Anna Kanevskaya
@annakanevskaya.bsky.social
Postdoc | bacterial defence systems ⚔️🛡️🦠
Pinned
News from the world of pAgos:
We explored a distinct clade of short pAgos associated with HNH nuclease partners, which we named SPARHA, and discovered that they protect bacteria from phages and plasmids via abortive infection. Upon activation, SPARHA oligomerizes, forming filaments.
A long 🧵
We explored a distinct clade of short pAgos associated with HNH nuclease partners, which we named SPARHA, and discovered that they protect bacteria from phages and plasmids via abortive infection. Upon activation, SPARHA oligomerizes, forming filaments.
A long 🧵
Reposted by Anna Kanevskaya
Perfect timing in the field for a beautiful review on NAD+ in bacterial immunity by @hugovaysset.bsky.social and @audeber.bsky.social @cp-molcell.bsky.social
#MicroSky
www.cell.com/molecular-ce...
#MicroSky
www.cell.com/molecular-ce...
October 16, 2025 at 2:58 PM
Perfect timing in the field for a beautiful review on NAD+ in bacterial immunity by @hugovaysset.bsky.social and @audeber.bsky.social @cp-molcell.bsky.social
#MicroSky
www.cell.com/molecular-ce...
#MicroSky
www.cell.com/molecular-ce...
Reposted by Anna Kanevskaya
You’ve heard of ubiquitination, meet deazaguanylation: Doug Wassarman in our lab discovered phage defense pathways have co-opted Q nucleobase biosynthetic enzymes to catalyze a new form of protein conjugation chemistry @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
September 25, 2025 at 7:16 PM
You’ve heard of ubiquitination, meet deazaguanylation: Doug Wassarman in our lab discovered phage defense pathways have co-opted Q nucleobase biosynthetic enzymes to catalyze a new form of protein conjugation chemistry @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Anna Kanevskaya
Excited for the start of #argonautes2025 tomorrow! This year we're in Prague, @imgprague.bsky.social. Looking forward to sharing science and community with Argonaute aficionados and Argonaute Syndromes Alliance families! 🐙
August 26, 2025 at 12:18 PM
Excited for the start of #argonautes2025 tomorrow! This year we're in Prague, @imgprague.bsky.social. Looking forward to sharing science and community with Argonaute aficionados and Argonaute Syndromes Alliance families! 🐙
News from the world of pAgos:
We explored a distinct clade of short pAgos associated with HNH nuclease partners, which we named SPARHA, and discovered that they protect bacteria from phages and plasmids via abortive infection. Upon activation, SPARHA oligomerizes, forming filaments.
A long 🧵
We explored a distinct clade of short pAgos associated with HNH nuclease partners, which we named SPARHA, and discovered that they protect bacteria from phages and plasmids via abortive infection. Upon activation, SPARHA oligomerizes, forming filaments.
A long 🧵
April 7, 2025 at 1:03 PM
News from the world of pAgos:
We explored a distinct clade of short pAgos associated with HNH nuclease partners, which we named SPARHA, and discovered that they protect bacteria from phages and plasmids via abortive infection. Upon activation, SPARHA oligomerizes, forming filaments.
A long 🧵
We explored a distinct clade of short pAgos associated with HNH nuclease partners, which we named SPARHA, and discovered that they protect bacteria from phages and plasmids via abortive infection. Upon activation, SPARHA oligomerizes, forming filaments.
A long 🧵
Reposted by Anna Kanevskaya
Very cool (and long-awaited) structures of the Lamassu/DdmABC defense system. Seems to be another weird TA-like system?
Structure and Activation Mechanism of a Lamassu Phage Defence System https://www.biorxiv.org/content/10.1101/2025.03.14.643221v1
March 16, 2025 at 9:39 AM
Very cool (and long-awaited) structures of the Lamassu/DdmABC defense system. Seems to be another weird TA-like system?
Reposted by Anna Kanevskaya
Wait... what !? 😱
A new family of RNA-guided systems in prokaryotes ! Mind-blowing !
A new family of RNA-guided systems in prokaryotes ! Mind-blowing !
TIGR-Tas: A family of modular RNA-guided DNA-targeting systems in prokaryotes and their viruses
RNA-guided systems provide remarkable versatility, enabling diverse biological functions. Through iterative structural and sequence homology-based mining starting with a guide RNA-interaction domain o...
www.science.org
February 28, 2025 at 8:47 AM
Wait... what !? 😱
A new family of RNA-guided systems in prokaryotes ! Mind-blowing !
A new family of RNA-guided systems in prokaryotes ! Mind-blowing !
Reposted by Anna Kanevskaya
What is the diversity of antiphage systems out there ?
We used protein and genomic language models (and defense score!) to start bringing some answers: >45 000 protein families.
Leb by E. Mordret.
www.biorxiv.org/content/10.1...
Interactive UMAP to have fun
mdmparis.github.io/antiphage-la...
We used protein and genomic language models (and defense score!) to start bringing some answers: >45 000 protein families.
Leb by E. Mordret.
www.biorxiv.org/content/10.1...
Interactive UMAP to have fun
mdmparis.github.io/antiphage-la...
January 9, 2025 at 1:18 PM
What is the diversity of antiphage systems out there ?
We used protein and genomic language models (and defense score!) to start bringing some answers: >45 000 protein families.
Leb by E. Mordret.
www.biorxiv.org/content/10.1...
Interactive UMAP to have fun
mdmparis.github.io/antiphage-la...
We used protein and genomic language models (and defense score!) to start bringing some answers: >45 000 protein families.
Leb by E. Mordret.
www.biorxiv.org/content/10.1...
Interactive UMAP to have fun
mdmparis.github.io/antiphage-la...