Last week we held our Mouse Embryo and Sperm Cryopreservation course for the 34th time, this time with delegates from Lancaster, Leeds, and Kuwait!

Thanks to all our colleagues who helped make the course such a success!

@lydiateboul.bsky.social at #FELASA2025 reports on the recent development of the lag-r.org guidelines, an international for the correct and standardised reporting of animal models’ genetic makeup. This system will have a significant impact on #reproducibility and #rigour. Great attendance! #LAG-R

Sharing what we know again!
Decades of experience distilled into a workshop at #FELASA2025 in which, our senior team talk about how to reduce severity of animal procedures right from the start of a project using GA mice, and limiting welfare issues. #3Rs #AnimalWelfare #training

The MRC and the @mrcharwell.bsky.social were a strong presence at the @ox.ac.uk Biomedical Services Research Delivery Day, From Insight to Impact: Delivering Research for Real-World Change, a full day dedicated to cutting-edge research, fostering collaboration between researchers and research cores

Arl13bCerulean-Fucci2a is a fluorescent cilia and cell cycle biosensor that allows live imaging of cell cycle progression and cilia assembly/disassembly kinetics in cells and mice.

archive.har.mrc.ac.uk/stock?id=9690

#MouseMuse #Cilia #CellCycle

Image source: doi.org/10.1016/j.de...

Today we are delighted to host RYUSEI MAEDA from our long standing friend and collaborator Toru Takeo’s lab in Japan. It’s great to find out about his work and interest in science communication as he spends a bit of time in our labs. And it’sa full lecture room! #collaboration #ReproductiveBiology

The genetic cause for hearing loss due to otitis media with effusion was investigated in a recent panel of #DownSyndrome (DS) #MouseModels. Find the DS mouse models used in the study in the National Mouse Archive

#MouseMuse #WorldDownSyndromeDay

archive.har.mrc.ac.uk/stock?id=6435

Thymosin β4 knockout mice have been used to study vascular smooth muscle cell development, vascular wall stability and podocyte cytoskeleton in glomerular disease.

Find more phenotypic information via the National Mouse Archive:

archive.har.mrc.ac.uk/stock?id=1572

#MouseMuse

#RareDiseaseDay

Visit the National Mouse Archive for mouse strains useful for investigating #RareDiseases, including Marshall-Smith Syndrome, which is characterized by abnormal bone maturation, developmental delay, and distinctive facial features

#MouseMuse

archive.har.mrc.ac.uk/search?s=Nfix

We are ready to have some fun and let you know what we do and why! @festivaloftomorrow.bsky.social #FestivalOfTomorrow

Find us at the #FestivalOfTomorrow 2025!

We are going to be at The Deanery Academy, in Wichelstowe, Swindon, for the Festival Finale tomorrow and Saturday. Come say hello 👋 and find out how we use models to better understand human disease!

Book your tickets now:

www.festivaloftomorrow.com

The genetic cause for hearing loss due to otitis media with effusion was investigated in a recent panel of #DownSyndrome (DS) #MouseModels. Find the DS mouse models used in the study in the National Mouse Archive

#MouseMuse

archive.har.mrc.ac.uk/stock?id=6435

We are very pleased to be once again offering two positions (with the @mrcmousenetwork.bsky.social) as part of the fantastic #GenerationResearch programme.

This programme offers paid internships for students at the University of York and across Yorkshire.

Find out more: bit.ly/3POoWKb

We'll be sending the next edition of our quarterly newsletter later this week, but here's a quick preview. To see the full thing, subscribe now to make sure you're kept up-to-date with all of our latest news:
mrc.us5.list-manage.com/subscribe?u=...

Conditional Ramp1 alleles have been used to study the role of Ramp1 signaling in Schwann cells, endothelial cells, meningeal macrophages and intestinal goblet cells.
archive.har.mrc.ac.uk/stock?id=009702
#MouseMuse #Migraine #Allodynia

Pseudopregnant matings: Prm1-EGFP overexpression results in complete male sterility without affecting the ability to mate or produce a copulation plug.

#MouseMuse #3Rs #MouseModels