Organelles do NOT have a single uniform pH.
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n

🚨We are recruiting two PhD students 🚨

1) Quantitative & dynamic analysis of limb-regenerative signaling centers w/ @osvaldo-chara.bsky.social 📶🧮💻
🔗https://www.phd.tuebingen.mpg.de/80704/Quantitative-and-dynamic-analysis-of-limb-regenerative-signaling-center-interactions

Congratulations to @ehannezo.bsky.social​ and Maksym Serbyn! Both win an @erc.europa.eu​ Consolidator Grant of € 2 Mio. With it, they develop new theories – in biophysics to understand embryonic development and in quantum physics to advance quantum simulators.
👉 https://bit.ly/4rICmco

#ERCCoG

🎉 Our deconstructed, stem-cell–based approach to studying signaling centers and limb-development cell types is out! 🥳 So nice to see it in its final form after the preprint— and huge thanks to the community for all the enthusiasm and interest since then!
www.science.org/doi/10.1126/...

An 8-nm precise map in live cells, which revealed #actin aster formation by #myosin V-driven transport of #formin.

Happy to see this work now out! 😃

In collaboration with @kaksonen.bsky.social lab

#yeast #pombe #cell_fusion

@biology-unige.bsky.social

New work by @valthomas.bsky.social et al. in @sophiemartinlab.bsky.social provides a live, 8-nm precision map of the actin fusion focus for cell-cell fusion in S. #pombe. This reveals #actin aster formation by #myosin Myo52-driven transport of the formin Fus1 nucleator rupress.org/jcb/article/...

It’s time to talk about epithelial geometry and cancer. How can the architecture of an epithelium affect how tumors will grow and spread? In this thread, @jorgealmagro.bsky.social

Motivational video for #MigrationMovieMonday. A persistent 4T1 breast cancer cell squeezing itself through a tight constriction despite undergoing repetitive nuclear envelope rupture. Credit: Kristen Nedza @weillinstitute.bsky.social

Greg Alushin (@alushinlab.bsky.social) is decoding how the body’s building blocks sense and respond to force, with implications for everything from cancer to developmental disorders. In this Q&A, he discusses where his work on the cytoskeleton could lead us:

🧵1/14 Preprint thread! Can we predict a cell’s fate based on its dynamics? 🔮 Our new study unveils a framework for watching development unfold in real-time, revealing how a cell's shape and movement encode info about its future fate. 🔬📄 Preprint: tinyurl.com/4shf8v4x

Scientists have used low-error genome-sequencing methods in normal tissues from large cohorts of individuals to scan for mutations that set the stage for cancer

go.nature.com/42vakWS

New paper alert! We report in @cp-cellmetabolism.bsky.social how serine regulates stem cell fate in physiology and upon wounding.
Good work, Jesse and collabs!
www.cell.com/cell-metabol...

90% of you probably don’t need to read this.
But maybe some of you are curious & 10% will feel seen. Or a little less alone. This isn’t about seeking sympathy.
It’s about sharing something hard to say out loud;
partly to heal, partly in case someone needs to hear it too. (1/3)
tinyurl.com/DudinO

🎉 Kicking off the festive season with our first lab outing, celebrating two incredible months together! 🥂✨ Excited for the journey ahead ❤️

“Omnis cellula e cellula”

—Rudolf Virchow, 1855