MaRtiNA Hallegger
@martinahallegger.bsky.social
RNA biochemist, RNA-network enthusiast and IMCM fellow @NDMOxford at the @UniofOxford, former @UKDRI at King’s and @TheCrick. Condenses RNA to study ALS and Dementia. High 5 4 RNA
Reposted by MaRtiNA Hallegger
🤯🤯
✨New preprint!
🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al!
Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬
🔗👇
🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al!
Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬
🔗👇
December 9, 2025 at 7:55 AM
🤯🤯
Reposted by MaRtiNA Hallegger
Excited to share the latest work from postdocs Ameya
and Zach! We thought about how multinucleate cells are able to maintain N:C ratio, and found a condensate rheostat that regulates translation of cell cycle + growth mRNAs. Check it out! www.biorxiv.org/content/10.1...
and Zach! We thought about how multinucleate cells are able to maintain N:C ratio, and found a condensate rheostat that regulates translation of cell cycle + growth mRNAs. Check it out! www.biorxiv.org/content/10.1...
Condensates act as translation hubs to coordinate multinucleate cell growth
Coordination between growth and division is a fundamental feature of cells. In many syncytia, cell growth must couple with multiple nuclear divisions in one cytoplasm. In the fungus, Ashbya gossypii, ...
www.biorxiv.org
January 8, 2025 at 8:53 PM
Excited to share the latest work from postdocs Ameya
and Zach! We thought about how multinucleate cells are able to maintain N:C ratio, and found a condensate rheostat that regulates translation of cell cycle + growth mRNAs. Check it out! www.biorxiv.org/content/10.1...
and Zach! We thought about how multinucleate cells are able to maintain N:C ratio, and found a condensate rheostat that regulates translation of cell cycle + growth mRNAs. Check it out! www.biorxiv.org/content/10.1...
Reposted by MaRtiNA Hallegger
We also have a range of posters today, so please come and check them out this evening! #alsmndsymp
December 6, 2025 at 4:43 PM
We also have a range of posters today, so please come and check them out this evening! #alsmndsymp
Reposted by MaRtiNA Hallegger
🚨 NEW: One of the largest COVID-19 vaccine studies ever (28 MILLION people in France) just dropped.
Results?
• 74% lower risk of death from severe COVID-19
• 25% lower risk of all-cause mortality
• No increase in 4-year mortality
#BlueSky #MedSky #IDSky #SciSky #NewsSky #PedsSky #ObSky #NurseSky
Results?
• 74% lower risk of death from severe COVID-19
• 25% lower risk of all-cause mortality
• No increase in 4-year mortality
#BlueSky #MedSky #IDSky #SciSky #NewsSky #PedsSky #ObSky #NurseSky
December 5, 2025 at 2:50 AM
Reposted by MaRtiNA Hallegger
Research Assistant Vacancy Oxford Centre for Human Genetics for iPSC dopamine neuron studies in the Lang Group exploring glial neuronal roles in Parkinsons disease. Closing date: 2nd January
www.dementiaresearcher.nihr.ac.uk/job/research...
www.dementiaresearcher.nihr.ac.uk/job/research...
Research Assistant: iPSC Dopamine Neuron Models
Research Assistant Oxford Centre for Human Genetics for iPSC dopamine neuron studies in the Lang Group exploring glial neuronal roles in Parkinsons disease
www.dementiaresearcher.nihr.ac.uk
December 5, 2025 at 9:36 AM
Research Assistant Vacancy Oxford Centre for Human Genetics for iPSC dopamine neuron studies in the Lang Group exploring glial neuronal roles in Parkinsons disease. Closing date: 2nd January
www.dementiaresearcher.nihr.ac.uk/job/research...
www.dementiaresearcher.nihr.ac.uk/job/research...
Reposted by MaRtiNA Hallegger
New pipeline to implant human chromosomes into mouse cells and back again signals first step in mammoth undertaking to synthesise the human genome.
Read more about the achievement from LMB’s PNAC Division as part of the SynHG project: www2.mrc-lmb.cam.ac.uk/transplant-o...
#LMBResearch
Read more about the achievement from LMB’s PNAC Division as part of the SynHG project: www2.mrc-lmb.cam.ac.uk/transplant-o...
#LMBResearch
December 5, 2025 at 9:51 AM
New pipeline to implant human chromosomes into mouse cells and back again signals first step in mammoth undertaking to synthesise the human genome.
Read more about the achievement from LMB’s PNAC Division as part of the SynHG project: www2.mrc-lmb.cam.ac.uk/transplant-o...
#LMBResearch
Read more about the achievement from LMB’s PNAC Division as part of the SynHG project: www2.mrc-lmb.cam.ac.uk/transplant-o...
#LMBResearch
Reposted by MaRtiNA Hallegger
I am happy to share that my postdoctoral work in the @gerlichlab.bsky.social at @imbavienna.bsky.social is finally out 🎉!
Our study reveals how cohesin guides focused and accurate homology search.
Read more 👉 www.science.org/doi/10.1126/...
Follow along for key insights and updates! 🧵
Our study reveals how cohesin guides focused and accurate homology search.
Read more 👉 www.science.org/doi/10.1126/...
Follow along for key insights and updates! 🧵
Cohesin guides homology search during DNA repair using loops and sister chromatid linkages
Accurate repair of DNA double-strand breaks (DSBs) is essential for genome stability, and defective repair underlies diseases such as cancer. Homologous recombination uses an intact homologous sequenc...
www.science.org
December 4, 2025 at 8:18 PM
I am happy to share that my postdoctoral work in the @gerlichlab.bsky.social at @imbavienna.bsky.social is finally out 🎉!
Our study reveals how cohesin guides focused and accurate homology search.
Read more 👉 www.science.org/doi/10.1126/...
Follow along for key insights and updates! 🧵
Our study reveals how cohesin guides focused and accurate homology search.
Read more 👉 www.science.org/doi/10.1126/...
Follow along for key insights and updates! 🧵
Reposted by MaRtiNA Hallegger
Very nice paper from Yi Liu's lab on how the CCR4-NOT and PAXT complexes repress expression of mRNAs with low codon usage values by promoting their nuclear decay. Many codon effects likely boil down to GC-content.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Nuclear effects play an important role in determining codon usage-dependent human gene expression - Nature Communications
Codon usage influences gene expression by affecting how efficiently genes are read and processed. Here, the authors identify nuclear factors, including CNOT4, the RNA exosome, and the PAXT complex, th...
www.nature.com
December 4, 2025 at 8:13 PM
Very nice paper from Yi Liu's lab on how the CCR4-NOT and PAXT complexes repress expression of mRNAs with low codon usage values by promoting their nuclear decay. Many codon effects likely boil down to GC-content.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by MaRtiNA Hallegger
To Oxford, to talk to the Biochemistry Society about DNA and Rosalind Franklin. Talk is at 19:00 in St Peter's College if you fancy coming along.
December 4, 2025 at 9:42 AM
To Oxford, to talk to the Biochemistry Society about DNA and Rosalind Franklin. Talk is at 19:00 in St Peter's College if you fancy coming along.
Reposted by MaRtiNA Hallegger
PolyA_DB v4: systematic polyA site identification and isoform annotation in human and mouse genomes using 3′ end and long-read sequencing data.#PolyA #IsoformAnnotation #Genomics #Bioinformatics #NAR @narjournal.bsky.social 🧪🧬 🖥️
academic.oup.com/nar/advance-...
academic.oup.com/nar/advance-...
November 30, 2025 at 9:31 AM
PolyA_DB v4: systematic polyA site identification and isoform annotation in human and mouse genomes using 3′ end and long-read sequencing data.#PolyA #IsoformAnnotation #Genomics #Bioinformatics #NAR @narjournal.bsky.social 🧪🧬 🖥️
academic.oup.com/nar/advance-...
academic.oup.com/nar/advance-...
Reposted by MaRtiNA Hallegger
Researchers at the Crick, @psich.bsky.social and @esrf.fr have developed a new way to look deeper into brain cell connections by using a particle accelerator and a kind of resin borrowed from the aerospace industry.
www.crick.ac.uk/news/2025-11...
www.crick.ac.uk/news/2025-11...
From aerospace to neuroscience: new imaging tech captures the brain’s intricate connections
Inspired by technologies used in aerospace engineering, scientists have developed a way to capture the brain’s intricate structures using X-rays without destroying the samples.
www.crick.ac.uk
November 27, 2025 at 12:10 PM
Researchers at the Crick, @psich.bsky.social and @esrf.fr have developed a new way to look deeper into brain cell connections by using a particle accelerator and a kind of resin borrowed from the aerospace industry.
www.crick.ac.uk/news/2025-11...
www.crick.ac.uk/news/2025-11...
Reposted by MaRtiNA Hallegger
We show structural details of TDP-43's C-terminal helix assembly into functional multimers, explaining dysfunction caused by several disease mutations (in Nature Comm). Appropriate for Thanksgiving day, there is a critical tryptophan! with @mittalgrouptamu.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Structural details of helix-mediated multimerization of the conserved region of TDP-43 C-terminal domain - Nature Communications
RNA-binding protein TDP-43 contains a region forming a dynamic α-helical multimer that accounts for its functional role, evolutionary conservation, and disruption in amyotrophic lateral sclerosis, mak...
www.nature.com
November 27, 2025 at 7:13 PM
We show structural details of TDP-43's C-terminal helix assembly into functional multimers, explaining dysfunction caused by several disease mutations (in Nature Comm). Appropriate for Thanksgiving day, there is a critical tryptophan! with @mittalgrouptamu.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by MaRtiNA Hallegger
I wish I didn’t have to share this. But the BBC has decided to censor my first Reith Lecture.
They deleted the line in which I describe Donald Trump as “the most openly corrupt president in American history.” /1
They deleted the line in which I describe Donald Trump as “the most openly corrupt president in American history.” /1
November 25, 2025 at 9:26 AM
I wish I didn’t have to share this. But the BBC has decided to censor my first Reith Lecture.
They deleted the line in which I describe Donald Trump as “the most openly corrupt president in American history.” /1
They deleted the line in which I describe Donald Trump as “the most openly corrupt president in American history.” /1
Reposted by MaRtiNA Hallegger
Exciting Symposium on Biopolymers coming up in Mainz in March 2026!
Great lineup of speakers from both the polymer and life sciences 👇
Great lineup of speakers from both the polymer and life sciences 👇
Registrations are now open for the 1st International Symposium on Polymer Concepts in Cellular Function
📍Venue: Gonsberg Lounge, Mainz
📅 Dates: 4–6 Mar. 2026
🗓️ Registration & Abstract Submission Deadline: 15 Jan. 2026
Register: crc1551.com/sfb1551-inte...
We look forward to welcoming you in Mainz!
📍Venue: Gonsberg Lounge, Mainz
📅 Dates: 4–6 Mar. 2026
🗓️ Registration & Abstract Submission Deadline: 15 Jan. 2026
Register: crc1551.com/sfb1551-inte...
We look forward to welcoming you in Mainz!
November 25, 2025 at 5:54 PM
Exciting Symposium on Biopolymers coming up in Mainz in March 2026!
Great lineup of speakers from both the polymer and life sciences 👇
Great lineup of speakers from both the polymer and life sciences 👇
Which TDP-43 regulated events go first? Very exciting to read this! No need for Angst on here!
Man do I miss the good ole days when I could tweet a new paper without thinking about the existential dread of feeding the algorithms.
Anyway - on the off chance this still works in the way I remember,
We've got a new preprint!
www.biorxiv.org/content/10.1...
Anyway - on the off chance this still works in the way I remember,
We've got a new preprint!
www.biorxiv.org/content/10.1...
Sensitivity to TDP-43 loss and degradation resistance determine cryptic exon biomarker potential
Cryptic splicing caused by TDP-43 proteinopathy is a hallmark of the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). However, which cryptic splicing e...
www.biorxiv.org
November 24, 2025 at 12:09 PM
Which TDP-43 regulated events go first? Very exciting to read this! No need for Angst on here!
Reposted by MaRtiNA Hallegger
Man do I miss the good ole days when I could tweet a new paper without thinking about the existential dread of feeding the algorithms.
Anyway - on the off chance this still works in the way I remember,
We've got a new preprint!
www.biorxiv.org/content/10.1...
Anyway - on the off chance this still works in the way I remember,
We've got a new preprint!
www.biorxiv.org/content/10.1...
Sensitivity to TDP-43 loss and degradation resistance determine cryptic exon biomarker potential
Cryptic splicing caused by TDP-43 proteinopathy is a hallmark of the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). However, which cryptic splicing e...
www.biorxiv.org
November 24, 2025 at 11:28 AM
Man do I miss the good ole days when I could tweet a new paper without thinking about the existential dread of feeding the algorithms.
Anyway - on the off chance this still works in the way I remember,
We've got a new preprint!
www.biorxiv.org/content/10.1...
Anyway - on the off chance this still works in the way I remember,
We've got a new preprint!
www.biorxiv.org/content/10.1...
One week left to apply! Great Opportunity! Make sure to check out the joint project in the Hallegger and Fowler lab! Please, share and repost!
A new round of Oxford-GSK Clinical DPhil applications are open, deadline Dec 2nd. If you are ST4 and above, check out the projects in neurodegeneration, liver, respiratory and fibrotic pathology. www.ox.ac.uk/admissions/g...
DPhil in Biomedical and Clinical Sciences (Oxford-GSK) | University
About the courseThe DPhil in Biomedical and Clinical Sciences (Oxford-GSK) aims to address an unmet need among clinicians for training in data science and translational medicine.
www.ox.ac.uk
November 24, 2025 at 12:06 PM
One week left to apply! Great Opportunity! Make sure to check out the joint project in the Hallegger and Fowler lab! Please, share and repost!
Reposted by MaRtiNA Hallegger
(Part 2/2) The model uncovers how homotypic and heterotypic interactions shape condensate architecture and reveals how protein dynamics differ depending on whether they are DNA-bound, in the dense phase, or freely diffusing.
November 18, 2025 at 8:03 PM
(Part 2/2) The model uncovers how homotypic and heterotypic interactions shape condensate architecture and reveals how protein dynamics differ depending on whether they are DNA-bound, in the dense phase, or freely diffusing.
Reposted by MaRtiNA Hallegger
This work is now officially published
@natsmb.nature.com
with some fun new analyses included in the revised version. Congratulations to all the authors! @connyyu.bsky.social @rappsilber.bsky.social @lrsinn.bsky.social @fjoreilly.bsky.social www.nature.com/articles/s41...
@natsmb.nature.com
with some fun new analyses included in the revised version. Congratulations to all the authors! @connyyu.bsky.social @rappsilber.bsky.social @lrsinn.bsky.social @fjoreilly.bsky.social www.nature.com/articles/s41...
November 15, 2025 at 9:51 AM
This work is now officially published
@natsmb.nature.com
with some fun new analyses included in the revised version. Congratulations to all the authors! @connyyu.bsky.social @rappsilber.bsky.social @lrsinn.bsky.social @fjoreilly.bsky.social www.nature.com/articles/s41...
@natsmb.nature.com
with some fun new analyses included in the revised version. Congratulations to all the authors! @connyyu.bsky.social @rappsilber.bsky.social @lrsinn.bsky.social @fjoreilly.bsky.social www.nature.com/articles/s41...
Reposted by MaRtiNA Hallegger
Developing new treatments is essential for MND, but the process is lengthy and people with MND don’t have time to wait.
Repurposing means we can quickly see if any already available treatments could be effective in MND and get them into clinical trials as soon as possible.
Read more👇
Repurposing means we can quickly see if any already available treatments could be effective in MND and get them into clinical trials as soon as possible.
Read more👇
Drug development is a complex and costly process.
By using medicines approved for other conditions, we can overcome barriers in drug development.
Read our blog explaining why we believe repurposed drugs could help us find new treatments for #MND/#ALS.
ukmndri.org/2025/11/13/r...
By using medicines approved for other conditions, we can overcome barriers in drug development.
Read our blog explaining why we believe repurposed drugs could help us find new treatments for #MND/#ALS.
ukmndri.org/2025/11/13/r...
Repurposed Drugs: Accelerating MND Treatment Discovery
Discover how repurposed drugs are helping accelerate the search for effective treatments for MND through innovative UK research.
ukmndri.org
November 14, 2025 at 12:28 PM
Developing new treatments is essential for MND, but the process is lengthy and people with MND don’t have time to wait.
Repurposing means we can quickly see if any already available treatments could be effective in MND and get them into clinical trials as soon as possible.
Read more👇
Repurposing means we can quickly see if any already available treatments could be effective in MND and get them into clinical trials as soon as possible.
Read more👇
Reposted by MaRtiNA Hallegger
Our story on GroEL/ES action during cotranslational folding is now published @natcomms.nature.com. Led by former-student Alzbeta Roeselova, and in collaboration with Rado Enchev's lab @crick.ac.uk.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
GroEL/ES chaperonin unfolds then encapsulates a nascent protein on the ribosome - Nature Communications
The GroEL/ES chaperonin can act during protein synthesis to promote folding. Here, Roeselová et al. show how GroEL captures, remodels and sequesters nascent proteins in its central chamber, while they...
www.nature.com
November 14, 2025 at 1:49 PM
Our story on GroEL/ES action during cotranslational folding is now published @natcomms.nature.com. Led by former-student Alzbeta Roeselova, and in collaboration with Rado Enchev's lab @crick.ac.uk.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by MaRtiNA Hallegger
It's coming again!! Can't wait...
How to tackle emerging questions in cellular organisation, adaptation, and robustness? Join #EESPhaseSeparation! 🧬🦠
Bringing together scientists from diverse fields to foster new discoveries in condensate biology.
Submit your abstract by 10 Feb: s.embl.org/ees26-08-bl
📅 19 – 22 May 2026
Bringing together scientists from diverse fields to foster new discoveries in condensate biology.
Submit your abstract by 10 Feb: s.embl.org/ees26-08-bl
📅 19 – 22 May 2026
November 13, 2025 at 6:58 PM
It's coming again!! Can't wait...
Reposted by MaRtiNA Hallegger
Latest #CDlab paper on nanopore protein sequencing on @biorxivpreprint.bsky.social: www.biorxiv.org/cgi/content/...
Here, Justas Ritmejeris, @xiuqichen.bsky.social, collaborator @albadalab.bsky.social and me developed a conjugation chemistry strategy for nanopore sequencing of natural peptides!
Here, Justas Ritmejeris, @xiuqichen.bsky.social, collaborator @albadalab.bsky.social and me developed a conjugation chemistry strategy for nanopore sequencing of natural peptides!
November 13, 2025 at 7:16 PM
Latest #CDlab paper on nanopore protein sequencing on @biorxivpreprint.bsky.social: www.biorxiv.org/cgi/content/...
Here, Justas Ritmejeris, @xiuqichen.bsky.social, collaborator @albadalab.bsky.social and me developed a conjugation chemistry strategy for nanopore sequencing of natural peptides!
Here, Justas Ritmejeris, @xiuqichen.bsky.social, collaborator @albadalab.bsky.social and me developed a conjugation chemistry strategy for nanopore sequencing of natural peptides!
Reposted by MaRtiNA Hallegger
Check out our work on RNA structure in introns! Testing >100k base pairing patterns, we found that RNA structure can predictably tune gene expression. Just by changing intron sequence, we see a dynamic range of regulation comparable to messing e.g. with promoters. @karlaneugebauer.bsky.social
Control of gene output by intron RNA structure https://www.biorxiv.org/content/10.1101/2025.11.08.687378v1
November 10, 2025 at 5:32 PM
Check out our work on RNA structure in introns! Testing >100k base pairing patterns, we found that RNA structure can predictably tune gene expression. Just by changing intron sequence, we see a dynamic range of regulation comparable to messing e.g. with promoters. @karlaneugebauer.bsky.social