Miriam Lisci
@miriamlisci.bsky.social
EMBO postdoc fellow @jourdainlab.bsky.social at @dib-unil.bsky.social diving into the metabolism of cancer and immune cells | Previously @griffithslab.bsky.social @thecimr.bsky.social @Cambridge_Uni | City Coordinator of @pintofscience.ch
Pinned
Miriam Lisci
@miriamlisci.bsky.social
· Nov 20
Could you live without glutamine?
I am delighted to share our preprint @jourdainlab.bsky.social: we employed parallel nutrient and genetic screening to tackle the mechanisms promoting survival in glutamine-limiting conditions. Check it out 👇 more details below!
www.biorxiv.org/content/10.1...
I am delighted to share our preprint @jourdainlab.bsky.social: we employed parallel nutrient and genetic screening to tackle the mechanisms promoting survival in glutamine-limiting conditions. Check it out 👇 more details below!
www.biorxiv.org/content/10.1...
Reposted by Miriam Lisci
How can mitophagy be an effective quality control mechanism if mtDNA mutations reach high enough levels to cause disease?
This question led us into a dark path, full of concepts of evolutionary genetics, germline stem cell biology and mito-nuclear compatibility.
www.science.org/doi/10.1126/...
This question led us into a dark path, full of concepts of evolutionary genetics, germline stem cell biology and mito-nuclear compatibility.
www.science.org/doi/10.1126/...
Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations
Mitochondrial synthesis of adenosine triphosphate is essential for eukaryotic life but is dependent on the cooperation of two genomes: nuclear and mitochondrial DNA (mtDNA). mtDNA mutates ~15 times as...
www.science.org
October 10, 2025 at 8:45 AM
How can mitophagy be an effective quality control mechanism if mtDNA mutations reach high enough levels to cause disease?
This question led us into a dark path, full of concepts of evolutionary genetics, germline stem cell biology and mito-nuclear compatibility.
www.science.org/doi/10.1126/...
This question led us into a dark path, full of concepts of evolutionary genetics, germline stem cell biology and mito-nuclear compatibility.
www.science.org/doi/10.1126/...
Reposted by Miriam Lisci
Super excited to share our new preprint from @cssheehan.bsky.social on how the tumor microenvironment causes drug resistance in pancreatic cancer: www.biorxiv.org/content/10.1...
Tumor nutrient stress gives rise to a drug tolerant cell state in pancreatic cancer
Cytotoxic chemotherapy remains the standard-of-care treatment for patients with pancreatic ductal adenocarcinoma (PDAC). However, chemotherapy only has modest effects at improving patient survival due...
www.biorxiv.org
September 9, 2025 at 9:38 PM
Super excited to share our new preprint from @cssheehan.bsky.social on how the tumor microenvironment causes drug resistance in pancreatic cancer: www.biorxiv.org/content/10.1...
It was great to meet so many EMBO fellows from all around the world!
Thank you EMBO for inviting us and for giving us the opportunity to discuss our projects and network with such a diverse group of scientist.
Thank you EMBO for inviting us and for giving us the opportunity to discuss our projects and network with such a diverse group of scientist.
119 EMBO Fellows from 30+ countries attended the EMBO Fellows’ Meeting in Heidelberg, DE from 27 June–1 July. #Research was shared and connections formed – an incredible opportunity for #networking and #collaboration. Thank you to all who joined and were part of this vibrant community! 🧪
July 3, 2025 at 4:08 PM
It was great to meet so many EMBO fellows from all around the world!
Thank you EMBO for inviting us and for giving us the opportunity to discuss our projects and network with such a diverse group of scientist.
Thank you EMBO for inviting us and for giving us the opportunity to discuss our projects and network with such a diverse group of scientist.
Reposted by Miriam Lisci
Pint of Science was again a great success in Lausanne, with >500 people attending our events!
Kudos to co-coordinators @miriamlisci.bsky.social and @juliensluneau.bsky.social, and to the fantastic team of 19 volunteers at the bars 🥳!
#PINT25 #scicomm
Kudos to co-coordinators @miriamlisci.bsky.social and @juliensluneau.bsky.social, and to the fantastic team of 19 volunteers at the bars 🥳!
#PINT25 #scicomm
May 24, 2025 at 9:07 AM
Pint of Science was again a great success in Lausanne, with >500 people attending our events!
Kudos to co-coordinators @miriamlisci.bsky.social and @juliensluneau.bsky.social, and to the fantastic team of 19 volunteers at the bars 🥳!
#PINT25 #scicomm
Kudos to co-coordinators @miriamlisci.bsky.social and @juliensluneau.bsky.social, and to the fantastic team of 19 volunteers at the bars 🥳!
#PINT25 #scicomm
Get ready for a night full of surprises in Lausanne!
With talks in both EN and FR, and topics ranging from AI & privacy, viruses and green revolution, your thirst for science in a fun and relaxed setting will be satisfied starting tonight!
Time: 7-9pm
Locations: Cylure, Sidewalk, On va où
#Pint25
With talks in both EN and FR, and topics ranging from AI & privacy, viruses and green revolution, your thirst for science in a fun and relaxed setting will be satisfied starting tonight!
Time: 7-9pm
Locations: Cylure, Sidewalk, On va où
#Pint25
✨#pintCH is starting today!✨3 nights of fun science talks for everyone!
🗓️ 19–21 May 2025
📍12 cities
🎤58 events
🎟️free entry
🌐 pintofscience.ch
#Baden #Basel #Bern #Brig #Fribourg #Geneva #Lausanne #Lugano #Neuchatel #Sion #StGallen #Zurich
#Pint25
@pintsworld.bsky.social
🗓️ 19–21 May 2025
📍12 cities
🎤58 events
🎟️free entry
🌐 pintofscience.ch
#Baden #Basel #Bern #Brig #Fribourg #Geneva #Lausanne #Lugano #Neuchatel #Sion #StGallen #Zurich
#Pint25
@pintsworld.bsky.social
May 19, 2025 at 10:56 AM
Get ready for a night full of surprises in Lausanne!
With talks in both EN and FR, and topics ranging from AI & privacy, viruses and green revolution, your thirst for science in a fun and relaxed setting will be satisfied starting tonight!
Time: 7-9pm
Locations: Cylure, Sidewalk, On va où
#Pint25
With talks in both EN and FR, and topics ranging from AI & privacy, viruses and green revolution, your thirst for science in a fun and relaxed setting will be satisfied starting tonight!
Time: 7-9pm
Locations: Cylure, Sidewalk, On va où
#Pint25
The latest pre-print from the lab is out! 🥳
In this work led by our PhD student Abigail, the @jourdainlab.bsky.social adds a piece to the puzzle of mechanisms balancing #pyrimidines and #purine synthesis, and hints at #NUDT5 expression as a potential predictor of chemotherapy resistance.
In this work led by our PhD student Abigail, the @jourdainlab.bsky.social adds a piece to the puzzle of mechanisms balancing #pyrimidines and #purine synthesis, and hints at #NUDT5 expression as a potential predictor of chemotherapy resistance.
🚨 New preprint available! Third and final in the #CRISPR screen series!🚨
👉🏻 Uridine-sensitized screening identifies genes and metabolic regulators of #nucleotide synthesis
www.biorxiv.org/content/10.1...
By A. Strefeler in collaboration with Dave Pagliarini and team.
@DIB_UNIL @FBM_UNIL
🧵 1/9
👉🏻 Uridine-sensitized screening identifies genes and metabolic regulators of #nucleotide synthesis
www.biorxiv.org/content/10.1...
By A. Strefeler in collaboration with Dave Pagliarini and team.
@DIB_UNIL @FBM_UNIL
🧵 1/9
www.biorxiv.org
March 14, 2025 at 9:17 AM
The latest pre-print from the lab is out! 🥳
In this work led by our PhD student Abigail, the @jourdainlab.bsky.social adds a piece to the puzzle of mechanisms balancing #pyrimidines and #purine synthesis, and hints at #NUDT5 expression as a potential predictor of chemotherapy resistance.
In this work led by our PhD student Abigail, the @jourdainlab.bsky.social adds a piece to the puzzle of mechanisms balancing #pyrimidines and #purine synthesis, and hints at #NUDT5 expression as a potential predictor of chemotherapy resistance.
Check out our new pre-print from the @jourdainlab.bsky.social, featuring work led by @marcellharhai.bsky.social!
How do growth and death screens compare when uncovering novel regulators of mitochondrial function? Is Ménière disease a mitochondrial disorder?
Find out below 👇
How do growth and death screens compare when uncovering novel regulators of mitochondrial function? Is Ménière disease a mitochondrial disorder?
Find out below 👇
New preprint from the lab! 🚨
🧫 New galactose #CRISPR screening strategy
🎯 481 genes required for #OXPHOS
⚙️ #FAM136A in IMS proteostasis
👂Mito defects in #Menieres disease
by @marcellharhai.bsky.social @fbm-unil.bsky.social
A short thread 1/5
www.biorxiv.org/content/10.1...
🧫 New galactose #CRISPR screening strategy
🎯 481 genes required for #OXPHOS
⚙️ #FAM136A in IMS proteostasis
👂Mito defects in #Menieres disease
by @marcellharhai.bsky.social @fbm-unil.bsky.social
A short thread 1/5
www.biorxiv.org/content/10.1...
January 30, 2025 at 10:07 AM
Check out our new pre-print from the @jourdainlab.bsky.social, featuring work led by @marcellharhai.bsky.social!
How do growth and death screens compare when uncovering novel regulators of mitochondrial function? Is Ménière disease a mitochondrial disorder?
Find out below 👇
How do growth and death screens compare when uncovering novel regulators of mitochondrial function? Is Ménière disease a mitochondrial disorder?
Find out below 👇
Reposted by Miriam Lisci
Celebrating the New Year in style! Best wishes from the Jourdain Lab 🥌🫕🇨🇭
January 18, 2025 at 11:48 AM
Celebrating the New Year in style! Best wishes from the Jourdain Lab 🥌🫕🇨🇭
Reposted by Miriam Lisci
Stoked to share TWO preprints on mitochondrial pearling! 🎉
We uncover how spontaneous #mitochondria pearling drives #mtDNA nucleoid distribution (doi.org/10.1101/2024...), and
@gavsturm.bsky.social
et al. dissect the biophysics behind it (doi.org/10.1101/2024...). Details below! 🔬🧵🧪
We uncover how spontaneous #mitochondria pearling drives #mtDNA nucleoid distribution (doi.org/10.1101/2024...), and
@gavsturm.bsky.social
et al. dissect the biophysics behind it (doi.org/10.1101/2024...). Details below! 🔬🧵🧪
December 23, 2024 at 4:37 PM
Stoked to share TWO preprints on mitochondrial pearling! 🎉
We uncover how spontaneous #mitochondria pearling drives #mtDNA nucleoid distribution (doi.org/10.1101/2024...), and
@gavsturm.bsky.social
et al. dissect the biophysics behind it (doi.org/10.1101/2024...). Details below! 🔬🧵🧪
We uncover how spontaneous #mitochondria pearling drives #mtDNA nucleoid distribution (doi.org/10.1101/2024...), and
@gavsturm.bsky.social
et al. dissect the biophysics behind it (doi.org/10.1101/2024...). Details below! 🔬🧵🧪
Could you live without glutamine?
I am delighted to share our preprint @jourdainlab.bsky.social: we employed parallel nutrient and genetic screening to tackle the mechanisms promoting survival in glutamine-limiting conditions. Check it out 👇 more details below!
www.biorxiv.org/content/10.1...
I am delighted to share our preprint @jourdainlab.bsky.social: we employed parallel nutrient and genetic screening to tackle the mechanisms promoting survival in glutamine-limiting conditions. Check it out 👇 more details below!
www.biorxiv.org/content/10.1...
November 20, 2024 at 1:58 PM
Could you live without glutamine?
I am delighted to share our preprint @jourdainlab.bsky.social: we employed parallel nutrient and genetic screening to tackle the mechanisms promoting survival in glutamine-limiting conditions. Check it out 👇 more details below!
www.biorxiv.org/content/10.1...
I am delighted to share our preprint @jourdainlab.bsky.social: we employed parallel nutrient and genetic screening to tackle the mechanisms promoting survival in glutamine-limiting conditions. Check it out 👇 more details below!
www.biorxiv.org/content/10.1...
Reposted by Miriam Lisci
Stressed mitochondrial RNA granules from our recent work on the cover of PNAS!
A photo by E. Recazens illustrating our new story led by M. Foged on the cytosolic control of mitochondrial RNA processing and innate immunity by #N6AMT1.
#mitochondria #dsRNA
A photo by E. Recazens illustrating our new story led by M. Foged on the cytosolic control of mitochondrial RNA processing and innate immunity by #N6AMT1.
#mitochondria #dsRNA
November 19, 2024 at 8:08 PM
Stressed mitochondrial RNA granules from our recent work on the cover of PNAS!
A photo by E. Recazens illustrating our new story led by M. Foged on the cytosolic control of mitochondrial RNA processing and innate immunity by #N6AMT1.
#mitochondria #dsRNA
A photo by E. Recazens illustrating our new story led by M. Foged on the cytosolic control of mitochondrial RNA processing and innate immunity by #N6AMT1.
#mitochondria #dsRNA