We believe that maintaining MAP kinase signaling when ATP levels have been depleted, for example under hypoxic conditions, that occur under a number of cell stresses, such as cancer and atherosclerosis, would be an advantage.

Using radiolabeled nucleotides @PaulineJYX was able to demonstrate clearly that the beta-phosphate is transferred to p38. She then also showed that the other MAP2Ks also show this property, but that RIP2K does not.

While preparing the MKK6-p38 complex for structural studies (science.org/doi/10.1126/sc…) we noticed that p38 was activated by MKK6 in the presence of ADP as well as ATP