Daan C. Swarts
@dcswarts.bsky.social
Group leader at Wageningen University & Research, NL | Prokaryotic immune systems | Views are my own
Reposted by Daan C. Swarts
Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
October 28, 2025 at 3:07 PM
Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Reposted by Daan C. Swarts
One week left to apply!!
Hiring! 🧬🔬
Ever wondered how bacteria fight off viruses? We’re looking for a PhD student to dive into the molecular basis of newly discovered microbial immune systems, an area of biology where much remains to be uncovered.
RT/share to help us find our next team member!
www.lumc.nl/en/about-lum...
Ever wondered how bacteria fight off viruses? We’re looking for a PhD student to dive into the molecular basis of newly discovered microbial immune systems, an area of biology where much remains to be uncovered.
RT/share to help us find our next team member!
www.lumc.nl/en/about-lum...
PhD-positie Bacteriële Verdedigingssystemen tegen Virussen | LUMC
Wij zoeken een getalenteerde en gemotiveerde PhD-kandidaat om het onderzoeksteam van Luuk Loeff te versterken. In dit project maak je gebruik van geavanceerde technologieën om te ontrafelen hoe bacter...
www.lumc.nl
October 10, 2025 at 10:36 AM
One week left to apply!!
BindCraft can be used to design synthetic protein binders with incredible accuracy and success rate - Out now in Nature.
BindCraft displays perfectly how AI-based tools can be used to accelerate biological research (and clinical applications). I think this is a must-read paper.
BindCraft displays perfectly how AI-based tools can be used to accelerate biological research (and clinical applications). I think this is a must-read paper.
Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian, @sokrypton.org, Bruno and many other amazing lab members and collaborators.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 28, 2025 at 9:03 AM
BindCraft can be used to design synthetic protein binders with incredible accuracy and success rate - Out now in Nature.
BindCraft displays perfectly how AI-based tools can be used to accelerate biological research (and clinical applications). I think this is a must-read paper.
BindCraft displays perfectly how AI-based tools can be used to accelerate biological research (and clinical applications). I think this is a must-read paper.
Fantastic work, congrats Anna!
These filaments are so cool :)
These filaments are so cool :)
News from the world of pAgos:
We explored a distinct clade of short pAgos associated with HNH nuclease partners, which we named SPARHA, and discovered that they protect bacteria from phages and plasmids via abortive infection. Upon activation, SPARHA oligomerizes, forming filaments.
A long 🧵
We explored a distinct clade of short pAgos associated with HNH nuclease partners, which we named SPARHA, and discovered that they protect bacteria from phages and plasmids via abortive infection. Upon activation, SPARHA oligomerizes, forming filaments.
A long 🧵
May 14, 2025 at 10:45 AM
Fantastic work, congrats Anna!
These filaments are so cool :)
These filaments are so cool :)
Out now: Cyanobacterial Argonautes and Cas4 family nucleases cooperate to interfere with invading DNA
cell.com/molecular-ce...
Most long-A pAgos interfere with invading DNA solo. Why then are cyanobacterial pAgos co-encoded with a Cas4-like protein?
cell.com/molecular-ce...
Most long-A pAgos interfere with invading DNA solo. Why then are cyanobacterial pAgos co-encoded with a Cas4-like protein?
May 13, 2025 at 7:41 AM
Out now: Cyanobacterial Argonautes and Cas4 family nucleases cooperate to interfere with invading DNA
cell.com/molecular-ce...
Most long-A pAgos interfere with invading DNA solo. Why then are cyanobacterial pAgos co-encoded with a Cas4-like protein?
cell.com/molecular-ce...
Most long-A pAgos interfere with invading DNA solo. Why then are cyanobacterial pAgos co-encoded with a Cas4-like protein?
Reposted by Daan C. Swarts
Bioinformatics junior group leader position in Lund, specialising in infection and/or epidemiology. These are really nice positions with generous support. Please spread the word to anyone who might be interested in becoming our colleague! lu.varbi.com/en/what:job/...
Associate Senior Lecturer (DDLS fellow) in data driven epidemiology and biology of infection
Lund is strategically positioned close to the continent, hosting major national and European research infrastructures, such as MAX.IV Laboratory and the European Spallation Source (ESS). In the field
lu.varbi.com
March 7, 2025 at 4:52 PM
Bioinformatics junior group leader position in Lund, specialising in infection and/or epidemiology. These are really nice positions with generous support. Please spread the word to anyone who might be interested in becoming our colleague! lu.varbi.com/en/what:job/...
Reposted by Daan C. Swarts
Congratulations to LS1 #ERC grantees @dcswarts.bsky.social and Geert van den Bogaart @unigroningen.bsky.social for their POC grants! 🥳 🥳 🥳 🥳 🥳#ERCPoC erc.europa.eu/news-events/...
134 researchers supported to turn their science into practice
In the final round of the 2024 European Research Council (ERC) Proof of Concept grant competition, 134 projects will receive support, bringing the total number of grants awarded under the 2024 work pr...
erc.europa.eu
January 23, 2025 at 11:13 AM
Congratulations to LS1 #ERC grantees @dcswarts.bsky.social and Geert van den Bogaart @unigroningen.bsky.social for their POC grants! 🥳 🥳 🥳 🥳 🥳#ERCPoC erc.europa.eu/news-events/...
Excited to have been awarded an ERC Proof-of-Concept grant to further explore the possibilities to use prokaryotic Argonautes for diagnostics applications! 🥳
January 23, 2025 at 11:47 AM
Excited to have been awarded an ERC Proof-of-Concept grant to further explore the possibilities to use prokaryotic Argonautes for diagnostics applications! 🥳
🚨New review🚨
Evolution and ecology of anti-defence systems in phages and plasmids
Link: www.cell.com/current-biol...
Evolution and ecology of anti-defence systems in phages and plasmids
Link: www.cell.com/current-biol...
January 7, 2025 at 10:27 AM
🚨New review🚨
Evolution and ecology of anti-defence systems in phages and plasmids
Link: www.cell.com/current-biol...
Evolution and ecology of anti-defence systems in phages and plasmids
Link: www.cell.com/current-biol...
Reposted by Daan C. Swarts
What a great way to end the year! ✨
Today in @cellpress.bsky.social we report the structure and function of the Shedu anti-phage defense system.
tinyurl.com/4crj6dnx
A long 🧵...
Today in @cellpress.bsky.social we report the structure and function of the Shedu anti-phage defense system.
tinyurl.com/4crj6dnx
A long 🧵...
December 31, 2024 at 3:38 PM
What a great way to end the year! ✨
Today in @cellpress.bsky.social we report the structure and function of the Shedu anti-phage defense system.
tinyurl.com/4crj6dnx
A long 🧵...
Today in @cellpress.bsky.social we report the structure and function of the Shedu anti-phage defense system.
tinyurl.com/4crj6dnx
A long 🧵...
Distribution of bacterial DNA repair proteins and their co-occurrence with immune systems (cell.com/cell-reports...
It started with a simple question: Are certain prokaryotic immune systems always (or never) encoded with specific DNA repair proteins?...
It started with a simple question: Are certain prokaryotic immune systems always (or never) encoded with specific DNA repair proteins?...
January 7, 2025 at 8:46 AM
Distribution of bacterial DNA repair proteins and their co-occurrence with immune systems (cell.com/cell-reports...
It started with a simple question: Are certain prokaryotic immune systems always (or never) encoded with specific DNA repair proteins?...
It started with a simple question: Are certain prokaryotic immune systems always (or never) encoded with specific DNA repair proteins?...