borders are rarely fuzzy
Nature Communications - It is commonly thought that bacterial species borders tend to be fuzzy, due to frequent exchange of DNA. Here, Diop et al. quantify the patterns of gene flow between core...
rdcu.be
November 18, 2025 at 9:01 PM
Our latest paper is out with @adiop.bsky.social and @gmdouglas.bsky.social. We analyzed the extent of homologous recombination between bacterial species (introgression) and how it affects species borders (it can vary a lot depending on the approach used to classify species!). rdcu.be/eQAMf
Reposted by William Wade
Reposted by William Wade
The oral microbiome of King Richard III of England
Metagenomic investigation of archaeological dental calculus has provided insights into the changing oral health, disease, and diet of past human societies, but little is known about the oral microbiot...
www.biorxiv.org
September 22, 2025 at 5:31 AM
Reposted by William Wade
Reposted by William Wade
📣 We are proud of the publication of the second paper of @bbaker24.bsky.social PhD thesis. In collaboration with friends in Halifax we have studied the difficult question of the phylogeny of the DPANN archaea, composed of several phyla of highly reduced, fast-evolving epiparasites 🧵
rdcu.be/erkkU
rdcu.be/erkkU
Phylogenomic analyses indicate the archaeal superphylum DPANN originated from free-living euryarchaeal-like ancestors
Nature Microbiology - Phylogenetic reconstructions with conserved protein markers from the 11 known DPANN phyla reveal their monophyletic placement within the Euryarchaeota.
rdcu.be
June 17, 2025 at 12:35 PM
📣 We are proud of the publication of the second paper of @bbaker24.bsky.social PhD thesis. In collaboration with friends in Halifax we have studied the difficult question of the phylogeny of the DPANN archaea, composed of several phyla of highly reduced, fast-evolving epiparasites 🧵
rdcu.be/erkkU
rdcu.be/erkkU
Reposted by William Wade
Thrilled to share our new paper in @science.org describing our discovery that bacteria can switch from competitors to bonafide predators when resources run dry—arming nanoscale “spears” (T6SS) to stab & consume neighbours.
www.science.org/doi/10.1126/...
#MicroSKy #Microbiology
www.science.org/doi/10.1126/...
#MicroSKy #Microbiology
Antagonism as a foraging strategy in microbial communities
In natural habitats, nutrient availability limits bacterial growth. We discovered that bacteria can overcome this limitation by acquiring nutrients by lysing neighboring cells through contact-dependen...
www.science.org
June 13, 2025 at 5:39 AM
Thrilled to share our new paper in @science.org describing our discovery that bacteria can switch from competitors to bonafide predators when resources run dry—arming nanoscale “spears” (T6SS) to stab & consume neighbours.
www.science.org/doi/10.1126/...
#MicroSKy #Microbiology
www.science.org/doi/10.1126/...
#MicroSKy #Microbiology
Reposted by William Wade
📢 Big day for archaeal microbiology!
Today, we jointly shed light on the mysterious world of archaeal extracellular vesicles from human gut archaea - published in @natcomms.nature.com in parallel with our precious colleagues around @mkrupovic.bsky.social 🇦🇹🤝🇫🇷.
Today, we jointly shed light on the mysterious world of archaeal extracellular vesicles from human gut archaea - published in @natcomms.nature.com in parallel with our precious colleagues around @mkrupovic.bsky.social 🇦🇹🤝🇫🇷.
June 3, 2025 at 2:13 PM
📢 Big day for archaeal microbiology!
Today, we jointly shed light on the mysterious world of archaeal extracellular vesicles from human gut archaea - published in @natcomms.nature.com in parallel with our precious colleagues around @mkrupovic.bsky.social 🇦🇹🤝🇫🇷.
Today, we jointly shed light on the mysterious world of archaeal extracellular vesicles from human gut archaea - published in @natcomms.nature.com in parallel with our precious colleagues around @mkrupovic.bsky.social 🇦🇹🤝🇫🇷.
Reposted by William Wade
Exciting progress! In our new preprint, we show that episymbiont Saccharibacteria can directly modulate epithelial immunity—a big step in understanding how these elusive microbes interact with the human host. Kudos to Deepak Chouhan and our amazing collaborators! www.biorxiv.org/content/10.1...
June 3, 2025 at 12:30 PM
Exciting progress! In our new preprint, we show that episymbiont Saccharibacteria can directly modulate epithelial immunity—a big step in understanding how these elusive microbes interact with the human host. Kudos to Deepak Chouhan and our amazing collaborators! www.biorxiv.org/content/10.1...
Reposted by William Wade
London study finds L. crispatus in the vaginal microbiome reduces inflammation by blocking harmful signals and activating anti-inflammatory pathways.
May protect against infections and preterm birth.
www.nature.com/articles/s41...
May protect against infections and preterm birth.
www.nature.com/articles/s41...
Lactobacillus crispatus S-layer proteins modulate innate immune response and inflammation in the lower female reproductive tract - Nature Communications
Here, the authors show that vaginal lactobacilli associated with optimal health interact selectively with a restricted subset of anti-inflammatory receptors through their Surface Layer Proteins, both ...
www.nature.com
December 30, 2024 at 7:39 PM
London study finds L. crispatus in the vaginal microbiome reduces inflammation by blocking harmful signals and activating anti-inflammatory pathways.
May protect against infections and preterm birth.
www.nature.com/articles/s41...
May protect against infections and preterm birth.
www.nature.com/articles/s41...
Reposted by William Wade
In a world of Matts, be a Derek.
March 10, 2025 at 7:44 PM
In a world of Matts, be a Derek.
Reposted by William Wade
President Zelenskyy has been one of the greatest leaders of our time, guiding Ukraine through the darkest period of its recent history, rising up to Russia’s unwarranted aggression, being an inspiration to the Ukrainian people and ensuring that Ukraine’s voice is heard on the world stage.
February 20, 2025 at 12:14 AM
President Zelenskyy has been one of the greatest leaders of our time, guiding Ukraine through the darkest period of its recent history, rising up to Russia’s unwarranted aggression, being an inspiration to the Ukrainian people and ensuring that Ukraine’s voice is heard on the world stage.
Reposted by William Wade
EDITORIAL: Ensuring rigour of low-biomass microbiome research
Read it here: www.nature.com/articles/s41...
#microsky #microbiomesky 🧪
Read it here: www.nature.com/articles/s41...
#microsky #microbiomesky 🧪
Ensuring rigour of low-biomass microbiome research - Nature Microbiology
Determining whether human organs house a resident microbiome is challenging and the findings can be controversial. However, forging collaborations and careful study design can help overcome these issu...
www.nature.com
February 4, 2025 at 5:48 PM
EDITORIAL: Ensuring rigour of low-biomass microbiome research
Read it here: www.nature.com/articles/s41...
#microsky #microbiomesky 🧪
Read it here: www.nature.com/articles/s41...
#microsky #microbiomesky 🧪
Reposted by William Wade
🌟 Exciting news! Our latest collaborative research with team @aarhusuni.bsky.social introduces pH-FISH, a novel technique combining pH ratiometry and FISH to simultaneously unravel microbial identity and local biofilm pH. 🔬 🧪 #MicroSky
link.springer.com/article/10.1...
#Microbiome #Biofilms
pH-FISH: coupled microscale analysis of microbial identity and acid–base metabolism in complex biofilm samples - Microbiome
Background Correlative structural and chemical imaging of biofilms allows for the combined analysis of microbial identity and metabolism at the microscale. Here, we developed pH-FISH, a method that co...
link.springer.com
December 20, 2024 at 9:57 PM
🌟 Exciting news! Our latest collaborative research with team @aarhusuni.bsky.social introduces pH-FISH, a novel technique combining pH ratiometry and FISH to simultaneously unravel microbial identity and local biofilm pH. 🔬 🧪 #MicroSky
link.springer.com/article/10.1...
#Microbiome #Biofilms
Reposted by William Wade
The Porphyromonas gingivalis lipid A 1-phosphatase LpxE has unique features and requires a functional type IX secretion system for its activity https://www.biorxiv.org/content/10.1101/2024.12.20.629629v1
December 21, 2024 at 1:18 PM
The Porphyromonas gingivalis lipid A 1-phosphatase LpxE has unique features and requires a functional type IX secretion system for its activity https://www.biorxiv.org/content/10.1101/2024.12.20.629629v1
Reposted by William Wade
An important read for all microbiome researchers #microbiomania www.theguardian.com/science/2024...
There’s little evidence of a ‘brain microbiome’ | Letter
Letters: Prof Mark Pallen, Dr Aimee Parker, Prof Nick Loman and Prof Alan Walker take issue with an article that discussed the existence of a brain microbiome and its impact on diseases
www.theguardian.com
December 20, 2024 at 3:28 PM
An important read for all microbiome researchers #microbiomania www.theguardian.com/science/2024...
Reposted by William Wade
Big news from Finnish publication forum. Almost all MDPI and Frontiers journals will be downgraded to level 0 and thus are not considered as properly peer reviewed trustworthy scientific journals.
julkaisufoorumi.fi/en/news/chan...
julkaisufoorumi.fi/en/news/chan...
Changes to the classification
julkaisufoorumi.fi
December 16, 2024 at 10:12 AM
Big news from Finnish publication forum. Almost all MDPI and Frontiers journals will be downgraded to level 0 and thus are not considered as properly peer reviewed trustworthy scientific journals.
julkaisufoorumi.fi/en/news/chan...
julkaisufoorumi.fi/en/news/chan...
Reposted by William Wade
Excited to share our new preprint on the detailed investigation of Type 4 pili in epibiont oral Saccharibacteria! Led by Alex Grossman from our lab, and with Jun Liu (Yale), Jeff McLean (UW) and Xuesong He. Check it out: biorxiv.org/content/10.1...
December 4, 2024 at 11:09 AM
Excited to share our new preprint on the detailed investigation of Type 4 pili in epibiont oral Saccharibacteria! Led by Alex Grossman from our lab, and with Jun Liu (Yale), Jeff McLean (UW) and Xuesong He. Check it out: biorxiv.org/content/10.1...
Reposted by William Wade
The final chapter of my PhD thesis is finally out! Led by the brilliant Irina Velsko, we investigated if we can study past migrations in Oceania using #aDNA from archaeological dental calculus: www.nature.com/articles/s41...
Exploring the potential of dental calculus to shed light on past human migrations in Oceania - Nature Communications
Preservation of oral microbiome ancient DNA from Oceania is much better than human ancient DNA. The authors leverage this to demonstrate that oral microbial community composition in Oceania is not onl...
www.nature.com
November 25, 2024 at 12:20 PM
The final chapter of my PhD thesis is finally out! Led by the brilliant Irina Velsko, we investigated if we can study past migrations in Oceania using #aDNA from archaeological dental calculus: www.nature.com/articles/s41...
Reposted by William Wade
This Perspective was a fun one to work on recently, examining the characteristics & role of small intestinal #microbiota, somewhat overlooked (tech difficulties in sampling, low microbial biomass) but important to health
www.nature.com/articles/s41...
🔓 rdcu.be/d0hBg
#GastroSky #Microsky
www.nature.com/articles/s41...
🔓 rdcu.be/d0hBg
#GastroSky #Microsky
November 15, 2024 at 9:34 AM
This Perspective was a fun one to work on recently, examining the characteristics & role of small intestinal #microbiota, somewhat overlooked (tech difficulties in sampling, low microbial biomass) but important to health
www.nature.com/articles/s41...
🔓 rdcu.be/d0hBg
#GastroSky #Microsky
www.nature.com/articles/s41...
🔓 rdcu.be/d0hBg
#GastroSky #Microsky
Reposted by William Wade
Planning and Analyzing a Low-Biomass Microbiome Study: A Data Analysis Perspective academic.oup.com/jid/advance-... paging @faecalmatters.bsky.social
Planning and Analyzing a Low-Biomass Microbiome Study: A Data Analysis Perspective
Low-biomass microbiome studies show great potential alongside major controversies. This review surveys key methodological challenges and discusses experime
academic.oup.com
August 29, 2024 at 7:20 PM
Planning and Analyzing a Low-Biomass Microbiome Study: A Data Analysis Perspective academic.oup.com/jid/advance-... paging @faecalmatters.bsky.social
Reposted by William Wade
Spatial mapping of mobile genetic elements and their bacterial hosts in complex microbiomes (June 2024)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Spatial mapping of mobile genetic elements and their bacterial hosts in complex microbiomes - Nature Microbiology
Simultaneous DNA-FISH and multiplexed rRNA-FISH spatially map antimicrobial resistance plasmids and phage with their host taxa in polyspecies human oral biofilm samples, revealing hotspots of genetic ...
www.nature.com
August 12, 2024 at 4:22 AM
Spatial mapping of mobile genetic elements and their bacterial hosts in complex microbiomes (June 2024)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by William Wade
Inaccurate viral prediction leads to overestimated diversity of the archaeal virome in the human gut
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Inaccurate viral prediction leads to overestimated diversity of the archaeal virome in the human gut - Nature Communications
Nature Communications - Inaccurate viral prediction leads to overestimated diversity of the archaeal virome in the human gut
www.nature.com
July 20, 2024 at 8:50 AM
Inaccurate viral prediction leads to overestimated diversity of the archaeal virome in the human gut
www.nature.com/articles/s41...
www.nature.com/articles/s41...