Matthew Bowler
@mattbowler.bsky.social
🇪🇺 🇬🇧 🇺🇸 🇫🇷 scientist, project leader @EMBL @esrfsynchrotron #beamline @ID30_MASSIF1 #kinases #pathogens co-editor 📓 @ActaCrystF opinions my own
Another amazing drug repurposing study from Silvia Diaz Martin Alexandre Bougdour Christopher Swale and @hakimi.bsky.social Very pleased to have supported the structural work on our favorite protein family - the kinases!
Nature Com. now live! 🎉 Silvia’s amazing PhD supervised by Alex “the Greatest” & Christopher’s big-bang contribution. Huge thanks to our stellar team & collaborators. We went fishing in the FDA pond and hooked LY2090314 🎣 Blocks GSK3 🎯in #Toxoplasma & #Crypto
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Structural and functional characterization of TgGSK3, a druggable kinase in Toxoplasma gondii - Nature Communications
Researchers identify the cancer drug LY2090314 as a potent inhibitor of Toxoplasma gondii and Cryptosporidium and report the first crystal structure of the parasite kinase TgGSK3 bound to it, validati...
www.nature.com
November 5, 2025 at 6:10 PM
Another amazing drug repurposing study from Silvia Diaz Martin Alexandre Bougdour Christopher Swale and @hakimi.bsky.social Very pleased to have supported the structural work on our favorite protein family - the kinases!
Reposted by Matthew Bowler
Nature Com. now live! 🎉 Silvia’s amazing PhD supervised by Alex “the Greatest” & Christopher’s big-bang contribution. Huge thanks to our stellar team & collaborators. We went fishing in the FDA pond and hooked LY2090314 🎣 Blocks GSK3 🎯in #Toxoplasma & #Crypto
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Structural and functional characterization of TgGSK3, a druggable kinase in Toxoplasma gondii - Nature Communications
Researchers identify the cancer drug LY2090314 as a potent inhibitor of Toxoplasma gondii and Cryptosporidium and report the first crystal structure of the parasite kinase TgGSK3 bound to it, validati...
www.nature.com
November 5, 2025 at 3:24 PM
Nature Com. now live! 🎉 Silvia’s amazing PhD supervised by Alex “the Greatest” & Christopher’s big-bang contribution. Huge thanks to our stellar team & collaborators. We went fishing in the FDA pond and hooked LY2090314 🎣 Blocks GSK3 🎯in #Toxoplasma & #Crypto
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Matthew Bowler
For sure, Macron’s troubles are partly of his own making. But there is something immensely sad about a pro-European leader and standard-bearer for the democratic centre ending up with such a political mess
October 8, 2025 at 4:11 PM
For sure, Macron’s troubles are partly of his own making. But there is something immensely sad about a pro-European leader and standard-bearer for the democratic centre ending up with such a political mess
Reposted by Matthew Bowler
These results are truly impressive! But I do worry that #cryoEM is moving into a phase where progress is made by optimizing parameter settings for black box programs. The devil is often in the details, and I am not sure how this could be implemented in #relion, as stated, without more info.
This one is a bit of a departure from the usual and definitely a work in progress!
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
September 21, 2025 at 7:42 AM
Reposted by Matthew Bowler
Zeus had his Hydra ⚔️, now Toxoplasma has its own.
Meet Hydra: not a monster, but a brand-new protein domain.
It multimerizes like crazy & rewrites the chromatin landscape 🧬 in Toxoplasma.
Our team and colleagues from @embl.org #Grenoble just dropped the preprint 👉
www.biorxiv.org/content/10.1...
Meet Hydra: not a monster, but a brand-new protein domain.
It multimerizes like crazy & rewrites the chromatin landscape 🧬 in Toxoplasma.
Our team and colleagues from @embl.org #Grenoble just dropped the preprint 👉
www.biorxiv.org/content/10.1...
September 6, 2025 at 9:03 AM
Zeus had his Hydra ⚔️, now Toxoplasma has its own.
Meet Hydra: not a monster, but a brand-new protein domain.
It multimerizes like crazy & rewrites the chromatin landscape 🧬 in Toxoplasma.
Our team and colleagues from @embl.org #Grenoble just dropped the preprint 👉
www.biorxiv.org/content/10.1...
Meet Hydra: not a monster, but a brand-new protein domain.
It multimerizes like crazy & rewrites the chromatin landscape 🧬 in Toxoplasma.
Our team and colleagues from @embl.org #Grenoble just dropped the preprint 👉
www.biorxiv.org/content/10.1...
In our new paper @asbmb.bsky.social JBC we detail our surprising discovery that the MAP2Ks can use ADP to phosphorylate their substrate MAPKs – driven by @paulineJYX @ErikaPellegri13 and @jvonvelsen
t.co/spLZbaz5Wk
t.co/spLZbaz5Wk
https://www.jbc.org/article/S0021-9258(25)02429-9/fulltext
t.co
August 20, 2025 at 5:28 AM
In our new paper @asbmb.bsky.social JBC we detail our surprising discovery that the MAP2Ks can use ADP to phosphorylate their substrate MAPKs – driven by @paulineJYX @ErikaPellegri13 and @jvonvelsen
t.co/spLZbaz5Wk
t.co/spLZbaz5Wk
Reposted by Matthew Bowler
Thrilled to share my first paper, now out in
@natmicrobiol.nature.com! Huge thanks to my amazing supervisor @hakimi.bsky.social and everyone who contributed to this work!
www.nature.com/articles/s41...
@natmicrobiol.nature.com! Huge thanks to my amazing supervisor @hakimi.bsky.social and everyone who contributed to this work!
www.nature.com/articles/s41...
An ISWI-related chromatin remodeller regulates stage-specific gene expression in Toxoplasma gondii - Nature Microbiology
Toxoplasma gondii evolved two ISWI remodellers, TgSNF2h and TgSNF2L. TgSNF2h forms a complex that insulates active genes, regulates MORC-driven sexual commitment and ensures precise gene expression, s...
www.nature.com
April 13, 2025 at 11:03 AM
Thrilled to share my first paper, now out in
@natmicrobiol.nature.com! Huge thanks to my amazing supervisor @hakimi.bsky.social and everyone who contributed to this work!
www.nature.com/articles/s41...
@natmicrobiol.nature.com! Huge thanks to my amazing supervisor @hakimi.bsky.social and everyone who contributed to this work!
www.nature.com/articles/s41...
Reposted by Matthew Bowler
1/ Today is #WorldMalariaDay.
At EMBL, we join the global efforts to control malaria with innovative biological approaches.
👉 Swipe through to discover how scientists at EMBL study the malaria parasite and drive progress in global health.
🔗 Read more: www.embl.org/news/tag/mal...
At EMBL, we join the global efforts to control malaria with innovative biological approaches.
👉 Swipe through to discover how scientists at EMBL study the malaria parasite and drive progress in global health.
🔗 Read more: www.embl.org/news/tag/mal...
April 25, 2025 at 8:58 AM
1/ Today is #WorldMalariaDay.
At EMBL, we join the global efforts to control malaria with innovative biological approaches.
👉 Swipe through to discover how scientists at EMBL study the malaria parasite and drive progress in global health.
🔗 Read more: www.embl.org/news/tag/mal...
At EMBL, we join the global efforts to control malaria with innovative biological approaches.
👉 Swipe through to discover how scientists at EMBL study the malaria parasite and drive progress in global health.
🔗 Read more: www.embl.org/news/tag/mal...
Reposted by Matthew Bowler
We are very happy. The Editors of Journal of Applied Crystallography have chosen figures from our article (journals.iucr.org/j/issues/202...) to feature as the cover image for the February 2025 issue. THANKS
February 4, 2025 at 9:20 PM
We are very happy. The Editors of Journal of Applied Crystallography have chosen figures from our article (journals.iucr.org/j/issues/202...) to feature as the cover image for the February 2025 issue. THANKS
RIP Sine. She hired me as beamline scientist on ID14 @esrfsynchrotron 17 years ago and was a great director putting automation to the fore ultimately leading to @ID30_MASSIF1
It is with profound sadness that the ESRF mourns the passing of Professor Sine Larsen, former ESRF Director of Research for Life Sciences from 2003 to 2009, Professor Emerita at the University of Copenhagen and President of IUCr from 2008 to 2014.
www.esrf.fr/home/news/ge...
www.esrf.fr/home/news/ge...
January 4, 2025 at 9:47 PM
RIP Sine. She hired me as beamline scientist on ID14 @esrfsynchrotron 17 years ago and was a great director putting automation to the fore ultimately leading to @ID30_MASSIF1
Reposted by Matthew Bowler
Counter-diffusion studies of human transthyretin: the growth of high-quality crystals for X-ray and neutron crystallography doi.org/10.1107/S160...
Counter-diffusion studies of human transthyretin: the growth of high-quality crystals for X-ray and neutron crystallography
X-ray and neutron diffraction studies of human transthyretin crystallized using the non-convective counter-diffusion method provide important insights into crystallization quality relevant for the gro...
doi.org
December 24, 2024 at 8:35 PM
Counter-diffusion studies of human transthyretin: the growth of high-quality crystals for X-ray and neutron crystallography doi.org/10.1107/S160...
Reposted by Matthew Bowler
EMBL scientists discovered that dextromethorphan (DXM) may treat lung #fibrosis. 🫁
DXM is an @fda.gov-approved active ingredient in nonprescription cough syrups. This study, published in Science Translational Medicine, shows how this drug may reduce lung scars.
🧪💊 www.embl.org/news/science...
DXM is an @fda.gov-approved active ingredient in nonprescription cough syrups. This study, published in Science Translational Medicine, shows how this drug may reduce lung scars.
🧪💊 www.embl.org/news/science...
December 18, 2024 at 7:08 PM
EMBL scientists discovered that dextromethorphan (DXM) may treat lung #fibrosis. 🫁
DXM is an @fda.gov-approved active ingredient in nonprescription cough syrups. This study, published in Science Translational Medicine, shows how this drug may reduce lung scars.
🧪💊 www.embl.org/news/science...
DXM is an @fda.gov-approved active ingredient in nonprescription cough syrups. This study, published in Science Translational Medicine, shows how this drug may reduce lung scars.
🧪💊 www.embl.org/news/science...
Reposted by Matthew Bowler
ChimeraX 1.9 has been released and is available now on our website
Download UCSF ChimeraX
www.cgl.ucsf.edu
December 13, 2024 at 5:49 PM
ChimeraX 1.9 has been released and is available now on our website
Reposted by Matthew Bowler
A top european science job opened to applications:
Scientific director @pasteur.fr
research.pasteur.fr/en/job/insti...
Scientific director @pasteur.fr
research.pasteur.fr/en/job/insti...
The Institut Pasteur is looking for a Scientific Director | Research - Institut Pasteur
research.pasteur.fr
November 22, 2024 at 6:14 PM
A top european science job opened to applications:
Scientific director @pasteur.fr
research.pasteur.fr/en/job/insti...
Scientific director @pasteur.fr
research.pasteur.fr/en/job/insti...
📢This year marks 10 years of fully automatic data collection @esrfsynchrotron @EMBLGrenoble ! Join us on the 5th Dec to celebrate the technical developments and scientific successes of @ID30_MASSIF1 👉 esrf.fr/home/events/co…
November 18, 2024 at 1:05 PM
📢This year marks 10 years of fully automatic data collection @esrfsynchrotron @EMBLGrenoble ! Join us on the 5th Dec to celebrate the technical developments and scientific successes of @ID30_MASSIF1 👉 esrf.fr/home/events/co…
Reposted by Matthew Bowler
ok to all synchrotron and cryoEM people out there ...a hastily put together starter pack! go.bsky.app/UThze5z
November 15, 2024 at 9:45 PM
ok to all synchrotron and cryoEM people out there ...a hastily put together starter pack! go.bsky.app/UThze5z