Nicole Nuckolls
@nuckollsn.bsky.social
Postdoctoral Researcher in Zanders Lab in KC, MO | Stowers Institute | studying meiosis/spores in fission yeast | views are my own | she/her
Reposted by Nicole Nuckolls
Does anyone want a survivorship bias shortbread
November 29, 2025 at 4:50 AM
Does anyone want a survivorship bias shortbread
Reposted by Nicole Nuckolls
How can multidisciplinary research—from biology to public health—help prevent decline and promote lifelong well-being?
Discover more: plos.io/49A0FTf plos.io/49A0FTf
#AgingResearch #OpenScience #Longevity
Discover more: plos.io/49A0FTf plos.io/49A0FTf
#AgingResearch #OpenScience #Longevity
Aging research - PLOS
Explore leading PLOS aging research. Multidisciplinary, open access studies that help us take action to promote health and well-being at every stage of life.
plos.io
November 27, 2025 at 8:36 PM
How can multidisciplinary research—from biology to public health—help prevent decline and promote lifelong well-being?
Discover more: plos.io/49A0FTf plos.io/49A0FTf
#AgingResearch #OpenScience #Longevity
Discover more: plos.io/49A0FTf plos.io/49A0FTf
#AgingResearch #OpenScience #Longevity
Reposted by Nicole Nuckolls
Rapid compensatory evolution within a multiprotein complex preserves telomere integrity www.science.org/doi/10.1126/... @levine-lab.bsky.social very cool work
Rapid compensatory evolution within a multiprotein complex preserves telomere integrity
Intragenomic conflict with selfish genetic elements spurs adaptive changes in subunits of essential multiprotein complexes. Whether and how these adaptive changes disrupt interactions within such comp...
www.science.org
November 27, 2025 at 8:43 PM
Rapid compensatory evolution within a multiprotein complex preserves telomere integrity www.science.org/doi/10.1126/... @levine-lab.bsky.social very cool work
Reposted by Nicole Nuckolls
How do new centromeres evolve while staying compatible with the division machinery?
Discover it in our new Nature paper! We show centromeres transition gradually via a mix of drift, selection, and sex, reaching new states that still work with the kinetochore.
👉 doi.org/10.1038/s41586-025-09779-1
Discover it in our new Nature paper! We show centromeres transition gradually via a mix of drift, selection, and sex, reaching new states that still work with the kinetochore.
👉 doi.org/10.1038/s41586-025-09779-1
November 26, 2025 at 4:21 PM
How do new centromeres evolve while staying compatible with the division machinery?
Discover it in our new Nature paper! We show centromeres transition gradually via a mix of drift, selection, and sex, reaching new states that still work with the kinetochore.
👉 doi.org/10.1038/s41586-025-09779-1
Discover it in our new Nature paper! We show centromeres transition gradually via a mix of drift, selection, and sex, reaching new states that still work with the kinetochore.
👉 doi.org/10.1038/s41586-025-09779-1
Reposted by Nicole Nuckolls
𝘐𝘯𝘤𝘦𝘯𝘥𝘪𝘢𝘮𝘰𝘦𝘣𝘢 𝘤𝘢𝘴𝘤𝘢𝘥𝘦𝘯𝘴𝘪𝘴 at 63°C 🔥 sure enough, wheels on fire... and faaast like the ayrton senna of amoebae
November 25, 2025 at 9:01 PM
𝘐𝘯𝘤𝘦𝘯𝘥𝘪𝘢𝘮𝘰𝘦𝘣𝘢 𝘤𝘢𝘴𝘤𝘢𝘥𝘦𝘯𝘴𝘪𝘴 at 63°C 🔥 sure enough, wheels on fire... and faaast like the ayrton senna of amoebae
Reposted by Nicole Nuckolls
Let people live their lives as they want and we'll have a better world
1. A landmark study was just published in The Journal of Pediatrics.
It found a 68% reduction in suicidality for trans youth getting HRT.
It also found only 7 of more than 400 stopped taking HRT... and of those that did, 4 still identified as gender-diverse.
Transgender care saves lives.
It found a 68% reduction in suicidality for trans youth getting HRT.
It also found only 7 of more than 400 stopped taking HRT... and of those that did, 4 still identified as gender-diverse.
Transgender care saves lives.
Study In The Journal Of Pediatrics Finds Trans Youth Care Lowers Suicidality, Few Detransition
The groundbreaking study found that suicidality dropped for transgender youth receiving hormone therapy by nearly 70%, with only 7 patients of 432 discontinuing treatment.
www.erininthemorning.com
November 25, 2025 at 12:24 PM
Let people live their lives as they want and we'll have a better world
Reposted by Nicole Nuckolls
Fungal friends: The University of Minnesota is hiring a tenure track medical mycologist, with emphasis on emergence of pathogens, genomics and evolution!
www.nature.com/naturecareer...
www.nature.com/naturecareer...
New Assistant Professor: Tenure Track - Fungal Biology/Medical Mycology - Minneapolis, Minnesota job with University of Minnesota - Medical School | 12848307
About the Job: The Department of Microbiology & Immunology and the Institute on Infectious Diseases (UMIID) at the University of Minnesota Medical ...
www.nature.com
November 23, 2025 at 11:42 AM
Fungal friends: The University of Minnesota is hiring a tenure track medical mycologist, with emphasis on emergence of pathogens, genomics and evolution!
www.nature.com/naturecareer...
www.nature.com/naturecareer...
Reposted by Nicole Nuckolls
That’s about right.
November 22, 2025 at 4:06 AM
That’s about right.
Reposted by Nicole Nuckolls
Check out this beautiful paper by @richardcsilva.bsky.social et al., out now in @natcomms.nature.com. Great new DSB sensors to track DNA break formation and repair in real-time
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Engineered chromatin readers track damaged chromatin dynamics in live cells and animals - Nature Communications
DNA damage threatens genome stability, but its dynamics in living systems remain difficult to track. Here, the authors engineer MCPH1-based protein probes that specifically recognize γH2AX, enabling r...
www.nature.com
November 22, 2025 at 12:13 PM
Check out this beautiful paper by @richardcsilva.bsky.social et al., out now in @natcomms.nature.com. Great new DSB sensors to track DNA break formation and repair in real-time
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Spores surviving space
This moss survived 9 months outside the International Space Station in the harshness of space
Researchers hope findings can be applied to humans living in space
www.cbc.ca/news/science...
Researchers hope findings can be applied to humans living in space
www.cbc.ca/news/science...
This moss survived 9 months outside the International Space Station in the harshness of space | CBC News
Space is a harsh environment: it's a vacuum with freezing temperatures, super high ultraviolet radiation and, of course, almost no oxygen. But Japanese researchers have found a type of moss that doesn...
www.cbc.ca
November 21, 2025 at 1:11 AM
Spores surviving space
Reposted by Nicole Nuckolls
What is the best strategy to win any contest?
Eliminate your opponents of course.
Recently, my friend @fernpizza.bsky.social showed how plasmids compete intracellularly (check out his paper published in Science today!). With @baym.lol, we now know they can fight.
www.biorxiv.org/content/10.1...
Eliminate your opponents of course.
Recently, my friend @fernpizza.bsky.social showed how plasmids compete intracellularly (check out his paper published in Science today!). With @baym.lol, we now know they can fight.
www.biorxiv.org/content/10.1...
November 20, 2025 at 10:12 PM
What is the best strategy to win any contest?
Eliminate your opponents of course.
Recently, my friend @fernpizza.bsky.social showed how plasmids compete intracellularly (check out his paper published in Science today!). With @baym.lol, we now know they can fight.
www.biorxiv.org/content/10.1...
Eliminate your opponents of course.
Recently, my friend @fernpizza.bsky.social showed how plasmids compete intracellularly (check out his paper published in Science today!). With @baym.lol, we now know they can fight.
www.biorxiv.org/content/10.1...
Reposted by Nicole Nuckolls
Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Intracellular competition shapes plasmid population dynamics
From populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g...
www.science.org
November 20, 2025 at 9:42 PM
Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Nicole Nuckolls
Check out our latest issue where we interview Cassandra Extavour, who studies the evolution of the genetic mechanisms employed during early animal embryogenesis to specify cell fate, development, and differentiation at Harvard University. www.cell.com/current-biol...
Q & A
Interview with Cassandra Extavour, who studies the evolution of the genetic mechanisms
employed during early animal embryogenesis to specify cell fate, development, and
differentiation at Harvard Univ...
www.cell.com
November 20, 2025 at 10:34 AM
Check out our latest issue where we interview Cassandra Extavour, who studies the evolution of the genetic mechanisms employed during early animal embryogenesis to specify cell fate, development, and differentiation at Harvard University. www.cell.com/current-biol...
Reposted by Nicole Nuckolls
Reposted by Nicole Nuckolls
Speaking of things that are going to need to be fixed:
The second Trump administration’s deep federal spending cuts, including at the NIH, have halted at least 383 clinical trials, affecting more than 74,000 patients, according to a new analysis.
www.fiercebiotech.com/research/nih...
www.fiercebiotech.com/research/nih...
NIH grant cuts have disrupted hundreds of clinical trials, study finds
The second Trump administration has been defined by widespread cuts to federal spending, including at the National Institutes of Health (NIH). | The second Trump administration has been defined by wid...
www.fiercebiotech.com
November 18, 2025 at 12:23 AM
Speaking of things that are going to need to be fixed:
Reposted by Nicole Nuckolls
A bittersweet acceptance: Between a manuscript and grief
Stefanie Williams @sillysciencelady.bsky.social shares the story behind her paper on the synaptonemal complex, including a tribute to her supervisor Scott Hawley, who passed away while Stefanie was completing the research.
Stefanie Williams @sillysciencelady.bsky.social shares the story behind her paper on the synaptonemal complex, including a tribute to her supervisor Scott Hawley, who passed away while Stefanie was completing the research.
A bittersweet acceptance: Between a manuscript and grief - the Node
I was so excited when I received notification that my first first-author research paper was accepted. My excitement quickly turned into sadness with the realization that my co-PI was not seeing our vi...
thenode.biologists.com
November 17, 2025 at 9:58 AM
A bittersweet acceptance: Between a manuscript and grief
Stefanie Williams @sillysciencelady.bsky.social shares the story behind her paper on the synaptonemal complex, including a tribute to her supervisor Scott Hawley, who passed away while Stefanie was completing the research.
Stefanie Williams @sillysciencelady.bsky.social shares the story behind her paper on the synaptonemal complex, including a tribute to her supervisor Scott Hawley, who passed away while Stefanie was completing the research.
Reposted by Nicole Nuckolls
Opening for a tenure-track biology Assistant Professor at the University of Washington's Bothell campus, just northeast of Seattle.
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
November 14, 2025 at 1:24 AM
Opening for a tenure-track biology Assistant Professor at the University of Washington's Bothell campus, just northeast of Seattle.
Reposted by Nicole Nuckolls
Celebrating 25 years! ✨ Pres. & CSO @planaria1.bsky.social spoke with @kshb41.bsky.social about what 25 years of #discovery means and what he hopes for the next quarter century.
Learn more about #Stowers25: bit.ly/477ywSr
Learn more about #Stowers25: bit.ly/477ywSr
November 14, 2025 at 2:20 PM
Celebrating 25 years! ✨ Pres. & CSO @planaria1.bsky.social spoke with @kshb41.bsky.social about what 25 years of #discovery means and what he hopes for the next quarter century.
Learn more about #Stowers25: bit.ly/477ywSr
Learn more about #Stowers25: bit.ly/477ywSr
Reposted by Nicole Nuckolls
THE BOOK OF SPORES 🍄 is officially live on Kickstarter—and it funded already in just 50 minutes!
Thank you to everyone who has supported our anthology, and to everyone discovering it for the first time. Excited to share what we've been cooking with you all. 💙📚🪐
www.kickstarter.com/projects/fan...
Thank you to everyone who has supported our anthology, and to everyone discovering it for the first time. Excited to share what we've been cooking with you all. 💙📚🪐
www.kickstarter.com/projects/fan...
November 13, 2025 at 3:11 PM
THE BOOK OF SPORES 🍄 is officially live on Kickstarter—and it funded already in just 50 minutes!
Thank you to everyone who has supported our anthology, and to everyone discovering it for the first time. Excited to share what we've been cooking with you all. 💙📚🪐
www.kickstarter.com/projects/fan...
Thank you to everyone who has supported our anthology, and to everyone discovering it for the first time. Excited to share what we've been cooking with you all. 💙📚🪐
www.kickstarter.com/projects/fan...
Reposted by Nicole Nuckolls
Here's a big thank you to everyone at NIH who is trying to get everything regarding grants and reviews re-started!!!
November 13, 2025 at 5:58 PM
Here's a big thank you to everyone at NIH who is trying to get everything regarding grants and reviews re-started!!!
Reposted by Nicole Nuckolls
New work led by members of the @rokaslab.bsky.social! ☺️ 1,154 yeast genomes in the Saccharomycotina subphylum were surveyed for their relationship between reduced gene repertoires broadly associated with genome stability functions and elevated evolutionary rates.🧬
academic.oup.com/mbe/advance-...
academic.oup.com/mbe/advance-...
Stable hypermutators revealed by the genomic landscape of genes involved in genome stability among yeast species
Abstract. Mutator phenotypes are short-lived due to the rapid accumulation of deleterious mutations. Yet, recent observations reveal that certain fungi can
academic.oup.com
November 11, 2025 at 4:51 PM
New work led by members of the @rokaslab.bsky.social! ☺️ 1,154 yeast genomes in the Saccharomycotina subphylum were surveyed for their relationship between reduced gene repertoires broadly associated with genome stability functions and elevated evolutionary rates.🧬
academic.oup.com/mbe/advance-...
academic.oup.com/mbe/advance-...
Reposted by Nicole Nuckolls
Three German universities offering post-docs for researchers "who cannot conduct or continue their work in the USA appropriately because of actual political pressure. "
www.uni-konstanz.de/zukunftskoll...
www.uni-konstanz.de/zukunftskoll...
Early Career Rescue Fellowship
www.uni-konstanz.de
November 11, 2025 at 7:10 PM
Three German universities offering post-docs for researchers "who cannot conduct or continue their work in the USA appropriately because of actual political pressure. "
www.uni-konstanz.de/zukunftskoll...
www.uni-konstanz.de/zukunftskoll...
Reposted by Nicole Nuckolls
Investigator Jennifer Gerton presented her groundbreaking chromosome #research at National Academy of Sciences offering new insights into how #DNA fusions shaped human #evolution. 🧬
Learn more about the discovery: bit.ly/4pJxSBw
Learn more about the discovery: bit.ly/4pJxSBw
November 10, 2025 at 4:46 PM
Investigator Jennifer Gerton presented her groundbreaking chromosome #research at National Academy of Sciences offering new insights into how #DNA fusions shaped human #evolution. 🧬
Learn more about the discovery: bit.ly/4pJxSBw
Learn more about the discovery: bit.ly/4pJxSBw
Reposted by Nicole Nuckolls
Dr. Florence Sabin | Immunologist and educator, born #OTD in 1871.
The first woman to hold a full professorship at Johns Hopkins School of Medicine (where she graduated from in 1900) and the first woman elected to the National Academy of Sciences. #WomenInSTEM
The first woman to hold a full professorship at Johns Hopkins School of Medicine (where she graduated from in 1900) and the first woman elected to the National Academy of Sciences. #WomenInSTEM
November 10, 2025 at 4:03 AM
Dr. Florence Sabin | Immunologist and educator, born #OTD in 1871.
The first woman to hold a full professorship at Johns Hopkins School of Medicine (where she graduated from in 1900) and the first woman elected to the National Academy of Sciences. #WomenInSTEM
The first woman to hold a full professorship at Johns Hopkins School of Medicine (where she graduated from in 1900) and the first woman elected to the National Academy of Sciences. #WomenInSTEM
Reposted by Nicole Nuckolls
Congratulations to all the Democratic candidates who won tonight. It’s a reminder that when we come together around strong, forward-looking leaders who care about the issues that matter, we can win. We’ve still got plenty of work to do, but the future looks a little bit brighter.
November 5, 2025 at 2:47 AM
Congratulations to all the Democratic candidates who won tonight. It’s a reminder that when we come together around strong, forward-looking leaders who care about the issues that matter, we can win. We’ve still got plenty of work to do, but the future looks a little bit brighter.