Moi Bhattacharyya
@moitrayee-lab.bsky.social
science enthusiasts in Pharmacology @Yale studying molecular mechanisms of cell signaling in cancer, pain, and neurodegeneration (https://www.bhattacharyya-lab.org/)
New preprint alert! biorxiv.org/content/10.1...
Nerve growth factor binding to TrkA helps neuronal growth and survival, but also triggers pain. This dual role has long complicated therapeutic targeting of this highly sought-after pathway in #Clinicaltrials for #chronicPain and #neurodegeneration.
Nerve growth factor binding to TrkA helps neuronal growth and survival, but also triggers pain. This dual role has long complicated therapeutic targeting of this highly sought-after pathway in #Clinicaltrials for #chronicPain and #neurodegeneration.
A painless nerve growth factor variant uncouples nociceptive and neurotrophic TrkA signaling
Nerve growth factor (NGF) binding to the receptor tyrosine kinase, TrkA, drives neurotrophic signaling essential for neuronal development and survival. This interaction simultaneously drives periphera...
biorxiv.org
November 18, 2025 at 11:28 PM
New preprint alert! biorxiv.org/content/10.1...
Nerve growth factor binding to TrkA helps neuronal growth and survival, but also triggers pain. This dual role has long complicated therapeutic targeting of this highly sought-after pathway in #Clinicaltrials for #chronicPain and #neurodegeneration.
Nerve growth factor binding to TrkA helps neuronal growth and survival, but also triggers pain. This dual role has long complicated therapeutic targeting of this highly sought-after pathway in #Clinicaltrials for #chronicPain and #neurodegeneration.
Reposted by Moi Bhattacharyya
1/🚨 New preprint out!🚨
We uncovered that #PI3K-driven wild-type RAS activation bypasses #KRAS inhibition in pancreatic adenocarcinoma (#PDAC) to drive #resistance.
🔑PI3K isn’t just a downstream RAS effector – it can be an upstream RAS regulator.
📄 www.biorxiv.org/content/10.1...
We uncovered that #PI3K-driven wild-type RAS activation bypasses #KRAS inhibition in pancreatic adenocarcinoma (#PDAC) to drive #resistance.
🔑PI3K isn’t just a downstream RAS effector – it can be an upstream RAS regulator.
📄 www.biorxiv.org/content/10.1...
Phosphoinositide 3-kinase regulates wild-type RAS signaling to confer resistance to KRAS inhibition
Despite the availability of RAS inhibitors and the dependence of >90% of pancreatic ductal adenocarcinomas (PDAC) on oncogenic KRAS mutations, resistance to KRAS inhibition remains a serious obstacle....
www.biorxiv.org
June 25, 2025 at 7:32 PM
1/🚨 New preprint out!🚨
We uncovered that #PI3K-driven wild-type RAS activation bypasses #KRAS inhibition in pancreatic adenocarcinoma (#PDAC) to drive #resistance.
🔑PI3K isn’t just a downstream RAS effector – it can be an upstream RAS regulator.
📄 www.biorxiv.org/content/10.1...
We uncovered that #PI3K-driven wild-type RAS activation bypasses #KRAS inhibition in pancreatic adenocarcinoma (#PDAC) to drive #resistance.
🔑PI3K isn’t just a downstream RAS effector – it can be an upstream RAS regulator.
📄 www.biorxiv.org/content/10.1...
Excited to attend and speak at the GRC grc.org/neurotrophic-m… about our work on NGF receptor TrkA @yalepharm.bsky.social @yaleschoolofmed.bsky.social! Dr. Shailesh Kumar from my lab is also presenting a poster. Looking forward to hearing about cool new discoveries in the area!
https://grc.org/neurotrophic-m…
June 1, 2025 at 5:22 PM
Excited to attend and speak at the GRC grc.org/neurotrophic-m… about our work on NGF receptor TrkA @yalepharm.bsky.social @yaleschoolofmed.bsky.social! Dr. Shailesh Kumar from my lab is also presenting a poster. Looking forward to hearing about cool new discoveries in the area!
Thank you @hypothesisfund.bsky.social and @krishnanyamuna.bsky.social for this opportunity to shed ‘light’ on membrane contacts! Honored to be part of this and congratulations to my fellow awardees. Can’t wait to start this scientific adventure @yalepharm.bsky.social @yaleschoolofmed.bsky.social!
4/ With a 'molecular scalpel'🔪 to 'biopsy' membrane sites where cells/organoids make contact, Awardee @moitrayee-lab.bsky.social's research may reveal new insights into cellular processes & disease development (e.g. ALS).
🎉Congrats Dr. Bhattacharyya! @yale.edu
🙏#HFScout @krishnanyamuna.bsky.social
🎉Congrats Dr. Bhattacharyya! @yale.edu
🙏#HFScout @krishnanyamuna.bsky.social
April 3, 2025 at 4:38 PM
Thank you @hypothesisfund.bsky.social and @krishnanyamuna.bsky.social for this opportunity to shed ‘light’ on membrane contacts! Honored to be part of this and congratulations to my fellow awardees. Can’t wait to start this scientific adventure @yalepharm.bsky.social @yaleschoolofmed.bsky.social!
Very excited to host Dr. Stephen Sligar this Thursday! Anyone doing membrane protein biophysics will immediately recognize his immense contributions in enabling reconstitution of membrane proteins in lipid nanodiscs and subsequent applications! Hope to see many of you there!
Join us in welcoming our next 2025 Pharmacology Seminar Series speaker, Stephen Sligar. He will be presenting his work at 12 pm on Thursday, February 27th in the Brady Auditorium.
February 25, 2025 at 3:46 AM
Very excited to host Dr. Stephen Sligar this Thursday! Anyone doing membrane protein biophysics will immediately recognize his immense contributions in enabling reconstitution of membrane proteins in lipid nanodiscs and subsequent applications! Hope to see many of you there!
Reposted by Moi Bhattacharyya
ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS 🍬🍭🔬
For the first time, we’re able to study the molecular architecture of the glycocalyx at single-sugar resolution—a longstanding challenge in glycobiology! #glycotime
Preprint and #bluetorial below!!
For the first time, we’re able to study the molecular architecture of the glycocalyx at single-sugar resolution—a longstanding challenge in glycobiology! #glycotime
Preprint and #bluetorial below!!
February 11, 2025 at 11:29 AM
ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS 🍬🍭🔬
For the first time, we’re able to study the molecular architecture of the glycocalyx at single-sugar resolution—a longstanding challenge in glycobiology! #glycotime
Preprint and #bluetorial below!!
For the first time, we’re able to study the molecular architecture of the glycocalyx at single-sugar resolution—a longstanding challenge in glycobiology! #glycotime
Preprint and #bluetorial below!!
I am excited to host @eboyden3.bsky.social for a seminar in @yalepharm.bsky.social on Thursday, Feb 13. I hope to see many of you there!
Join us in welcoming our next 2025 Pharmacology Seminar Series speaker, Ed Boyden (@eboyden3.bsky.social). He will be presenting his work at 12 pm on Thursday, February 13th in the Brady Auditorium.
February 10, 2025 at 7:48 PM
I am excited to host @eboyden3.bsky.social for a seminar in @yalepharm.bsky.social on Thursday, Feb 13. I hope to see many of you there!
Reposted by Moi Bhattacharyya
@fda.govFDA Approves Novel Non-Opioid Treatment for Moderate to Severe Acute Pain www.fda.gov/news-events/...
FDA Approves Novel Non-Opioid Treatment for Moderate to Severe Acute Pain
The FDA approved Journavx (suzetrigine) 50 mg oral tablets, a first-in-class non-opioid analgesic to treat moderate to severe acute pain in adults.
www.fda.gov
January 31, 2025 at 12:34 AM
@fda.govFDA Approves Novel Non-Opioid Treatment for Moderate to Severe Acute Pain www.fda.gov/news-events/...
Reposted by Moi Bhattacharyya
Every once in a while we publish a paper that moves a whole field forward. I think that's the case for this one from the Bugaj lab, where they describe proteins for THERMOGENETIC control of cellular behavior. www.nature.com/articles/s41...
A temperature-inducible protein module for control of mammalian cell fate - Nature Methods
The Melt (Membrane localization using temperature) protein translocates to the plasma membrane upon temperature shift. Melt variants with a range of switching temperatures enable straightforward therm...
www.nature.com
January 23, 2025 at 6:34 PM
Every once in a while we publish a paper that moves a whole field forward. I think that's the case for this one from the Bugaj lab, where they describe proteins for THERMOGENETIC control of cellular behavior. www.nature.com/articles/s41...
Reposted by Moi Bhattacharyya
Amazing new work from the lab of @aliceyting.bsky.social @stanfordmedicine.bsky.social @stanfordbiosci.bsky.social, engineered GPCRs for ligand-activated cell responses
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Synthetic GPCRs for programmable sensing and control of cell behaviour - Nature
Modular synthetic G-protein-coupled receptors with nanobody-based ligand-recognition domains can be designed and used to programme transgene expression, real-time fluorescence or endogenous G-protein ...
www.nature.com
December 5, 2024 at 2:02 PM
Amazing new work from the lab of @aliceyting.bsky.social @stanfordmedicine.bsky.social @stanfordbiosci.bsky.social, engineered GPCRs for ligand-activated cell responses
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Moi Bhattacharyya
Book rec: Neanderthal Man by 2022 @nobelprize.bsky.social laureate Svante Pääbo. A fascinating dive into sequencing ancient 🧬. Captures the thrills, setbacks, and Pääbo’s personal vulnerabilities during groundbreaking science.
December 2, 2024 at 11:23 PM
Book rec: Neanderthal Man by 2022 @nobelprize.bsky.social laureate Svante Pääbo. A fascinating dive into sequencing ancient 🧬. Captures the thrills, setbacks, and Pääbo’s personal vulnerabilities during groundbreaking science.