Big congratulations! MicroPublication is a so valuable initiative to inform the community of accomplished work that will save time and effort to other researchers! I am superhappy to see you joined this initiative! Congratulations to Louison! 🎉

Massive congratulations, Felipe! This work is a gigantic endeavour! And a fantastic resource! Mechanistically, is the absence of Homologous Recombination intrinsic to the pathways dictated by using Cas9 to create the cut? In S. cerevisiae Cas9 cuts very efficiently engage HR. Felicidades de nuevo! 😍

I would like to read what @marcofumasoni.bsky.social has to say about these data…!

Coincident with loss of Rev1, however… 🤔

Thanks so much, this is very interesting, so do you think (or can know) if they co-lost the fatty acid synthase and the DNA polymerase delta??? I now wonder if there might exist a functional association if this is the case…

Cool… can you provide me with the original work about fatty acid synthase dependency? We study the control that lipids exert onto genome (in)stability… thus not sure the two events you name are unrelated…!!! 🧐

Hi, super nice story! Just to mention that in S. cerevisiae it has been shown that DNA synthesis can be replicated (at least for initiation) by DNA polymerase delta!, both basally and, most importantly with respect to your findings, in the absence of Pol ε! doi.org/10.1038/s414...

Huge congratulations, Milena! This is fantastic! You are going to make awesome things