Thomas Arnesen
@natmachinery.bsky.social
Prof. Univ. of Bergen & Helse Bergen | Basic & translational science | Molecular Biology | Cancer | Endocrinology | Rare diseases | Cytoskeleton | Ribosome | Protein biogenesis | PTMs | N-terminal acetylation
https://www.uib.no/en/rg/protein
https://www.uib.no/en/rg/protein
Pinned
Protein N-terminal modifications - Feature Review and cover in the recent issue of @cp-trendsbiochem.bsky.social Thanks to all authors, Editor @sanniejculbertson.bsky.social and reviewers for great work and support! @ispt-proteinterm.bsky.social www.cell.com/trends/bioch...
Reposted by Thomas Arnesen
📝 Online now - the Review "Emerging functions for nonhistone protein acetylation in budding yeast" from Michael Downey and colleagues.
#PostTranslationalModifications #DNADamageResponse #Proteostasis #Autophagy #MetabolicRegulation
Read it here: authors.elsevier.com/a/1m4nM3S6Gf...
#PostTranslationalModifications #DNADamageResponse #Proteostasis #Autophagy #MetabolicRegulation
Read it here: authors.elsevier.com/a/1m4nM3S6Gf...
November 12, 2025 at 2:28 PM
📝 Online now - the Review "Emerging functions for nonhistone protein acetylation in budding yeast" from Michael Downey and colleagues.
#PostTranslationalModifications #DNADamageResponse #Proteostasis #Autophagy #MetabolicRegulation
Read it here: authors.elsevier.com/a/1m4nM3S6Gf...
#PostTranslationalModifications #DNADamageResponse #Proteostasis #Autophagy #MetabolicRegulation
Read it here: authors.elsevier.com/a/1m4nM3S6Gf...
Reposted by Thomas Arnesen
Want to assess N-terminal acetyltransferases without radioactive labelling or mass spec? Look here! @ispt-proteinterm.bsky.social @cellsignal.com
October 27, 2025 at 8:25 PM
Want to assess N-terminal acetyltransferases without radioactive labelling or mass spec? Look here! @ispt-proteinterm.bsky.social @cellsignal.com
Reposted by Thomas Arnesen
See you at Palazzo dei Normanni in Palermo for the 2026 Protein Termini Conference | Co- and post-translational modifications | Proteolytic processing and degradation pathways | Microbes, plants, animals #ProteinTermini2026 #Proteostasis #ProteinModifications #PalazzoDeiNormanni #Palermo2026
October 26, 2025 at 6:59 PM
See you at Palazzo dei Normanni in Palermo for the 2026 Protein Termini Conference | Co- and post-translational modifications | Proteolytic processing and degradation pathways | Microbes, plants, animals #ProteinTermini2026 #Proteostasis #ProteinModifications #PalazzoDeiNormanni #Palermo2026
Reposted by Thomas Arnesen
We are advertising a PhD project investigating a cellular mechanism that ensures protein quality control during mRNA translation in plants. Please get in touch on here or via email if you are interested and I can provide further details!
Lab website: sites.google.com/site/danielg...
Lab website: sites.google.com/site/danielg...
Daniel Gibbs Lab
Welcome to the lab website of Professor Daniel Gibbs
@ University of Birmingham
sites.google.com
October 14, 2025 at 2:07 PM
We are advertising a PhD project investigating a cellular mechanism that ensures protein quality control during mRNA translation in plants. Please get in touch on here or via email if you are interested and I can provide further details!
Lab website: sites.google.com/site/danielg...
Lab website: sites.google.com/site/danielg...
Uptake of anti-cancer drugs depends on N-terminally acetylated anion channels | @ispt-proteinterm.bsky.social www.nature.com/articles/s42...
NAA60 facilitates LRRC8A- and LRRC8D-mediated platinum drug uptake - Communications Biology
Genome-wide CRISPR/Cas9 screening identifies the N-terminal acetyltransferase NAA60 to facilitate cis- and carboplatin drug sensitivity, most likely by neutralizing Nt acetylation of the LRRC8A/D VRAC subunits regulating substrate permeability.
www.nature.com
October 7, 2025 at 11:03 AM
Uptake of anti-cancer drugs depends on N-terminally acetylated anion channels | @ispt-proteinterm.bsky.social www.nature.com/articles/s42...
Reposted by Thomas Arnesen
📢 Our October issue is now online. Access the full issue 👉 www.cell.com/trends/bioch....
🎨 The cover highlights a Review from @chiosislabmskcc.bsky.social and co on how PTMs reprogram chaperones into epichaperomes.
🎨 The cover highlights a Review from @chiosislabmskcc.bsky.social and co on how PTMs reprogram chaperones into epichaperomes.
October 6, 2025 at 2:40 PM
📢 Our October issue is now online. Access the full issue 👉 www.cell.com/trends/bioch....
🎨 The cover highlights a Review from @chiosislabmskcc.bsky.social and co on how PTMs reprogram chaperones into epichaperomes.
🎨 The cover highlights a Review from @chiosislabmskcc.bsky.social and co on how PTMs reprogram chaperones into epichaperomes.
Reposted by Thomas Arnesen
And now for something completely different in co-translational targeting: Molecular Cell www.cell.com/molecular-ce...
And now for something completely different in co-translational targeting
In two recent papers in Cell, Zhu et al. and Luo et al. use selective ribosome profiling
to identify the substrates and timing of co-translational protein targeting to mitochondria.
The results sugges...
www.cell.com
October 6, 2025 at 4:41 AM
And now for something completely different in co-translational targeting: Molecular Cell www.cell.com/molecular-ce...
A Cell-Potent Bisubstrate Inhibitor to Probe NatD Acetyltransferase Activity | The inhibitor effectively reduced cellular Nα-acetylation on histone H4, leading to reduced migration in lung cancer cells | @acs.org ACS Chemical Biology @ispt-proteinterm.bsky.social pubs.acs.org/doi/10.1021/...
A Cell-Potent Bisubstrate Inhibitor to Probe NatD Acetyltransferase Activity
N-terminal acetyltransferase D (NatD) is a highly selective enzyme that acetylates the α-N-terminal amine of histones H4 and H2A, which share the SGRGK motif. Elevated NatD expression has been observe...
pubs.acs.org
October 5, 2025 at 12:07 PM
A Cell-Potent Bisubstrate Inhibitor to Probe NatD Acetyltransferase Activity | The inhibitor effectively reduced cellular Nα-acetylation on histone H4, leading to reduced migration in lung cancer cells | @acs.org ACS Chemical Biology @ispt-proteinterm.bsky.social pubs.acs.org/doi/10.1021/...
Reposted by Thomas Arnesen
Protein N-terminal acetylation regulates the growth of rice plants | #NAA30 #NatC #rice #acetylation www.sciencedirect.com/science/arti...
September 25, 2025 at 9:45 AM
Protein N-terminal acetylation regulates the growth of rice plants | #NAA30 #NatC #rice #acetylation www.sciencedirect.com/science/arti...
Two new volumes of Methods in Enzymology with 29 chapters/papers on Protein termini methods and reviews are now out! Thx to all authors!🙌 @ispt-proteinterm.bsky.social #N-degron #prenylation #myristoylation #formylation #arginylation #oxidation #acetylation www.sciencedirect.com/bookseries/m...
Methods in Enzymology | Volume 719: Protein Termini - Part B | ScienceDirect.com by Elsevier
Read the latest chapters of Methods in Enzymology at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature
www.sciencedirect.com
September 25, 2025 at 9:17 AM
Two new volumes of Methods in Enzymology with 29 chapters/papers on Protein termini methods and reviews are now out! Thx to all authors!🙌 @ispt-proteinterm.bsky.social #N-degron #prenylation #myristoylation #formylation #arginylation #oxidation #acetylation www.sciencedirect.com/bookseries/m...
Reposted by Thomas Arnesen
Are you excited?? Because I am!
25 years ago I was 10 and had just started secondary school yet our journal was already covering groundbreaking science, long before I'd even heard of molecular cell biology 🧐
Safe to say I'm fairly familiar with it now 🤭
Enjoy our issue!!!!!!!!!!!
25 years ago I was 10 and had just started secondary school yet our journal was already covering groundbreaking science, long before I'd even heard of molecular cell biology 🧐
Safe to say I'm fairly familiar with it now 🤭
Enjoy our issue!!!!!!!!!!!
Hello Bluesky! We're celebrating ✨25th years of NRMCB✨ with our October Issue - out now!
It offers a glimpse into our journal's scope - cell death, enhancers, cell cycle, migration, transposable elements, membrane contact sites & AI!
go.nature.com/4nJUz6w
It offers a glimpse into our journal's scope - cell death, enhancers, cell cycle, migration, transposable elements, membrane contact sites & AI!
go.nature.com/4nJUz6w
September 23, 2025 at 12:58 PM
Are you excited?? Because I am!
25 years ago I was 10 and had just started secondary school yet our journal was already covering groundbreaking science, long before I'd even heard of molecular cell biology 🧐
Safe to say I'm fairly familiar with it now 🤭
Enjoy our issue!!!!!!!!!!!
25 years ago I was 10 and had just started secondary school yet our journal was already covering groundbreaking science, long before I'd even heard of molecular cell biology 🧐
Safe to say I'm fairly familiar with it now 🤭
Enjoy our issue!!!!!!!!!!!
Developing leaves form a spatiotemporal oxygen gradient that is sensed through the oxygen sensing machinery and directs morphogenesis | New preprint from @daanweits.bsky.social and @syno2xis.bsky.social labs #N-degron #Cysteine #hypoxia @ispt-proteinterm.bsky.social www.biorxiv.org/content/10.1...
September 23, 2025 at 7:38 AM
Developing leaves form a spatiotemporal oxygen gradient that is sensed through the oxygen sensing machinery and directs morphogenesis | New preprint from @daanweits.bsky.social and @syno2xis.bsky.social labs #N-degron #Cysteine #hypoxia @ispt-proteinterm.bsky.social www.biorxiv.org/content/10.1...
Anatomy and habitat shape the oxygen sensing machinery of flowering plants | new preprint from Licausi lab @syno2xis.bsky.social #hypoxia #N-degron @ispt-proteinterm.bsky.social www.biorxiv.org/content/10.1...
Anatomy and habitat shape the oxygen sensing machinery of angiosperms
Hypoxia sensing via the Cys/Arg branch of the N-degron pathway (Cys-NDP) is central for flooding responses in plants, yet how evolutionary and ecological factors have shaped the core oxygen sensing me...
www.biorxiv.org
September 18, 2025 at 12:40 PM
Anatomy and habitat shape the oxygen sensing machinery of flowering plants | new preprint from Licausi lab @syno2xis.bsky.social #hypoxia #N-degron @ispt-proteinterm.bsky.social www.biorxiv.org/content/10.1...
Reposted by Thomas Arnesen
New review on the generation and consequences of N-terminal proteoform diversity from Evan Morrison and Olivia Rissland | #N-degron #RNA @cp-cellreports.bsky.social www.sciencedirect.com/science/arti...
The generation and consequences of N-terminal proteoform diversity
N-terminal proteoforms are protein variants with altered N termini that arise from RNA-driven processes, such as alternative promoter usage, splicing,…
www.sciencedirect.com
September 17, 2025 at 8:09 AM
New review on the generation and consequences of N-terminal proteoform diversity from Evan Morrison and Olivia Rissland | #N-degron #RNA @cp-cellreports.bsky.social www.sciencedirect.com/science/arti...
Reposted by Thomas Arnesen
🎉 As we prep for #TIBSCelebrates50, I'd love for participation from YOU! Share your creativity and have your artwork featured on the cover of @cp-trendsbiochem.bsky.social!
📆 Deadline is Sept 30!!
📆 Deadline is Sept 30!!
🚨 The #TIBSCelebrates50 call for cover art is open thru Sept 30 - share your ideas now!
🎨 Have your original artwork featured on the cover of the January issue! One design will be selected to celebrate this milestone with us.
More info here 👉 www.cell.com/trends/bioch...
#TIBS50 #CoverArt
🎨 Have your original artwork featured on the cover of the January issue! One design will be selected to celebrate this milestone with us.
More info here 👉 www.cell.com/trends/bioch...
#TIBS50 #CoverArt
September 16, 2025 at 4:07 PM
🎉 As we prep for #TIBSCelebrates50, I'd love for participation from YOU! Share your creativity and have your artwork featured on the cover of @cp-trendsbiochem.bsky.social!
📆 Deadline is Sept 30!!
📆 Deadline is Sept 30!!
Reposted by Thomas Arnesen
Targeted degradation of pathogenic TDP-43 proteins in amyotrophic lateral sclerosis using the AUTOTAC platform | Yong Tae Kwon lab | #N-degron www.biorxiv.org/content/10.1...
Targeted degradation of pathogenic TDP-43 proteins in amyotrophic lateral sclerosis using the AUTOTAC platform
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons and the cytoplasmic aggregation of misfolded proteins in the spinal cord...
www.biorxiv.org
September 8, 2025 at 11:07 AM
Targeted degradation of pathogenic TDP-43 proteins in amyotrophic lateral sclerosis using the AUTOTAC platform | Yong Tae Kwon lab | #N-degron www.biorxiv.org/content/10.1...
Reposted by Thomas Arnesen
A synthetic ERFVII-dependent circuit in yeast sheds light on the regulation of early hypoxic responses of plants | Preprint from @mikellavi.bsky.social @beagiuntoli.bsky.social @syno2xis.bsky.social #N-degron #hypoxia www.biorxiv.org/content/10.1...
A synthetic ERFVII-dependent circuit in yeast sheds light on the regulation of early hypoxic responses of plants
Plants face hypoxic conditions either chronically, as particular tissues are characterized by fluctuating or stable low oxygen levels, or acutely, when flooded. In vascular plants, transcriptional ada...
www.biorxiv.org
September 8, 2025 at 10:15 AM
A synthetic ERFVII-dependent circuit in yeast sheds light on the regulation of early hypoxic responses of plants | Preprint from @mikellavi.bsky.social @beagiuntoli.bsky.social @syno2xis.bsky.social #N-degron #hypoxia www.biorxiv.org/content/10.1...
Reposted by Thomas Arnesen
Glad to share the final version of our story about the UBR4 complex, an E4 ligase protein quality control hub @science.org. Now with more cryo-EM structures and a deeper dive into substrate recognition, especially escaped mitochondrial proteins @clausenlab.bsky.social www.science.org/doi/10.1126/...
August 28, 2025 at 6:54 PM
Glad to share the final version of our story about the UBR4 complex, an E4 ligase protein quality control hub @science.org. Now with more cryo-EM structures and a deeper dive into substrate recognition, especially escaped mitochondrial proteins @clausenlab.bsky.social www.science.org/doi/10.1126/...
Reposted by Thomas Arnesen
Very cool stuff on the co-translational folding of dimers by Sander Tans and his team @amolf-nl.bsky.social:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Co-translational ribosome pairing enables native assembly of misfolding-prone subunits - Nature Communications
Protein complexes are essential for cell function. Here, authors show that paired ribosomes can help each other’s nascent chains fold correctly, enabling proper dimer assembly and preventing misfoldin...
www.nature.com
August 28, 2025 at 12:07 PM
Very cool stuff on the co-translational folding of dimers by Sander Tans and his team @amolf-nl.bsky.social:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Thomas Arnesen
Want to know how lipidation of some nascent chains takes place by NMT2-- Check our latest work on how NAC couples Protein Synthesis with Nascent Polypeptide Myristoylation on the Ribosome out today @embojournal.org: www.embopress.org/doi/full/10....
August 26, 2025 at 11:00 AM
Want to know how lipidation of some nascent chains takes place by NMT2-- Check our latest work on how NAC couples Protein Synthesis with Nascent Polypeptide Myristoylation on the Ribosome out today @embojournal.org: www.embopress.org/doi/full/10....
Reposted by Thomas Arnesen
Structural basis for the recognition and ubiquitylation of type-2 N-degron substrate by PRT1 plant N-recognin
nature.com/articles/s41...
#plantscience
nature.com/articles/s41...
#plantscience
August 23, 2025 at 5:13 PM
Structural basis for the recognition and ubiquitylation of type-2 N-degron substrate by PRT1 plant N-recognin
nature.com/articles/s41...
#plantscience
nature.com/articles/s41...
#plantscience
Reposted by Thomas Arnesen
Emmanuel Levy @elevylab.bsky.social has joined BlueSky 🌟 with a fantastic Cell paper with Shu-ou Shan, showing the interactome of the TOM complex and how cotranslational mito import prioritizes large globular domains. Beautiful science!
Give him a warm welcome 🎉
link: www.cell.com/cell/fulltex...
Give him a warm welcome 🎉
link: www.cell.com/cell/fulltex...
Principles of cotranslational mitochondrial protein import
Selective ribosome profiling reveals that nearly 20% of mitochondrial proteins in
human cells are imported during translation on cytosolic ribosomes. Cotranslational
import requires an N-terminal pres...
www.cell.com
August 22, 2025 at 3:00 AM
Emmanuel Levy @elevylab.bsky.social has joined BlueSky 🌟 with a fantastic Cell paper with Shu-ou Shan, showing the interactome of the TOM complex and how cotranslational mito import prioritizes large globular domains. Beautiful science!
Give him a warm welcome 🎉
link: www.cell.com/cell/fulltex...
Give him a warm welcome 🎉
link: www.cell.com/cell/fulltex...
Nitric oxide promotes cysteine N-degron proteolysis through control of oxygen availability | Important finding by Kim, Tian, Ratcliffe and Keeley @ox.ac.uk @ispt-proteinterm.bsky.social #N-degron www.pnas.org/doi/10.1073/...
Nitric oxide promotes cysteine N-degron proteolysis through control of oxygen availability | PNAS
Selected proteins containing an N-terminal cysteine (Nt-Cys) are subjected to rapid,
O2-dependent proteolysis via the Cys/Arg-branch of the N-degro...
www.pnas.org
August 20, 2025 at 10:39 AM
Nitric oxide promotes cysteine N-degron proteolysis through control of oxygen availability | Important finding by Kim, Tian, Ratcliffe and Keeley @ox.ac.uk @ispt-proteinterm.bsky.social #N-degron www.pnas.org/doi/10.1073/...
Disease resistance in rice steered by a long non-coding RNA via protein N-terminal acetylation | @ispt-proteinterm.bsky.social advanced.onlinelibrary.wiley.com/doi/10.1002/...
Gene Editing of a Susceptibility LncRNA Enhances Broad‐Spectrum Disease Resistance in Rice without Developmental Trade‐Offs
Editing susceptibility lncRNAs offers a strategy to enhance disease resistance without yield loss. RESIS, a domestication-acquired, pathogen-induced lncRNA, promotes protein N-terminal acetylation th...
advanced.onlinelibrary.wiley.com
August 19, 2025 at 12:51 PM
Disease resistance in rice steered by a long non-coding RNA via protein N-terminal acetylation | @ispt-proteinterm.bsky.social advanced.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Thomas Arnesen
Melon wrinkles linked to protein N-terminal acetylation. link.springer.com/article/10.1...
Fine mapping and prediction of a candidate gene for wrinkled rind in melon (Cucumis melo L.) - Theoretical and Applied Genetics
Key message The Cmwr locus was fine mapped to chromosome 2 in wrinkled-rind melon, and MELO3C010304.2 (CmNaa35, encoding an N-α-acetyltransferase) was identified as the most likely candidate gene for ...
link.springer.com
August 19, 2025 at 12:20 PM
Melon wrinkles linked to protein N-terminal acetylation. link.springer.com/article/10.1...