mattgroeschel.bsky.social
@mattgroeschel.bsky.social
Physician scientist at Charité Berlin, interest in TB genomic epidemiology, host pathogen diversity, and clinical AI
Reposted by mattgroeschel.bsky.social
In this 60-Second Journal Club, NEJM Editorial Fellow Abarna Pearl, MD, MPH, summarizes the BALANCE trial comparing antibiotic treatment for 7 versus 14 days in patients with bloodstream infections. Read the full article and accompanying Research Summary: nej.md/3Z5bTJD
#MedSky #IDSky
#MedSky #IDSky
July 9, 2025 at 5:11 PM
In this 60-Second Journal Club, NEJM Editorial Fellow Abarna Pearl, MD, MPH, summarizes the BALANCE trial comparing antibiotic treatment for 7 versus 14 days in patients with bloodstream infections. Read the full article and accompanying Research Summary: nej.md/3Z5bTJD
#MedSky #IDSky
#MedSky #IDSky
Reposted by mattgroeschel.bsky.social
Come and work with me and use the 53,897 samples of M. tuberculosis we have collated to help tackle this important disease!
We are part of the OxCoD4TB consortium that is developing new therapeutics for tuberculosis.
Grade 7, funding until 28 Feb 2028, deadline noon Fri 4 July
bit.ly/4ndKOhF
We are part of the OxCoD4TB consortium that is developing new therapeutics for tuberculosis.
Grade 7, funding until 28 Feb 2028, deadline noon Fri 4 July
bit.ly/4ndKOhF
Job Details
bit.ly
June 25, 2025 at 8:37 AM
Come and work with me and use the 53,897 samples of M. tuberculosis we have collated to help tackle this important disease!
We are part of the OxCoD4TB consortium that is developing new therapeutics for tuberculosis.
Grade 7, funding until 28 Feb 2028, deadline noon Fri 4 July
bit.ly/4ndKOhF
We are part of the OxCoD4TB consortium that is developing new therapeutics for tuberculosis.
Grade 7, funding until 28 Feb 2028, deadline noon Fri 4 July
bit.ly/4ndKOhF
Reposted by mattgroeschel.bsky.social
Important changes on @erc.europa.eu grants‼️Grant structure & most importantly eligibility timeframes (10 years for starting, 15 years for consolidator post PhD-but you can have them only once) changes: erc.europa.eu/news-events/...
Changes to the 2026 and 2027 Work Programmes
With the launch of the competitions for grants under ERC Work Programme 2026 in July of this year, several changes to the submission of applications and the evaluation of proposals will apply. The mai...
erc.europa.eu
June 2, 2025 at 2:18 PM
Important changes on @erc.europa.eu grants‼️Grant structure & most importantly eligibility timeframes (10 years for starting, 15 years for consolidator post PhD-but you can have them only once) changes: erc.europa.eu/news-events/...
Reposted by mattgroeschel.bsky.social
𝘔𝘺𝘤𝘰𝘣𝘢𝘤𝘵𝘦𝘳𝘪𝘶𝘮 𝘵𝘶𝘣𝘦𝘳𝘤𝘶𝘭𝘰𝘴𝘪𝘴 continues to cause substantial illness globally. In this phase 2b randomized trial, BCG revaccination did not prevent sustained 𝘔. 𝘵𝘶𝘣𝘦𝘳𝘤𝘶𝘭𝘰𝘴𝘪𝘴 infection in IGRA-negative, HIV-negative adolescents. Full BCG REVAX trial results: nej.md/3GKdPkf
#MedSky #IDSky
#MedSky #IDSky
May 7, 2025 at 9:13 PM
𝘔𝘺𝘤𝘰𝘣𝘢𝘤𝘵𝘦𝘳𝘪𝘶𝘮 𝘵𝘶𝘣𝘦𝘳𝘤𝘶𝘭𝘰𝘴𝘪𝘴 continues to cause substantial illness globally. In this phase 2b randomized trial, BCG revaccination did not prevent sustained 𝘔. 𝘵𝘶𝘣𝘦𝘳𝘤𝘶𝘭𝘰𝘴𝘪𝘴 infection in IGRA-negative, HIV-negative adolescents. Full BCG REVAX trial results: nej.md/3GKdPkf
#MedSky #IDSky
#MedSky #IDSky
congrats Peter and team
Distribution and transmission of
#tuberculosis in a high-HIV prevalence city
in Malawi: A genomic and spatial analysis 🛟🧪
journals.plos.org/globalpublic...
@uofgshw.bsky.social @jasonandrews.bsky.social @rachaelburke.bsky.social @jsalomon.bsky.social
#tuberculosis in a high-HIV prevalence city
in Malawi: A genomic and spatial analysis 🛟🧪
journals.plos.org/globalpublic...
@uofgshw.bsky.social @jasonandrews.bsky.social @rachaelburke.bsky.social @jsalomon.bsky.social
April 4, 2025 at 8:21 AM
congrats Peter and team
Reposted by mattgroeschel.bsky.social
New review of "Everything Is Tuberculosis" in the @nytimes.com, which calls the book "earnest and empathetic," which is really all I wanted it to be. (And also all I want to be.) www.nytimes.com/2025/03/20/b...
Book Review: ‘Everything Is Tuberculosis,’ by John Green
In a new nonfiction book, the Y.A. novelist describes the disease as a window into “the folly and brilliance and cruelty and compassion of humans.”
www.nytimes.com
March 20, 2025 at 10:46 AM
New review of "Everything Is Tuberculosis" in the @nytimes.com, which calls the book "earnest and empathetic," which is really all I wanted it to be. (And also all I want to be.) www.nytimes.com/2025/03/20/b...
Reposted by mattgroeschel.bsky.social
It’s the world’s most deadly infectious disease. But it strikes the world’s most downtrodden and neglected, including here at home. So we turn our eyes.
Not you, @johngreensbluesky.bsky.social. You’ve made the story of TB personal. And your vivid, moving, vital book makes us grateful you did.
Not you, @johngreensbluesky.bsky.social. You’ve made the story of TB personal. And your vivid, moving, vital book makes us grateful you did.
New review of "Everything Is Tuberculosis" in the @nytimes.com, which calls the book "earnest and empathetic," which is really all I wanted it to be. (And also all I want to be.) www.nytimes.com/2025/03/20/b...
Book Review: ‘Everything Is Tuberculosis,’ by John Green
In a new nonfiction book, the Y.A. novelist describes the disease as a window into “the folly and brilliance and cruelty and compassion of humans.”
www.nytimes.com
March 20, 2025 at 11:18 AM
It’s the world’s most deadly infectious disease. But it strikes the world’s most downtrodden and neglected, including here at home. So we turn our eyes.
Not you, @johngreensbluesky.bsky.social. You’ve made the story of TB personal. And your vivid, moving, vital book makes us grateful you did.
Not you, @johngreensbluesky.bsky.social. You’ve made the story of TB personal. And your vivid, moving, vital book makes us grateful you did.
Reposted by mattgroeschel.bsky.social
Out now in @thelancetinfdis.bsky.social our study demonstrates that the MVA-BN (Imvanex/Jynneos) vaccine is safe & effective against mpox, but a single dose does not sufficiently protect people living with #HIV.
Thank you @ema.europa.eu for support
www.thelancet.com/journals/lan...
1/7
Thank you @ema.europa.eu for support
www.thelancet.com/journals/lan...
1/7
March 19, 2025 at 3:48 PM
Out now in @thelancetinfdis.bsky.social our study demonstrates that the MVA-BN (Imvanex/Jynneos) vaccine is safe & effective against mpox, but a single dose does not sufficiently protect people living with #HIV.
Thank you @ema.europa.eu for support
www.thelancet.com/journals/lan...
1/7
Thank you @ema.europa.eu for support
www.thelancet.com/journals/lan...
1/7
Reposted by mattgroeschel.bsky.social
Gerade breiten sich Maserninfektionen wieder in den USA aus & es gibt wieder Todesfälle. Auch in 🇩🇪 gibt es weiter viele Masernfälle. Dabei ist die MMR Impfung die vielleicht beste & effektivste Impfung aller Zeiten.
Meine Gedanken zu Masern, Impf- u Wissenschaftsskepsis in der @faznet.bsky.social
Meine Gedanken zu Masern, Impf- u Wissenschaftsskepsis in der @faznet.bsky.social
Masern: So gefährlich ist das Geschehen in den USA
Die Masern sind eine der gefährlichsten Infektionskrankheiten. In den USA gibt es nun einen großen Ausbruch. Warum uns das auch in Deutschland interessieren muss.
www.faz.net
March 18, 2025 at 7:12 PM
Gerade breiten sich Maserninfektionen wieder in den USA aus & es gibt wieder Todesfälle. Auch in 🇩🇪 gibt es weiter viele Masernfälle. Dabei ist die MMR Impfung die vielleicht beste & effektivste Impfung aller Zeiten.
Meine Gedanken zu Masern, Impf- u Wissenschaftsskepsis in der @faznet.bsky.social
Meine Gedanken zu Masern, Impf- u Wissenschaftsskepsis in der @faznet.bsky.social
Love it! Time to move beyond SNP clustering = transmission. Although important to not forget host infectiousness, exposure time and contact susceptibility in the equation next to pathogen genomes
We published a cool new paper showing that some M tuberculosis lineages (mainly L1 and L6) seem less transmissible but that's mainly because they have longer initial non-infectious 'latent' periods.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Onset of infectiousness explains differences in transmissibility across Mycobacterium tuberculosis lineages
Mycobacterium tuberculosis complex (MTBC) lineages show substantial variability in virulence, but the epidemiological consequences of this variability…
www.sciencedirect.com
March 15, 2025 at 11:38 AM
Love it! Time to move beyond SNP clustering = transmission. Although important to not forget host infectiousness, exposure time and contact susceptibility in the equation next to pathogen genomes
Reposted by mattgroeschel.bsky.social
see, this plane got measles and was perfectly fine
March 12, 2025 at 5:12 PM
see, this plane got measles and was perfectly fine
Reposted by mattgroeschel.bsky.social
Hello, Bluesky!👋 We are excited to connect with you!🌟
Europe PMC is an open database of global life science research - discover articles, preprints, theses, grants, and more. We talk about scholarly communication, open science, bioinformatics, and meta research. Follow us and join the conversation!
Europe PMC is an open database of global life science research - discover articles, preprints, theses, grants, and more. We talk about scholarly communication, open science, bioinformatics, and meta research. Follow us and join the conversation!
January 28, 2025 at 9:45 AM
Hello, Bluesky!👋 We are excited to connect with you!🌟
Europe PMC is an open database of global life science research - discover articles, preprints, theses, grants, and more. We talk about scholarly communication, open science, bioinformatics, and meta research. Follow us and join the conversation!
Europe PMC is an open database of global life science research - discover articles, preprints, theses, grants, and more. We talk about scholarly communication, open science, bioinformatics, and meta research. Follow us and join the conversation!
Reposted by mattgroeschel.bsky.social
If pubmed is inaccessible at the moment, try @europepmc.org
March 1, 2025 at 5:31 PM
If pubmed is inaccessible at the moment, try @europepmc.org
Reposted by mattgroeschel.bsky.social
🚨 Groundbreaking study reveals how hypoxia shapes immune cell organization in #Tuberculosis granulomas, promoting Mtb persistence. Targeting these metabolic niches could revolutionize TB treatment strategies. A technical tour de force and a major scientific advance!
📖 shorturl.at/WkTgq
📖 shorturl.at/WkTgq
February 24, 2025 at 6:38 AM
🚨 Groundbreaking study reveals how hypoxia shapes immune cell organization in #Tuberculosis granulomas, promoting Mtb persistence. Targeting these metabolic niches could revolutionize TB treatment strategies. A technical tour de force and a major scientific advance!
📖 shorturl.at/WkTgq
📖 shorturl.at/WkTgq
Reposted by mattgroeschel.bsky.social
While the US trashes public research, the ERC proposes to double its budget. That would be huge and an excellent opportunity for scientists in the US to come to democratic 🇪🇺
“ERC succeeds because it’s different. Its simple, tailored procedures allow Europe’s best researchers to thrive. Bureaucratic processes designed for other programmes should not be imposed on it.”
@marialep.bsky.social spoke up for an independent ERC with a doubled budget today @europarl.europa.eu
@marialep.bsky.social spoke up for an independent ERC with a doubled budget today @europarl.europa.eu
February 19, 2025 at 6:06 PM
While the US trashes public research, the ERC proposes to double its budget. That would be huge and an excellent opportunity for scientists in the US to come to democratic 🇪🇺
‚Gaps in TB funding could lead to increased transmission globally.‘ Rapid communication from StopTB on the impact of foreign aid freeze.
StopTB has a new report estimating the impact of the foreign aid freeze.
It's useful to understand the huge impact that global health efforts have everyday, and worrying. Some highlights... 🧵
It's useful to understand the huge impact that global health efforts have everyday, and worrying. Some highlights... 🧵
www.stoptb.org
February 15, 2025 at 8:44 PM
‚Gaps in TB funding could lead to increased transmission globally.‘ Rapid communication from StopTB on the impact of foreign aid freeze.
Reposted by mattgroeschel.bsky.social
We'll try and keep the political posts to a minimum. That said; the only way to defend our wildlife is to become active politically and go after the politicians going after our parks.
Get in this fight, retweet it and follow us at
@altyellonatpark.org
Because it's a world worth saving
Get in this fight, retweet it and follow us at
@altyellonatpark.org
Because it's a world worth saving
November 20, 2024 at 2:51 PM
We'll try and keep the political posts to a minimum. That said; the only way to defend our wildlife is to become active politically and go after the politicians going after our parks.
Get in this fight, retweet it and follow us at
@altyellonatpark.org
Because it's a world worth saving
Get in this fight, retweet it and follow us at
@altyellonatpark.org
Because it's a world worth saving
Reposted by mattgroeschel.bsky.social
Get a first look at the exciting IAS 2025 speaker lineup! Join us this July in Kigali!
👥 We are pleased to share the first round of featured speakers at #IAS2025!
The exciting line-up consists of global health experts who will highlight the latest progress towards ending the #HIV pandemic, from service delivery to treatment & prevention.
The exciting line-up consists of global health experts who will highlight the latest progress towards ending the #HIV pandemic, from service delivery to treatment & prevention.
Featured speakers | IAS 2025
Alinane Linda Nyondo-Mipando Kamuzu University of Health Sciences, Malawi View Alinane Linda Nyondo-Mipando Linda Nyondo-Mipando is a registered nurse midwife and an Associate Professor of Health Syst...
www.iasociety.org
January 30, 2025 at 6:22 PM
Get a first look at the exciting IAS 2025 speaker lineup! Join us this July in Kigali!
Reposted by mattgroeschel.bsky.social
Friendly reminder that tuberculosis isn’t an “1800s disease” and is in fact THE infectious disease that kills the most people in the 21st century. It is preventable, treatable, and curable, and yet it still kills over 1.2 million people a year because we don’t put the resources where the disease is.
“An ongoing tuberculosis outbreak in Kansas has become the largest in recorded history in the United States”
Kansas tuberculosis outbreak is now America's largest in recorded history
Kansas public health officials say the state's ongoing tuberculosis outbreak is the largest since the CDC started reporting TB cases in the 1950s.
www.cjonline.com
January 25, 2025 at 10:48 PM
Friendly reminder that tuberculosis isn’t an “1800s disease” and is in fact THE infectious disease that kills the most people in the 21st century. It is preventable, treatable, and curable, and yet it still kills over 1.2 million people a year because we don’t put the resources where the disease is.
Important lessons from South Africa on screening contacts of active TB: ‚more than 80% of confirmed TB cases among HHC were asymptomatic. CXR screening missed more than 40% of these asymptomatic cases‘
Sharing our latest preprint about screening for asymptomatic TB in adults, led by Simon Mendelsohn. The more you look the more you find!
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Screening for Asymptomatic Tuberculosis among Adults with Household Exposure to a Patient with Pulmonary Tuberculosis
Background More than half of tuberculosis (TB) detected by community prevalence surveys is classified as asymptomatic. We evaluated yield of symptom and chest radiograph (CXR) screening of TB-exposed ...
www.medrxiv.org
January 21, 2025 at 5:33 PM
Important lessons from South Africa on screening contacts of active TB: ‚more than 80% of confirmed TB cases among HHC were asymptomatic. CXR screening missed more than 40% of these asymptomatic cases‘
Great that your book will be available in German.
Coming March 18th from my long-time German publisher Hanser. Very grateful for their support!
January 13, 2025 at 3:55 PM
Great that your book will be available in German.
Reposted by mattgroeschel.bsky.social
Big Change in TB treatment recommendations. 6 months of RIPE (also called RHEZ) was once the only treatment in town for susceptible TB. Now there's an all oral FOUR months of:
Rifapentine
INH
PZA
Moxifloxacin
t.co/8EHiWEhEk8
Rifapentine
INH
PZA
Moxifloxacin
t.co/8EHiWEhEk8
January 2, 2025 at 8:57 PM
Big Change in TB treatment recommendations. 6 months of RIPE (also called RHEZ) was once the only treatment in town for susceptible TB. Now there's an all oral FOUR months of:
Rifapentine
INH
PZA
Moxifloxacin
t.co/8EHiWEhEk8
Rifapentine
INH
PZA
Moxifloxacin
t.co/8EHiWEhEk8
Reposted by mattgroeschel.bsky.social
Immunopeptidomics (impep) friends, have you ever done impep to ID peptides after soluble protein delivery to phagocytes to look at peptides generated by XP?
December 12, 2024 at 1:28 PM
Immunopeptidomics (impep) friends, have you ever done impep to ID peptides after soluble protein delivery to phagocytes to look at peptides generated by XP?
Reposted by mattgroeschel.bsky.social
HIV - Heilung in Sicht?
Sehr informativer und differenzierter Artikel in der @taz.de über die Fortschritte und Herausforderungen in der HIV-Forschung & Therapie und der Lange Weg zur Heilung.
@cgaebler.bsky.social gibt spannende Einblicke in seine Forschung an der Klinik f. Infektiologie #Charité
Sehr informativer und differenzierter Artikel in der @taz.de über die Fortschritte und Herausforderungen in der HIV-Forschung & Therapie und der Lange Weg zur Heilung.
@cgaebler.bsky.social gibt spannende Einblicke in seine Forschung an der Klinik f. Infektiologie #Charité
HIV-Forschung: Kurz vor der Heilung?
Einst bedeutete Aids den Tod, heute ist es eine gut behandelbare Erkrankung. Aber heilen lässt sie sich noch nicht. In Berlin will man das ändern.
taz.de
December 4, 2024 at 2:44 PM
HIV - Heilung in Sicht?
Sehr informativer und differenzierter Artikel in der @taz.de über die Fortschritte und Herausforderungen in der HIV-Forschung & Therapie und der Lange Weg zur Heilung.
@cgaebler.bsky.social gibt spannende Einblicke in seine Forschung an der Klinik f. Infektiologie #Charité
Sehr informativer und differenzierter Artikel in der @taz.de über die Fortschritte und Herausforderungen in der HIV-Forschung & Therapie und der Lange Weg zur Heilung.
@cgaebler.bsky.social gibt spannende Einblicke in seine Forschung an der Klinik f. Infektiologie #Charité
Interesting study showing several host RNA signatures poorly generalized to a new cohort predicting sputum conversion at 8 weeks.
🆕️⚡️⚡️Selected TB blood RNA signatures& CRP do not provide biomarkers of microbiological clearance to support TB treatment cessation at 8 weeks
CRP achieved marginal albeit statistically significant discrimination/AUROC 0.69(95%CI 0.52–0.87) #idsky #medsky #tbsky
publications.ersnet.org/content/erj/...
CRP achieved marginal albeit statistically significant discrimination/AUROC 0.69(95%CI 0.52–0.87) #idsky #medsky #tbsky
publications.ersnet.org/content/erj/...
December 3, 2024 at 7:30 PM
Interesting study showing several host RNA signatures poorly generalized to a new cohort predicting sputum conversion at 8 weeks.