Muzumdar Lab
@muzumdarlab.bsky.social
Studying genetic, environmental, and host factors in tumor progression of #PancreaticCancer and #LungCancer at Yale
Register now! www.eventbrite.com/e/the-sixth-...
The Sixth Annual Diabetes & Cancer Interface Symposium: Connecting the Dots
City of Hope’s annual Diabetes & Cancer Interface Symposium explores the research and treatment links between obesity, diabetes, and cancer.
www.eventbrite.com
September 26, 2025 at 1:41 AM
Register now! www.eventbrite.com/e/the-sixth-...
7/ This was a close collaboration with @sstevenwang.bsky.social. Kudos to #MiaoLiu, #SherryAgabiti, and #ShengyanJin for leading the effort with critical collaboration from @christianfruiz.bsky.social @jeffreytownsend.bsky.social @yalecancer.bsky.social and funding from #NCI @theaacr.bsky.social
August 26, 2025 at 1:20 PM
7/ This was a close collaboration with @sstevenwang.bsky.social. Kudos to #MiaoLiu, #SherryAgabiti, and #ShengyanJin for leading the effort with critical collaboration from @christianfruiz.bsky.social @jeffreytownsend.bsky.social @yalecancer.bsky.social and funding from #NCI @theaacr.bsky.social
6/ 🚀 Take-home:
The first single-cell 3D genome atlas of cancer in situ. Stage-specific shifts + new gene regulators = a 3D genomics roadmap for potential biomarkers and targets for precision oncology.
August 26, 2025 at 1:20 PM
6/ 🚀 Take-home:
The first single-cell 3D genome atlas of cancer in situ. Stage-specific shifts + new gene regulators = a 3D genomics roadmap for potential biomarkers and targets for precision oncology.
5/ 🤖 The twist:
3D genome signatures don’t just classify tumor states—they add predictive & prognostic power beyond RNA-seq alone 📈.
Compartment changes flagged key genes, spotlighting Rnf2 as a novel regulator of cancer genome folding.
August 26, 2025 at 1:20 PM
5/ 🤖 The twist:
3D genome signatures don’t just classify tumor states—they add predictive & prognostic power beyond RNA-seq alone 📈.
Compartment changes flagged key genes, spotlighting Rnf2 as a novel regulator of cancer genome folding.
4/ 📊 The discovery:
3D genome changes are non-linear and exhibit convergent evolution across tumors. Tumors go through stage-specific shifts in compaction, compartment identity & heterogeneity—with a “structural bottleneck” early on. ⏳
August 26, 2025 at 1:20 PM
4/ 📊 The discovery:
3D genome changes are non-linear and exhibit convergent evolution across tumors. Tumors go through stage-specific shifts in compaction, compartment identity & heterogeneity—with a “structural bottleneck” early on. ⏳
3/ 🛠 The tech:
Using chromatin tracing, we imaged hundreds of loci across all 19 mouse autosomes in situ, mapping 3D genomic evolution in single #LungCancer and #PancreaticCancer cells within intact tissues. 📸
August 26, 2025 at 1:20 PM
3/ 🛠 The tech:
Using chromatin tracing, we imaged hundreds of loci across all 19 mouse autosomes in situ, mapping 3D genomic evolution in single #LungCancer and #PancreaticCancer cells within intact tissues. 📸
2/ 🔍 Why it matters:
Cancer isn’t just about mutations—it’s also how DNA folds in 3D. This study maps genome architecture from normal → pre-cancer → advanced cancer, at single-cell resolution.
August 26, 2025 at 1:20 PM
2/ 🔍 Why it matters:
Cancer isn’t just about mutations—it’s also how DNA folds in 3D. This study maps genome architecture from normal → pre-cancer → advanced cancer, at single-cell resolution.
1/ 🚨 New in Nature Genetics @naturegenet.bsky.social:
“Tracing the evolution of single-cell 3D genomes in Kras-driven cancers” 🧬🧩
👉 The first atlas of how genome folding changes during cancer progression.
www.nature.com/articles/s41...
Tracing the evolution of single-cell 3D genomes in Kras-driven cancers - Nature Genetics
This study uses chromatin tracing to identify alterations in single-cell 3D genome conformation during the progression of Kras-driven mouse lung adenocarcinoma and pancreatic ductal adenocarcinoma, an...
www.nature.com
August 26, 2025 at 1:20 PM
1/ 🚨 New in Nature Genetics @naturegenet.bsky.social:
“Tracing the evolution of single-cell 3D genomes in Kras-driven cancers” 🧬🧩
👉 The first atlas of how genome folding changes during cancer progression.
www.nature.com/articles/s41...
Wonderful to collaborate with you and the team on this study, Steven!
August 19, 2025 at 5:03 PM
Wonderful to collaborate with you and the team on this study, Steven!
Reposted by Muzumdar Lab
This work was done in collaboration with my @yaleschoolofmed.bsky.social colleague Professor Mandar Muzumdar @muzumdarlab.bsky.social and co-led by Drs. Miao Liu, Shengyan Jin, and Sherry Agabiti. Congrats to all authors! Also thank you National Cancer Institute for funding this work! 10/12
August 19, 2025 at 4:53 PM
This work was done in collaboration with my @yaleschoolofmed.bsky.social colleague Professor Mandar Muzumdar @muzumdarlab.bsky.social and co-led by Drs. Miao Liu, Shengyan Jin, and Sherry Agabiti. Congrats to all authors! Also thank you National Cancer Institute for funding this work! 10/12
Reposted by Muzumdar Lab
Link to YSM News article about this work: medicine.yale.edu/news-article... 12/12
Cancer's Progress Detailed by 3D Genomic Maps
Using new technology, Yale researchers examine cancer progression in single cells to visualize and understand its evolution from pre-cancerous to advanced
medicine.yale.edu
August 19, 2025 at 4:53 PM
Link to YSM News article about this work: medicine.yale.edu/news-article... 12/12
8/👏 Kudos to lead author @xiangyuge.bsky.social with key contributions from Jaffar, Wenxue, Cassie, @christianfruiz.bsky.social, @moitrayee-lab.bsky.social, and Yansheng. #YCBI #YaleGenetics #YalePharm @yalecancer.bsky.social @lustgarten.org
June 25, 2025 at 7:32 PM
8/👏 Kudos to lead author @xiangyuge.bsky.social with key contributions from Jaffar, Wenxue, Cassie, @christianfruiz.bsky.social, @moitrayee-lab.bsky.social, and Yansheng. #YCBI #YaleGenetics #YalePharm @yalecancer.bsky.social @lustgarten.org