Nitzan Gonen
@nitzan-gonen.bsky.social
Group leader @Bar Ilan University. Interested in sex determination, stem cells and 3D genome organisation. Head of the BIU transgenic unit. ERC StG 2022. Mom of 4.
What happens when you change the promoter of my favorite gene? Sox9?
What is a promoter? And how does it work?
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
Enhancer-promoter compatibility is mediated by the promoter-proximal region
Gene promoters induce transcription in response to distal enhancers. How enhancers specifically activate their target promoter while bypassing other promoters remains unclear. Here, we find that the p...
www.biorxiv.org
October 25, 2025 at 8:04 AM
What happens when you change the promoter of my favorite gene? Sox9?
Reposted by Nitzan Gonen
⚠️ Paper alert: Using a novel CRISPR screening approach, we mapped the entire regulatory network controlling Xist—key for X-chromosome inactivation.
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial
Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus - Nature Structural & Molecular Biology
Here Schwämmle et al. develop CRISPR reporter screens to map transcription-factor-regulatory element interactions at the Xist locus, revealing a two-step mechanism integrating developmental and X-dosage signals to initiate X-chromosome inactivation.
www.nature.com
October 6, 2025 at 1:02 PM
⚠️ Paper alert: Using a novel CRISPR screening approach, we mapped the entire regulatory network controlling Xist—key for X-chromosome inactivation.
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial
📢To all the sex determination lovers! 📢
Get ready for the 10th International Symposium on the Biology of Vertabrate Sex Determination (VSD).
We exchange the nostalgic Hawaii beaches with the gorgeous Crete beaches 🏖!
The meeting will take place on 23-27 March 2026.
biology-of-vsd.my.canva.site
Get ready for the 10th International Symposium on the Biology of Vertabrate Sex Determination (VSD).
We exchange the nostalgic Hawaii beaches with the gorgeous Crete beaches 🏖!
The meeting will take place on 23-27 March 2026.
biology-of-vsd.my.canva.site
September 29, 2025 at 7:08 PM
📢To all the sex determination lovers! 📢
Get ready for the 10th International Symposium on the Biology of Vertabrate Sex Determination (VSD).
We exchange the nostalgic Hawaii beaches with the gorgeous Crete beaches 🏖!
The meeting will take place on 23-27 March 2026.
biology-of-vsd.my.canva.site
Get ready for the 10th International Symposium on the Biology of Vertabrate Sex Determination (VSD).
We exchange the nostalgic Hawaii beaches with the gorgeous Crete beaches 🏖!
The meeting will take place on 23-27 March 2026.
biology-of-vsd.my.canva.site
Publishing an exciting paper and getting an ISF grant, both at the same week, is a good justification of Pizza and Prosecco in the middle of the day! 🍾🥂 Huge congrats to Isabelle, Meshi and Elisheva for this superb publication 💪
August 4, 2025 at 2:40 PM
Publishing an exciting paper and getting an ISF grant, both at the same week, is a good justification of Pizza and Prosecco in the middle of the day! 🍾🥂 Huge congrats to Isabelle, Meshi and Elisheva for this superb publication 💪
1/n Very excited to share our recent paper published on
@ScienceAdvances
where we dissect the gene regulatory landscape guiding mouse sex determination!
science.org/doi/10.1126/...
A huge well done to @IsabelleStevant.genomic.social.ap.brid.gy, Meshi and Elisheva who spearhead this project!
@ScienceAdvances
where we dissect the gene regulatory landscape guiding mouse sex determination!
science.org/doi/10.1126/...
A huge well done to @IsabelleStevant.genomic.social.ap.brid.gy, Meshi and Elisheva who spearhead this project!
The gene regulatory landscape driving mouse gonadal supporting cell differentiation
Multiomics analysis revealed the regulatory elements and transcription factors responsible for gonadal sex determination.
science.org
July 27, 2025 at 6:04 AM
1/n Very excited to share our recent paper published on
@ScienceAdvances
where we dissect the gene regulatory landscape guiding mouse sex determination!
science.org/doi/10.1126/...
A huge well done to @IsabelleStevant.genomic.social.ap.brid.gy, Meshi and Elisheva who spearhead this project!
@ScienceAdvances
where we dissect the gene regulatory landscape guiding mouse sex determination!
science.org/doi/10.1126/...
A huge well done to @IsabelleStevant.genomic.social.ap.brid.gy, Meshi and Elisheva who spearhead this project!
Reposted by Nitzan Gonen
Male mouse fetuses can develop female organs in utero if their mother is iron deficient during pregnancy
https://go.nature.com/43N7f4s
https://go.nature.com/43N7f4s
Male mice can grow ovaries if their pregnant mums are iron deficient
The study is the first to show that low iron levels can affect fetal sexual development.
go.nature.com
June 4, 2025 at 4:41 PM
Male mouse fetuses can develop female organs in utero if their mother is iron deficient during pregnancy
https://go.nature.com/43N7f4s
https://go.nature.com/43N7f4s
One of the coolest papers in the field of sex determination!
It is the first evidence that environmental aspects can affect mammalian sex determination!!
www.nature.com/articles/s41...
It is the first evidence that environmental aspects can affect mammalian sex determination!!
www.nature.com/articles/s41...
Maternal iron deficiency causes male-to-female sex reversal in mouse embryos - Nature
Iron-deficient conditions in pregnant mice can cause XY mouse embryos to develop female rather than male genitalia, revealing that iron metabolism has a role in determining male sex in mice.
www.nature.com
June 5, 2025 at 5:37 AM
One of the coolest papers in the field of sex determination!
It is the first evidence that environmental aspects can affect mammalian sex determination!!
www.nature.com/articles/s41...
It is the first evidence that environmental aspects can affect mammalian sex determination!!
www.nature.com/articles/s41...
Reposted by Nitzan Gonen
How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭
Check out our paper - fresh off the press!!!
We find widespread functional conservation of enhancers in absence of sequence homology
Including: a bioinformatic tool to map sequence-diverged enhancers!
rdcu.be/enVDN
github.com/tobiaszehnde...
Check out our paper - fresh off the press!!!
We find widespread functional conservation of enhancers in absence of sequence homology
Including: a bioinformatic tool to map sequence-diverged enhancers!
rdcu.be/enVDN
github.com/tobiaszehnde...
Conservation of regulatory elements with highly diverged sequences across large evolutionary distances
Nature Genetics - Combining functional genomic data from mouse and chicken with a synteny-based strategy identifies positionally conserved cis-regulatory elements in the absence of direct sequence...
rdcu.be
May 27, 2025 at 12:19 PM
How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭
Check out our paper - fresh off the press!!!
We find widespread functional conservation of enhancers in absence of sequence homology
Including: a bioinformatic tool to map sequence-diverged enhancers!
rdcu.be/enVDN
github.com/tobiaszehnde...
Check out our paper - fresh off the press!!!
We find widespread functional conservation of enhancers in absence of sequence homology
Including: a bioinformatic tool to map sequence-diverged enhancers!
rdcu.be/enVDN
github.com/tobiaszehnde...
Had the best time in Geneva, visiting my friend and collaborator Serge Nef.
I saw the beautiful city of Geneva, gave a seminar at the Medicine Faculty of Geneva University and met many brilliant scientists!!
Heading next to Zurich for the #TT2025 meeting to hear about transgenic mice technologies!
I saw the beautiful city of Geneva, gave a seminar at the Medicine Faculty of Geneva University and met many brilliant scientists!!
Heading next to Zurich for the #TT2025 meeting to hear about transgenic mice technologies!
April 23, 2025 at 9:15 PM
Had the best time in Geneva, visiting my friend and collaborator Serge Nef.
I saw the beautiful city of Geneva, gave a seminar at the Medicine Faculty of Geneva University and met many brilliant scientists!!
Heading next to Zurich for the #TT2025 meeting to hear about transgenic mice technologies!
I saw the beautiful city of Geneva, gave a seminar at the Medicine Faculty of Geneva University and met many brilliant scientists!!
Heading next to Zurich for the #TT2025 meeting to hear about transgenic mice technologies!
Reposted by Nitzan Gonen
A tour de force study from Taipale&Yin labs. It expands the vocabulary of the Regulatory Code by adding 1131 TF:TF composite motifs that are different from the individual TF motifs. The new composite motifs are enriched in cell-type specific elements and active in vivo
www.nature.com/articles/s41...
www.nature.com/articles/s41...
DNA-guided transcription factor interactions extend human gene regulatory code - Nature
A large-scale analysis of DNA-bound transcription factors (TFs) shows how the presence of DNA markedly affects the landscape of TF interactions, and identifies composite motifs that are recognized by ...
www.nature.com
April 9, 2025 at 4:51 PM
A tour de force study from Taipale&Yin labs. It expands the vocabulary of the Regulatory Code by adding 1131 TF:TF composite motifs that are different from the individual TF motifs. The new composite motifs are enriched in cell-type specific elements and active in vivo
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Highly recommend all scientist to watch the movie Joy on Netflix! It tells the story of IVF and the birth of Louise Joy Brown in 1978 and all the scientific endeavour behind. Millions of failures for 1 amazing success! This is what science is all about
m.imdb.com/title/tt1024...
m.imdb.com/title/tt1024...
Joy (2024) ⭐ 7.1 | Biography, Drama, History
1h 55m | PG-13
m.imdb.com
April 4, 2025 at 9:01 PM
Highly recommend all scientist to watch the movie Joy on Netflix! It tells the story of IVF and the birth of Louise Joy Brown in 1978 and all the scientific endeavour behind. Millions of failures for 1 amazing success! This is what science is all about
m.imdb.com/title/tt1024...
m.imdb.com/title/tt1024...
Reposted by Nitzan Gonen
Among the fun parts of being a scientist is going to conferences!!
A first time in Washington D.C where I will present our work at the #asa_ica25conf tomorrow. Come and hear me if you are here
A first time in Washington D.C where I will present our work at the #asa_ica25conf tomorrow. Come and hear me if you are here
March 29, 2025 at 4:01 PM
Among the fun parts of being a scientist is going to conferences!!
A first time in Washington D.C where I will present our work at the #asa_ica25conf tomorrow. Come and hear me if you are here
A first time in Washington D.C where I will present our work at the #asa_ica25conf tomorrow. Come and hear me if you are here
Ready for it???
To all the **sex determination lovers**
📢 Save the date to the 10th International Symposium on the Biology of Vertebrate Sex Determination (VSD) held in the beautiful Hawaii!!
Great community, amazing science, excellent speakers and superb location 🏝
📢 March 23-26, 2026 📢
To all the **sex determination lovers**
📢 Save the date to the 10th International Symposium on the Biology of Vertebrate Sex Determination (VSD) held in the beautiful Hawaii!!
Great community, amazing science, excellent speakers and superb location 🏝
📢 March 23-26, 2026 📢
March 25, 2025 at 5:45 AM
Ready for it???
To all the **sex determination lovers**
📢 Save the date to the 10th International Symposium on the Biology of Vertebrate Sex Determination (VSD) held in the beautiful Hawaii!!
Great community, amazing science, excellent speakers and superb location 🏝
📢 March 23-26, 2026 📢
To all the **sex determination lovers**
📢 Save the date to the 10th International Symposium on the Biology of Vertebrate Sex Determination (VSD) held in the beautiful Hawaii!!
Great community, amazing science, excellent speakers and superb location 🏝
📢 March 23-26, 2026 📢
Reposted by Nitzan Gonen
Israeli friends! Interested in learning & practicing the thinking tools of the creative process in science? Join the Night Science workshop in Tel Aviv University next week!
Register here: forms.office.com/r/xVhzcHTy1t
Thank you @judithberman11.bsky.social for organizing! @odedrechavi.bsky.social
Register here: forms.office.com/r/xVhzcHTy1t
Thank you @judithberman11.bsky.social for organizing! @odedrechavi.bsky.social
March 19, 2025 at 9:57 AM
Israeli friends! Interested in learning & practicing the thinking tools of the creative process in science? Join the Night Science workshop in Tel Aviv University next week!
Register here: forms.office.com/r/xVhzcHTy1t
Thank you @judithberman11.bsky.social for organizing! @odedrechavi.bsky.social
Register here: forms.office.com/r/xVhzcHTy1t
Thank you @judithberman11.bsky.social for organizing! @odedrechavi.bsky.social
Reposted by Nitzan Gonen
📣 We are advertising for a postdoc to join our team at the University of Edinburgh! Our lab studies gene regulatory mechanisms in development, and how genetic changes may impact these processes to alter development and shape human craniofacial form and function 🧬🧪
Postdoctoral Researcher
Our research is focused on understanding how genetic changes in the non-coding genome can impact gene regulatory mechanisms, alter developmental processes and ultimately affect human craniofacial shap...
elxw.fa.em3.oraclecloud.com
March 20, 2025 at 9:22 AM
📣 We are advertising for a postdoc to join our team at the University of Edinburgh! Our lab studies gene regulatory mechanisms in development, and how genetic changes may impact these processes to alter development and shape human craniofacial form and function 🧬🧪
An excellent article about the biology of sex and how it is being regarded by the US government
thehill.com/opinion/whit...
thehill.com/opinion/whit...
thehill.com
March 21, 2025 at 7:29 AM
An excellent article about the biology of sex and how it is being regarded by the US government
thehill.com/opinion/whit...
thehill.com/opinion/whit...
Me and all my XYs... Love them!
March 11, 2025 at 9:00 PM
Me and all my XYs... Love them!
After many postpones due to war, military service and just general depression, we went out today for a super fun day in Tel Aviv.
I have such an AMAZING lab and I am so happy to be thier friend, mentor, and just doing science and fun togerher ❤️
I have such an AMAZING lab and I am so happy to be thier friend, mentor, and just doing science and fun togerher ❤️
March 11, 2025 at 8:58 PM
After many postpones due to war, military service and just general depression, we went out today for a super fun day in Tel Aviv.
I have such an AMAZING lab and I am so happy to be thier friend, mentor, and just doing science and fun togerher ❤️
I have such an AMAZING lab and I am so happy to be thier friend, mentor, and just doing science and fun togerher ❤️
It will be very bad if this will happen. Far less research on females in many topics that will eventually harm 50% of the population
www.thetransmitter.org/policy/exclu...
www.thetransmitter.org/policy/exclu...
Exclusive: NIH appears to archive policy requiring female animals in studies
Such a shift would “put us back in the dark ages in terms of our science,” says neuroscientist Anne Murphy, who helped to formulate the original policy.
www.thetransmitter.org
February 25, 2025 at 9:31 PM
It will be very bad if this will happen. Far less research on females in many topics that will eventually harm 50% of the population
www.thetransmitter.org/policy/exclu...
www.thetransmitter.org/policy/exclu...
www.ynet.co.il/environment-...
ושום גרנט לא יוקרתי כמו פרסום ב YNET 🤣
שמחה להיות ה XX היחידה ברשימה יוקרתית ונכבדת של 11 XY.
ושום גרנט לא יוקרתי כמו פרסום ב YNET 🤣
שמחה להיות ה XX היחידה ברשימה יוקרתית ונכבדת של 11 XY.
ממיפוי עננים ועד גידול אשכים במעבדה: מענק יוקרתי ל-12 פרופסורים מישראל
שלושה חוקרים ממכון ויצמן למדע, שלושה מהאוניברסיטה העברית, שניים מהטכניון, שניים מבית החולים שיבא, חוקר מאוניברסיטת תל אביב וחוקרת מאוניברסיטת בר-אילן יקבלו מהאיחוד האירופי מענק "הוכחת היתכנות", שנועד ...
www.ynet.co.il
January 23, 2025 at 1:42 PM
www.ynet.co.il/environment-...
ושום גרנט לא יוקרתי כמו פרסום ב YNET 🤣
שמחה להיות ה XX היחידה ברשימה יוקרתית ונכבדת של 11 XY.
ושום גרנט לא יוקרתי כמו פרסום ב YNET 🤣
שמחה להיות ה XX היחידה ברשימה יוקרתית ונכבדת של 11 XY.
Thankful for the @ERC_Research for their continuous support in our research with an ERC PoC.
We plan to generate testis organoids from pre-pubertal boys testis biopsies, taken prior to chemotherapy.
We plan to generate testis organoids from pre-pubertal boys testis biopsies, taken prior to chemotherapy.
January 23, 2025 at 1:40 PM
Thankful for the @ERC_Research for their continuous support in our research with an ERC PoC.
We plan to generate testis organoids from pre-pubertal boys testis biopsies, taken prior to chemotherapy.
We plan to generate testis organoids from pre-pubertal boys testis biopsies, taken prior to chemotherapy.