@brookscrickard1.bsky.social
You say board of peace, I say legion of Doom. I think we can work this out.
January 22, 2026 at 1:16 PM
You say board of peace, I say legion of Doom. I think we can work this out.
And now we wait
January 20, 2026 at 8:47 PM
And now we wait
Remember when data not shown was a thing
January 17, 2026 at 4:26 PM
Remember when data not shown was a thing
Reposted
A wonderful collaboration between Jess Tyler lab, @epicypher.bsky.social, @gcloner.bsky.social, James Kadonaga and our lab at PSU. In this article, we provide the significance of the nucleosome acidic patch.
doi.org/10.64898/202...
doi.org/10.64898/202...
doi.org
January 16, 2026 at 2:15 PM
A wonderful collaboration between Jess Tyler lab, @epicypher.bsky.social, @gcloner.bsky.social, James Kadonaga and our lab at PSU. In this article, we provide the significance of the nucleosome acidic patch.
doi.org/10.64898/202...
doi.org/10.64898/202...
Reposted
My first first-author paper is posted! Glad to have this out! 🦠🚨🕺
We show that pGpp production depletes GTP, inhibits translation, and remodels the transcriptome faster than (p)ppGpp.
...and more!
We show that pGpp production depletes GTP, inhibits translation, and remodels the transcriptome faster than (p)ppGpp.
...and more!
Starvation-independent alarmone production inhibits translation through GTP depletion https://www.biorxiv.org/content/10.64898/2026.01.12.699007v1
January 13, 2026 at 2:09 AM
My first first-author paper is posted! Glad to have this out! 🦠🚨🕺
We show that pGpp production depletes GTP, inhibits translation, and remodels the transcriptome faster than (p)ppGpp.
...and more!
We show that pGpp production depletes GTP, inhibits translation, and remodels the transcriptome faster than (p)ppGpp.
...and more!
Reposted
We are excited to share that our latest work from the lab aimed at understanding how the tRNA nuclease SLFN11 is activated in response to DNA damage and replication stress has just been published in @natcellbio.nature.com!
Open access link: www.nature.com/articles/s41...
(1/9)
Open access link: www.nature.com/articles/s41...
(1/9)
Client Challenge
www.nature.com
January 9, 2026 at 2:42 PM
We are excited to share that our latest work from the lab aimed at understanding how the tRNA nuclease SLFN11 is activated in response to DNA damage and replication stress has just been published in @natcellbio.nature.com!
Open access link: www.nature.com/articles/s41...
(1/9)
Open access link: www.nature.com/articles/s41...
(1/9)
Manuscript accepted. I have allowed myself 30 minutes to celebrate and will move on to the next.
January 8, 2026 at 5:42 PM
Manuscript accepted. I have allowed myself 30 minutes to celebrate and will move on to the next.
Reposted
Excited to start 2026 out with a new manuscript from our lab, please check out this thread from superstar postdoc @rvig.bsky.social about how he discovered the function of a conserved secretory protein, and how this also led him to the identification of a new family of GAP proteins!
Mind the GAP 🚧🕳️🚧
Excited to share the latest preprint from the Fromme Lab (@fromme-lab.bsky.social), showing that the DENN domain protein Avl9 functions as an Arf-GAP, revising long-standing assumptions about DENN protein function, 🧵:
www.biorxiv.org/content/10.6...
Excited to share the latest preprint from the Fromme Lab (@fromme-lab.bsky.social), showing that the DENN domain protein Avl9 functions as an Arf-GAP, revising long-standing assumptions about DENN protein function, 🧵:
www.biorxiv.org/content/10.6...
Avl9 defines a family of GTPase-activating proteins that regulate diverse cell biological functions
Ras-related GTPases are molecular switches regulating hundreds of signaling and trafficking pathways in cells. Many GTPase regulators remain to be identified despite extensive genetic and biochemical ...
www.biorxiv.org
January 6, 2026 at 3:54 PM
Excited to start 2026 out with a new manuscript from our lab, please check out this thread from superstar postdoc @rvig.bsky.social about how he discovered the function of a conserved secretory protein, and how this also led him to the identification of a new family of GAP proteins!
Reposted
Alessandro Costa @costalaboratory.bsky.social, Dana Branzei and myself are co-organising the 2026 Machines on Genes meeting in beautiful Crete as the 94th Harden Conference hosted by @biochemsoc.bsky.social
Register now - lots of opportunities for selected talks www.eventsforce.net/biochemsoc/f...
Register now - lots of opportunities for selected talks www.eventsforce.net/biochemsoc/f...
www.eventsforce.net
January 5, 2026 at 4:52 PM
Alessandro Costa @costalaboratory.bsky.social, Dana Branzei and myself are co-organising the 2026 Machines on Genes meeting in beautiful Crete as the 94th Harden Conference hosted by @biochemsoc.bsky.social
Register now - lots of opportunities for selected talks www.eventsforce.net/biochemsoc/f...
Register now - lots of opportunities for selected talks www.eventsforce.net/biochemsoc/f...
Reposted
The sporulation phosphorelay protein Spo0B is membrane localized in Paenibacillus! The transmembrane domain appears to increase interaction with relay partners. Congrats to former lab undergrad @isabellalin.bsky.social and her grad mentor @cassidyprints.bsky.social
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
journals.asm.org
December 30, 2025 at 1:50 PM
The sporulation phosphorelay protein Spo0B is membrane localized in Paenibacillus! The transmembrane domain appears to increase interaction with relay partners. Congrats to former lab undergrad @isabellalin.bsky.social and her grad mentor @cassidyprints.bsky.social
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
Jingyi is harnessing the awesome power of yeast genetics...
December 17, 2025 at 9:46 PM
Jingyi is harnessing the awesome power of yeast genetics...
Reposted
To top off the end of 2025, a new preprint from our lab! We find an unanticipated new answer to an old question in DNA repair.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Human MutLa activates methylpurine DNA glycosylase to induce alkylation damage cytotoxicity
Alkylation chemotherapy is commonly used against tumors such as glioblastoma, yet resistance often develops through downregulation of mismatch repair (MMR). Previous work has established that loss of ...
www.biorxiv.org
December 17, 2025 at 2:53 PM
To top off the end of 2025, a new preprint from our lab! We find an unanticipated new answer to an old question in DNA repair.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Reposted
We are hiring!
We are looking for a motivated and enthusiastic postdoc to study mammalian DSB repair using innovative genomic approaches.
Our lab is at the Curie Institute in Paris and offers vibrant scientific environnement and cutting edge platforms.
Please repost or apply here:
lnkd.in/eJ9q3QrR
We are looking for a motivated and enthusiastic postdoc to study mammalian DSB repair using innovative genomic approaches.
Our lab is at the Curie Institute in Paris and offers vibrant scientific environnement and cutting edge platforms.
Please repost or apply here:
lnkd.in/eJ9q3QrR
Institut Curie hiring Postdoctoral Position in Mammalian DSB Repair (F/M) in Paris, Île-de-France, France | LinkedIn
Posted 8:04:09 PM. About UsInstitut Curie Research CenterInstitut Curie is a major player in the research and fight…See this and similar jobs on LinkedIn.
lnkd.in
August 1, 2025 at 9:38 AM
We are hiring!
We are looking for a motivated and enthusiastic postdoc to study mammalian DSB repair using innovative genomic approaches.
Our lab is at the Curie Institute in Paris and offers vibrant scientific environnement and cutting edge platforms.
Please repost or apply here:
lnkd.in/eJ9q3QrR
We are looking for a motivated and enthusiastic postdoc to study mammalian DSB repair using innovative genomic approaches.
Our lab is at the Curie Institute in Paris and offers vibrant scientific environnement and cutting edge platforms.
Please repost or apply here:
lnkd.in/eJ9q3QrR
Aaron Rodgers is doing a perfect 40-year-old impression right now. I can empathize so hard.
December 1, 2025 at 12:04 AM
Aaron Rodgers is doing a perfect 40-year-old impression right now. I can empathize so hard.
Congrats to Jingyi Hu the first PhD thesis defender of the Crickard lab
November 21, 2025 at 4:30 PM
Congrats to Jingyi Hu the first PhD thesis defender of the Crickard lab
Harry Potter hits differently when you realize it's the revenge tale of Severus Snape
November 20, 2025 at 11:38 PM
Harry Potter hits differently when you realize it's the revenge tale of Severus Snape
Reposted
Interested in analyzing kinase activity with subcellular spatial resolution? Want to learn more about peptide barcoding?
@smolka-lab.bsky.social and @wjcomstock.bsky.social have something just for you!
@smolka-lab.bsky.social and @wjcomstock.bsky.social have something just for you!
Check out our new biosensor technology to study DDR kinase signaling: ProKAS.
We combine:
-proteomics
-engineered peptide sensors
-a new concept of amino acid barcodes
ProKAS tracks kinase signaling with spatial resolution and produces highly quantitative data.
Just published today: rdcu.be/ePNo0
We combine:
-proteomics
-engineered peptide sensors
-a new concept of amino acid barcodes
ProKAS tracks kinase signaling with spatial resolution and produces highly quantitative data.
Just published today: rdcu.be/ePNo0
November 13, 2025 at 6:53 PM
Interested in analyzing kinase activity with subcellular spatial resolution? Want to learn more about peptide barcoding?
@smolka-lab.bsky.social and @wjcomstock.bsky.social have something just for you!
@smolka-lab.bsky.social and @wjcomstock.bsky.social have something just for you!
Reposted
Delighted to see our study finally out in "print". Thanks to all the (many) contributors, collaborators and reviewers!
Mismatch repair disturbs meiotic crossover control in S. cerevisiae academic.oup.com/nar/article/...
Mismatch repair disturbs meiotic crossover control in S. cerevisiae academic.oup.com/nar/article/...
Mismatch repair disturbs meiotic crossover control in S. cerevisiae
Abstract. Crossover formation during meiosis generates genetic diversity. In many species most crossovers display interference, meaning they are spaced mor
academic.oup.com
November 13, 2025 at 8:40 PM
Delighted to see our study finally out in "print". Thanks to all the (many) contributors, collaborators and reviewers!
Mismatch repair disturbs meiotic crossover control in S. cerevisiae academic.oup.com/nar/article/...
Mismatch repair disturbs meiotic crossover control in S. cerevisiae academic.oup.com/nar/article/...
Reposted
Happy to share our @narjournal.bsky.social paper on the mechanism of Dmc1 filament stabilization by Mei5-Sae3!
We show that Mei5-Sae3 can stabilize both active and inactive Dmc1 filaments, and that this is independent of the ATP hydrolytic cycle.
doi.org/10.1093/nar/...
We show that Mei5-Sae3 can stabilize both active and inactive Dmc1 filaments, and that this is independent of the ATP hydrolytic cycle.
doi.org/10.1093/nar/...
Mei5–Sae3 stabilizes both active and inactive forms of Dmc1 filaments independently of its impact on ATP hydrolysis
Abstract. In budding yeast, Dmc1’s recombinogenic activity is controlled by the meiosis-specific heterodimer Mei5–Sae3. Mei5–Sae3 is required for assembly
doi.org
November 9, 2025 at 2:19 PM
Happy to share our @narjournal.bsky.social paper on the mechanism of Dmc1 filament stabilization by Mei5-Sae3!
We show that Mei5-Sae3 can stabilize both active and inactive Dmc1 filaments, and that this is independent of the ATP hydrolytic cycle.
doi.org/10.1093/nar/...
We show that Mei5-Sae3 can stabilize both active and inactive Dmc1 filaments, and that this is independent of the ATP hydrolytic cycle.
doi.org/10.1093/nar/...
Be careful the gates of hell are temporarily open
November 4, 2025 at 11:47 AM
Be careful the gates of hell are temporarily open
Reposted
Members of @acsbiol.bsky.social, the Fall 2025 Election is occurring now & will run until 11/28. To ensure you receive your ballot, be sure that your ACS membership is up to date & your email filters are set to receive from elections@vote-now.com.
October 31, 2025 at 8:20 PM
Members of @acsbiol.bsky.social, the Fall 2025 Election is occurring now & will run until 11/28. To ensure you receive your ballot, be sure that your ACS membership is up to date & your email filters are set to receive from elections@vote-now.com.
in the crucible
October 30, 2025 at 1:33 PM
in the crucible
I'm happy to post this recent work from our lab. Trying to keep things going under challenging times.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Rad54 separation of function mutation highlights unique roles during homologous recombination
Homologous recombination (HR) is a DNA repair pathway that utilizes a template-based approach to repair double-strand breaks within the genome. Template utilization requires the exchange of individual...
www.biorxiv.org
October 15, 2025 at 10:48 PM
I'm happy to post this recent work from our lab. Trying to keep things going under challenging times.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
remember when data not shown and personal communication would appear at least once or twice in a paper, and error bars were optional...
October 15, 2025 at 6:26 PM
remember when data not shown and personal communication would appear at least once or twice in a paper, and error bars were optional...