Muzumdar Lab
@muzumdarlab.bsky.social
Studying genetic, environmental, and host factors in tumor progression of #PancreaticCancer and #LungCancer at Yale
Reposted by Muzumdar Lab
A career development grant from the AACR enabled Yale Cancer's Luisa Escobar-Hoyos, MSc, PhD, to secure two major multi-year federal grants for her pancreatic cancer research: Learn more in #AACRStories: www.aacr.org/about-the-aa... #PancreaticCancerAwarenessMonth
November 12, 2025 at 8:25 PM
A career development grant from the AACR enabled Yale Cancer's Luisa Escobar-Hoyos, MSc, PhD, to secure two major multi-year federal grants for her pancreatic cancer research: Learn more in #AACRStories: www.aacr.org/about-the-aa... #PancreaticCancerAwarenessMonth
Congrats to the newly minted Dr. Ge @xiangyuge.bsky.social for defending her thesis today! A tour de force talk on her work unraveling signaling interactions between #PI3K and #KRAS. @yalecancer.bsky.social. Check out her preprint: www.biorxiv.org/content/10.1...
October 25, 2025 at 12:03 AM
Congrats to the newly minted Dr. Ge @xiangyuge.bsky.social for defending her thesis today! A tour de force talk on her work unraveling signaling interactions between #PI3K and #KRAS. @yalecancer.bsky.social. Check out her preprint: www.biorxiv.org/content/10.1...
Reposted by Muzumdar Lab
A new study led by Dr. Prasanna Ananth explores how the
21st Century Cures Act—giving patients immediate access to electronic health records, impacts #cancer care in the pediatric oncology population.
yalecancercenter.org/news-article...
21st Century Cures Act—giving patients immediate access to electronic health records, impacts #cancer care in the pediatric oncology population.
yalecancercenter.org/news-article...
October 6, 2025 at 12:12 PM
A new study led by Dr. Prasanna Ananth explores how the
21st Century Cures Act—giving patients immediate access to electronic health records, impacts #cancer care in the pediatric oncology population.
yalecancercenter.org/news-article...
21st Century Cures Act—giving patients immediate access to electronic health records, impacts #cancer care in the pediatric oncology population.
yalecancercenter.org/news-article...
Excited to present at the sixth annual #ConnectingTheDots symposium with @cityofhope.bsky.social. Join us Nov. 7 for a deep dive into the #diabetes-#cancer interface.
September 26, 2025 at 1:41 AM
Excited to present at the sixth annual #ConnectingTheDots symposium with @cityofhope.bsky.social. Join us Nov. 7 for a deep dive into the #diabetes-#cancer interface.
Reposted by Muzumdar Lab
🎉PUBLISHED @natgenet.nature.com
📰Tracing the evolution of single-cell 3D genomes in Kras-driven #cancers.
By Miao Liu, @muzumdarlab.bsky.social, @sstevenwang.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...
📰Tracing the evolution of single-cell 3D genomes in Kras-driven #cancers.
By Miao Liu, @muzumdarlab.bsky.social, @sstevenwang.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...
Tracing the evolution of single-cell 3D genomes in Kras-driven cancers - Nature Genetics
This study uses chromatin tracing to identify alterations in single-cell 3D genome conformation during the progression of Kras-driven mouse lung adenocarcinoma and pancreatic ductal adenocarcinoma, an...
www.nature.com
August 27, 2025 at 1:33 PM
🎉PUBLISHED @natgenet.nature.com
📰Tracing the evolution of single-cell 3D genomes in Kras-driven #cancers.
By Miao Liu, @muzumdarlab.bsky.social, @sstevenwang.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...
📰Tracing the evolution of single-cell 3D genomes in Kras-driven #cancers.
By Miao Liu, @muzumdarlab.bsky.social, @sstevenwang.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...
💡 Cancer cells don’t just mutate—they reorganize their DNA in 3D space.
Our new study shows how the genome’s folding pattern shifts as tumors progress, cell by cell 🧩🧬.
It’s the first 3D genome atlas of cancer progression.
Thread 👇
Our new study shows how the genome’s folding pattern shifts as tumors progress, cell by cell 🧩🧬.
It’s the first 3D genome atlas of cancer progression.
Thread 👇
August 26, 2025 at 1:20 PM
💡 Cancer cells don’t just mutate—they reorganize their DNA in 3D space.
Our new study shows how the genome’s folding pattern shifts as tumors progress, cell by cell 🧩🧬.
It’s the first 3D genome atlas of cancer progression.
Thread 👇
Our new study shows how the genome’s folding pattern shifts as tumors progress, cell by cell 🧩🧬.
It’s the first 3D genome atlas of cancer progression.
Thread 👇
Reposted by Muzumdar Lab
New paper on the role of H3K4me3 at enhancers! We (led by Haoming Yu) used dCas9 epigenome editing to add H3K4me3 to intergenic enhancers. This was (1) sufficient to turn up transcription at open, active regions and (2) has no effect on target gene transcription. genesdev.cshlp.org/content/earl...
H3K4me3 amplifies transcription at intergenic active regulatory elements
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields
genesdev.cshlp.org
August 20, 2025 at 1:29 AM
New paper on the role of H3K4me3 at enhancers! We (led by Haoming Yu) used dCas9 epigenome editing to add H3K4me3 to intergenic enhancers. This was (1) sufficient to turn up transcription at open, active regions and (2) has no effect on target gene transcription. genesdev.cshlp.org/content/earl...
Reposted by Muzumdar Lab
New @natgenet.nature.com study from @muzumdarlab.bsky.social + @sstevenwang.bsky.social
maps 3D genomes in KRAS-driven lung & pancreatic #cancer, revealing stage-specific changes + potential biomarkers.
➡️ yalecancercenter.org/news-article...
maps 3D genomes in KRAS-driven lung & pancreatic #cancer, revealing stage-specific changes + potential biomarkers.
➡️ yalecancercenter.org/news-article...
Cancer's Progress Detailed by 3D Genomic Maps
Using new technology, Yale researchers examine cancer progression in single cells to visualize and understand its evolution from pre-cancerous to advanced
yalecancercenter.org
August 19, 2025 at 6:41 PM
New @natgenet.nature.com study from @muzumdarlab.bsky.social + @sstevenwang.bsky.social
maps 3D genomes in KRAS-driven lung & pancreatic #cancer, revealing stage-specific changes + potential biomarkers.
➡️ yalecancercenter.org/news-article...
maps 3D genomes in KRAS-driven lung & pancreatic #cancer, revealing stage-specific changes + potential biomarkers.
➡️ yalecancercenter.org/news-article...
Reposted by Muzumdar Lab
This work was done in collaboration with my @yaleschoolofmed.bsky.social colleague Professor Mandar Muzumdar @muzumdarlab.bsky.social and co-led by Drs. Miao Liu, Shengyan Jin, and Sherry Agabiti. Congrats to all authors! Also thank you National Cancer Institute for funding this work! 10/12
August 19, 2025 at 4:53 PM
This work was done in collaboration with my @yaleschoolofmed.bsky.social colleague Professor Mandar Muzumdar @muzumdarlab.bsky.social and co-led by Drs. Miao Liu, Shengyan Jin, and Sherry Agabiti. Congrats to all authors! Also thank you National Cancer Institute for funding this work! 10/12
Reposted by Muzumdar Lab
Link to YSM News article about this work: medicine.yale.edu/news-article... 12/12
Cancer's Progress Detailed by 3D Genomic Maps
Using new technology, Yale researchers examine cancer progression in single cells to visualize and understand its evolution from pre-cancerous to advanced
medicine.yale.edu
August 19, 2025 at 4:53 PM
Link to YSM News article about this work: medicine.yale.edu/news-article... 12/12
Reposted by Muzumdar Lab
Glad to share our latest publication in Nature Genetics: Tracing the evolution of single-cell 3D genomes in Kras-driven cancers. In this work, we generated the first single-cell 3D genome atlases of any cancer using any technique. 1/12
August 19, 2025 at 4:53 PM
Glad to share our latest publication in Nature Genetics: Tracing the evolution of single-cell 3D genomes in Kras-driven cancers. In this work, we generated the first single-cell 3D genome atlases of any cancer using any technique. 1/12
Excited to share our latest paper in @natgenet.nature.com with #SiyuanWang @yale.edu on the evolution of 3D genome organization in 🐁 models of #LungCancer and #PancreaticCancer. Kudos to #MiaoLiu #SherrySu! @yalecancer.bsky.social www.nature.com/articles/s41...
Tracing the evolution of single-cell 3D genomes in Kras-driven cancers - Nature Genetics
This study uses chromatin tracing to identify alterations in single-cell 3D genome conformation during the progression of Kras-driven mouse lung adenocarcinoma and pancreatic ductal adenocarcinoma, an...
www.nature.com
August 18, 2025 at 11:16 AM
Excited to share our latest paper in @natgenet.nature.com with #SiyuanWang @yale.edu on the evolution of 3D genome organization in 🐁 models of #LungCancer and #PancreaticCancer. Kudos to #MiaoLiu #SherrySu! @yalecancer.bsky.social www.nature.com/articles/s41...
Reposted by Muzumdar Lab
🎉 So proud of my wife
Natasha Pinto Medici on her latest co–first author paper in @ScienceTransMed!
🚀 Her team introduces TMAB3 — a tumor-targeted, RNA-binding antibody that delivers RNA directly into tumors after systemic injection.
www.science.org/doi/10.1126/...
Natasha Pinto Medici on her latest co–first author paper in @ScienceTransMed!
🚀 Her team introduces TMAB3 — a tumor-targeted, RNA-binding antibody that delivers RNA directly into tumors after systemic injection.
www.science.org/doi/10.1126/...
Systemic administration of an RNA binding and cell-penetrating antibody targets therapeutic RNA to multiple mouse models of cancer
A cell-penetrating and RNA binding antibody forms noncovalent complexes with an immunogenic RNA to target tumors and achieve antitumor efficacy.
www.science.org
July 16, 2025 at 8:51 PM
🎉 So proud of my wife
Natasha Pinto Medici on her latest co–first author paper in @ScienceTransMed!
🚀 Her team introduces TMAB3 — a tumor-targeted, RNA-binding antibody that delivers RNA directly into tumors after systemic injection.
www.science.org/doi/10.1126/...
Natasha Pinto Medici on her latest co–first author paper in @ScienceTransMed!
🚀 Her team introduces TMAB3 — a tumor-targeted, RNA-binding antibody that delivers RNA directly into tumors after systemic injection.
www.science.org/doi/10.1126/...
Stellar flash talk and poster presentation on #ubiquitination regulators in #KRAS inhibitor resistance by our own #CassieMarkham @faseborg.bsky.social Protein Phosphorylation! @yalecancer.bsky.social
July 16, 2025 at 8:47 PM
Stellar flash talk and poster presentation on #ubiquitination regulators in #KRAS inhibitor resistance by our own #CassieMarkham @faseborg.bsky.social Protein Phosphorylation! @yalecancer.bsky.social
Way to go, @xiangyuge.bsky.social, for a fantastic talk on how #PI3K governs resistance to #KRAS inhibition in #PancreaticCancer cells @faseborg.bsky.social Protein Phosphorylation! @yalepathology.bsky.social @yalecancer.bsky.social. Check out her preprint: www.biorxiv.org/content/10.1...
Phosphoinositide 3-kinase regulates wild-type RAS signaling to confer resistance to KRAS inhibition
Despite the availability of RAS inhibitors and the dependence of >90% of pancreatic ductal adenocarcinomas (PDAC) on oncogenic KRAS mutations, resistance to KRAS inhibition remains a serious obstacle....
www.biorxiv.org
July 15, 2025 at 8:14 PM
Way to go, @xiangyuge.bsky.social, for a fantastic talk on how #PI3K governs resistance to #KRAS inhibition in #PancreaticCancer cells @faseborg.bsky.social Protein Phosphorylation! @yalepathology.bsky.social @yalecancer.bsky.social. Check out her preprint: www.biorxiv.org/content/10.1...
1/🚨 New preprint out!🚨
We uncovered that #PI3K-driven wild-type RAS activation bypasses #KRAS inhibition in pancreatic adenocarcinoma (#PDAC) to drive #resistance.
🔑PI3K isn’t just a downstream RAS effector – it can be an upstream RAS regulator.
📄 www.biorxiv.org/content/10.1...
We uncovered that #PI3K-driven wild-type RAS activation bypasses #KRAS inhibition in pancreatic adenocarcinoma (#PDAC) to drive #resistance.
🔑PI3K isn’t just a downstream RAS effector – it can be an upstream RAS regulator.
📄 www.biorxiv.org/content/10.1...
Phosphoinositide 3-kinase regulates wild-type RAS signaling to confer resistance to KRAS inhibition
Despite the availability of RAS inhibitors and the dependence of >90% of pancreatic ductal adenocarcinomas (PDAC) on oncogenic KRAS mutations, resistance to KRAS inhibition remains a serious obstacle....
www.biorxiv.org
June 25, 2025 at 7:32 PM
1/🚨 New preprint out!🚨
We uncovered that #PI3K-driven wild-type RAS activation bypasses #KRAS inhibition in pancreatic adenocarcinoma (#PDAC) to drive #resistance.
🔑PI3K isn’t just a downstream RAS effector – it can be an upstream RAS regulator.
📄 www.biorxiv.org/content/10.1...
We uncovered that #PI3K-driven wild-type RAS activation bypasses #KRAS inhibition in pancreatic adenocarcinoma (#PDAC) to drive #resistance.
🔑PI3K isn’t just a downstream RAS effector – it can be an upstream RAS regulator.
📄 www.biorxiv.org/content/10.1...
Reposted by Muzumdar Lab
🚨New preprint!🚨
Venturing out of the nuclear genome to explore #mtDNA:
"Germline and somatic variation influence nuclear-mitochondrial crosstalk in tumourigenesis"
www.biorxiv.org/content/10.1...
Led by Dr. Maëlle Daunesse and @paulflicek.bsky.social - and many other #LCEConsortium members ⬇️
Venturing out of the nuclear genome to explore #mtDNA:
"Germline and somatic variation influence nuclear-mitochondrial crosstalk in tumourigenesis"
www.biorxiv.org/content/10.1...
Led by Dr. Maëlle Daunesse and @paulflicek.bsky.social - and many other #LCEConsortium members ⬇️
Germline and somatic variation influence nuclear-mitochondrial crosstalk in tumourigenesis
Hepatocellular carcinoma is the most prevalent primary liver cancer and arises from hepatocytes, which are very metabolically active and contain abundant mitochondria. Despite extensive characterisati...
www.biorxiv.org
May 5, 2025 at 3:18 PM
🚨New preprint!🚨
Venturing out of the nuclear genome to explore #mtDNA:
"Germline and somatic variation influence nuclear-mitochondrial crosstalk in tumourigenesis"
www.biorxiv.org/content/10.1...
Led by Dr. Maëlle Daunesse and @paulflicek.bsky.social - and many other #LCEConsortium members ⬇️
Venturing out of the nuclear genome to explore #mtDNA:
"Germline and somatic variation influence nuclear-mitochondrial crosstalk in tumourigenesis"
www.biorxiv.org/content/10.1...
Led by Dr. Maëlle Daunesse and @paulflicek.bsky.social - and many other #LCEConsortium members ⬇️
Reposted by Muzumdar Lab
My lab at hiring! - we have TWO postdoc positions (one computational, one wet lab focussed) at Yale @yaleschoolofmed.bsky.social, working closely with our group members at University of Cambridge, UK @cambridgeuni.bsky.social
Please help to spread the word!
Adverts with full details below ⬇️
Please help to spread the word!
Adverts with full details below ⬇️
March 26, 2025 at 3:31 PM
My lab at hiring! - we have TWO postdoc positions (one computational, one wet lab focussed) at Yale @yaleschoolofmed.bsky.social, working closely with our group members at University of Cambridge, UK @cambridgeuni.bsky.social
Please help to spread the word!
Adverts with full details below ⬇️
Please help to spread the word!
Adverts with full details below ⬇️
📢 New preprint alert! 🚨 We show that diet quality, not just quantity, is a key player in driving pancreatic cancer progression. 🔑 What you eat matters for cancer risk—much more than we previously thought. #PancreaticCancer #CancerBiology #DietAndCancer
April 7, 2025 at 1:24 PM
📢 New preprint alert! 🚨 We show that diet quality, not just quantity, is a key player in driving pancreatic cancer progression. 🔑 What you eat matters for cancer risk—much more than we previously thought. #PancreaticCancer #CancerBiology #DietAndCancer