Congrats to the newly minted Dr. Ge @xiangyuge.bsky.social for defending her thesis today! A tour de force talk on her work unraveling signaling interactions between #PI3K and #KRAS. @yalecancer.bsky.social. Check out her preprint: www.biorxiv.org/content/10.1...

Excited to present at the sixth annual #ConnectingTheDots symposium with @cityofhope.bsky.social. Join us Nov. 7 for a deep dive into the #diabetes-#cancer interface.

5/ 🤖 The twist:
3D genome signatures don’t just classify tumor states—they add predictive & prognostic power beyond RNA-seq alone 📈.
Compartment changes flagged key genes, spotlighting Rnf2 as a novel regulator of cancer genome folding.

4/ 📊 The discovery:
3D genome changes are non-linear and exhibit convergent evolution across tumors. Tumors go through stage-specific shifts in compaction, compartment identity & heterogeneity—with a “structural bottleneck” early on. ⏳

3/ 🛠 The tech:
Using chromatin tracing, we imaged hundreds of loci across all 19 mouse autosomes in situ, mapping 3D genomic evolution in single #LungCancer and #PancreaticCancer cells within intact tissues. 📸

2/ 🔍 Why it matters:
Cancer isn’t just about mutations—it’s also how DNA folds in 3D. This study maps genome architecture from normal → pre-cancer → advanced cancer, at single-cell resolution.

💡 Cancer cells don’t just mutate—they reorganize their DNA in 3D space.
Our new study shows how the genome’s folding pattern shifts as tumors progress, cell by cell 🧩🧬.
It’s the first 3D genome atlas of cancer progression.
Thread 👇

Stellar flash talk and poster presentation on #ubiquitination regulators in #KRAS inhibitor resistance by our own #CassieMarkham @faseborg.bsky.social Protein Phosphorylation! @yalecancer.bsky.social