Joe Peters Lab
@joepeterslab.bsky.social
Professor and Chair, Dept Microbiology Cornell Ithaca. Interested in genome evolution and mobile DNA, especially Tn7 and CRISPR-Cas transposition systems
The Peters lab is looking for a new team member! The role transposons play in evolution, basic mechanisms regulating transposition, and applying transposons as tools for genome modification with a special focus on guide RNA-directed transposition. cornell.wd1.myworkdayjobs.com/CornellCaree...
Technician III - Department of Microbiology
Position Summary This position will be in the lab of Dr. Joseph E. Peters in the Department of Microbiology. Research in the Peters’ lab broadly involves deciphering mechanisms in genome stability and...
cornell.wd1.myworkdayjobs.com
October 3, 2025 at 1:01 PM
The Peters lab is looking for a new team member! The role transposons play in evolution, basic mechanisms regulating transposition, and applying transposons as tools for genome modification with a special focus on guide RNA-directed transposition. cornell.wd1.myworkdayjobs.com/CornellCaree...
De novo engineered guide RNA-directed transposition with TnpB-family proteins reveals features of naturally evolved systems www.biorxiv.org/content/10.1...
De novo engineered guide RNA-directed transposition with TnpB-family proteins reveals features of naturally evolved systems
Programmable DNA integration using CRISPR-associated transposons (CASTs) offers powerful capabilities for genome engineering. The single effector Cas12k CAST examples evolved from a fixed guide TnpB n...
www.biorxiv.org
August 28, 2025 at 12:23 PM
De novo engineered guide RNA-directed transposition with TnpB-family proteins reveals features of naturally evolved systems www.biorxiv.org/content/10.1...
Reposted by Joe Peters Lab
The RecBCD complex interacts directly with the DNA sliding clamp in Escherichia coli https://www.biorxiv.org/content/10.1101/2025.08.20.671105v1
August 21, 2025 at 4:16 AM
The RecBCD complex interacts directly with the DNA sliding clamp in Escherichia coli https://www.biorxiv.org/content/10.1101/2025.08.20.671105v1
Great to have former lab member Mike Petassi for a seminar with our Replication, Recombination, and Repair group! Presenting some of his postdoc work in the @dnacurtain.bsky.social lab. cals.cornell.edu/microbiology...
August 11, 2025 at 7:03 PM
Great to have former lab member Mike Petassi for a seminar with our Replication, Recombination, and Repair group! Presenting some of his postdoc work in the @dnacurtain.bsky.social lab. cals.cornell.edu/microbiology...
Reposted by Joe Peters Lab
Looking forward to this new installment of the Woods Hole Mobile DNA Meeting! Fantastic program, laid-back atmosphere, and gorgeous setting at the Marine Biological Laboratory ⛵️🪼🐋
Abstract submission closes Aug 7 but registration after that date is possible. www.eventsquid.com/event.cfm?ev...
Abstract submission closes Aug 7 but registration after that date is possible. www.eventsquid.com/event.cfm?ev...
August 5, 2025 at 8:47 PM
Looking forward to this new installment of the Woods Hole Mobile DNA Meeting! Fantastic program, laid-back atmosphere, and gorgeous setting at the Marine Biological Laboratory ⛵️🪼🐋
Abstract submission closes Aug 7 but registration after that date is possible. www.eventsquid.com/event.cfm?ev...
Abstract submission closes Aug 7 but registration after that date is possible. www.eventsquid.com/event.cfm?ev...
Tn7 family transposons that include all of the guide RNA-directed transposons (CAST) are common in bacteria. We now find diverse representatives across archaea, with many in the Asgard group. Reviving an Asgard element confirmed the exciting behaviors of the family #MicroSky #TESky
Tn7 family bacterial transposons known for tightly controlled target site selection are distributed across Asgard and archaeal groups https://www.biorxiv.org/content/10.1101/2025.07.27.667033v1
July 30, 2025 at 8:31 PM
Very excited about our work from @jordanthesier.bsky.social and @popomicro.bsky.social et al. We find that Tn7 family elements common in bacteria (that include all of the guide RNA-directed transposons, CAST) are also found across archaea including many in the exciting Asgard group! #MicroSky #TESky
My first co–first author paper with the amazing PoPo @popomicro.bsky.social is now on bioRxiv ! 🧬
We found that Tn7-like transposons - known for finding specific insertion sites before they jump - aren’t just in bacteria. They're in archaea distributed across all major superphyla!
We found that Tn7-like transposons - known for finding specific insertion sites before they jump - aren’t just in bacteria. They're in archaea distributed across all major superphyla!
Tn7 family bacterial transposons known for tightly controlled target site selection are distributed across Asgard and archaeal groups https://www.biorxiv.org/content/10.1101/2025.07.27.667033v1
July 30, 2025 at 8:27 PM
Very excited about our work from @jordanthesier.bsky.social and @popomicro.bsky.social et al. We find that Tn7 family elements common in bacteria (that include all of the guide RNA-directed transposons, CAST) are also found across archaea including many in the exciting Asgard group! #MicroSky #TESky
Today is the last day to submit to be considered for a podium presentation at the EMBO transposon meeting this Fall. The organizers prioritized speaker slots sourced from submitted abstracts, we want to hear about your science!
last call!
submit your abstract by tonight to be selected for one of the many oral presentations at the leading European Transposon Meeting. We are very much looking forward to your contribution and attendance!
submit your abstract by tonight to be selected for one of the many oral presentations at the leading European Transposon Meeting. We are very much looking forward to your contribution and attendance!
⏰ Abstract deadline for 'The mobile genome' is 29 July!
👉 https://s.embl.org/mge25-01-bl
Join us 4–7 Nov 2025 at EMBL Heidelberg (or online) to explore the impact of TEs across biology. 🧬🔍
⭐🧑🏼🔬 24 talks + 15 flash talks from posters – don't miss out!
#EMBOMobileGenome
👉 https://s.embl.org/mge25-01-bl
Join us 4–7 Nov 2025 at EMBL Heidelberg (or online) to explore the impact of TEs across biology. 🧬🔍
⭐🧑🏼🔬 24 talks + 15 flash talks from posters – don't miss out!
#EMBOMobileGenome
July 29, 2025 at 12:59 PM
Today is the last day to submit to be considered for a podium presentation at the EMBO transposon meeting this Fall. The organizers prioritized speaker slots sourced from submitted abstracts, we want to hear about your science!
Reposted by Joe Peters Lab
Metal ions are universally required for life, and many of the foundational principles of metal homeostasis have emerged from studies of microbial systems. In this review, I provide a introductory overview targeted to those new to the field.
#MicroSky #Metals
rdcu.be/eycU2
#MicroSky #Metals
rdcu.be/eycU2
Microbial metal physiology: ions to ecosystems
Nature Reviews Microbiology - Metal ions are required for all cells, and their homeostasis relies on ancient mechanisms that facilitate their import, distribution and storage. In this Review,...
rdcu.be
July 28, 2025 at 5:08 PM
Metal ions are universally required for life, and many of the foundational principles of metal homeostasis have emerged from studies of microbial systems. In this review, I provide a introductory overview targeted to those new to the field.
#MicroSky #Metals
rdcu.be/eycU2
#MicroSky #Metals
rdcu.be/eycU2
Reposted by Joe Peters Lab
We're hiring! Do you have experience engineering yeast and using CRISPR? Jose Avalos and I are hiring a joint postdoc to work on an exciting fast-paced DARPA project with a great team at Neochromosome, Fermeate, and @joepeterslab.bsky.social
puwebp.princeton.edu/AcadHire/app...
puwebp.princeton.edu/AcadHire/app...
puwebp.princeton.edu
June 17, 2025 at 3:01 PM
We're hiring! Do you have experience engineering yeast and using CRISPR? Jose Avalos and I are hiring a joint postdoc to work on an exciting fast-paced DARPA project with a great team at Neochromosome, Fermeate, and @joepeterslab.bsky.social
puwebp.princeton.edu/AcadHire/app...
puwebp.princeton.edu/AcadHire/app...
Happy Transposon Day! 🧬➰🧬 Commemorating Barbara McClintock's birthday (June 16th, 1902-1992). #TransposonDay2025
June 16, 2025 at 3:53 PM
Happy Transposon Day! 🧬➰🧬 Commemorating Barbara McClintock's birthday (June 16th, 1902-1992). #TransposonDay2025
Linking to #microsky #transposon
Exciting work from the Guarné lab indicating how the elusive TnsE pathway of prototypic Tn7 recognizes DNA replication features using an asymmetric dimer to integrate multiple signals at DNA replication forks linking target recognition to transposase recruitment doi.org/10.1093/nar/...
June 15, 2025 at 11:51 AM
Linking to #microsky #transposon
Exciting work from the Guarné lab indicating how the elusive TnsE pathway of prototypic Tn7 recognizes DNA replication features using an asymmetric dimer to integrate multiple signals at DNA replication forks linking target recognition to transposase recruitment doi.org/10.1093/nar/...
June 15, 2025 at 11:43 AM
Exciting work from the Guarné lab indicating how the elusive TnsE pathway of prototypic Tn7 recognizes DNA replication features using an asymmetric dimer to integrate multiple signals at DNA replication forks linking target recognition to transposase recruitment doi.org/10.1093/nar/...
Reposted by Joe Peters Lab
First podcast recording of the day. Guest is Dr. Tory Hendry of Cornell University, chatting about interactions between fluorescent Pseudomonas and aphids!
May 23, 2025 at 12:42 AM
First podcast recording of the day. Guest is Dr. Tory Hendry of Cornell University, chatting about interactions between fluorescent Pseudomonas and aphids!
Reposted by Joe Peters Lab
𝘢𝘧𝘪𝘤𝘪𝘰𝘯𝘢𝘥𝘢𝘴 & 𝘢𝘧𝘪𝘯𝘰𝘯𝘢𝘥𝘰𝘴 of chromosome ends (bacterial!) take note 👇
#MicroSky
#MicroSky
A thread from the Postdoc who led the work on bacterial Telomeric transposons. A wonderful collaboration with the Barabas lab. Officially out in the journal today!
In eukaryotes, some transposons target telomeres; in Drosophila, they even replace them. Peters lab and Barabas group show that bacteria with linear genomes also harbor diverse telomeric transposons.
doi.org/10.1126/scie...
@joepeterslab.bsky.social
doi.org/10.1126/scie...
@joepeterslab.bsky.social
March 29, 2025 at 4:43 PM
𝘢𝘧𝘪𝘤𝘪𝘰𝘯𝘢𝘥𝘢𝘴 & 𝘢𝘧𝘪𝘯𝘰𝘯𝘢𝘥𝘰𝘴 of chromosome ends (bacterial!) take note 👇
#MicroSky
#MicroSky
Reposted by Joe Peters Lab
wow, telomeric transposons in bacteria with linear chromosomes! (of course this was first figured out in flies, inc by Bob Levis, who i was happy to see few days ago at the fly meeting). 🪰
www.science.org/doi/10.1126/...
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
www.science.org/doi/10.1126/...
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Telomeric transposons are pervasive in linear bacterial genomes
Eukaryotes have linear DNA, and their telomeres are hotspots for transposons, which in some cases took over telomere maintenance. We identified several families of independently evolved telomeric tran...
www.science.org
March 27, 2025 at 8:55 PM
wow, telomeric transposons in bacteria with linear chromosomes! (of course this was first figured out in flies, inc by Bob Levis, who i was happy to see few days ago at the fly meeting). 🪰
www.science.org/doi/10.1126/...
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
www.science.org/doi/10.1126/...
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
A thread from the Postdoc who led the work on bacterial Telomeric transposons. A wonderful collaboration with the Barabas lab. Officially out in the journal today!
In eukaryotes, some transposons target telomeres; in Drosophila, they even replace them. Peters lab and Barabas group show that bacteria with linear genomes also harbor diverse telomeric transposons.
doi.org/10.1126/scie...
@joepeterslab.bsky.social
doi.org/10.1126/scie...
@joepeterslab.bsky.social
March 27, 2025 at 7:55 PM
A thread from the Postdoc who led the work on bacterial Telomeric transposons. A wonderful collaboration with the Barabas lab. Officially out in the journal today!
Reposted by Joe Peters Lab
Did you know that two jumping sequences (LINE-1 and Alu) make up nearly 30% of our genomes? Ever wonder how they jump into new genomic sites? We have some exciting discoveries to share new in @science.org on the structural mechanisms of LINE-1 retrotransposition (aka jumping 🧬➡️🧬) 🧪 #ScienceResearch
March 7, 2025 at 12:22 AM
Did you know that two jumping sequences (LINE-1 and Alu) make up nearly 30% of our genomes? Ever wonder how they jump into new genomic sites? We have some exciting discoveries to share new in @science.org on the structural mechanisms of LINE-1 retrotransposition (aka jumping 🧬➡️🧬) 🧪 #ScienceResearch
Telomeric transposons are pervasive in linear bacterial genomes | Science www.science.org/doi/10.1126/...
Telomeric transposons are pervasive in linear bacterial genomes
Eukaryotes have linear DNA and their telomeres are hotspots for transposons, which in some cases took over telomere maintenance. Here we identify several families of independently evolved telomeric tr...
www.science.org
March 6, 2025 at 8:02 PM
Telomeric transposons are pervasive in linear bacterial genomes | Science www.science.org/doi/10.1126/...
Our preprint is now published www.science.org/doi/10.1126/...
March 6, 2025 at 7:47 PM
Our preprint is now published www.science.org/doi/10.1126/...
Very excited about this work from graduate student Laura Chacon Machado now published in Mobile DNA, "A family of Tn7-like transposons evolved to target CRISPR repeats"! #TESky
Our preprint describing a family of Tn7-like transposons that evolved to target CRISPR repeats is now published at Mobile DNA #Tn7 #transposons #mobileDNA 1/10
mobilednajournal.biomedcentral.com/articles/10....
mobilednajournal.biomedcentral.com/articles/10....
A family of Tn7-like transposons evolved to target CRISPR repeats - Mobile DNA
Tn7 family transposons are mobile genetic elements known for precise target site selection, with some co-opting CRISPR-Cas systems for RNA-guided transposition. We identified a novel group of Tn7-like...
mobilednajournal.biomedcentral.com
February 18, 2025 at 10:05 PM
Very excited about this work from graduate student Laura Chacon Machado now published in Mobile DNA, "A family of Tn7-like transposons evolved to target CRISPR repeats"! #TESky
Reposted by Joe Peters Lab
AIR-BORNE EXCERPT! Louis Pasteur climbed a glacier to hunt for floating germs. There he discovered a fundamental truth about all life. Here's the story, from my new book. [Gift link] Artwork by Antoine Maillard. 🧪 1/2 www.nytimes.com/2025/02/17/s...
February 17, 2025 at 3:20 PM
AIR-BORNE EXCERPT! Louis Pasteur climbed a glacier to hunt for floating germs. There he discovered a fundamental truth about all life. Here's the story, from my new book. [Gift link] Artwork by Antoine Maillard. 🧪 1/2 www.nytimes.com/2025/02/17/s...
I had the great pleasure of interacting with Bik Tye and her lab for many years at Cornell where she was one of the founding members of our DNA Replication, Recombination, and Repair (R3) group. It was wonderful to see this profile in PNAS www.pnas.org/doi/10.1073/...
www.pnas.org
February 17, 2025 at 2:27 PM
I had the great pleasure of interacting with Bik Tye and her lab for many years at Cornell where she was one of the founding members of our DNA Replication, Recombination, and Repair (R3) group. It was wonderful to see this profile in PNAS www.pnas.org/doi/10.1073/...
Reposted by Joe Peters Lab
Want to learn more about genetic tools for studying bacteria and phage, check out the summer ABG Course at CSHL. This will be the 80th anniversary of the original CSHL Phage course, so you'll also meet many additional visiting genetics gurus! <https://meetings.cshl.edu/courses.aspx?course=C-ABG>
January 29, 2025 at 3:53 AM
Want to learn more about genetic tools for studying bacteria and phage, check out the summer ABG Course at CSHL. This will be the 80th anniversary of the original CSHL Phage course, so you'll also meet many additional visiting genetics gurus! <https://meetings.cshl.edu/courses.aspx?course=C-ABG>
Reposted by Joe Peters Lab
If there's something we don't understand I assume transposons are responsible unless proven otherwise
January 18, 2025 at 6:23 PM
If there's something we don't understand I assume transposons are responsible unless proven otherwise