Nick Leigh
@niche-leigh.bsky.social
Group Leader at Lund University, Sweden
interested in comparative immunology, comparative oncology, and regenerative biology, open and equitable science, and fishing | he/him | https://leighnd.github.io/
interested in comparative immunology, comparative oncology, and regenerative biology, open and equitable science, and fishing | he/him | https://leighnd.github.io/
Pinned
Nick Leigh
@niche-leigh.bsky.social
· Feb 13
The newt Pleurodeles waltl has amazing biological features, like the ability to regenerate tail and limbs!
Are the secrets to this regenerative capacity in their genome?
In this collaborative work from the Leigh, Yun, and Simon labs we explored this question.
www.cell.com/cell-genomic... (1/x)
Are the secrets to this regenerative capacity in their genome?
In this collaborative work from the Leigh, Yun, and Simon labs we explored this question.
www.cell.com/cell-genomic... (1/x)
Yesterday @jacoates.bsky.social and I gave talks on pre-prints hosted by the @lunduniversity-med.bsky.social . Jonny gave a great primer on the history of pre-prints and debunked myths about them. I spoke on our experiences with preprints and was encouraged to see this feedback after the talks👇
October 8, 2025 at 9:22 AM
Yesterday @jacoates.bsky.social and I gave talks on pre-prints hosted by the @lunduniversity-med.bsky.social . Jonny gave a great primer on the history of pre-prints and debunked myths about them. I spoke on our experiences with preprints and was encouraged to see this feedback after the talks👇
Reposted by Nick Leigh
💥OUR LAB IS HIRING!!💥
We are hiring a research assistant/lab manager to assist with managing our axolotl colony and enabling some kick-ass science! Looking for high levels of organization, collaboration, problem solving and curiosity.
Application link: tinyurl.com/3tpvphpm
#SciJob #JobAlert
We are hiring a research assistant/lab manager to assist with managing our axolotl colony and enabling some kick-ass science! Looking for high levels of organization, collaboration, problem solving and curiosity.
Application link: tinyurl.com/3tpvphpm
#SciJob #JobAlert
September 18, 2025 at 7:30 PM
💥OUR LAB IS HIRING!!💥
We are hiring a research assistant/lab manager to assist with managing our axolotl colony and enabling some kick-ass science! Looking for high levels of organization, collaboration, problem solving and curiosity.
Application link: tinyurl.com/3tpvphpm
#SciJob #JobAlert
We are hiring a research assistant/lab manager to assist with managing our axolotl colony and enabling some kick-ass science! Looking for high levels of organization, collaboration, problem solving and curiosity.
Application link: tinyurl.com/3tpvphpm
#SciJob #JobAlert
Reposted by Nick Leigh
I'm thrilled to share that my first co-authored review, "Decoding sex differences in human immunity through systems immunology," on Oxford Open Immunology! I'm so grateful for the opportunity to have worked with Tianze Cao and @consigliocr.bsky.social on this. doi.org/10.1093/oxfi...
Decoding sex differences in human immunity through systems immunology
Abstract. Immune function varies widely across humans. Biological sex is a key factor underlying human immune variability, with men presenting with more se
doi.org
July 22, 2025 at 12:15 PM
I'm thrilled to share that my first co-authored review, "Decoding sex differences in human immunity through systems immunology," on Oxford Open Immunology! I'm so grateful for the opportunity to have worked with Tianze Cao and @consigliocr.bsky.social on this. doi.org/10.1093/oxfi...
Reposted by Nick Leigh
‼️Our first review is out‼️
Decoding sex differences in human immunity through systems immunology shorturl.at/EsAkE
We discuss how #SystemsImmunology decodes #SexDifferences in #HumanImmunity, paving the way for tailored, sex-informed treatments.
Excellent work by @resabut.bsky.social & Tianze Cao!
Decoding sex differences in human immunity through systems immunology shorturl.at/EsAkE
We discuss how #SystemsImmunology decodes #SexDifferences in #HumanImmunity, paving the way for tailored, sex-informed treatments.
Excellent work by @resabut.bsky.social & Tianze Cao!
Decoding sex differences in human immunity through systems immunology
Abstract. Immune function varies widely across humans. Biological sex is a key factor underlying human immune variability, with men presenting with more se
academic.oup.com
August 12, 2025 at 9:53 AM
‼️Our first review is out‼️
Decoding sex differences in human immunity through systems immunology shorturl.at/EsAkE
We discuss how #SystemsImmunology decodes #SexDifferences in #HumanImmunity, paving the way for tailored, sex-informed treatments.
Excellent work by @resabut.bsky.social & Tianze Cao!
Decoding sex differences in human immunity through systems immunology shorturl.at/EsAkE
We discuss how #SystemsImmunology decodes #SexDifferences in #HumanImmunity, paving the way for tailored, sex-informed treatments.
Excellent work by @resabut.bsky.social & Tianze Cao!
Reposted by Nick Leigh
🫀Job alert 🧬 come and be our colleague! Join a BBSRC-funded consortium aiming to understand how the human heart develops - you will be contributing multimodal single cell & spatial transcriptomics data using zebrafish and human cardiac organoids as models. Learn more: www.heartdevelopment.org (1/4)
CellTalk HHD | Human Heart Development Research
CellTalk-Human Heart Development is a BBSRC funded consortium established to find out more about how cells come together to build the heart as it grows inside the womb.
www.heartdevelopment.org
May 16, 2025 at 10:10 AM
🫀Job alert 🧬 come and be our colleague! Join a BBSRC-funded consortium aiming to understand how the human heart develops - you will be contributing multimodal single cell & spatial transcriptomics data using zebrafish and human cardiac organoids as models. Learn more: www.heartdevelopment.org (1/4)
Reposted by Nick Leigh
Just published! Our Review on how immune cells masterfully orchestrate heart development and regeneration. Beyond fighting pathogens, they're actually building & repairing your heart! Learn how cutting-edge technologies are driving therapeutic opportunities here www.sciencedirect.com/science/arti...
Immune-mediated cardiac development and regeneration
The complex interplay between the immune and cardiovascular systems during development, homeostasis and regeneration represents a rapidly evolving fie…
www.sciencedirect.com
May 8, 2025 at 11:36 AM
Just published! Our Review on how immune cells masterfully orchestrate heart development and regeneration. Beyond fighting pathogens, they're actually building & repairing your heart! Learn how cutting-edge technologies are driving therapeutic opportunities here www.sciencedirect.com/science/arti...
Reposted by Nick Leigh
Come and work with us OOH @oxforddpag.bsky.social: ❤️ organoids to study 1) failing hearts and 2) metabolite signalling, with @novonordisk.bsky.social and wonderful colleagues 1) Andrew Lewis & Chris Toepfer @rdmoxford.bsky.social; 2) Yimon Aye @oxfordchemistry.bsky.social. Reach out if interested!
The Novo Nordisk – Oxford Fellowship Programme open for applications
The programme is focused on research in diabetes, obesity, cardiovascular diseases, and other cardiometabolic conditions.
There are 4 fully funded fellowships (3 years).
For more info on how to apply, visit shorturl.at/3l47e
The programme is focused on research in diabetes, obesity, cardiovascular diseases, and other cardiometabolic conditions.
There are 4 fully funded fellowships (3 years).
For more info on how to apply, visit shorturl.at/3l47e
April 2, 2025 at 8:07 AM
Come and work with us OOH @oxforddpag.bsky.social: ❤️ organoids to study 1) failing hearts and 2) metabolite signalling, with @novonordisk.bsky.social and wonderful colleagues 1) Andrew Lewis & Chris Toepfer @rdmoxford.bsky.social; 2) Yimon Aye @oxfordchemistry.bsky.social. Reach out if interested!
Reposted by Nick Leigh
🔬👩🔬What sparked your interest in science?👨🔬🧫
For 10 years, #UniStemDay at Lund Stem Cell Center has invited students to step into the lab, meet scientists & explore science. This year, 200 joined us for hands-on experiments & career inspiration!
📖 Read more:
www.stemcellcenter.lu.se/article/unis...
For 10 years, #UniStemDay at Lund Stem Cell Center has invited students to step into the lab, meet scientists & explore science. This year, 200 joined us for hands-on experiments & career inspiration!
📖 Read more:
www.stemcellcenter.lu.se/article/unis...
UniStem Day 2025: A Decade of Inspiring Future Scientists in Lund
Lund University.
www.stemcellcenter.lu.se
March 21, 2025 at 2:41 PM
🔬👩🔬What sparked your interest in science?👨🔬🧫
For 10 years, #UniStemDay at Lund Stem Cell Center has invited students to step into the lab, meet scientists & explore science. This year, 200 joined us for hands-on experiments & career inspiration!
📖 Read more:
www.stemcellcenter.lu.se/article/unis...
For 10 years, #UniStemDay at Lund Stem Cell Center has invited students to step into the lab, meet scientists & explore science. This year, 200 joined us for hands-on experiments & career inspiration!
📖 Read more:
www.stemcellcenter.lu.se/article/unis...
Great write-up from Alexis! UniStem is an amazing initiative and given the current attacks on science it’s critical we work to educate and motivate the future generation to be pro-science.
🔬👩🔬What sparked your interest in science?👨🔬🧫
For 10 years, #UniStemDay at Lund Stem Cell Center has invited students to step into the lab, meet scientists & explore science. This year, 200 joined us for hands-on experiments & career inspiration!
📖 Read more:
www.stemcellcenter.lu.se/article/unis...
For 10 years, #UniStemDay at Lund Stem Cell Center has invited students to step into the lab, meet scientists & explore science. This year, 200 joined us for hands-on experiments & career inspiration!
📖 Read more:
www.stemcellcenter.lu.se/article/unis...
UniStem Day 2025: A Decade of Inspiring Future Scientists in Lund
Lund University.
www.stemcellcenter.lu.se
March 21, 2025 at 3:06 PM
Great write-up from Alexis! UniStem is an amazing initiative and given the current attacks on science it’s critical we work to educate and motivate the future generation to be pro-science.
The newt Pleurodeles waltl has amazing biological features, like the ability to regenerate tail and limbs!
Are the secrets to this regenerative capacity in their genome?
In this collaborative work from the Leigh, Yun, and Simon labs we explored this question.
www.cell.com/cell-genomic... (1/x)
Are the secrets to this regenerative capacity in their genome?
In this collaborative work from the Leigh, Yun, and Simon labs we explored this question.
www.cell.com/cell-genomic... (1/x)
February 13, 2025 at 4:23 PM
The newt Pleurodeles waltl has amazing biological features, like the ability to regenerate tail and limbs!
Are the secrets to this regenerative capacity in their genome?
In this collaborative work from the Leigh, Yun, and Simon labs we explored this question.
www.cell.com/cell-genomic... (1/x)
Are the secrets to this regenerative capacity in their genome?
In this collaborative work from the Leigh, Yun, and Simon labs we explored this question.
www.cell.com/cell-genomic... (1/x)
Reposted by Nick Leigh
A #Pleurodeles on the cover. Interested in this #giantgenome, #salamander #regeneration, #noncodingRNA landscape? Pls check out: www.cell.com/cell-genomic.... Many great labs involved, special thanks to co-senior authors
@maxyunlab.bsky.social, and @niche-leigh.bsky.social
@maxyunlab.bsky.social, and @niche-leigh.bsky.social
February 12, 2025 at 5:01 PM
A #Pleurodeles on the cover. Interested in this #giantgenome, #salamander #regeneration, #noncodingRNA landscape? Pls check out: www.cell.com/cell-genomic.... Many great labs involved, special thanks to co-senior authors
@maxyunlab.bsky.social, and @niche-leigh.bsky.social
@maxyunlab.bsky.social, and @niche-leigh.bsky.social
Reposted by Nick Leigh
Newt Genome assembly is out. Congratulations @andrassimon.bsky.social @maxyunlab.bsky.social @niche-leigh.bsky.social labs.🍻 www.cell.com/cell-genomic...
Chromosome-scale genome assembly reveals how repeat elements shape non-coding RNA landscapes active during newt limb regeneration
Understanding molecular mechanisms behind newts’ exceptional regenerative capability
has been limited because of their large, repeat-element-rich genome. Brown et al.
present the most complete chromos...
www.cell.com
January 30, 2025 at 5:06 PM
Newt Genome assembly is out. Congratulations @andrassimon.bsky.social @maxyunlab.bsky.social @niche-leigh.bsky.social labs.🍻 www.cell.com/cell-genomic...
Reposted by Nick Leigh
And the newt genome ms is finally out! www.cell.com/cell-genomic... Thanks @andrassimon.bsky.social @niche-leigh.bsky.social labs for an amazing collab, and specially Tom Brown for great assembly skills.
@dcgenomecenter.bsky.social
@crtd-tud.bsky.social
@mpicbg.bsky.social
@poldresden.bsky.social
@dcgenomecenter.bsky.social
@crtd-tud.bsky.social
@mpicbg.bsky.social
@poldresden.bsky.social
Chromosome-scale genome assembly reveals how repeat elements shape non-coding RNA landscapes active during newt limb regeneration
Understanding molecular mechanisms behind newts’ exceptional regenerative capability
has been limited because of their large, repeat-element-rich genome. Brown et al.
present the most complete chromos...
www.cell.com
January 30, 2025 at 6:21 PM
And the newt genome ms is finally out! www.cell.com/cell-genomic... Thanks @andrassimon.bsky.social @niche-leigh.bsky.social labs for an amazing collab, and specially Tom Brown for great assembly skills.
@dcgenomecenter.bsky.social
@crtd-tud.bsky.social
@mpicbg.bsky.social
@poldresden.bsky.social
@dcgenomecenter.bsky.social
@crtd-tud.bsky.social
@mpicbg.bsky.social
@poldresden.bsky.social
Reposted by Nick Leigh
🚀 Lund University's Faculty of Medicine seeks candidates for 2 Assoc. Senior Lecturer roles in:
➡️ Translational research in advanced therapies:
https://buff.ly/4aAb3ci
➡️ Basic research in regenerative medicine & disease mechanisms:
https://buff.ly/3E8BKsl
Apply by 10 Feb to join us in Lund!
➡️ Translational research in advanced therapies:
https://buff.ly/4aAb3ci
➡️ Basic research in regenerative medicine & disease mechanisms:
https://buff.ly/3E8BKsl
Apply by 10 Feb to join us in Lund!
January 27, 2025 at 8:46 AM
🚀 Lund University's Faculty of Medicine seeks candidates for 2 Assoc. Senior Lecturer roles in:
➡️ Translational research in advanced therapies:
https://buff.ly/4aAb3ci
➡️ Basic research in regenerative medicine & disease mechanisms:
https://buff.ly/3E8BKsl
Apply by 10 Feb to join us in Lund!
➡️ Translational research in advanced therapies:
https://buff.ly/4aAb3ci
➡️ Basic research in regenerative medicine & disease mechanisms:
https://buff.ly/3E8BKsl
Apply by 10 Feb to join us in Lund!
Reposted by Nick Leigh
Interested in working with 🐸, 🐭, stem cells, or computational methods 🖥️ to delve into the unknowns of regeneration in our new lab? Looking forward to enthusiastic and ambitious applicants! PhD program applications open! 🔗 www.phd.tuebingen.mpg.de/14722/phdpro... Please RT! 🙌
@mpi-bio-fml.bsky.social are now accepting applications or fully-funded biology #PhD positions at the Max Planck Institute for Biology and Friedrich Miescher Laboratory. The new cohort starts September 2025.
Find out more about the projects you could be working on: www.phd.tuebingen.mpg.de
#IMPRS
Find out more about the projects you could be working on: www.phd.tuebingen.mpg.de
#IMPRS
December 4, 2024 at 10:50 AM
Interested in working with 🐸, 🐭, stem cells, or computational methods 🖥️ to delve into the unknowns of regeneration in our new lab? Looking forward to enthusiastic and ambitious applicants! PhD program applications open! 🔗 www.phd.tuebingen.mpg.de/14722/phdpro... Please RT! 🙌
⚡We are recruiting an Assistant Professor in Regenerative Medicine⚡
Looking for a great place to start a lab? Look no further!
The center has a strong track record of developing new PIs and the position comes with substantial 💰. Get in touch if you have questions!
lu.varbi.com/en/what:job/...
Looking for a great place to start a lab? Look no further!
The center has a strong track record of developing new PIs and the position comes with substantial 💰. Get in touch if you have questions!
lu.varbi.com/en/what:job/...
Associate Senior Lecturer (WCMM Fellow) in Molecular Medicine with a focus on basic research into regenerative medicine and disease mechanisms
In this call for proposals ( Wallenberg Molecular Medicine Fellow ), we are looking for prominent researchers with international research experience. The position is located at the Faculty of Medicine
lu.varbi.com
January 8, 2025 at 8:41 AM
⚡We are recruiting an Assistant Professor in Regenerative Medicine⚡
Looking for a great place to start a lab? Look no further!
The center has a strong track record of developing new PIs and the position comes with substantial 💰. Get in touch if you have questions!
lu.varbi.com/en/what:job/...
Looking for a great place to start a lab? Look no further!
The center has a strong track record of developing new PIs and the position comes with substantial 💰. Get in touch if you have questions!
lu.varbi.com/en/what:job/...
Reposted by Nick Leigh
If you share our enthusiasm for #regeneration, share, follow, and (self-)nominate people to the list.
🧪
go.bsky.app/MGXL9Ra
🧪
go.bsky.app/MGXL9Ra
November 13, 2024 at 12:46 PM
If you share our enthusiasm for #regeneration, share, follow, and (self-)nominate people to the list.
🧪
go.bsky.app/MGXL9Ra
🧪
go.bsky.app/MGXL9Ra
🐸 Salamanders 🐸 are resistant to cancer!
🚨 5 days🚨 left to apply for a postdoc position to help us discover the origins of this resistance!
Come join us!!!
🚨 5 days🚨 left to apply for a postdoc position to help us discover the origins of this resistance!
Come join us!!!
June 10, 2024 at 6:49 PM
🐸 Salamanders 🐸 are resistant to cancer!
🚨 5 days🚨 left to apply for a postdoc position to help us discover the origins of this resistance!
Come join us!!!
🚨 5 days🚨 left to apply for a postdoc position to help us discover the origins of this resistance!
Come join us!!!
Reposted by Nick Leigh
A new preprint from our lab!
Axolotl mandible regeneration occurs through mechanical gap closure and a shared regenerative program with the limb https://www.biorxiv.org/content/10.1101/2024.02.14.580108v1
Axolotl mandible regeneration occurs through mechanical gap closure and a shared regenerative program with the limb https://www.biorxiv.org/content/10.1101/2024.02.14.580108v1
The mandible plays an essential part in human life and, thus, defects in this structure can dramatic
www.biorxiv.org
February 19, 2024 at 7:19 AM
A new preprint from our lab!
🐸 Salamanders 🐸 are extremely resistant to cancer.
Why?
We don't know!
We have a postdoc position now open to delve into to the tumor resistance mechanisms of salamanders. Big thanks to Cancerfonden for making this possible! Apply now!
Why?
We don't know!
We have a postdoc position now open to delve into to the tumor resistance mechanisms of salamanders. Big thanks to Cancerfonden for making this possible! Apply now!
November 15, 2023 at 9:28 AM
🐸 Salamanders 🐸 are extremely resistant to cancer.
Why?
We don't know!
We have a postdoc position now open to delve into to the tumor resistance mechanisms of salamanders. Big thanks to Cancerfonden for making this possible! Apply now!
Why?
We don't know!
We have a postdoc position now open to delve into to the tumor resistance mechanisms of salamanders. Big thanks to Cancerfonden for making this possible! Apply now!
Today I went with alumni of the Wallenberg Centre for Molecular Medicine Research School to a nearby English school to share science to 12-13 year olds. The energy and excitement from the both sets of students was amazing!! Hoping we see some of these bright minds in the lab soon!
October 24, 2023 at 5:27 PM
Today I went with alumni of the Wallenberg Centre for Molecular Medicine Research School to a nearby English school to share science to 12-13 year olds. The energy and excitement from the both sets of students was amazing!! Hoping we see some of these bright minds in the lab soon!
Happy to be over here...now time to reconnect with all the people who have made the migration over from Twitter. I'll share my thoughts on regeneration, immunology, and using high throughput sequencing in all types of animals!
October 18, 2023 at 4:50 PM
Happy to be over here...now time to reconnect with all the people who have made the migration over from Twitter. I'll share my thoughts on regeneration, immunology, and using high throughput sequencing in all types of animals!