GPSai: A Clinically Validated AI Tool for Tissue of Origin Prediction During Routine Tumor Profiling url: aacrjournals.org/cancerrescom...
GPSai: A Clinically Validated AI Tool for Tissue of Origin Prediction During Routine Tumor Profiling
Abstract. A subset of cancers presents with unclear or potentially incorrect primary histopathologic diagnoses, including cancers of unknown primary (CUP). We aimed to develop and validate an artifici...
aacrjournals.org
August 1, 2025 at 3:21 AM
GPSai: A Clinically Validated AI Tool for Tissue of Origin Prediction During Routine Tumor Profiling url: aacrjournals.org/cancerrescom...
Tumor-Infiltrating Clonal Hematopoiesis | New England Journal of Medicine www.nejm.org/doi/full/10....
Tumor-Infiltrating Clonal Hematopoiesis | NEJM
To the Editor: The provocative findings by Pich et al. (Apr. 24 issue)1 showing the
influence of tumor-infiltrating clonal hematopoiesis (TI-CH) on patient outcomes in
early-stage cancers support t...
www.nejm.org
July 12, 2025 at 5:14 AM
Tumor-Infiltrating Clonal Hematopoiesis | New England Journal of Medicine www.nejm.org/doi/full/10....
Reposted by Matt Oberley
A 𝐧𝐨𝐧𝐬𝐞𝐧𝐬𝐞 𝐯𝐚𝐫𝐢𝐚𝐧𝐭 is a single DNA nucleotide that has been altered such that an amino acid codon becomes a stop codon, leading to truncation of the encoded protein.
#ScienceSky
#ScienceSky
May 23, 2025 at 8:45 PM
A 𝐧𝐨𝐧𝐬𝐞𝐧𝐬𝐞 𝐯𝐚𝐫𝐢𝐚𝐧𝐭 is a single DNA nucleotide that has been altered such that an amino acid codon becomes a stop codon, leading to truncation of the encoded protein.
#ScienceSky
#ScienceSky
Reposted by Matt Oberley
Among patients with smoldering multiple myeloma at high risk for progression, progression-free survival at 5 years was 63.1% with daratumumab monotherapy, as compared with 40.8% with active monitoring. Full AQUILA trial results and Research Summary: nej.md/3Zh3pOJ
#MedSky #Hematology
#MedSky #Hematology
May 12, 2025 at 4:47 PM
Among patients with smoldering multiple myeloma at high risk for progression, progression-free survival at 5 years was 63.1% with daratumumab monotherapy, as compared with 40.8% with active monitoring. Full AQUILA trial results and Research Summary: nej.md/3Zh3pOJ
#MedSky #Hematology
#MedSky #Hematology
Reposted by Matt Oberley
Relapsed Burkitt’s lymphoma is nearly always fatal. Three patients had a complete metabolic response with the combination of the bispecific antibody glofitamab and the antibody–drug conjugate polatuzumab vedotin. Full correspondence: nej.md/4lS7kfe
#MedSky #Hematology
#MedSky #Hematology
May 4, 2025 at 4:03 PM
Relapsed Burkitt’s lymphoma is nearly always fatal. Three patients had a complete metabolic response with the combination of the bispecific antibody glofitamab and the antibody–drug conjugate polatuzumab vedotin. Full correspondence: nej.md/4lS7kfe
#MedSky #Hematology
#MedSky #Hematology
Reposted by Matt Oberley
This is amazing work, I have no words!! This is inspiring and this is the goal !!!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
RNA polymerase II at histone genes predicts outcome in human cancer
Genome-wide hypertranscription is common in human cancer and predicts poor prognosis. To understand how hypertranscription might drive cancer, we applied our formalin-fixed paraffin-embedded (FFPE)–cl...
www.science.org
February 14, 2025 at 4:40 AM
This is amazing work, I have no words!! This is inspiring and this is the goal !!!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Matt Oberley
New method for identifying spatially variable genes in spatial transcriptomics.
We use spectral graph theory to extract 1D curves related to tissue morphology, creating a more relevant coordinate system. Improves sensitivity.
with @PhillipNicol et al.
www.biorxiv.org/content/10.1...
We use spectral graph theory to extract 1D curves related to tissue morphology, creating a more relevant coordinate system. Improves sensitivity.
with @PhillipNicol et al.
www.biorxiv.org/content/10.1...
November 22, 2024 at 8:04 PM
New method for identifying spatially variable genes in spatial transcriptomics.
We use spectral graph theory to extract 1D curves related to tissue morphology, creating a more relevant coordinate system. Improves sensitivity.
with @PhillipNicol et al.
www.biorxiv.org/content/10.1...
We use spectral graph theory to extract 1D curves related to tissue morphology, creating a more relevant coordinate system. Improves sensitivity.
with @PhillipNicol et al.
www.biorxiv.org/content/10.1...
Reposted by Matt Oberley
On Wall Street, dental stocks are trading up today on the anticipation of more cavities
Dental supply stock surges on RFK's anti-fluoride stance, activist involvement
Henry Schein shares tracked for their best day since 2022 on Monday.
www.cnbc.com
November 18, 2024 at 7:34 PM
On Wall Street, dental stocks are trading up today on the anticipation of more cavities
Reposted by Matt Oberley
The migration of MedTwitter, along with a large cohort of science journalists, to BlueSky is striking in its scale and rapidity. In a short time, this shift has effectively transformed BlueSky into the essential hub for breaking medical news and vibrant scientific discourse.
November 17, 2024 at 8:21 PM
The migration of MedTwitter, along with a large cohort of science journalists, to BlueSky is striking in its scale and rapidity. In a short time, this shift has effectively transformed BlueSky into the essential hub for breaking medical news and vibrant scientific discourse.
Reposted by Matt Oberley
"Next-generation sequencing" started to be a misnomer after the subsequent generation of sequencing came along.
Now that we have users who were born after the commercial availability of "next-generation sequencing" it is truly ridiculous. 🧪🧬🖥️
Now that we have users who were born after the commercial availability of "next-generation sequencing" it is truly ridiculous. 🧪🧬🖥️
November 17, 2024 at 4:22 PM
"Next-generation sequencing" started to be a misnomer after the subsequent generation of sequencing came along.
Now that we have users who were born after the commercial availability of "next-generation sequencing" it is truly ridiculous. 🧪🧬🖥️
Now that we have users who were born after the commercial availability of "next-generation sequencing" it is truly ridiculous. 🧪🧬🖥️
Reposted by Matt Oberley
All oncology clinicians - MD’s, Nurses, Advocates - need to be aware of the rapidly evolving genomic landscape of biomarkers in order to provide high quality care to individuals living w/cancer
(Hoping the link opens!) #oncsky #medsky @oncoalert.bsky.social
ascopubs.org/doi/10.1200/...
(Hoping the link opens!) #oncsky #medsky @oncoalert.bsky.social
ascopubs.org/doi/10.1200/...
ASCO Publications
ascopubs.org
November 17, 2024 at 12:37 PM
All oncology clinicians - MD’s, Nurses, Advocates - need to be aware of the rapidly evolving genomic landscape of biomarkers in order to provide high quality care to individuals living w/cancer
(Hoping the link opens!) #oncsky #medsky @oncoalert.bsky.social
ascopubs.org/doi/10.1200/...
(Hoping the link opens!) #oncsky #medsky @oncoalert.bsky.social
ascopubs.org/doi/10.1200/...
Reposted by Matt Oberley
Let me tell you about the work that we published last year in Nature Cancer (@natureportfolio.bsky.social). It was a tremendous effort from Jacquelin Taylor within Andreas Fischer's lab. In it, we describe a new role of endothelial cells to promote cancer cachexia: nature.com/articles/s4301… 1/6
November 16, 2024 at 2:39 PM
Let me tell you about the work that we published last year in Nature Cancer (@natureportfolio.bsky.social). It was a tremendous effort from Jacquelin Taylor within Andreas Fischer's lab. In it, we describe a new role of endothelial cells to promote cancer cachexia: nature.com/articles/s4301… 1/6
Reposted by Matt Oberley
Dear new #science #STEM community-
@abireland.bsky.social and I are thrilled to share our latest. The basal cell changes everything for #SCLC #plasticity! Despite prevailing dogma, we now believe the basal cell is the most plausible origin for SCLC because:
@abireland.bsky.social and I are thrilled to share our latest. The basal cell changes everything for #SCLC #plasticity! Despite prevailing dogma, we now believe the basal cell is the most plausible origin for SCLC because:
November 16, 2024 at 1:01 PM
Dear new #science #STEM community-
@abireland.bsky.social and I are thrilled to share our latest. The basal cell changes everything for #SCLC #plasticity! Despite prevailing dogma, we now believe the basal cell is the most plausible origin for SCLC because:
@abireland.bsky.social and I are thrilled to share our latest. The basal cell changes everything for #SCLC #plasticity! Despite prevailing dogma, we now believe the basal cell is the most plausible origin for SCLC because:
Reposted by Matt Oberley
(1/8) 🚀 Excited to share our findings on a large-scale ChIP-seq assay for 166 previously uncharacterized human transcription factors (TFs) and their roles in both regulatory regions, and more strikingly, the “dark matter” genome. 🌌 doi.org/10.1101/2024....
Extensive binding of uncharacterized human transcription factors to genomic dark matter
Most of the human genome is thought to be non-functional, and includes large segments often referred to as “dark matter” DNA. The genome also encodes hundreds of putative and poorly characterized tran...
doi.org
November 15, 2024 at 7:02 PM
(1/8) 🚀 Excited to share our findings on a large-scale ChIP-seq assay for 166 previously uncharacterized human transcription factors (TFs) and their roles in both regulatory regions, and more strikingly, the “dark matter” genome. 🌌 doi.org/10.1101/2024....
Reposted by Matt Oberley
Re-airing this one from 5 years ago
November 15, 2024 at 7:04 PM
Re-airing this one from 5 years ago