@MorieLAB
@morielab.bsky.social
20 years already… It is true it looks like long ago when we started populating those empty rooms… and making the first agar plates look as normal ones…
In 2026 we are celebrating the 20th anniversary of our institute with, among others, and International Workshop "From Fundamental Mechanisms to Disease" with a top-level list of speakers. Please join us!!!
Registration open until January 31st 2026 at www.cabimer.es/workshop/
Registration open until January 31st 2026 at www.cabimer.es/workshop/
November 18, 2025 at 9:30 PM
20 years already… It is true it looks like long ago when we started populating those empty rooms… and making the first agar plates look as normal ones…
Reposted by @MorieLAB
EXCELLENT graphic on the drain of scientific publishing! zenodo.org/records/1759...
November 15, 2025 at 4:04 AM
EXCELLENT graphic on the drain of scientific publishing! zenodo.org/records/1759...
Reposted by @MorieLAB
Janaki Ammal was born 128 years ago today! A legend of botanical genetics, she studied how polyploidy plays into the resilience of agricultural crops, compiled a sprawling chromosomal atlas of plants, and fought for the preservation of India's natural legacy.
tinyurl.com/2j9hxmjb
#WomenInSTEM
tinyurl.com/2j9hxmjb
#WomenInSTEM
Janaki Ammal And the Fight for India’s Botanical Future.
Caste. Race. Gender. These were the three categories that, in early twentieth century Madras, combined to determine the boundaries of an individual’s potential. Being of an undesirable categorizat...
tinyurl.com
November 4, 2025 at 3:13 PM
Janaki Ammal was born 128 years ago today! A legend of botanical genetics, she studied how polyploidy plays into the resilience of agricultural crops, compiled a sprawling chromosomal atlas of plants, and fought for the preservation of India's natural legacy.
tinyurl.com/2j9hxmjb
#WomenInSTEM
tinyurl.com/2j9hxmjb
#WomenInSTEM
Reposted by @MorieLAB
Sharing a new in-depth review article on intrinsic lipid curvature and models of lipidome adaptation to the environment that I recently wrote with Jacob Winnikoff for Progress in Lipid Research (open access).
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
October 16, 2025 at 1:53 PM
Sharing a new in-depth review article on intrinsic lipid curvature and models of lipidome adaptation to the environment that I recently wrote with Jacob Winnikoff for Progress in Lipid Research (open access).
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by @MorieLAB
After years in the making, Joe McKellar @viroscope.bsky.social’s final PhD paper is finally out today in PNAS! 🎉 🎉🎉
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Human MX1 orchestrates the cytoplasmic sequestration of neosynthesized influenza A virus vRNPs | PNAS
Interferon-inducible Myxovirus resistance 1 (MX1) proteins are known to restrict influenza
A virus (IAV) transcription/replication process. Herein,...
www.pnas.org
October 7, 2025 at 6:26 PM
After years in the making, Joe McKellar @viroscope.bsky.social’s final PhD paper is finally out today in PNAS! 🎉 🎉🎉
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Reposted by @MorieLAB
Did you know that all nuclear pore complexes (NPCs) are not the same? @luskinglab.bsky.social propose a new hypothesis for how nuclear mechanics may impact the compositional plasticity of NPCs with implications for tissue-specific diseases caused by NPC dysfunction.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Nuclear mechanics as a determinant of nuclear pore complex plasticity - Nature Cell Biology
In this Review, Lusk et al. discuss emerging insights into nuclear pore complex variability with regard to composition and dilation state, and propose nuclear mechanics as a key determinant of driving...
www.nature.com
September 19, 2025 at 3:50 PM
Did you know that all nuclear pore complexes (NPCs) are not the same? @luskinglab.bsky.social propose a new hypothesis for how nuclear mechanics may impact the compositional plasticity of NPCs with implications for tissue-specific diseases caused by NPC dysfunction.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by @MorieLAB
A significant conceptual advance in the field of DNA recombination… great work by the labs of @brookscrickard1.bsky.social
and Michelle Wang
and Michelle Wang
Just throwing this out there as a significant conceptual advance in the field
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The Eukaryotic homology search complex distorts donor DNA structure to probe for homology
Homologous recombination (HR) is a DNA double-strand break repair pathway that facilitates genetic exchange and protects damaged replication forks during DNA synthesis. As a template-based repair proc...
www.biorxiv.org
September 18, 2025 at 10:57 AM
A significant conceptual advance in the field of DNA recombination… great work by the labs of @brookscrickard1.bsky.social
and Michelle Wang
and Michelle Wang
Reposted by @MorieLAB
Our PhD students @albamena.bsky.social & @annasjung.bsky.social wrote a thing on our ongoing efforts for understanding adipocytes & metabolism @erc.europa.eu
👇
www.europeandissemination.eu/article/fat-...
👇
www.europeandissemination.eu/article/fat-...
Fat, stress, and survival: exploring the secret life of adipocytes
Physical activity and exercise have beneficial effects on overall fitness and health. However, exercise-induced increases in metabolism require specific molecular adaptation of the muscle cells. This ...
www.europeandissemination.eu
August 28, 2025 at 9:49 AM
Our PhD students @albamena.bsky.social & @annasjung.bsky.social wrote a thing on our ongoing efforts for understanding adipocytes & metabolism @erc.europa.eu
👇
www.europeandissemination.eu/article/fat-...
👇
www.europeandissemination.eu/article/fat-...
Reposted by @MorieLAB
I am very happy to share that my PhD work in the Mansfeld lab (www.mansfeldlab.com) was published yesterday! 🎉 In this study, we characterized a novel redox switch on p21 that regulates proliferation: www.cell.com/molecular-ce...
Huge thanks to everyone involved for making this possible 🙏@icr.ac.uk
Huge thanks to everyone involved for making this possible 🙏@icr.ac.uk
A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision
ROS oxidize cell cycle proteins and regulate cell proliferation. Vorhauser et al.
show that oxidation of the cyclin-dependent kinase (CDK) inhibitor p21 at cysteine
41 (C41) during the G2 phase contro...
www.cell.com
August 26, 2025 at 7:18 AM
I am very happy to share that my PhD work in the Mansfeld lab (www.mansfeldlab.com) was published yesterday! 🎉 In this study, we characterized a novel redox switch on p21 that regulates proliferation: www.cell.com/molecular-ce...
Huge thanks to everyone involved for making this possible 🙏@icr.ac.uk
Huge thanks to everyone involved for making this possible 🙏@icr.ac.uk
Reposted by @MorieLAB
New work from stellar scientists Jeremy Williams and Roman Camarda. Many contributors including the amazing Zena Werb and Atul Butte
Work explores how breast cancer cells interact directly with adipocytes via gap junctions, leading to lipid release.
@ctbatucsf.bsky.social @ucsfcancer.bsky.social
Work explores how breast cancer cells interact directly with adipocytes via gap junctions, leading to lipid release.
@ctbatucsf.bsky.social @ucsfcancer.bsky.social
Tumor cell-adipocyte gap junctions activate lipolysis and contribute to breast tumorigenesis
Nature Communications - Breast cancer cells interact with neighbouring adipocytes, but the mechanisms are not fully understood. Here, the authors show that triple-negative breast cancer (TNBC)...
www.nature.com
August 20, 2025 at 10:19 AM
New work from stellar scientists Jeremy Williams and Roman Camarda. Many contributors including the amazing Zena Werb and Atul Butte
Work explores how breast cancer cells interact directly with adipocytes via gap junctions, leading to lipid release.
@ctbatucsf.bsky.social @ucsfcancer.bsky.social
Work explores how breast cancer cells interact directly with adipocytes via gap junctions, leading to lipid release.
@ctbatucsf.bsky.social @ucsfcancer.bsky.social
Reposted by @MorieLAB
Ne manquez pas le 20e GERLI International Lipid Meeting, Strasbourg, 3-5 nov 2025
Rejoignez chercheurs et experts pour explorer les dernières avancées en biologie des lipides, assistez à des conférences, posters et prix scientifiques !
Plus d'info : : www.gerli.com/congres/welc...
Rejoignez chercheurs et experts pour explorer les dernières avancées en biologie des lipides, assistez à des conférences, posters et prix scientifiques !
Plus d'info : : www.gerli.com/congres/welc...
August 21, 2025 at 10:03 AM
Ne manquez pas le 20e GERLI International Lipid Meeting, Strasbourg, 3-5 nov 2025
Rejoignez chercheurs et experts pour explorer les dernières avancées en biologie des lipides, assistez à des conférences, posters et prix scientifiques !
Plus d'info : : www.gerli.com/congres/welc...
Rejoignez chercheurs et experts pour explorer les dernières avancées en biologie des lipides, assistez à des conférences, posters et prix scientifiques !
Plus d'info : : www.gerli.com/congres/welc...
Reposted by @MorieLAB
Ryosuke Seino, Kai Nishikubo and Hisanori Fukunaga interrogate cell cycle- and dose-dependent effects on mitochondrial DNA copy number variation following irradiation.
#OpenAccess #ReadandPublish
journals.biologists.com/jcs/article/...
#OpenAccess #ReadandPublish
journals.biologists.com/jcs/article/...
August 18, 2025 at 9:47 AM
Ryosuke Seino, Kai Nishikubo and Hisanori Fukunaga interrogate cell cycle- and dose-dependent effects on mitochondrial DNA copy number variation following irradiation.
#OpenAccess #ReadandPublish
journals.biologists.com/jcs/article/...
#OpenAccess #ReadandPublish
journals.biologists.com/jcs/article/...
Reposted by @MorieLAB
Boumard, B., Le Meur, G., Aboutine, L., Stefanutti, M., Maalouf, T., El-Hajj, M., Choi, B. J., Bauer, R., Bardin, A. J. (2025). Cell-type-specific nucleotide sharing through gap junctions impacts sensitivity to replication stress in #Drosophila. Dev Cell, www.sciencedirect.com/science/arti...
Cell-type-specific nucleotide sharing through gap junctions impacts sensitivity to replication stress in Drosophila
Cell proliferation, which underlies tissue growth and homeostasis, requires high levels of metabolites such as deoxynucleotides (dNTPs). The dNTP pool…
www.sciencedirect.com
August 12, 2025 at 11:44 PM
Boumard, B., Le Meur, G., Aboutine, L., Stefanutti, M., Maalouf, T., El-Hajj, M., Choi, B. J., Bauer, R., Bardin, A. J. (2025). Cell-type-specific nucleotide sharing through gap junctions impacts sensitivity to replication stress in #Drosophila. Dev Cell, www.sciencedirect.com/science/arti...
Reposted by @MorieLAB
@morielab.bsky.social proudly presents a tool to induce, in S. cerevisiae, DNA double strand breaks in a site-specific AND in a dose-dependent manner, in a very simple way: just transform two plasmids!!! It allows you to assess many aspects of DNA damage signaling & repair!
doi.org/10.1111/febs...
doi.org/10.1111/febs...
FEBS Press
Using CRISPR-Cas9, we engineered a genetic system allowing the dose-dependent induction of a controllable number of DNA double-strand breaks in Saccharomyces cerevisiae. The tool was used to study th....
doi.org
July 9, 2025 at 6:25 PM
@morielab.bsky.social proudly presents a tool to induce, in S. cerevisiae, DNA double strand breaks in a site-specific AND in a dose-dependent manner, in a very simple way: just transform two plasmids!!! It allows you to assess many aspects of DNA damage signaling & repair!
doi.org/10.1111/febs...
doi.org/10.1111/febs...
Tardigrades tardigrades tardigrades
New preprint from @morielab.bsky.social: tardigrades are super resistant to DNA insult, yet are not immortal. We asked: why & how do they die? We have discovered their Achilles’ heel! Check it to know (spoiler: it has to do of course with DNA… but also lipids!! 😍)
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
August 5, 2025 at 12:56 PM
Tardigrades tardigrades tardigrades
Reminiscent to how mitochondria can selectively extrude damaged mtDNA, locally, along with mitochondrial membranes (or through them) towards the cytoplasm… DNA-lipids interactions at play!!
📣 New paper alert! Just out in Cell Reports! pubmed.ncbi.nlm.nih.gov/40644298/
Thrilled to share that we have discovered a brand-new anti-phage defense system! Bacteria have evolved various defense strategies (CRISPR etc) to counter phage attacks. We found a new one - fascinating and dramatic
⚔️🦠❄️🔬
Thrilled to share that we have discovered a brand-new anti-phage defense system! Bacteria have evolved various defense strategies (CRISPR etc) to counter phage attacks. We found a new one - fascinating and dramatic
⚔️🦠❄️🔬
August 3, 2025 at 8:39 PM
Reminiscent to how mitochondria can selectively extrude damaged mtDNA, locally, along with mitochondrial membranes (or through them) towards the cytoplasm… DNA-lipids interactions at play!!
Reposted by @MorieLAB
🚀 Today we're launching the 'Night Science Institute', a non-for-profit organization to lead a cultural shift in science! You may say we're dreamers 😉, but we think we're not the only ones. Perhaps today you will join us to make the Day Science and Night Science parts of the process live as one!
July 29, 2025 at 2:59 PM
🚀 Today we're launching the 'Night Science Institute', a non-for-profit organization to lead a cultural shift in science! You may say we're dreamers 😉, but we think we're not the only ones. Perhaps today you will join us to make the Day Science and Night Science parts of the process live as one!
Reposted by @MorieLAB
I am happy to share our last preprint, where we identified FASN as an endogenous dsRNA-associated factor and demonstrated that its depletion triggers endodsRNA accumulation and a stronger antiviral response to exogenous dsRNAs,#RNA, #interferon,#immunometabolism
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Fatty Acid Synthase binds endogenous dsRNAs and dampens the innate immune response to exogenous dsRNAs by limiting their accumulation.
In mammalian cells, the presence of double-stranded RNA (dsRNA) in the cytoplasm is a danger signal indicative of viral infection. Cells establish and maintain an antiviral state via the production of...
www.biorxiv.org
July 18, 2025 at 8:37 PM
I am happy to share our last preprint, where we identified FASN as an endogenous dsRNA-associated factor and demonstrated that its depletion triggers endodsRNA accumulation and a stronger antiviral response to exogenous dsRNAs,#RNA, #interferon,#immunometabolism
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Reposted by @MorieLAB
New preprint from @morielab.bsky.social: tardigrades are super resistant to DNA insult, yet are not immortal. We asked: why & how do they die? We have discovered their Achilles’ heel! Check it to know (spoiler: it has to do of course with DNA… but also lipids!! 😍)
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
July 25, 2025 at 6:51 AM
New preprint from @morielab.bsky.social: tardigrades are super resistant to DNA insult, yet are not immortal. We asked: why & how do they die? We have discovered their Achilles’ heel! Check it to know (spoiler: it has to do of course with DNA… but also lipids!! 😍)
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
New preprint from @morielab.bsky.social: tardigrades are super resistant to DNA insult, yet are not immortal. We asked: why & how do they die? We have discovered their Achilles’ heel! Check it to know (spoiler: it has to do of course with DNA… but also lipids!! 😍)
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
July 25, 2025 at 6:51 AM
New preprint from @morielab.bsky.social: tardigrades are super resistant to DNA insult, yet are not immortal. We asked: why & how do they die? We have discovered their Achilles’ heel! Check it to know (spoiler: it has to do of course with DNA… but also lipids!! 😍)
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Reposted by @MorieLAB
Phase II of our Fast & Fair peer review experiment is testing scalability. Results so far are promising. Read more at bit.ly/41N31tO.
#FastandFairPeerReview #PeerReview #ScientificPublishing
#FastandFairPeerReview #PeerReview #ScientificPublishing
July 22, 2025 at 1:21 PM
Phase II of our Fast & Fair peer review experiment is testing scalability. Results so far are promising. Read more at bit.ly/41N31tO.
#FastandFairPeerReview #PeerReview #ScientificPublishing
#FastandFairPeerReview #PeerReview #ScientificPublishing
Reposted by @MorieLAB
Excited for our next special issue and looking forward to working with Abby Buchwalter (@abbybuch.bsky.social) and Megan King (@luskinglab.bsky.social)! Working on the cell biology of the nucleus? Send your papers our way!
#notforprofit
#notforprofit
Call for papers: Cell Biology of the Nucleus
We invite you to submit your latest research to our special issue: Cell Biology of the Nucleus, guest edited by Abby Buchwalter @abbybuch.bsky.social, working alongside Megan King @luskinglab.bsky.social.
journals.biologists.com/jcs/pages/nu...
We invite you to submit your latest research to our special issue: Cell Biology of the Nucleus, guest edited by Abby Buchwalter @abbybuch.bsky.social, working alongside Megan King @luskinglab.bsky.social.
journals.biologists.com/jcs/pages/nu...
July 16, 2025 at 3:55 PM
Excited for our next special issue and looking forward to working with Abby Buchwalter (@abbybuch.bsky.social) and Megan King (@luskinglab.bsky.social)! Working on the cell biology of the nucleus? Send your papers our way!
#notforprofit
#notforprofit
Reposted by @MorieLAB
Moutushi Islam, Masato Kanemaki and colleagues describe their single-chain antibody-based auxin-inducible degron system which enables degradation of GFP-tagged and untagged proteins.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
July 10, 2025 at 10:09 AM
Moutushi Islam, Masato Kanemaki and colleagues describe their single-chain antibody-based auxin-inducible degron system which enables degradation of GFP-tagged and untagged proteins.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
Reposted by @MorieLAB
They are a REMARKABLE supporter of scientists and the community. In addition to their five journals, they support dozens of scientific meetings each year, and provide travel grants and other support 2/n
www.biologists.com/grants/
www.biologists.com/grants/
July 9, 2025 at 8:49 PM
They are a REMARKABLE supporter of scientists and the community. In addition to their five journals, they support dozens of scientific meetings each year, and provide travel grants and other support 2/n
www.biologists.com/grants/
www.biologists.com/grants/
@morielab.bsky.social proudly presents a tool to induce, in S. cerevisiae, DNA double strand breaks in a site-specific AND in a dose-dependent manner, in a very simple way: just transform two plasmids!!! It allows you to assess many aspects of DNA damage signaling & repair!
doi.org/10.1111/febs...
doi.org/10.1111/febs...
FEBS Press
Using CRISPR-Cas9, we engineered a genetic system allowing the dose-dependent induction of a controllable number of DNA double-strand breaks in Saccharomyces cerevisiae. The tool was used to study th....
doi.org
July 9, 2025 at 6:25 PM
@morielab.bsky.social proudly presents a tool to induce, in S. cerevisiae, DNA double strand breaks in a site-specific AND in a dose-dependent manner, in a very simple way: just transform two plasmids!!! It allows you to assess many aspects of DNA damage signaling & repair!
doi.org/10.1111/febs...
doi.org/10.1111/febs...