Mary Lyon Centre at MRC Harwell
@mrcharwell.bsky.social
The UK’s national facility for mouse genetics and the use of mouse models for the pre-clinical study of human disease
#Training: Our new Laboratory Skills for Animal Technicians course is for #technicians who would like to develop their lab skills, including processing blood samples, dose calculations, and use of standard equipment.
Join us in February:
www.har.mrc.ac.uk/training/cou...
Join us in February:
www.har.mrc.ac.uk/training/cou...
Laboratory Skills for Animal Technicians | Mary Lyon Centre
Having the knowledge and confidence to work safely in the laboratory is a valuable skill for all animal technicians. This course will cover basic theoretical and practical laboratory skills including following COSHH risk assessments, best laboratory practice, use of fume hoods/biosafety cabinets, centrifuges and other laboratory equipment, pipetting skills, using balances and preparing reagents and […]
www.har.mrc.ac.uk
November 25, 2025 at 8:11 AM
#Training: Our new Laboratory Skills for Animal Technicians course is for #technicians who would like to develop their lab skills, including processing blood samples, dose calculations, and use of standard equipment.
Join us in February:
www.har.mrc.ac.uk/training/cou...
Join us in February:
www.har.mrc.ac.uk/training/cou...
Still using Sanger for validation of genome engineering?
Discover how long read sequencing transforms genome editing and gene targeting workflows. Learn from real datasets, sharpen your skills for increased confidence in the quality of cellular and animal models.
www.har.mrc.ac.uk/training/cou...
Discover how long read sequencing transforms genome editing and gene targeting workflows. Learn from real datasets, sharpen your skills for increased confidence in the quality of cellular and animal models.
www.har.mrc.ac.uk/training/cou...
Genome Engineering and Validation by Long Read Sequencing | Mary Lyon Centre
This interactive training session explores the use of long read sequencing (LRS) technologies for validating engineered alleles in both cellular and embryonic genome engineering contexts. Participants will learn the principles of genome editing design, how LRS compares to traditional validation methods, and how to select the appropriate sequencing modality for different allele types and experimental […]
www.har.mrc.ac.uk
November 18, 2025 at 8:35 AM
Still using Sanger for validation of genome engineering?
Discover how long read sequencing transforms genome editing and gene targeting workflows. Learn from real datasets, sharpen your skills for increased confidence in the quality of cellular and animal models.
www.har.mrc.ac.uk/training/cou...
Discover how long read sequencing transforms genome editing and gene targeting workflows. Learn from real datasets, sharpen your skills for increased confidence in the quality of cellular and animal models.
www.har.mrc.ac.uk/training/cou...
We are #hiring an Animal Technician to provide high quality husbandry and ensure the health and welfare of experimental mice, while maintaining meticulous record-keeping of all animal-related work.
Apply by 16th November:
Apply by 16th November:
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mrc.tal.net
November 14, 2025 at 8:45 AM
We are #hiring an Animal Technician to provide high quality husbandry and ensure the health and welfare of experimental mice, while maintaining meticulous record-keeping of all animal-related work.
Apply by 16th November:
Apply by 16th November:
#Training: Basic lab skills are key to high quality, reproducible research. Our Practical Laboratory Skills course covers a range of basic skills, including use of standard equipment, such as centrifuges and fume hoods
Join us on 14th January:
www.har.mrc.ac.uk/training/cou...
Join us on 14th January:
www.har.mrc.ac.uk/training/cou...
Practical Laboratory Skills | Mary Lyon Centre
Having the knowledge and confidence to work safely in the laboratory is an essential skill for all staff working in laboratories. This course will cover basic theoretical and practical laboratory skills including preparing COSHH risk assessments, good laboratory practice, use of fume hoods/biosafety cabinets, centrifuges and other laboratory equipment, pipetting skills, using balances and preparing […]
www.har.mrc.ac.uk
November 12, 2025 at 11:45 AM
#Training: Basic lab skills are key to high quality, reproducible research. Our Practical Laboratory Skills course covers a range of basic skills, including use of standard equipment, such as centrifuges and fume hoods
Join us on 14th January:
www.har.mrc.ac.uk/training/cou...
Join us on 14th January:
www.har.mrc.ac.uk/training/cou...
We welcome the government’s effort to provide a clear roadmap for the phasing out of the use of animals in research, while maintaining scientific rigour and safety standards.
Today the UK government has released a strategy to support the development, validation and uptake of alternative methods.
Read more: www.gov.uk/government/n...
Read more: www.gov.uk/government/n...
Animal testing to be phased out faster as UK unveils roadmap for alternative methods
New plan backs researchers to seize on new and developing opportunities to phase out animal tests with specific commitments for the coming years.
www.gov.uk
November 12, 2025 at 11:31 AM
We welcome the government’s effort to provide a clear roadmap for the phasing out of the use of animals in research, while maintaining scientific rigour and safety standards.
In a new article in Disease Models & Mechanisms, the COST Action TEATIME welfare group makes the argument for increased use of automated welfare and phenotypic analysis in animal research, while discussing the significant challenges that need to be overcome:
www.har.mrc.ac.uk/news/advocat...
www.har.mrc.ac.uk/news/advocat...
Advocating for automation in animal research | Mary Lyon Centre
In a new article in Disease Models & Mechanisms, the COST Action TEATIME welfare group, which includes the Mary Lyon Centre’s Hilary Gates, Sonia Bains, and Sara Wells, makes the argument for increased use of automated welfare and phenotypic analysis in animal research, while discussing the significant challenges that need to be overcome to realise […]
www.har.mrc.ac.uk
November 7, 2025 at 2:35 PM
In a new article in Disease Models & Mechanisms, the COST Action TEATIME welfare group makes the argument for increased use of automated welfare and phenotypic analysis in animal research, while discussing the significant challenges that need to be overcome:
www.har.mrc.ac.uk/news/advocat...
www.har.mrc.ac.uk/news/advocat...
We are #hiring an Animal #Technician to provide high quality husbandry and ensure the health and welfare of experimental mice, while maintaining meticulous record-keeping of all animal-related work.
Apply by 16th November:
mrc.tal.net/vx/appcentre...
Apply by 16th November:
mrc.tal.net/vx/appcentre...
Quick Check Needed
We use a small session cookie to keep our site running smoothly. This cookie doesn’t track any personal details or what you do online. By clicking "Continue" you agree to its use. Thanks for your patience.
mrc.tal.net
November 6, 2025 at 12:55 PM
We are #hiring an Animal #Technician to provide high quality husbandry and ensure the health and welfare of experimental mice, while maintaining meticulous record-keeping of all animal-related work.
Apply by 16th November:
mrc.tal.net/vx/appcentre...
Apply by 16th November:
mrc.tal.net/vx/appcentre...
Validate with Confidence
Join our 1-day workshop on Genome Engineering & Long Read Sequencing and gain hands-on skills to design, sequence, and troubleshoot engineered alleles with precision
www.har.mrc.ac.uk/training/cou...
Join our 1-day workshop on Genome Engineering & Long Read Sequencing and gain hands-on skills to design, sequence, and troubleshoot engineered alleles with precision
www.har.mrc.ac.uk/training/cou...
Genome Engineering and Validation by Long Read Sequencing | Mary Lyon Centre
This interactive training session explores the use of long read sequencing (LRS) technologies for validating engineered alleles in both cellular and embryonic genome engineering contexts. Participants will learn the principles of genome editing design, how LRS compares to traditional validation methods, and how to select the appropriate sequencing modality for different allele types and experimental […]
www.har.mrc.ac.uk
November 6, 2025 at 8:45 AM
Validate with Confidence
Join our 1-day workshop on Genome Engineering & Long Read Sequencing and gain hands-on skills to design, sequence, and troubleshoot engineered alleles with precision
www.har.mrc.ac.uk/training/cou...
Join our 1-day workshop on Genome Engineering & Long Read Sequencing and gain hands-on skills to design, sequence, and troubleshoot engineered alleles with precision
www.har.mrc.ac.uk/training/cou...
In a new publication in Disease Models & Mechanisms, the @cost-teatime.bsky.social Welfare group advocate for automation in animal research to advance welfare, reproducibility and scientific openness.
journals.biologists.com
October 31, 2025 at 1:05 PM
In a new publication in Disease Models & Mechanisms, the @cost-teatime.bsky.social Welfare group advocate for automation in animal research to advance welfare, reproducibility and scientific openness.
Reposted by Mary Lyon Centre at MRC Harwell
If you want advice on selecting the most appropriate model for your research, contact the NMGN Best Models Working Group to be connected with researchers with expertise in diverse biological models and computational tools:
nmgn.mrc.ukri.org/working-grou...
#MeetTheExpert #3Rs
nmgn.mrc.ukri.org/working-grou...
#MeetTheExpert #3Rs
Meet the Experts | National Mouse Genetics Network
We connect researchers with specialists in diverse model systems to support innovation and refinement.
nmgn.mrc.ukri.org
October 31, 2025 at 12:20 PM
If you want advice on selecting the most appropriate model for your research, contact the NMGN Best Models Working Group to be connected with researchers with expertise in diverse biological models and computational tools:
nmgn.mrc.ukri.org/working-grou...
#MeetTheExpert #3Rs
nmgn.mrc.ukri.org/working-grou...
#MeetTheExpert #3Rs
Reposted by Mary Lyon Centre at MRC Harwell
This work, initiated and supported by #FPWR, represents an international collaboration involving @mrcharwell.bsky.social, #CardiffUniversity, #INMED and #IIT, to establish a standardised and open-access preclinical ‘Resource’ for Prader-Willi syndrome #PWS
🐭🧬
🐭🧬
The Preclinical Animal Network (PCAN): Integrative high-throughput phenotyping of standardized mouse models for Prader-Willi syndrome https://www.biorxiv.org/content/10.1101/2025.10.24.684371v1
October 29, 2025 at 1:33 PM
This work, initiated and supported by #FPWR, represents an international collaboration involving @mrcharwell.bsky.social, #CardiffUniversity, #INMED and #IIT, to establish a standardised and open-access preclinical ‘Resource’ for Prader-Willi syndrome #PWS
🐭🧬
🐭🧬
Last week we held our Mouse Embryo and Sperm Cryopreservation course for the 34th time, this time with delegates from Lancaster, Leeds, and Kuwait!
Thanks to all our colleagues who helped make the course such a success!
Thanks to all our colleagues who helped make the course such a success!
October 29, 2025 at 8:21 AM
Last week we held our Mouse Embryo and Sperm Cryopreservation course for the 34th time, this time with delegates from Lancaster, Leeds, and Kuwait!
Thanks to all our colleagues who helped make the course such a success!
Thanks to all our colleagues who helped make the course such a success!
We are #hiring an Animal #Technician to provide high quality husbandry and ensure the health and welfare of experimental mice, while maintaining meticulous record-keeping of all animal-related work.
Apply by 16th November:
mrc.tal.net/vx/appcentre...
Apply by 16th November:
mrc.tal.net/vx/appcentre...
Quick Check Needed
We use a small session cookie to keep our site running smoothly. This cookie doesn’t track any personal details or what you do online. By clicking "Continue" you agree to its use. Thanks for your patience.
mrc.tal.net
October 28, 2025 at 12:15 PM
We are #hiring an Animal #Technician to provide high quality husbandry and ensure the health and welfare of experimental mice, while maintaining meticulous record-keeping of all animal-related work.
Apply by 16th November:
mrc.tal.net/vx/appcentre...
Apply by 16th November:
mrc.tal.net/vx/appcentre...
Reposted by Mary Lyon Centre at MRC Harwell
Really pleased to see this huge project out in the wild... fantastic collaborative effort with @valtertucci.bsky.social Francoise Muscatelli & @mrcharwell.bsky.social, with strong support and funding from the Foundation for Prader-Willi Research #FPWR
🐭🧬🐭🧬
🐭🧬🐭🧬
The Preclinical Animal Network (PCAN): Integrative high-throughput phenotyping of standardized mouse models for Prader-Willi syndrome https://www.biorxiv.org/content/10.1101/2025.10.24.684371v1
October 27, 2025 at 10:43 AM
Really pleased to see this huge project out in the wild... fantastic collaborative effort with @valtertucci.bsky.social Francoise Muscatelli & @mrcharwell.bsky.social, with strong support and funding from the Foundation for Prader-Willi Research #FPWR
🐭🧬🐭🧬
🐭🧬🐭🧬
Recently, the MRC published an impact report for the MRC’s sustainability programme for 2024-2025, showcasing progress, challenges, and future plans to achieve net zero. This is the section of the report that covers sustainability and biodiversity work at the MLC:
www.har.mrc.ac.uk/news/sustain...
www.har.mrc.ac.uk/news/sustain...
Sustainability and biodiversity at the Mary Lyon Centre | Mary Lyon Centre
Recently, the MRC published an impact report for the MRC’s sustainability programme for 2024-2025, showcasing progress, challenges, and future plans to achieve net zero and improve environmental practices. Below is the section of the report that covers sustainability work at the Mary Lyon Centre. The past twelve months have been exciting at MRC Harwell, with […]
www.har.mrc.ac.uk
October 20, 2025 at 11:57 AM
Recently, the MRC published an impact report for the MRC’s sustainability programme for 2024-2025, showcasing progress, challenges, and future plans to achieve net zero. This is the section of the report that covers sustainability and biodiversity work at the MLC:
www.har.mrc.ac.uk/news/sustain...
www.har.mrc.ac.uk/news/sustain...
#Training: Book your place on our Mouse Necropsy practical training course to learn how to perform a basic standard mouse necropsy and describe gross observations made during this process
This course is running again in November. Book now!
This course is running again in November. Book now!
Mouse Necropsy
This course provides practical training in how to perform a basic standard mouse necropsy and describe gross observations made during this process.
www.har.mrc.ac.uk
October 16, 2025 at 8:15 AM
#Training: Book your place on our Mouse Necropsy practical training course to learn how to perform a basic standard mouse necropsy and describe gross observations made during this process
This course is running again in November. Book now!
This course is running again in November. Book now!
#Training: Our Practical Laboratory Skills course covers basic theoretical and practical lab skills, including use of standard equipment, such as biosafety cabinets, centrifuges, and balances
We have multiple dates through the next year, including 14th January:
www.har.mrc.ac.uk/training/cou...
We have multiple dates through the next year, including 14th January:
www.har.mrc.ac.uk/training/cou...
October 7, 2025 at 8:45 AM
#Training: Our Practical Laboratory Skills course covers basic theoretical and practical lab skills, including use of standard equipment, such as biosafety cabinets, centrifuges, and balances
We have multiple dates through the next year, including 14th January:
www.har.mrc.ac.uk/training/cou...
We have multiple dates through the next year, including 14th January:
www.har.mrc.ac.uk/training/cou...
We have an exciting opportunity to join our Site Operational Team as a Senior Health and Safety adviser with radiation protection supervisor responsibilities.
Apply by 5th October
Apply by 5th October
Senior Health and Safety Adviser with Radiation Protection Supervisor Responsibilities - MLC 2713 - Medical Research Council
Location: Harwell Campus, Oxfordshire. Vacancy: Senior Health and Safety Adviser with Radiation Protection Supervisor Responsibilities - MLC 2713. Closing Date: 05/10/2025, 23:55
mrc.tal.net
October 2, 2025 at 8:05 AM
We have an exciting opportunity to join our Site Operational Team as a Senior Health and Safety adviser with radiation protection supervisor responsibilities.
Apply by 5th October
Apply by 5th October
#Training: Our new Laboratory Skills for Animal Technicians course is for #technicians who would like to develop their lab skills, including processing blood samples, dose calculations, and use of standard equipment.
Join us in February:
www.har.mrc.ac.uk/training/cou...
Join us in February:
www.har.mrc.ac.uk/training/cou...
Laboratory Skills for Animal Technicians | Mary Lyon Centre
Having the knowledge and confidence to work safely in the laboratory is a valuable skill for all animal technicians. This course will cover basic theoretical and practical laboratory skills including following COSHH risk assessments, best laboratory practice, use of fume hoods/biosafety cabinets, centrifuges and other laboratory equipment, pipetting skills, using balances and preparing reagents and […]
www.har.mrc.ac.uk
September 30, 2025 at 12:40 PM
#Training: Our new Laboratory Skills for Animal Technicians course is for #technicians who would like to develop their lab skills, including processing blood samples, dose calculations, and use of standard equipment.
Join us in February:
www.har.mrc.ac.uk/training/cou...
Join us in February:
www.har.mrc.ac.uk/training/cou...
We have an exciting opportunity to join our Site Operational Team as a Senior Health and Safety adviser with radiation protection supervisor responsibilities.
Apply by 5th October
Apply by 5th October
Senior Health and Safety Adviser with Radiation Protection Supervisor Responsibilities - MLC 2713 - Medical Research Council
Location: Harwell Campus, Oxfordshire. Vacancy: Senior Health and Safety Adviser with Radiation Protection Supervisor Responsibilities - MLC 2713. Closing Date: 05/10/2025, 23:55
mrc.tal.net
September 26, 2025 at 8:55 AM
We have an exciting opportunity to join our Site Operational Team as a Senior Health and Safety adviser with radiation protection supervisor responsibilities.
Apply by 5th October
Apply by 5th October
#Training: Basic lab skills are key to high quality, reproducible research. Our Practical Laboratory Skills course covers a range of basic skills, including use of standard equipment, such as centrifuges, balances, pipettes, and fume hoods
www.har.mrc.ac.uk/training/cou...
www.har.mrc.ac.uk/training/cou...
Practical Laboratory Skills | Mary Lyon Centre
Having the knowledge and confidence to work safely in the laboratory is an essential skill for all staff working in laboratories. This course will cover basic theoretical and practical laboratory skills including preparing COSHH risk assessments, good laboratory practice, use of fume hoods/biosafety cabinets, centrifuges and other laboratory equipment, pipetting skills, using balances and preparing […]
www.har.mrc.ac.uk
September 25, 2025 at 11:20 AM
#Training: Basic lab skills are key to high quality, reproducible research. Our Practical Laboratory Skills course covers a range of basic skills, including use of standard equipment, such as centrifuges, balances, pipettes, and fume hoods
www.har.mrc.ac.uk/training/cou...
www.har.mrc.ac.uk/training/cou...
📢 Job Opportunity: Scientific Training and Marketing Manager
We are looking for a motivated, dynamic, hands-on, and positive individual to support the delivery of training courses, symposia, and networking events at our Advance Training Centre
Apply by 28th September
We are looking for a motivated, dynamic, hands-on, and positive individual to support the delivery of training courses, symposia, and networking events at our Advance Training Centre
Apply by 28th September
Scientific Training and Marketing Manager- MLC 2706 - Medical Research Council
Location: Harwell Campus, Oxfordshire. Vacancy: Scientific Training and Marketing Manager- MLC 2706. Closing Date: 28/09/2025, 23:55
mrc.tal.net
September 25, 2025 at 8:40 AM
📢 Job Opportunity: Scientific Training and Marketing Manager
We are looking for a motivated, dynamic, hands-on, and positive individual to support the delivery of training courses, symposia, and networking events at our Advance Training Centre
Apply by 28th September
We are looking for a motivated, dynamic, hands-on, and positive individual to support the delivery of training courses, symposia, and networking events at our Advance Training Centre
Apply by 28th September
Don't forget to put together your application for our current Genome Editing Mice for Medicine call to be in with a chance of getting your free, novel, genetically altered mouse model generated by the Mary Lyon Centre
Extended deadline: 29th September
www.har.mrc.ac.uk/projects/gem...
Extended deadline: 29th September
www.har.mrc.ac.uk/projects/gem...
GEMM | Mary Lyon Centre
Submit an application to have your free, novel, genetically altered mouse model generated by the Mary Lyon Centre
www.har.mrc.ac.uk
September 24, 2025 at 2:10 PM
Don't forget to put together your application for our current Genome Editing Mice for Medicine call to be in with a chance of getting your free, novel, genetically altered mouse model generated by the Mary Lyon Centre
Extended deadline: 29th September
www.har.mrc.ac.uk/projects/gem...
Extended deadline: 29th September
www.har.mrc.ac.uk/projects/gem...
Reposted by Mary Lyon Centre at MRC Harwell
Opening session sponsored by @stemcell.com and OLS with a welcome from Director Owen Sansom @cruk-si.bsky.social and Elizabeth Vincan @unimelb.bsky.social . Our plenary speaker Prof Hans Clevers from @utrechtuniversity.bsky.social talks about human epithelial organoids. #OrganoidsAreUs2025
September 23, 2025 at 5:01 PM
Opening session sponsored by @stemcell.com and OLS with a welcome from Director Owen Sansom @cruk-si.bsky.social and Elizabeth Vincan @unimelb.bsky.social . Our plenary speaker Prof Hans Clevers from @utrechtuniversity.bsky.social talks about human epithelial organoids. #OrganoidsAreUs2025
#Training: Our Mouse Necropsy course is aimed at animal technicians & PhD students wanting to learn how to perform a basic standard mouse necropsy and describe gross observations made during this process
This course is next running in November. Book now!
www.har.mrc.ac.uk/training/cou...
This course is next running in November. Book now!
www.har.mrc.ac.uk/training/cou...
Mouse Necropsy
This course provides practical training in how to perform a basic standard mouse necropsy and describe gross observations made during this process.
www.har.mrc.ac.uk
September 23, 2025 at 12:30 PM
#Training: Our Mouse Necropsy course is aimed at animal technicians & PhD students wanting to learn how to perform a basic standard mouse necropsy and describe gross observations made during this process
This course is next running in November. Book now!
www.har.mrc.ac.uk/training/cou...
This course is next running in November. Book now!
www.har.mrc.ac.uk/training/cou...