Morgan Lamberioux
@morgan-lamberioux.bsky.social
PhD. PharmD. currently in Post-Doc in Bacterial Genome Plasticity unit, Institut Pasteur, Paris.
Genetics 🧬, plasmids, microbiology 🔬 translation, Vibrio 🦠
Genetics 🧬, plasmids, microbiology 🔬 translation, Vibrio 🦠
Thrilled to share my first PhD paper, out of the Mazel lab! @amazeld.bsky.social
We discovered that accessory peptide deformylases (PDFs) are widespread in bacteria and may provide resistance to natural inhibitors, posing a challenge to future antibiotic strategies
doi.org/10.1101/2025...
We discovered that accessory peptide deformylases (PDFs) are widespread in bacteria and may provide resistance to natural inhibitors, posing a challenge to future antibiotic strategies
doi.org/10.1101/2025...
Unraveling the prevalence and multifaceted roles of accessory peptide deformylases in bacterial adaptation and resistance
Peptide deformylases (PDFs) are enzymes that are essential for bacterial viability and attractive targets for antibiotic development. Yet, despite their conserved function, many bacteria encode multip...
doi.org
June 7, 2025 at 10:09 AM
Thrilled to share my first PhD paper, out of the Mazel lab! @amazeld.bsky.social
We discovered that accessory peptide deformylases (PDFs) are widespread in bacteria and may provide resistance to natural inhibitors, posing a challenge to future antibiotic strategies
doi.org/10.1101/2025...
We discovered that accessory peptide deformylases (PDFs) are widespread in bacteria and may provide resistance to natural inhibitors, posing a challenge to future antibiotic strategies
doi.org/10.1101/2025...
Reposted by Morgan Lamberioux
First preprint from my PhD is now online! We show that deep learning can recognise modes of action of antibiotics directly from brightfield images of bacteria. 🦠
Deep learning recognises antibiotic modes of action from brightfield images https://www.biorxiv.org/content/10.1101/2025.03.30.645928v1
April 1, 2025 at 8:22 AM
First preprint from my PhD is now online! We show that deep learning can recognise modes of action of antibiotics directly from brightfield images of bacteria. 🦠
Reposted by Morgan Lamberioux
Out today @ Science: TIR signaling activates caspase-like immunity in bacteria
We report a new immune signaling molecule: N7-cADPR. Produced by phage-induced TIRs and activates a defensive bacterial caspase
Congrats Francois Rousset, Ilya Osterman and coauthors!
www.science.org/doi/10.1126/...
We report a new immune signaling molecule: N7-cADPR. Produced by phage-induced TIRs and activates a defensive bacterial caspase
Congrats Francois Rousset, Ilya Osterman and coauthors!
www.science.org/doi/10.1126/...
January 30, 2025 at 9:57 PM
Out today @ Science: TIR signaling activates caspase-like immunity in bacteria
We report a new immune signaling molecule: N7-cADPR. Produced by phage-induced TIRs and activates a defensive bacterial caspase
Congrats Francois Rousset, Ilya Osterman and coauthors!
www.science.org/doi/10.1126/...
We report a new immune signaling molecule: N7-cADPR. Produced by phage-induced TIRs and activates a defensive bacterial caspase
Congrats Francois Rousset, Ilya Osterman and coauthors!
www.science.org/doi/10.1126/...
Reposted by Morgan Lamberioux
New preprint from our Lesterlin Lab! Yannick Baffert and @nfrk92.bsky.social, in collaboration with @macerwan.bsky.social and @val-meve.bsky.social, shed light on the molecular mechanisms driving pOXA-48 plasmid maintenance and transfer. We reveal novel TA system, regulators, and T4SS components!
Genetic Determinants of pOXA-48 Plasmid Maintenance and Propagation in Escherichia coli
Conjugative plasmids are the main drivers of antibiotic resistance dissemination contributing to the emergence and extensive spread of multidrug resistance clinical bacterial pathogens. pOXA-48 plasmi...
www.biorxiv.org
January 25, 2025 at 9:20 AM
New preprint from our Lesterlin Lab! Yannick Baffert and @nfrk92.bsky.social, in collaboration with @macerwan.bsky.social and @val-meve.bsky.social, shed light on the molecular mechanisms driving pOXA-48 plasmid maintenance and transfer. We reveal novel TA system, regulators, and T4SS components!
Reposted by Morgan Lamberioux
🚨 New preprint! We know that plasmids are associated with very variable fitness costs in their different bacterial hosts. But, what is the contribution of each of the plasmid-genes in these host-specific effects? Study led by @jorgesastred.bsky.social, @sanmillan.bsky.social and myself! 1/14
Dissecting pOXA-48 fitness effects in clinical enterobacteria using plasmid-wide CRISPRi screens
Conjugative plasmids are the main vehicle for the spread of antimicrobial resistance (AMR) genes in clinical bacteria. AMR plasmids allow bacteria to survive antibiotic treatments, but they also produ...
www.biorxiv.org
January 24, 2025 at 12:26 PM
🚨 New preprint! We know that plasmids are associated with very variable fitness costs in their different bacterial hosts. But, what is the contribution of each of the plasmid-genes in these host-specific effects? Study led by @jorgesastred.bsky.social, @sanmillan.bsky.social and myself! 1/14
Reposted by Morgan Lamberioux
Welcome to the official Bluesky page of the Institut Pasteur!
🔬 Explore with us the frontiers of biomedical research
🧪 Follow us to uncover groundbreaking discoveries
💡 Share knowledge for global health
🌍 Join a community passionate about progress and open science.
🔬 Explore with us the frontiers of biomedical research
🧪 Follow us to uncover groundbreaking discoveries
💡 Share knowledge for global health
🌍 Join a community passionate about progress and open science.
January 14, 2025 at 9:10 AM
Welcome to the official Bluesky page of the Institut Pasteur!
🔬 Explore with us the frontiers of biomedical research
🧪 Follow us to uncover groundbreaking discoveries
💡 Share knowledge for global health
🌍 Join a community passionate about progress and open science.
🔬 Explore with us the frontiers of biomedical research
🧪 Follow us to uncover groundbreaking discoveries
💡 Share knowledge for global health
🌍 Join a community passionate about progress and open science.
Reposted by Morgan Lamberioux
www.nature.com/articles/s41...
New paper out!!
New paper out!!
A plasmid-chromosome crosstalk in multidrug resistant enterobacteria - Nature Communications
The authors describe a new crosstalk between a globally disseminated carbapenem resistance plasmid and clinical enterobacteria clones. This crosstalk provides a fitness advantage to the plasmid-carryi...
www.nature.com
December 30, 2024 at 6:33 PM
www.nature.com/articles/s41...
New paper out!!
New paper out!!
Reposted by Morgan Lamberioux
👋 Hi antiphage defense community, we are soon releasing an update of DefenseFinder.
We are doing our best to include all the great discoveries from the community, but with so much going on we might miss things.
Please answer wt preprints/papers with new systems or mail/git them to us. 🙏
We are doing our best to include all the great discoveries from the community, but with so much going on we might miss things.
Please answer wt preprints/papers with new systems or mail/git them to us. 🙏
January 13, 2025 at 1:54 PM
👋 Hi antiphage defense community, we are soon releasing an update of DefenseFinder.
We are doing our best to include all the great discoveries from the community, but with so much going on we might miss things.
Please answer wt preprints/papers with new systems or mail/git them to us. 🙏
We are doing our best to include all the great discoveries from the community, but with so much going on we might miss things.
Please answer wt preprints/papers with new systems or mail/git them to us. 🙏
Reposted by Morgan Lamberioux
🚨New review🚨
Evolution and ecology of anti-defence systems in phages and plasmids
Link: www.cell.com/current-biol...
Evolution and ecology of anti-defence systems in phages and plasmids
Link: www.cell.com/current-biol...
January 7, 2025 at 10:27 AM
🚨New review🚨
Evolution and ecology of anti-defence systems in phages and plasmids
Link: www.cell.com/current-biol...
Evolution and ecology of anti-defence systems in phages and plasmids
Link: www.cell.com/current-biol...
Reposted by Morgan Lamberioux
1/ 🔬 Our work, "Dynamic transitions of initiator binding coordinate the replication of the two chromosomes in Vibrio cholerae", is now published in Nature Communications.
Here's a thread on how we think Chr1 and Chr2 replication is coordinated in Vibrio. 🧵
Link : www.nature.com/articles/s41...
Here's a thread on how we think Chr1 and Chr2 replication is coordinated in Vibrio. 🧵
Link : www.nature.com/articles/s41...
January 9, 2025 at 12:32 PM
1/ 🔬 Our work, "Dynamic transitions of initiator binding coordinate the replication of the two chromosomes in Vibrio cholerae", is now published in Nature Communications.
Here's a thread on how we think Chr1 and Chr2 replication is coordinated in Vibrio. 🧵
Link : www.nature.com/articles/s41...
Here's a thread on how we think Chr1 and Chr2 replication is coordinated in Vibrio. 🧵
Link : www.nature.com/articles/s41...
Reposted by Morgan Lamberioux
Our paper on 🦠queuosine 34 modification of tRNA tyrosine and antibiotic response is finally out in its final form in @eLife ... and quite different from the preprint version. Many thanks to reviewers, editors and kudos to all authors🙏 elifesciences.org/articles/96317
Aminoglycoside tolerance in Vibrio cholerae engages translational reprogramming associated with queuosine tRNA modification
tRNA Q34 modification impacts tyrosine codon decoding and leads to proteome reprogramming in response to antibiotic stress in Vibrio cholerae.
elifesciences.org
January 12, 2025 at 11:07 AM
Our paper on 🦠queuosine 34 modification of tRNA tyrosine and antibiotic response is finally out in its final form in @eLife ... and quite different from the preprint version. Many thanks to reviewers, editors and kudos to all authors🙏 elifesciences.org/articles/96317