Moneeza Siddiqui
@moneeza-ks.bsky.social
Genetic epidemiologist, diabetes, south Asian diabetes, genomic representation. Read more here: https://www.qmul.ac.uk/ceg/research/global-collaborations-in-genomic-health-research/
Pinned
Moneeza Siddiqui
@moneeza-ks.bsky.social
· Sep 26
Developing type 2 diabetes young+lean is not as uncommon as it may seem. This phenomenon is more common in people of South Asian and East Asian ancestry, but is observed across populations. Why does this happen, how should we screen and treat young+lean T2D.
👉 Read our paper here: rdcu.be/eH0YR
👉 Read our paper here: rdcu.be/eH0YR
Reposted by Moneeza Siddiqui
Up front & free to read in our Dec issue #editorspicks: Quantitative analysis of human adult pancreatic histology reveals separate fatty and fibrotic phenotypes in type 2 diabetes link.springer.com/article/10.1...
Quantitative analysis of human adult pancreatic histology reveals separate fatty and fibrotic phenotypes in type 2 diabetes - Diabetologia
Aims/hypothesis The role of intra-pancreatic lipid and collagen in type 2 diabetes pathogenesis remains unclear. We sought to examine this in pancreases from organ donors with and without diabetes. Me...
link.springer.com
December 15, 2025 at 9:12 AM
Up front & free to read in our Dec issue #editorspicks: Quantitative analysis of human adult pancreatic histology reveals separate fatty and fibrotic phenotypes in type 2 diabetes link.springer.com/article/10.1...
Reposted by Moneeza Siddiqui
We have a new open position to analyze large-scale genomic datasets and EHR data to better understand and improve care for type 2 diabetes and monogenic diabetes, in collaboration with Chirag Patel, Miriam Udler, Aaron Leong, and many others. Please share! broadinstitute.avature.net/en_US/career...
Computational Associate II- Translational Diabetes Genomics In Diverse Populations
Apply your computational and mathematical skills to solving the hardest problems in big-data genomics and have a wide impact on science and clinical practice, including diabetes and related...
broadinstitute.avature.net
November 15, 2025 at 4:32 PM
We have a new open position to analyze large-scale genomic datasets and EHR data to better understand and improve care for type 2 diabetes and monogenic diabetes, in collaboration with Chirag Patel, Miriam Udler, Aaron Leong, and many others. Please share! broadinstitute.avature.net/en_US/career...
Reposted by Moneeza Siddiqui
New pre-print "Mendelian randomization in a multi-ancestry world: reflections and practical advice" led by @amymariemason.bsky.social on - arxiv.org/abs/2510.17554
Mendelian randomization in a multi-ancestry world: reflections and practical advice
Many Mendelian randomization (MR) papers have been conducted only in people of European ancestry, limiting transportability of results to the global population. Expanding MR to diverse ancestry groups...
arxiv.org
October 27, 2025 at 8:43 AM
New pre-print "Mendelian randomization in a multi-ancestry world: reflections and practical advice" led by @amymariemason.bsky.social on - arxiv.org/abs/2510.17554
🔔 Excited to share our preprint from the largest ever exome-wide association study for T2D in South Asians. We make important discoveries implicating the genes HNF4A, GP2, RNF19A in the aetiology of diabetes and metabolic traits in south Asians. 👉 Read it here:
Exome-wide association study in 54,698 south Asians identifies novel type 2 diabetes associations with RNF19A, HNF4A, and dissects role of coding variants in GP2 and CDKAL1 https://www.medrxiv.org/content/10.1101/2025.09.24.25336527v1
October 9, 2025 at 6:48 AM
🔔 Excited to share our preprint from the largest ever exome-wide association study for T2D in South Asians. We make important discoveries implicating the genes HNF4A, GP2, RNF19A in the aetiology of diabetes and metabolic traits in south Asians. 👉 Read it here:
Reposted by Moneeza Siddiqui
Genetic subtyping of obesity reveals biological insights into the uncoupling of adiposity from its cardiometabolic comorbidities www.nature.com/articles/s41...
Cool findings: Two obesity GRSs for stratification, one with cardiometabolic comorbidities (GRS_BFP) and one without (GRS_uncoupling)
Cool findings: Two obesity GRSs for stratification, one with cardiometabolic comorbidities (GRS_BFP) and one without (GRS_uncoupling)
October 4, 2025 at 10:18 AM
Genetic subtyping of obesity reveals biological insights into the uncoupling of adiposity from its cardiometabolic comorbidities www.nature.com/articles/s41...
Cool findings: Two obesity GRSs for stratification, one with cardiometabolic comorbidities (GRS_BFP) and one without (GRS_uncoupling)
Cool findings: Two obesity GRSs for stratification, one with cardiometabolic comorbidities (GRS_BFP) and one without (GRS_uncoupling)
Developing type 2 diabetes young+lean is not as uncommon as it may seem. This phenomenon is more common in people of South Asian and East Asian ancestry, but is observed across populations. Why does this happen, how should we screen and treat young+lean T2D.
👉 Read our paper here: rdcu.be/eH0YR
👉 Read our paper here: rdcu.be/eH0YR
September 26, 2025 at 10:36 AM
Developing type 2 diabetes young+lean is not as uncommon as it may seem. This phenomenon is more common in people of South Asian and East Asian ancestry, but is observed across populations. Why does this happen, how should we screen and treat young+lean T2D.
👉 Read our paper here: rdcu.be/eH0YR
👉 Read our paper here: rdcu.be/eH0YR
Reposted by Moneeza Siddiqui
Body fat distribution predicts the pace of cardiovascular system aging, with sex-specific patterns, and protective effect of estrogen
academic.oup.com/eurheartj/ad...
academic.oup.com/eurheartj/ad...
Sex-specific body fat distribution predicts cardiovascular ageing
AbstractBackground and Aims. Cardiovascular ageing is a progressive loss of physiological reserve, modified by environmental and genetic risk factors, that
academic.oup.com
August 22, 2025 at 5:45 PM
Body fat distribution predicts the pace of cardiovascular system aging, with sex-specific patterns, and protective effect of estrogen
academic.oup.com/eurheartj/ad...
academic.oup.com/eurheartj/ad...
Reposted by Moneeza Siddiqui
🚨 NEW RESEARCH! ⚕️ 🩺
Dzando et al. identify frailty thresholds for older people in Sub-Saharan Africa, accounting for differences compared to frailty thresholds in high-income countries.
https://bit.ly/44QDcdy
#FrailtyResearch
Dzando et al. identify frailty thresholds for older people in Sub-Saharan Africa, accounting for differences compared to frailty thresholds in high-income countries.
https://bit.ly/44QDcdy
#FrailtyResearch
Determining frailty index thresholds for older people across multiple countries in sub-Saharan Africa - Communications Medicine
Dzando et al. identify locally relevant frailty thresholds for older people in Sub-Saharan Africa through Receiver Operating Characteristic analysis and random-effects meta-analysis. Findings demonstrate variability in population level thresholds with a pooled threshold of 0.29 demonstrating good sensitivity and specificity across the populations.
bit.ly
July 7, 2025 at 12:01 PM
🚨 NEW RESEARCH! ⚕️ 🩺
Dzando et al. identify frailty thresholds for older people in Sub-Saharan Africa, accounting for differences compared to frailty thresholds in high-income countries.
https://bit.ly/44QDcdy
#FrailtyResearch
Dzando et al. identify frailty thresholds for older people in Sub-Saharan Africa, accounting for differences compared to frailty thresholds in high-income countries.
https://bit.ly/44QDcdy
#FrailtyResearch
the deepest of sighs....
The University of Dundee has a women problem
“In our view this culture of sexism runs deeper than the sidelining of women speaking up and out and persists beyond the ignominious end of Iain Gillespie’s tenure as Principal of the university.”
www.thecourier.co.uk/fp/opinion/c...
“In our view this culture of sexism runs deeper than the sidelining of women speaking up and out and persists beyond the ignominious end of Iain Gillespie’s tenure as Principal of the university.”
www.thecourier.co.uk/fp/opinion/c...
'We're female professors, here's why we think Dundee University has a women problem'
Professors Angela Daly and Annalu Waller say Dundee University is destroying its commitment to gender equality in STEM.
www.thecourier.co.uk
June 27, 2025 at 12:52 PM
the deepest of sighs....
Exciting to see this lovely paper out! Many of us have been using the pre-print for a while to demonstrate ancestral heterogeneity in India. Congratulations to the authors!
Check out our dive into 50,000 years of Indian genetic history!🇮🇳
🧬~2,700 genomes
🦴Neanderthal/Denisovan DNA
🌾Hunter-gatherer, Iranian farmer & Steppe ancestry
🩺Health-linked, population-specific variants
@lauritsskov.bsky.social & Priya Moorjani
#Genomics #India #HumanEvolution #PopulationGenetics
🧬~2,700 genomes
🦴Neanderthal/Denisovan DNA
🌾Hunter-gatherer, Iranian farmer & Steppe ancestry
🩺Health-linked, population-specific variants
@lauritsskov.bsky.social & Priya Moorjani
#Genomics #India #HumanEvolution #PopulationGenetics
June 27, 2025 at 7:32 AM
Exciting to see this lovely paper out! Many of us have been using the pre-print for a while to demonstrate ancestral heterogeneity in India. Congratulations to the authors!
Reposted by Moneeza Siddiqui
Super exciting phase 1-2 results of restorative therapy for T1D just out at NEJM www.nejm.org/doi/full/10....
Imagine the transformative potential when paired with genetic + autoantibody screening in early life... nearly every T1D case could be prevented??🤞
Imagine the transformative potential when paired with genetic + autoantibody screening in early life... nearly every T1D case could be prevented??🤞
Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes | NEJM
Zimislecel is an allogeneic stem cell–derived islet-cell therapy. Data on the safety
and efficacy of zimislecel in persons with type 1 diabetes are needed. We conducted
a phase 1–2 study of zimisle...
www.nejm.org
June 22, 2025 at 12:27 AM
Super exciting phase 1-2 results of restorative therapy for T1D just out at NEJM www.nejm.org/doi/full/10....
Imagine the transformative potential when paired with genetic + autoantibody screening in early life... nearly every T1D case could be prevented??🤞
Imagine the transformative potential when paired with genetic + autoantibody screening in early life... nearly every T1D case could be prevented??🤞
Reposted by Moneeza Siddiqui
Preprint alert! 🚨
doi.org/10.1101/2025...
Our manuscript on Exome sequencing and analysis of 44,028 British South Asians, using @genesandhealth.bsky.social is now available at @medrxivpreprint.bsky.social!
We present several great results, and I’m thrilled to highlight the pieces I worked on:
doi.org/10.1101/2025...
Our manuscript on Exome sequencing and analysis of 44,028 British South Asians, using @genesandhealth.bsky.social is now available at @medrxivpreprint.bsky.social!
We present several great results, and I’m thrilled to highlight the pieces I worked on:
Exome sequencing and analysis of 44,028 British South Asians enriched for high autozygosity
Genes and Health (G&H) is a biomedical study of adult British-Pakistani and -Bangladeshi research volunteers enriched for autozygosity. We performed whole exome sequencing in 44,028 G&H participants, ...
doi.org
June 12, 2025 at 10:33 AM
Preprint alert! 🚨
doi.org/10.1101/2025...
Our manuscript on Exome sequencing and analysis of 44,028 British South Asians, using @genesandhealth.bsky.social is now available at @medrxivpreprint.bsky.social!
We present several great results, and I’m thrilled to highlight the pieces I worked on:
doi.org/10.1101/2025...
Our manuscript on Exome sequencing and analysis of 44,028 British South Asians, using @genesandhealth.bsky.social is now available at @medrxivpreprint.bsky.social!
We present several great results, and I’m thrilled to highlight the pieces I worked on:
Reposted by Moneeza Siddiqui
The war on science in the US is already having an effect on private sector research like AlphaFold. Bears repeating but the private sector builds on top of things created by academic research for the public good. This hurts everyone.
May 28, 2025 at 10:18 AM
The war on science in the US is already having an effect on private sector research like AlphaFold. Bears repeating but the private sector builds on top of things created by academic research for the public good. This hurts everyone.
Reposted by Moneeza Siddiqui
🎉 This paper has been a long time and a labour of love (and hardship) for multiple group members, but, finally: we MPRA'ed 25k introgressed variants (Denisovan and Neanderthal) segregating at allele frequencies > 0.15 in humans today to evaluate their potential to regulate gene expression.
Mapping the gene regulatory landscape of archaic hominin introgression in modern Papuans https://www.biorxiv.org/content/10.1101/2025.05.04.652069v1
May 5, 2025 at 2:43 AM
🎉 This paper has been a long time and a labour of love (and hardship) for multiple group members, but, finally: we MPRA'ed 25k introgressed variants (Denisovan and Neanderthal) segregating at allele frequencies > 0.15 in humans today to evaluate their potential to regulate gene expression.
Reposted by Moneeza Siddiqui
British Steel employs 3.6k people. Coventry Uni group, which auditors say may not survive, employs 7.7k. But there is an emergency debate in parliament for British Steel and nothing for the whole HE sector imploding
Why is the government and the news so indifferent to the meltdown happening in UK #HigherEd right now?
Our universities are the envy of the world. Yet we are at risk of losing a generation of academics and damaging the sector beyond repair.
Our universities are the envy of the world. Yet we are at risk of losing a generation of academics and damaging the sector beyond repair.
The UK car industry contributes £22bn to the economy and employs c 35k people.
Universities contribute £265bn and employ nearly 400k, over 10x as much.
Yet he seems ok to let that sector implode.
Universities contribute £265bn and employ nearly 400k, over 10x as much.
Yet he seems ok to let that sector implode.
April 12, 2025 at 7:47 AM
British Steel employs 3.6k people. Coventry Uni group, which auditors say may not survive, employs 7.7k. But there is an emergency debate in parliament for British Steel and nothing for the whole HE sector imploding
Reposted by Moneeza Siddiqui
"I cannot [bring] myself morally to spend Canadian taxpayers’ money in attending U.S. conferences."
My latest story for @science.org—about international scientists rethinking conferences on U.S. soil.
www.science.org/content/arti...
My latest story for @science.org—about international scientists rethinking conferences on U.S. soil.
www.science.org/content/arti...
International scientists rethink U.S. conference attendance
Opposition to Trump administration and fears of customs run-ins are shifting travel plans
www.science.org
April 1, 2025 at 5:00 PM
"I cannot [bring] myself morally to spend Canadian taxpayers’ money in attending U.S. conferences."
My latest story for @science.org—about international scientists rethinking conferences on U.S. soil.
www.science.org/content/arti...
My latest story for @science.org—about international scientists rethinking conferences on U.S. soil.
www.science.org/content/arti...
Reposted by Moneeza Siddiqui
Managing diabetes during Ramadan is key to fasting safely.
Check out this free online course by BIMA & DaR to help healthcare professionals & Muslim patients make informed decisions.
📅 6 Jan – 31 Mar 2025
🔗 Access here: pn.mydiabetes.com/resources/in...
Check out this free online course by BIMA & DaR to help healthcare professionals & Muslim patients make informed decisions.
📅 6 Jan – 31 Mar 2025
🔗 Access here: pn.mydiabetes.com/resources/in...
March 11, 2025 at 3:39 PM
Managing diabetes during Ramadan is key to fasting safely.
Check out this free online course by BIMA & DaR to help healthcare professionals & Muslim patients make informed decisions.
📅 6 Jan – 31 Mar 2025
🔗 Access here: pn.mydiabetes.com/resources/in...
Check out this free online course by BIMA & DaR to help healthcare professionals & Muslim patients make informed decisions.
📅 6 Jan – 31 Mar 2025
🔗 Access here: pn.mydiabetes.com/resources/in...
Reposted by Moneeza Siddiqui
Celebrating the incredible women of Genes & Health on #InternationalWomensDay 💜
👩⚕️ 35,920 women participating in the study
👩🔬 15 women working across London, Bradford, Manchester, and Birmingham
🙌 16 women on our Community Advisory Board
👩🏫 5 women on the Genes & Health Executive
Thank you to all!
👩⚕️ 35,920 women participating in the study
👩🔬 15 women working across London, Bradford, Manchester, and Birmingham
🙌 16 women on our Community Advisory Board
👩🏫 5 women on the Genes & Health Executive
Thank you to all!
March 8, 2025 at 3:54 PM
Celebrating the incredible women of Genes & Health on #InternationalWomensDay 💜
👩⚕️ 35,920 women participating in the study
👩🔬 15 women working across London, Bradford, Manchester, and Birmingham
🙌 16 women on our Community Advisory Board
👩🏫 5 women on the Genes & Health Executive
Thank you to all!
👩⚕️ 35,920 women participating in the study
👩🔬 15 women working across London, Bradford, Manchester, and Birmingham
🙌 16 women on our Community Advisory Board
👩🏫 5 women on the Genes & Health Executive
Thank you to all!
Reposted by Moneeza Siddiqui
Genes & Health contributed to a major study on heart failure genetics, published in Nature Genetics. Using data from 1.9M individuals, researchers identified 66 genetic loci, including 37 new discoveries. Inclusive research ensures prevention & treatment for all.
Read more: lnkd.in/dFmMHfKi
Read more: lnkd.in/dFmMHfKi
March 6, 2025 at 1:49 PM
Genes & Health contributed to a major study on heart failure genetics, published in Nature Genetics. Using data from 1.9M individuals, researchers identified 66 genetic loci, including 37 new discoveries. Inclusive research ensures prevention & treatment for all.
Read more: lnkd.in/dFmMHfKi
Read more: lnkd.in/dFmMHfKi
Reposted by Moneeza Siddiqui
New research by an international team led by @qmul.ac.uk have found new genetic links between genetically-predicted height and an individual’s likelihood of developing a range of diseases and conditions. These new data could help improve early diagnosis and risk monitoring for patients.
March 3, 2025 at 2:08 PM
New research by an international team led by @qmul.ac.uk have found new genetic links between genetically-predicted height and an individual’s likelihood of developing a range of diseases and conditions. These new data could help improve early diagnosis and risk monitoring for patients.
Many scientists like myself have held tepid liberal views, while ignoring genocides and colonisation. Now these forces have joined with research funding cuts, targeting minority, gender+LGBTQI research. Time to wake up and connect the dots. Be like Macklemore✊ youtu.be/sn9EKC9nqU4?...
MACKLEMORE - fucked up (official video)
YouTube video by Macklemore
youtu.be
February 12, 2025 at 8:50 AM
Many scientists like myself have held tepid liberal views, while ignoring genocides and colonisation. Now these forces have joined with research funding cuts, targeting minority, gender+LGBTQI research. Time to wake up and connect the dots. Be like Macklemore✊ youtu.be/sn9EKC9nqU4?...
Reposted by Moneeza Siddiqui
So delighted to be joining QMUL and Barts at the inaugural Professor of Clinical Epidemiology and Predictive Medicine. One of the most technically advanced and largest NHS Trusts in the country in the culturally richest and most diverse parts of the UK
A very warm welcome to Professor @juliahcox.bsky.social who will join @qmul-wiph.bsky.social at the beginning of February as the inaugural Professor of Clinical Epidemiology and Predictive Medicine. We're delighted she's joining our Faculty!
January 24, 2025 at 2:54 PM
So delighted to be joining QMUL and Barts at the inaugural Professor of Clinical Epidemiology and Predictive Medicine. One of the most technically advanced and largest NHS Trusts in the country in the culturally richest and most diverse parts of the UK
Reposted by Moneeza Siddiqui
It would be much clearer to call these studies differential methylation analyses, analogously to differential expression. THAT is actually the relevant reference in terms of hypothesis, model and caveats, rather than GWAS.
January 15, 2025 at 1:15 PM
It would be much clearer to call these studies differential methylation analyses, analogously to differential expression. THAT is actually the relevant reference in terms of hypothesis, model and caveats, rather than GWAS.
Reposted by Moneeza Siddiqui
1 h-PG can detect Asians at risk of developing T2DM within three years.
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
January 5, 2025 at 2:26 AM
1 h-PG can detect Asians at risk of developing T2DM within three years.
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Reposted by Moneeza Siddiqui
Comparing DXA and MRI body composition measurements in cross-sectional and longitudinal cohorts https://www.medrxiv.org/content/10.1101/2024.12.12.24318943v1
December 13, 2024 at 6:15 PM
Comparing DXA and MRI body composition measurements in cross-sectional and longitudinal cohorts https://www.medrxiv.org/content/10.1101/2024.12.12.24318943v1