Dr. Mark A. Hix
@markahix.bsky.social
PhD theoretical chemist for biomolecules, protein engineering, QM/MM, excited states, automation | he/him/his | Opinions my own.
This has to be the thing I hate most about the LLM/AI overhype. I school, I was taught sentence structure, spelling, and grammar. Because these models are trained on (stolen) published works, they also generally follow those rules. As a result, correct use of language leads to accusations of AI.
I just saw someone say that someone told them Oxford comma use is a telltale LLM sign
And I know it was probably ragebait but I took the bait and I'm raging 😂
And I know it was probably ragebait but I took the bait and I'm raging 😂
November 11, 2025 at 2:44 PM
This has to be the thing I hate most about the LLM/AI overhype. I school, I was taught sentence structure, spelling, and grammar. Because these models are trained on (stolen) published works, they also generally follow those rules. As a result, correct use of language leads to accusations of AI.
In three days' time, SNAP benefits will stop for millions of Americans. Millions of people are going to starve.
This is by design.
This is by design.
October 28, 2025 at 3:16 PM
In three days' time, SNAP benefits will stop for millions of Americans. Millions of people are going to starve.
This is by design.
This is by design.
Technology conferences are always amazing in terms of fashion. Everyone is either dressed to the nines in their sharpest professional clothes, or they look like someone wandered in from the wilderness.
There is like zero space between.
There is like zero space between.
October 27, 2025 at 12:48 PM
Technology conferences are always amazing in terms of fashion. Everyone is either dressed to the nines in their sharpest professional clothes, or they look like someone wandered in from the wilderness.
There is like zero space between.
There is like zero space between.
Dear Every Academic Journal,
You are *publishers*. Your submission templates should include LaTeX templates, and those templates should also actually make proper use of LaTeX functionality. It's not just for the math kids, it'll actually make your own jobs easier.
I'm dying here.
You are *publishers*. Your submission templates should include LaTeX templates, and those templates should also actually make proper use of LaTeX functionality. It's not just for the math kids, it'll actually make your own jobs easier.
I'm dying here.
October 9, 2025 at 6:18 PM
Dear Every Academic Journal,
You are *publishers*. Your submission templates should include LaTeX templates, and those templates should also actually make proper use of LaTeX functionality. It's not just for the math kids, it'll actually make your own jobs easier.
I'm dying here.
You are *publishers*. Your submission templates should include LaTeX templates, and those templates should also actually make proper use of LaTeX functionality. It's not just for the math kids, it'll actually make your own jobs easier.
I'm dying here.
just got an email from a company letting me know that as part of a settlement for a data breach class action lawsuit against them, they're giving out a discount code for *up to* $1.00 to affected users.
So to be clear. A company gets to turn a legal ruling AGAINST them into ... more revenue.
So to be clear. A company gets to turn a legal ruling AGAINST them into ... more revenue.
October 3, 2025 at 12:03 AM
just got an email from a company letting me know that as part of a settlement for a data breach class action lawsuit against them, they're giving out a discount code for *up to* $1.00 to affected users.
So to be clear. A company gets to turn a legal ruling AGAINST them into ... more revenue.
So to be clear. A company gets to turn a legal ruling AGAINST them into ... more revenue.
Reposted by Dr. Mark A. Hix
September 29, 2025 at 5:55 PM
Reposted by Dr. Mark A. Hix
@arkanil.bsky.social's article with pages and Front Cover now out:
"Comparison of Magnesium and Manganese Ions on the Structural and Catalytic Properties of Human DNA Polymerase Gamma"
doi.org/10.1021/acs....
"Comparison of Magnesium and Manganese Ions on the Structural and Catalytic Properties of Human DNA Polymerase Gamma"
doi.org/10.1021/acs....
September 23, 2025 at 1:40 PM
@arkanil.bsky.social's article with pages and Front Cover now out:
"Comparison of Magnesium and Manganese Ions on the Structural and Catalytic Properties of Human DNA Polymerase Gamma"
doi.org/10.1021/acs....
"Comparison of Magnesium and Manganese Ions on the Structural and Catalytic Properties of Human DNA Polymerase Gamma"
doi.org/10.1021/acs....
Really enjoy how my electricity provider sends me a bill that's 30% higher than the same time last year, yet their own year-over-year comparison of my electricity usage shows I used LESS this year.
That's just so fun for me.
That's just so fun for me.
August 24, 2025 at 3:54 AM
Really enjoy how my electricity provider sends me a bill that's 30% higher than the same time last year, yet their own year-over-year comparison of my electricity usage shows I used LESS this year.
That's just so fun for me.
That's just so fun for me.
Reposted by Dr. Mark A. Hix
Necessary tools from the bad old days (or: the smallest taste of why marriage equality matters.)
August 15, 2025 at 1:08 PM
Necessary tools from the bad old days (or: the smallest taste of why marriage equality matters.)
So it's gonna be that one clip of Kirk in the gym, followed by twelve years of black screen without audio?
I'm guessing Voyager and DS9 are right out.
I'm guessing Voyager and DS9 are right out.
Ah, yes... The company that owns Star Trek will now have someone that will censor the "woke" content.🙃
The time to cancel your CBS/Paramount+ subscriptions was yesterday, btw.
www.hollywoodreporter.com/business/bus...
The time to cancel your CBS/Paramount+ subscriptions was yesterday, btw.
www.hollywoodreporter.com/business/bus...
Skydance Tells FCC It Will Create CBS News Ombudsman, Eliminate DEI at Paramount
The company said it would commit to a "comprehensive review" post-transaction.
www.hollywoodreporter.com
July 24, 2025 at 11:07 AM
So it's gonna be that one clip of Kirk in the gym, followed by twelve years of black screen without audio?
I'm guessing Voyager and DS9 are right out.
I'm guessing Voyager and DS9 are right out.
Reposted by Dr. Mark A. Hix
July 21, 2025 at 6:26 PM
People blaming Murkowski need to also keep in mind there are an additional 49 other senators that need to be blamed for this.
Spread that blame around and hold them all accountable. Every single one. Didn't vote for them? Doesn't matter, they're still supposed to represent you.
Spread that blame around and hold them all accountable. Every single one. Didn't vote for them? Doesn't matter, they're still supposed to represent you.
July 2, 2025 at 2:48 AM
People blaming Murkowski need to also keep in mind there are an additional 49 other senators that need to be blamed for this.
Spread that blame around and hold them all accountable. Every single one. Didn't vote for them? Doesn't matter, they're still supposed to represent you.
Spread that blame around and hold them all accountable. Every single one. Didn't vote for them? Doesn't matter, they're still supposed to represent you.
Calling it "Alligator Alcatraz" intentionally evokes the idea of a prison, suggesting the people there have committed a crime.
Call it "Alligator Auschwitz", since that seems to be their actual intent.
Or better yet, call it directly what it is: a concentration camp.
Call it "Alligator Auschwitz", since that seems to be their actual intent.
Or better yet, call it directly what it is: a concentration camp.
July 1, 2025 at 11:15 PM
Calling it "Alligator Alcatraz" intentionally evokes the idea of a prison, suggesting the people there have committed a crime.
Call it "Alligator Auschwitz", since that seems to be their actual intent.
Or better yet, call it directly what it is: a concentration camp.
Call it "Alligator Auschwitz", since that seems to be their actual intent.
Or better yet, call it directly what it is: a concentration camp.
I am growing increasingly annoyed at the number of "AI trainer" and "Tutor for AI Model" jobs popping up on LinkedIn and other sites. I have no interest in training your AI model to be a worse version of me. Companies are relying on short-term desperation to fuel long-term obsolescence.
June 27, 2025 at 4:12 PM
I am growing increasingly annoyed at the number of "AI trainer" and "Tutor for AI Model" jobs popping up on LinkedIn and other sites. I have no interest in training your AI model to be a worse version of me. Companies are relying on short-term desperation to fuel long-term obsolescence.
Reposted by Dr. Mark A. Hix
Socialism is what they called public power.
Socialism is what they called social security.
Socialism is what they called the growth of free and independent labor organizations.
Socialism is their name for almost anything that helps all the people.
—Harry Truman, 1952
Socialism is what they called social security.
Socialism is what they called the growth of free and independent labor organizations.
Socialism is their name for almost anything that helps all the people.
—Harry Truman, 1952
June 25, 2025 at 4:45 PM
Socialism is what they called public power.
Socialism is what they called social security.
Socialism is what they called the growth of free and independent labor organizations.
Socialism is their name for almost anything that helps all the people.
—Harry Truman, 1952
Socialism is what they called social security.
Socialism is what they called the growth of free and independent labor organizations.
Socialism is their name for almost anything that helps all the people.
—Harry Truman, 1952
Quoting not just for the paper, but also because it includes a direct link to the github repository for the code.
More ML papers need to be doing this - if you don't include your code, it's pretty hard to reproduce the work.
Very nice job to Sengar et al.
More ML papers need to be doing this - if you don't include your code, it's pretty hard to reproduce the work.
Very nice job to Sengar et al.
🧪 New preprint: "Generative Modeling of Full-Atom Protein Conformations using Latent Diffusion on Graph Embeddings"
We generate complete, all-atom protein conformational ensembles, capturing both backbone and side-chain dynamics of, e.g., the Dopamine D2 receptor.
arxiv.org/abs/2506.17064
We generate complete, all-atom protein conformational ensembles, capturing both backbone and side-chain dynamics of, e.g., the Dopamine D2 receptor.
arxiv.org/abs/2506.17064
June 26, 2025 at 1:58 PM
Quoting not just for the paper, but also because it includes a direct link to the github repository for the code.
More ML papers need to be doing this - if you don't include your code, it's pretty hard to reproduce the work.
Very nice job to Sengar et al.
More ML papers need to be doing this - if you don't include your code, it's pretty hard to reproduce the work.
Very nice job to Sengar et al.
Reposted by Dr. Mark A. Hix
Vaccination schedules on the CDC website have already started changing under RFK Jr. So we published a guide to the evidence-based vaccine recommendations in place *before* all 17 members of the advisory panel were abruptly dismissed by the new admin. www.scientificamerican.com/article/see-... 🧪
Here’s Your Cheat Sheet for Vaccine Recommendations Backed by Science
These graphics will guide you through science-based vaccine guidelines for children and adults
www.scientificamerican.com
June 25, 2025 at 11:49 AM
Vaccination schedules on the CDC website have already started changing under RFK Jr. So we published a guide to the evidence-based vaccine recommendations in place *before* all 17 members of the advisory panel were abruptly dismissed by the new admin. www.scientificamerican.com/article/see-... 🧪
Photo I took a couple weeks back while on a walk around the neighborhood. This is a Cecropia Moth, I think, though I'll defer to expert lepidopterists if I'm wrong.
#moth #lepidopterists
#moth #lepidopterists
June 25, 2025 at 11:20 AM
Photo I took a couple weeks back while on a walk around the neighborhood. This is a Cecropia Moth, I think, though I'll defer to expert lepidopterists if I'm wrong.
#moth #lepidopterists
#moth #lepidopterists
They're fine killing off huge portions of their voting base because they don't think they'll ever need to worry about votes again.
How do they get away with this? The bill they passed cuts Medicaid by $793 BILLION.
$793 BILLION.
It's in the bill. They wrote it. Their own budget office says 10 million people will lose Medicaid coverage.
Just wild.
$793 BILLION.
It's in the bill. They wrote it. Their own budget office says 10 million people will lose Medicaid coverage.
Just wild.
Mike Johnson brazenly lies: "We are not cutting Medicaid. The president has said that and I have said that. We're all said that. We're strengthening the program."
June 25, 2025 at 11:02 AM
They're fine killing off huge portions of their voting base because they don't think they'll ever need to worry about votes again.
I've long said that if one party says it's raining and the other says it's sunny, the journalists job is to stick their head out the window and see what's true.
Not to report that the parties can't agree on anything.
Not to report that the parties can't agree on anything.
Note to media:
“Trump says” is not a story. He says A LOT. He lies a lot. Do some sifting, discerning, contextualizing. Otherwise it’s just stenography. And you’re embarrassing yourselves.
“Trump says” is not a story. He says A LOT. He lies a lot. Do some sifting, discerning, contextualizing. Otherwise it’s just stenography. And you’re embarrassing yourselves.
June 23, 2025 at 12:47 PM
I've long said that if one party says it's raining and the other says it's sunny, the journalists job is to stick their head out the window and see what's true.
Not to report that the parties can't agree on anything.
Not to report that the parties can't agree on anything.
Reposted by Dr. Mark A. Hix
One example of the many different reactions we observe - abstraction of hydrogen yields HClF2, which then forms a dihydrogen bond with the surface. The simulation lasts 2 picoseconds. #ChemSky #CompChemSky
June 19, 2025 at 2:10 PM
One example of the many different reactions we observe - abstraction of hydrogen yields HClF2, which then forms a dihydrogen bond with the surface. The simulation lasts 2 picoseconds. #ChemSky #CompChemSky
All those 2nd Amendment nuts sure are quiet right about now, despite the overwhelming presence of tyranny.
Let's be clear.
Strangers tried to steal six-year-olds from schools.
Let's be clear.
Strangers tried to steal six-year-olds from schools.
BREAKING: Federal agents in plain clothes and unmarked cars tried to snatch 1st graders from LA elementary schools—told staff they had “parental consent.”
They lied. When pressed, they HID THEIR IDS. DHS admits they sent them. This wasn’t a welfare check. It was a test run for a police state.
They lied. When pressed, they HID THEIR IDS. DHS admits they sent them. This wasn’t a welfare check. It was a test run for a police state.
June 10, 2025 at 6:53 PM
All those 2nd Amendment nuts sure are quiet right about now, despite the overwhelming presence of tyranny.
Let's be clear.
Strangers tried to steal six-year-olds from schools.
Let's be clear.
Strangers tried to steal six-year-olds from schools.
It's such a trip watching a documentary and seeing one of my mutuals providing their expertise on the subject.
Just makes it even more fun.
Just makes it even more fun.
June 9, 2025 at 8:38 PM
It's such a trip watching a documentary and seeing one of my mutuals providing their expertise on the subject.
Just makes it even more fun.
Just makes it even more fun.
Interestingly, I've found the standard of "don't abuse my child" to be an exceptionally easy bar to clear in this whole parenting gig.
June 1, 2025 at 12:40 PM
Interestingly, I've found the standard of "don't abuse my child" to be an exceptionally easy bar to clear in this whole parenting gig.
Absolutely insane that the headlines are blaming three Democrat House Reps for *dying* rather than absolutely any of the Republicans who voted in favor of this abomination.
Y'all aren't journalists, you're bootlickin' mouthpieces.
Y'all aren't journalists, you're bootlickin' mouthpieces.
May 22, 2025 at 7:06 PM
Absolutely insane that the headlines are blaming three Democrat House Reps for *dying* rather than absolutely any of the Republicans who voted in favor of this abomination.
Y'all aren't journalists, you're bootlickin' mouthpieces.
Y'all aren't journalists, you're bootlickin' mouthpieces.