Morgan Lamberioux
@morgan-lamberioux.bsky.social
PhD. PharmD. currently in Post-Doc in Bacterial Genome Plasticity unit, Institut Pasteur, Paris.
Genetics 🧬, plasmids, microbiology 🔬 translation, Vibrio 🦠
Genetics 🧬, plasmids, microbiology 🔬 translation, Vibrio 🦠
I'm thrilled this story on accessory PDFs is joined by two companion studies!
🧬 Julie Chen, Paul Blainey and Martin Polz → doi.org/10.1101/2025...
🧬 Alexander Rill, Eva Huber, Helge Bode → Coming soon!
Congrats to all the authors! 🎉🧬
5/5
🧬 Julie Chen, Paul Blainey and Martin Polz → doi.org/10.1101/2025...
🧬 Alexander Rill, Eva Huber, Helge Bode → Coming soon!
Congrats to all the authors! 🎉🧬
5/5
Bacterial peptide deformylase inhibitors induce prophages in competitors
While antibiotics mediate chemical warfare among microbes, their roles in the wild extend beyond direct growth inhibition. Some antibiotics have the potential to mediate interference competition by tr...
doi.org
June 7, 2025 at 10:15 AM
I'm thrilled this story on accessory PDFs is joined by two companion studies!
🧬 Julie Chen, Paul Blainey and Martin Polz → doi.org/10.1101/2025...
🧬 Alexander Rill, Eva Huber, Helge Bode → Coming soon!
Congrats to all the authors! 🎉🧬
5/5
🧬 Julie Chen, Paul Blainey and Martin Polz → doi.org/10.1101/2025...
🧬 Alexander Rill, Eva Huber, Helge Bode → Coming soon!
Congrats to all the authors! 🎉🧬
5/5
This reveals a cryptic resistance reservoir within the bacterial mobilome 🧪🦠
PDF-targeting antibiotics face a serious challenge 🚨:
Resistance may not only emerge,
but is already encoded, mobile, and ready to spread!
4/5
PDF-targeting antibiotics face a serious challenge 🚨:
Resistance may not only emerge,
but is already encoded, mobile, and ready to spread!
4/5
June 7, 2025 at 10:11 AM
This reveals a cryptic resistance reservoir within the bacterial mobilome 🧪🦠
PDF-targeting antibiotics face a serious challenge 🚨:
Resistance may not only emerge,
but is already encoded, mobile, and ready to spread!
4/5
PDF-targeting antibiotics face a serious challenge 🚨:
Resistance may not only emerge,
but is already encoded, mobile, and ready to spread!
4/5
Looking at mobile accessory PDF, we identified a highly recombinant integron cassette from Pseudoxanthomonas, encoding an active PDF 💥
When expressed under a native mobile integron promoter in V. cholerae, it confers high-level resistance to PDF inhibitors !
3/5
When expressed under a native mobile integron promoter in V. cholerae, it confers high-level resistance to PDF inhibitors !
3/5
June 7, 2025 at 10:11 AM
Looking at mobile accessory PDF, we identified a highly recombinant integron cassette from Pseudoxanthomonas, encoding an active PDF 💥
When expressed under a native mobile integron promoter in V. cholerae, it confers high-level resistance to PDF inhibitors !
3/5
When expressed under a native mobile integron promoter in V. cholerae, it confers high-level resistance to PDF inhibitors !
3/5
We uncovered an unexpected pattern:
➡️ ~50% of bacterial genomes encode multiple PDFs
➡️ Accessory PDFs are often found on mobile elements (including plasmids and integron)
➡️ In Vibrio cholerae, the accessory PDF confers resistance to actinonin, the first known PDF inhibitor
2/5
➡️ ~50% of bacterial genomes encode multiple PDFs
➡️ Accessory PDFs are often found on mobile elements (including plasmids and integron)
➡️ In Vibrio cholerae, the accessory PDF confers resistance to actinonin, the first known PDF inhibitor
2/5
June 7, 2025 at 10:10 AM
We uncovered an unexpected pattern:
➡️ ~50% of bacterial genomes encode multiple PDFs
➡️ Accessory PDFs are often found on mobile elements (including plasmids and integron)
➡️ In Vibrio cholerae, the accessory PDF confers resistance to actinonin, the first known PDF inhibitor
2/5
➡️ ~50% of bacterial genomes encode multiple PDFs
➡️ Accessory PDFs are often found on mobile elements (including plasmids and integron)
➡️ In Vibrio cholerae, the accessory PDF confers resistance to actinonin, the first known PDF inhibitor
2/5
PDFs are conserved and essential enzymes in bacteria.
They deformylate the initiator methionine, a crucial step in protein maturation.
They’ve also been proposed as promising antibiotic targets 💊
But no one had ever looked at the genomic distribution of PDF genes—so we did!
1/5
They deformylate the initiator methionine, a crucial step in protein maturation.
They’ve also been proposed as promising antibiotic targets 💊
But no one had ever looked at the genomic distribution of PDF genes—so we did!
1/5
June 7, 2025 at 10:10 AM
PDFs are conserved and essential enzymes in bacteria.
They deformylate the initiator methionine, a crucial step in protein maturation.
They’ve also been proposed as promising antibiotic targets 💊
But no one had ever looked at the genomic distribution of PDF genes—so we did!
1/5
They deformylate the initiator methionine, a crucial step in protein maturation.
They’ve also been proposed as promising antibiotic targets 💊
But no one had ever looked at the genomic distribution of PDF genes—so we did!
1/5
This reveals a cryptic resistance reservoir within the bacterial mobilome 🧪🦠
PDF-targeting antibiotics face a serious challenge 🚨:
Resistance may not only emerge,
but is already encoded, mobile, and ready to spread!
4/5
PDF-targeting antibiotics face a serious challenge 🚨:
Resistance may not only emerge,
but is already encoded, mobile, and ready to spread!
4/5
June 7, 2025 at 10:03 AM
This reveals a cryptic resistance reservoir within the bacterial mobilome 🧪🦠
PDF-targeting antibiotics face a serious challenge 🚨:
Resistance may not only emerge,
but is already encoded, mobile, and ready to spread!
4/5
PDF-targeting antibiotics face a serious challenge 🚨:
Resistance may not only emerge,
but is already encoded, mobile, and ready to spread!
4/5
Looking at mobile accessory PDF, we identified a highly recombinant integron cassette from Pseudoxanthomonas, encoding an active PDF 💥
When expressed under a native mobile integron promoter in V. cholerae, it confers high-level resistance to PDF inhibitors !
3/5
When expressed under a native mobile integron promoter in V. cholerae, it confers high-level resistance to PDF inhibitors !
3/5
June 7, 2025 at 10:03 AM
Looking at mobile accessory PDF, we identified a highly recombinant integron cassette from Pseudoxanthomonas, encoding an active PDF 💥
When expressed under a native mobile integron promoter in V. cholerae, it confers high-level resistance to PDF inhibitors !
3/5
When expressed under a native mobile integron promoter in V. cholerae, it confers high-level resistance to PDF inhibitors !
3/5
We uncovered an unexpected pattern:
➡️ ~50% of bacterial genomes encode multiple PDFs
➡️ Accessory PDFs are often found on mobile elements (including plasmids and integron)
➡️ In Vibrio cholerae, the accessory PDF confers resistance to actinonin, the first known PDF inhibitor
2/5
➡️ ~50% of bacterial genomes encode multiple PDFs
➡️ Accessory PDFs are often found on mobile elements (including plasmids and integron)
➡️ In Vibrio cholerae, the accessory PDF confers resistance to actinonin, the first known PDF inhibitor
2/5
June 7, 2025 at 10:03 AM
We uncovered an unexpected pattern:
➡️ ~50% of bacterial genomes encode multiple PDFs
➡️ Accessory PDFs are often found on mobile elements (including plasmids and integron)
➡️ In Vibrio cholerae, the accessory PDF confers resistance to actinonin, the first known PDF inhibitor
2/5
➡️ ~50% of bacterial genomes encode multiple PDFs
➡️ Accessory PDFs are often found on mobile elements (including plasmids and integron)
➡️ In Vibrio cholerae, the accessory PDF confers resistance to actinonin, the first known PDF inhibitor
2/5
PDFs are conserved and essential enzymes in bacteria.
They deformylate the initiator methionine, a crucial step in protein maturation.
They’ve also been proposed as promising antibiotic targets 💊
But no one had ever looked at the genomic distribution of PDF genes—so we did!
1/5
They deformylate the initiator methionine, a crucial step in protein maturation.
They’ve also been proposed as promising antibiotic targets 💊
But no one had ever looked at the genomic distribution of PDF genes—so we did!
1/5
June 7, 2025 at 10:02 AM
PDFs are conserved and essential enzymes in bacteria.
They deformylate the initiator methionine, a crucial step in protein maturation.
They’ve also been proposed as promising antibiotic targets 💊
But no one had ever looked at the genomic distribution of PDF genes—so we did!
1/5
They deformylate the initiator methionine, a crucial step in protein maturation.
They’ve also been proposed as promising antibiotic targets 💊
But no one had ever looked at the genomic distribution of PDF genes—so we did!
1/5