Nibal Badra
@nibal-badra.bsky.social
Postdoc in the @AguileraLab at @CABIMER.
Reposted by Nibal Badra
Thrilled to share our latest work, just published in @nature.com ⬇
www.nature.com/articles/s41...
We discovered that PARP inhibitors 💊 trigger histone eviction from the chromatin and this creates a hidden vulnerability in PARPi resistant tumors.
🧵 (1/8)
www.nature.com/articles/s41...
We discovered that PARP inhibitors 💊 trigger histone eviction from the chromatin and this creates a hidden vulnerability in PARPi resistant tumors.
🧵 (1/8)
NASP modulates histone turnover to drive PARP inhibitor resistance - Nature
PARP inhibitor treatment triggers histone release from the chromatin in cancer cells; consequently, targeting the histone chaperone NASP renders cells vulnerable to PARP inhibition.
www.nature.com
August 13, 2025 at 3:44 PM
Thrilled to share our latest work, just published in @nature.com ⬇
www.nature.com/articles/s41...
We discovered that PARP inhibitors 💊 trigger histone eviction from the chromatin and this creates a hidden vulnerability in PARPi resistant tumors.
🧵 (1/8)
www.nature.com/articles/s41...
We discovered that PARP inhibitors 💊 trigger histone eviction from the chromatin and this creates a hidden vulnerability in PARPi resistant tumors.
🧵 (1/8)
Reposted by Nibal Badra
If you are interested in pursuing a postdoc combining proteomics a genomics with functional molecular biology to study ubiquitin (-like) signaling in genome biology we are looking for candidates for the next MSCA Fellowships call!!!!
June 4, 2025 at 9:01 PM
If you are interested in pursuing a postdoc combining proteomics a genomics with functional molecular biology to study ubiquitin (-like) signaling in genome biology we are looking for candidates for the next MSCA Fellowships call!!!!
Reposted by Nibal Badra
Save de date! Join us at @cabimer.bsky.social on October 17th for the @GenomaHubCSIC Workshop in "Genome Dynamics in Development and Disease". Slots available for talks! Registration opens soon!!
May 30, 2025 at 12:44 PM
Save de date! Join us at @cabimer.bsky.social on October 17th for the @GenomaHubCSIC Workshop in "Genome Dynamics in Development and Disease". Slots available for talks! Registration opens soon!!
Reposted by Nibal Badra
Delighted to share that the results of my main postdoc project are now published in @nature.com
🔗 doi.org/10.1038/s415...
🔗 doi.org/10.1038/s415...
Multigenerational cell tracking of DNA replication and heritable DNA damage - Nature
A multigenerational single-cell tracking approach provides a framework to dissect phenotypic plasticity at the single-cell level, offering insights into cellular processes that may resemble early even...
doi.org
May 21, 2025 at 3:27 PM
Delighted to share that the results of my main postdoc project are now published in @nature.com
🔗 doi.org/10.1038/s415...
🔗 doi.org/10.1038/s415...
Reposted by Nibal Badra
Excited to share our latest from my postdoc at @mskcancercenter.bsky.social in the Sfeir Lab, in collaboration with the Simon Powell Lab! We uncovered a novel genome repair mechanism in human cells: RNA-templated DNA double-strand break repair (RT-DSBR). (1/5)
May 12, 2025 at 5:49 PM
Excited to share our latest from my postdoc at @mskcancercenter.bsky.social in the Sfeir Lab, in collaboration with the Simon Powell Lab! We uncovered a novel genome repair mechanism in human cells: RNA-templated DNA double-strand break repair (RT-DSBR). (1/5)
Reposted by Nibal Badra
Excited to see this out in @science.org today!! www.science.org/doi/10.1126/...
May 1, 2025 at 6:17 PM
Excited to see this out in @science.org today!! www.science.org/doi/10.1126/...
Reposted by Nibal Badra
FANCX=FAAP100, new Fanconi Anemia gene
Two new papers identify 3 families with FAAP100 homozygous mutations leading to severe developmental and hematologic abnormalities leading to death in utero or in early life.
www.jci.org/articles/vie...
www.jci.org/articles/vie...
Two new papers identify 3 families with FAAP100 homozygous mutations leading to severe developmental and hematologic abnormalities leading to death in utero or in early life.
www.jci.org/articles/vie...
www.jci.org/articles/vie...
JCI -
Genetic inactivation of FAAP100 causes Fanconi anemia due to disruption of the monoubiquitin ligase core complex
www.jci.org
April 25, 2025 at 4:56 PM
FANCX=FAAP100, new Fanconi Anemia gene
Two new papers identify 3 families with FAAP100 homozygous mutations leading to severe developmental and hematologic abnormalities leading to death in utero or in early life.
www.jci.org/articles/vie...
www.jci.org/articles/vie...
Two new papers identify 3 families with FAAP100 homozygous mutations leading to severe developmental and hematologic abnormalities leading to death in utero or in early life.
www.jci.org/articles/vie...
www.jci.org/articles/vie...
Reposted by Nibal Badra
Our latest study from my postdoctoral work has just been published in Science Advances!
Grateful to my mentor and collaborators who made it possible! @buissonlab.bsky.social @ucirvine.bsky.social
🔗 www.science.org/doi/10.1126/...
Grateful to my mentor and collaborators who made it possible! @buissonlab.bsky.social @ucirvine.bsky.social
🔗 www.science.org/doi/10.1126/...
Mechanism of DNA replication fork breakage and PARP1 hyperactivation during replication catastrophe
Upon ATR inhibition, APOBEC3B targets unprotected single-stranded DNA at replication forks, leading to fork breakage.
www.science.org
April 16, 2025 at 7:13 PM
Our latest study from my postdoctoral work has just been published in Science Advances!
Grateful to my mentor and collaborators who made it possible! @buissonlab.bsky.social @ucirvine.bsky.social
🔗 www.science.org/doi/10.1126/...
Grateful to my mentor and collaborators who made it possible! @buissonlab.bsky.social @ucirvine.bsky.social
🔗 www.science.org/doi/10.1126/...
Reposted by Nibal Badra
The EMBO Installation Grants support life scientists establishing laboratories in Croatia, Czechia, Estonia, Greece, Hungary, Lithuania, Luxembourg, Montenegro, Poland, Portugal and Türkiye. 🧪 The application deadline is 15 April: www.embo.org/funding/fell... #ResearchFunding #LifeSciences
Fellowships, grants and career support – Installation Grants – EMBO
Supporting group leaders who move to host countries that are part of the Installation Grant scheme
www.embo.org
April 2, 2025 at 11:08 AM
The EMBO Installation Grants support life scientists establishing laboratories in Croatia, Czechia, Estonia, Greece, Hungary, Lithuania, Luxembourg, Montenegro, Poland, Portugal and Türkiye. 🧪 The application deadline is 15 April: www.embo.org/funding/fell... #ResearchFunding #LifeSciences
Reposted by Nibal Badra
Delighted to share a chemical-genetic system we developed to rapidly inhibit a serine/threonine phosphatase complex (within secs). This will make it much easier to study #phosphatases. The system is also applicable to other “undruggable” enzymes.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A chemical-genetic system to rapidly inhibit the PP2A-B56 phosphatase reveals a role at metaphase kinetochores - Nature Communications
Phosphatase enzymes are challenging to study due to a lack of specific inhibitors. Here, authors develop a chemical-genetic system to inhibit and characterize a major Ser/Thr phosphatase complex, and ...
www.nature.com
April 1, 2025 at 5:58 PM
Delighted to share a chemical-genetic system we developed to rapidly inhibit a serine/threonine phosphatase complex (within secs). This will make it much easier to study #phosphatases. The system is also applicable to other “undruggable” enzymes.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Nibal Badra
Submit poster abstracts by 4/3, 11:59pm MST for DNA Replication Gaps, Cancer, and Disease in Daejeon, South Korea. Join experts to explore DNA errors and cancer. keysym.us/KSDNARep25.
youtu.be/_aPIkDQg1rw #KSDNARep25 @cantorlab.bsky.social @albertociccia.bsky.social @labvincenzo.bsky.social
youtu.be/_aPIkDQg1rw #KSDNARep25 @cantorlab.bsky.social @albertociccia.bsky.social @labvincenzo.bsky.social
KSQA: Dr. Kyungjae Myung (DNA Replication Gaps)
YouTube video by KeystoneSymposia
youtu.be
March 27, 2025 at 6:37 PM
Submit poster abstracts by 4/3, 11:59pm MST for DNA Replication Gaps, Cancer, and Disease in Daejeon, South Korea. Join experts to explore DNA errors and cancer. keysym.us/KSDNARep25.
youtu.be/_aPIkDQg1rw #KSDNARep25 @cantorlab.bsky.social @albertociccia.bsky.social @labvincenzo.bsky.social
youtu.be/_aPIkDQg1rw #KSDNARep25 @cantorlab.bsky.social @albertociccia.bsky.social @labvincenzo.bsky.social
Reposted by Nibal Badra
🚨𝐌𝐚𝐣𝐨𝐫 𝐉𝐨𝐛 𝐀𝐥𝐞𝐫𝐭!🚨The Groth @groth-anja.bsky.social, Mailand, Nilsson @nilssonlab.bsky.social & Krietenstein @nilskrietenstein.bsky.social labs are hiring 𝟔 𝐏𝐡𝐃&𝐩𝐨𝐬𝐭𝐝𝐨𝐜𝐬 to join the new Center for Epigenetic Cell Memory (EpiC) in Copenhagen, Denmark. Apply here: tinyurl.com/yvd93na2 & please share!
6 Postdoctoral and PhD positions in Center for Epigenetic Cell Memory (EpiC)
The Center for Epigenetic Cell Memory (EpiC) is a new Center of Excellence that will be established based on funding by the Danish National Research Foundation.
tinyurl.com
February 12, 2025 at 2:53 PM
🚨𝐌𝐚𝐣𝐨𝐫 𝐉𝐨𝐛 𝐀𝐥𝐞𝐫𝐭!🚨The Groth @groth-anja.bsky.social, Mailand, Nilsson @nilssonlab.bsky.social & Krietenstein @nilskrietenstein.bsky.social labs are hiring 𝟔 𝐏𝐡𝐃&𝐩𝐨𝐬𝐭𝐝𝐨𝐜𝐬 to join the new Center for Epigenetic Cell Memory (EpiC) in Copenhagen, Denmark. Apply here: tinyurl.com/yvd93na2 & please share!
Reposted by Nibal Badra
Check out our review on DNA end resection! With Raphael Ceccaldi, www.nature.com/articles/s41...
March 25, 2025 at 4:00 PM
Check out our review on DNA end resection! With Raphael Ceccaldi, www.nature.com/articles/s41...
Reposted by Nibal Badra
Exciting seminar series from Genome integrity italian Network (GiiN), chaired by myself and Raffaella Di Micco! Short talks (2x30’), at convenient time for EU/USA attendees. Big shots and raising stars in an expanding field. See flyers + link to receive email alerts. Please repost to your network!👇
March 17, 2025 at 9:58 PM
Exciting seminar series from Genome integrity italian Network (GiiN), chaired by myself and Raffaella Di Micco! Short talks (2x30’), at convenient time for EU/USA attendees. Big shots and raising stars in an expanding field. See flyers + link to receive email alerts. Please repost to your network!👇
Reposted by Nibal Badra
2) The histone chaperone CAF1 promotes PRIMPOL recruitment to restart stalled forks through ssDNA gap formation. doi.org/10.1093/nar/...
CAF-1 promotes efficient PrimPol recruitment to nascent DNA for single-stranded DNA gap formation
Abstract. Suppression of single-stranded DNA (ssDNA) gap accumulation at replication forks has emerged as a potential determinant of chemosensitivity in ho
doi.org
December 18, 2024 at 3:45 PM
2) The histone chaperone CAF1 promotes PRIMPOL recruitment to restart stalled forks through ssDNA gap formation. doi.org/10.1093/nar/...
Reposted by Nibal Badra
Excited to share my first co-first author paper! We uncovered a conserved role for RAD51/BRCA2 in protecting abasic sites at replication forks from MRE11 cleavage.
#ssDNA gaps, #DNMT1, #POLθ, #Cryo-EM of #RAD51 bound to AP sites, and much more! Check it out!
#ssDNA gaps, #DNMT1, #POLθ, #Cryo-EM of #RAD51 bound to AP sites, and much more! Check it out!
RAD51 protects abasic sites to prevent replication fork breakage
Hanthi et al. found that RAD51 recognizes and binds to abasic sites. Together with
BRCA2, RAD51 prevents the accumulation of abasic site-induced replicative DNA gaps
(caused by DNA methylation, oxidat...
www.cell.com
November 18, 2024 at 2:19 PM
Reposted by Nibal Badra
Cancer cells often harbor oncogenes outside chromosomes on extrachromosomal DNA (ecDNA), which is unevenly inherited by dividing cells. We reported in Nature last week that collectives of ecDNAs are inherited together by dividing cancer cells. 1/
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Coordinated inheritance of extrachromosomal DNAs in cancer cells - Nature
Cooperative species of extrachromosomal DNAs are coordinately inherited through mitotic co-segregation.
www.nature.com
November 18, 2024 at 5:37 PM
Cancer cells often harbor oncogenes outside chromosomes on extrachromosomal DNA (ecDNA), which is unevenly inherited by dividing cells. We reported in Nature last week that collectives of ecDNAs are inherited together by dividing cancer cells. 1/
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The drama going on in here.
November 17, 2024 at 4:45 PM
The drama going on in here.
Reposted by Nibal Badra
New Lab Preprint! We show that ATR inhibition results in hyperactivation of PARP1 at replication forks, driven by APOBEC3B, UNG2, and APE1 reaction cascade targeting unprotected single-stranded DNA at the forks. www.biorxiv.org/content/10.1...
November 16, 2024 at 4:54 PM
New Lab Preprint! We show that ATR inhibition results in hyperactivation of PARP1 at replication forks, driven by APOBEC3B, UNG2, and APE1 reaction cascade targeting unprotected single-stranded DNA at the forks. www.biorxiv.org/content/10.1...
Reposted by Nibal Badra
Download our database of 313 different postdoctoral fellowships.
For each entry, we provide link to funder, description, amount, deadline, and eligibility criteria (e.g. citizenship).
Download our database here: research.jhu.edu/rdt/funding-...
For each entry, we provide link to funder, description, amount, deadline, and eligibility criteria (e.g. citizenship).
Download our database here: research.jhu.edu/rdt/funding-...
November 16, 2024 at 7:05 PM
Download our database of 313 different postdoctoral fellowships.
For each entry, we provide link to funder, description, amount, deadline, and eligibility criteria (e.g. citizenship).
Download our database here: research.jhu.edu/rdt/funding-...
For each entry, we provide link to funder, description, amount, deadline, and eligibility criteria (e.g. citizenship).
Download our database here: research.jhu.edu/rdt/funding-...
Reposted by Nibal Badra
Announcing the next EMBO Chromosome Segregation and Aneuploidy Meeting! Italy 2025. Please register and join us for another exciting and friendly meeting in a beautiful location meetings.embo.org/event/25-ane...
Chromosome Segregation and Aneuploidy
Aneuploidy is a hallmark of cancer and developmental disorders such as Down syndrome. Understanding how cells accomplish faithful chromosome segregation and how chromosomal instability (CIN) impacts …
meetings.embo.org
November 14, 2024 at 7:43 AM
Announcing the next EMBO Chromosome Segregation and Aneuploidy Meeting! Italy 2025. Please register and join us for another exciting and friendly meeting in a beautiful location meetings.embo.org/event/25-ane...