Murat Sunbul
@murat-sunbul.bsky.social
Group leader @UniHeidelberg, @IPMB;
Chemical Biologist; RNA imaging 🦠 Super-resolution 🔬Fluorescent probes 🌈Alumni |@UChicago
Group Website: www.sunbulgroup.com
Chemical Biologist; RNA imaging 🦠 Super-resolution 🔬Fluorescent probes 🌈Alumni |@UChicago
Group Website: www.sunbulgroup.com
Reposted by Murat Sunbul
Excited to share my first PhD student’s @biorxivpreprint.bsky.social!
Tracking 5 dyes simultaneously Kavan Gor @embl.org tracks nascent #RNA folding during #ribosome assembly to correlate structural with functional information on single RNA molecules!
Check it out!
www.biorxiv.org/content/10.1...
Tracking 5 dyes simultaneously Kavan Gor @embl.org tracks nascent #RNA folding during #ribosome assembly to correlate structural with functional information on single RNA molecules!
Check it out!
www.biorxiv.org/content/10.1...
November 1, 2025 at 5:56 AM
Excited to share my first PhD student’s @biorxivpreprint.bsky.social!
Tracking 5 dyes simultaneously Kavan Gor @embl.org tracks nascent #RNA folding during #ribosome assembly to correlate structural with functional information on single RNA molecules!
Check it out!
www.biorxiv.org/content/10.1...
Tracking 5 dyes simultaneously Kavan Gor @embl.org tracks nascent #RNA folding during #ribosome assembly to correlate structural with functional information on single RNA molecules!
Check it out!
www.biorxiv.org/content/10.1...
Congratulations again, Xiao-Xiao! It is a pleasure to host you as a Humboldt Research Fellow @humboldt-foundation.de. Looking forward to the exciting science ahead!
Thrilled to share that my Alexander von Humboldt Research Fellowship officially started this month!✨
I am deeply grateful to @humboldt-foundation.de for this honor, to my host @murat-sunbul.bsky.social and to all collaborators for their support.
Excited to start on this new adventure in Germany!🇩🇪
I am deeply grateful to @humboldt-foundation.de for this honor, to my host @murat-sunbul.bsky.social and to all collaborators for their support.
Excited to start on this new adventure in Germany!🇩🇪
November 7, 2025 at 4:03 PM
Congratulations again, Xiao-Xiao! It is a pleasure to host you as a Humboldt Research Fellow @humboldt-foundation.de. Looking forward to the exciting science ahead!
Reposted by Murat Sunbul
A new Review by Agnese Nicoli and Michelle Frei examines the progress in developing synthetic small-molecule fluorophores and how these in combination with innovative labeling strategies can advance chemical biology
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Synthetic fluorophores for live-cell fluorescence microscopy and biosensing - Nature Chemical Biology
Performing live-cell microscopy experiments with high spatial and temporal resolution requires fluorophores with highly optimized properties. This Review examines the progress in developing synthetic ...
www.nature.com
November 4, 2025 at 5:26 PM
A new Review by Agnese Nicoli and Michelle Frei examines the progress in developing synthetic small-molecule fluorophores and how these in combination with innovative labeling strategies can advance chemical biology
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Murat Sunbul
A new paper from @aliceyting.bsky.social reports on LaccID, an engineered laccase, that enables hydrogen peroxide-free proximity labeling and electron microscopy of cell surfaces
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Directed evolution of LaccID for cell surface proximity labeling and electron microscopy - Nature Chemical Biology
LaccID, an engineered laccase, enables hydrogen-peroxide-free proximity labeling and electron microscopy (EM) in mammalian cells. Notably, LaccID is selectively active at the cell surface, enabling th...
www.nature.com
August 1, 2025 at 7:51 PM
A new paper from @aliceyting.bsky.social reports on LaccID, an engineered laccase, that enables hydrogen peroxide-free proximity labeling and electron microscopy of cell surfaces
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Murat Sunbul
Finally out!
I’m thrilled to share our new paper (Wolin et al., Cell 2025).
This paper describes SPIDR, a high-throughput method for mapping RBP binding sites.
By combining #SPIDR with #cryoEM, we identified the exact binding site of LARP1 within the #mRNA channel of the 40S ribosomal subunit.
I’m thrilled to share our new paper (Wolin et al., Cell 2025).
This paper describes SPIDR, a high-throughput method for mapping RBP binding sites.
By combining #SPIDR with #cryoEM, we identified the exact binding site of LARP1 within the #mRNA channel of the 40S ribosomal subunit.
July 22, 2025 at 5:12 PM
Reposted by Murat Sunbul
Teaching an old bacterial protein new tricks: Fast, bright and reversible rhodamine tags for live-cell imaging:
www.biorxiv.org/content/10.1...
Congratulations to Julian Kompa and the entire team.
www.biorxiv.org/content/10.1...
Congratulations to Julian Kompa and the entire team.
Fast, Bright and Reversible Rhodamine Tags for Live-Cell Imaging
We present Rho-tag and SiR-tag, engineered protein tags derived from bacterial multidrug-resistance proteins that bind unsubstituted (silicon-) rhodamines with nanomolar affinity, enabling fast, rever...
www.biorxiv.org
July 9, 2025 at 7:58 PM
Teaching an old bacterial protein new tricks: Fast, bright and reversible rhodamine tags for live-cell imaging:
www.biorxiv.org/content/10.1...
Congratulations to Julian Kompa and the entire team.
www.biorxiv.org/content/10.1...
Congratulations to Julian Kompa and the entire team.
Reposted by Murat Sunbul
Hello! Ever wonder what's "talking to" your favorite transcript, but were too scared to ask? In our review in @cp-cellreports.bsky.social, @mardakheh.bsky.social and I highlight new RNA-focused tools for discovering RNA interactions across organizational scales. Checkit!
tinyurl.com/ydn6e3ac
tinyurl.com/ydn6e3ac
June 30, 2025 at 9:15 PM
Hello! Ever wonder what's "talking to" your favorite transcript, but were too scared to ask? In our review in @cp-cellreports.bsky.social, @mardakheh.bsky.social and I highlight new RNA-focused tools for discovering RNA interactions across organizational scales. Checkit!
tinyurl.com/ydn6e3ac
tinyurl.com/ydn6e3ac
Reposted by Murat Sunbul
May 19, 2025 at 8:49 PM
Reposted by Murat Sunbul
Neat paper in JACS. They use a modified version of RhoBAST to do super-res imaging of demethylation of m6A by FTO pubs.acs.org/doi/10.1021/...
Developments of the mDZ-RhoBAST Probe for Super-Resolution Imaging of FTO Demethylation in Live Cells
Single-molecule localization microscopy (SMLM) provides precise, high-resolution visualization of target biomolecules in cellular imaging. Fluorescent light-up aptamers (FLAPs) offer a versatile appro...
pubs.acs.org
May 6, 2025 at 8:46 PM
Neat paper in JACS. They use a modified version of RhoBAST to do super-res imaging of demethylation of m6A by FTO pubs.acs.org/doi/10.1021/...
Reposted by Murat Sunbul
Happy to see my Postdoc work out @natbiotech.nature.com. Using HaloTag and synthetic fluorophores instead of FPs enables us to shift the spectral properties of kinase activity reporters (KARs) to the far-red 🔬. Huge thanks to everyone involved @jinzhanglab.bsky.social!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Far-red chemigenetic kinase biosensors enable multiplexed and super-resolved imaging of signaling networks - Nature Biotechnology
Far-red kinase biosensors are applied to image kinase signaling networks at super resolution.
www.nature.com
April 21, 2025 at 9:28 AM
Happy to see my Postdoc work out @natbiotech.nature.com. Using HaloTag and synthetic fluorophores instead of FPs enables us to shift the spectral properties of kinase activity reporters (KARs) to the far-red 🔬. Huge thanks to everyone involved @jinzhanglab.bsky.social!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Murat Sunbul
Reposted by Murat Sunbul
Single-molecule live-cell RNA imaging with CRISPR–Csm - @doudna-lab.bsky.social @qb3-berkeley.bsky.social @innovativegenomics.bsky.social go.nature.com/3EJPKsM
Single-molecule live-cell RNA imaging with CRISPR–Csm - Nature Biotechnology
Single-molecule live-cell fluorescence in situ hybridization uses an RNA-targeting CRISPR–Csm complex to image and track endogenous RNAs.
go.nature.com
February 18, 2025 at 3:29 PM
Single-molecule live-cell RNA imaging with CRISPR–Csm - @doudna-lab.bsky.social @qb3-berkeley.bsky.social @innovativegenomics.bsky.social go.nature.com/3EJPKsM
Reposted by Murat Sunbul
Nature research paper: De novo design of transmembrane fluorescence-activating proteins
https://go.nature.com/4k2OAZA
https://go.nature.com/4k2OAZA
De novo design of transmembrane fluorescence-activating proteins - Nature
A study describes the design of de novo ligand-binding transmembrane proteins, demonstrating their specific binding and activation of fluorogenic ligands.
go.nature.com
February 20, 2025 at 8:46 AM
Nature research paper: De novo design of transmembrane fluorescence-activating proteins
https://go.nature.com/4k2OAZA
https://go.nature.com/4k2OAZA