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madscienceyak.bsky.social
NIK-OI 🦬
@madscienceyak.bsky.social
Big fan of microscopes 🔬 | Autistic/Asperger's | 🇸🇸🇦🇺 | PhD candidate @QldBrainInst @AIBNatUQ 🧠 | She/Her 🏳️‍🌈 | @WestpacScholars Future Leader | @homewardbound HB8 🇦🇶| opinions=own
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📝 A new Nature study from Lippincott-Schwartz group at Howard Hughes Medical Institute reveals that secretome mRNAs are translated at specialized sites.

🔎 This uncovers a new spatial layer in how cells make secreted proteins with broad implications.

📖 Read more: https://go.nature.com/43zRK0t
November 17, 2025 at 2:49 PM
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From MBoC: Wallace F. Marshall (UCSF) and team profile the giant ciliate Stentor pyriformis—symbiotic algae in microtubule baskets, symbiont-dependent phototaxis, and a standard genetic code. Paper: www.molbiolcell.org/doi/10.1091/... #CellBiology
September 19, 2025 at 12:02 PM
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Exciting day for the lab: our 1rst paper is officially out in @currentbiology.bsky.social 🥳 Wonderful collaboration wt @gautamdey.bsky.social showing how Cryo-ExM achieves consistent immunostaining in diverse diatoms, from the lab and the natural environment 1/n
#ProtistsOnSky
tinyurl.com/2zxaund7
October 31, 2025 at 3:27 PM
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Delighted to start my next scientific adventure with Cecilia, Kari and Taija looking at lymphatic immune interfaces. Many thanks to the research council of Finland to fund our Center of Excellence www.abo.fi/en/news/the-...
The Research Council of Finland funds cutting edge research at Åbo Akademi University with €4.5 million
Researchers at Åbo Akademi University have been granted nearly €4.5 million by the Research Council of Finland. The funding supports high-level research in fields such as cancer biology…
www.abo.fi
November 1, 2025 at 8:30 AM
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Fall in Corrèze
October 28, 2025 at 8:19 PM
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Tomorrow Wednesday 29th at 11am, lesson #3 of @neilshubin.bsky.social guest Professor @college-de-france.fr on ‘The evolutionary origin of bones and teeth’. The second lesson is available @ www.youtube.com/watch?v=0B6y... . No registration, Free access, dentures accepted.
October 28, 2025 at 7:46 AM
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For #FluorescenceFriday - projection neurons from the mouse prefrontal cortex to the locus coeruleus 🔴 with Fos labeling activated cells 🟢. Image credit to the Circuits team in the Translational Neuroscience Division @lieberinstitute.bsky.social 🧠🔬🧪
October 24, 2025 at 11:45 AM
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Wonderful to see our paper on the #organelle signatures of #neurons and #astrocytes out in final form - congratulations, Shannon Rhoads and team!🎉 t.co/BPxKlbU6Ou
September 17, 2025 at 5:38 PM
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Are the lipids associated with static protein structures there as long-lived ligands or an effect of preferential solvation? This computational-experimental framework shows the way! #lipidtime #compchem

www.nature.com/articles/s41...
Molecular basis for the regulation of membrane proteins through preferential lipid solvation - Nature Chemical Biology
Static protein structures can capture the association of lipids, but it is unclear whether the association is due to lipids acting as long-lived ligands or the solvation of preferred lipids around the protein. A computational-experimental framework has now shown that for the protein CLC-ec1, it is the change in lipid solvation energies that drives dimerization, with preferred lipids around the protein modulating this driving force.
www.nature.com
September 26, 2025 at 3:29 PM
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I am super excited to announce that we have a tenure-track faculty position in biophysics open in the Department of Physics at Carnegie Mellon! 🧪

Interfolio link: apply.interfolio.com/174360

PLEASE, share widely across the blue skies!

Let me briefly explain what we're looking for:

1/10
September 26, 2025 at 3:35 PM
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Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...
Leaflet-specific phospholipid imaging using genetically encoded proximity sensors - Nature Chemical Biology
An approach combining bioorthogonal chemistry with genetically encoded fluorogen-activating proteins enables subcellular imaging of phospholipids and glycans, as well as the visualization of lipid tra...
www.nature.com
September 15, 2025 at 6:03 PM
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If you find yourself at @edrc2025.bsky.social please check my wonderful postdoc's talk @neurogut.bsky.social at the gut workshop this afternoon. Gut, sex, reproduction, our new story! In combo with @irenemiguel-aliaga.bsky.social! @fly-jedi.bsky.social #EDRC2025
September 25, 2025 at 9:20 AM
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This is really fantastic, whenever an old dogma is broken is worth highlighting it as one of the key papers of the year :)!
Congratulations, I have been following this article since it was posted on biorxiv, very huge contribution to the metabolism field 💪
October 4, 2025 at 10:30 AM
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🎉 Our discovery opens up exciting new research avenues for supporting healthy brain aging, and treating other metabolic brain disorders. 3/3 #raredisease #mitochondria #neuronalenergy #fattyacids #beta-oxidation #HSP #SPG #metabolism #lipids
October 1, 2025 at 4:11 AM
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💊 Loss of DDHD2-fatty acid pathway causes hereditary spastic paraplegia (HSP54), a childhood-onset neurodegenerative disorder. Excitingly, we found that a combination of activated fatty acids restored neuronal energy and function in HSP54-model neurons, identifying a potential therapy for HSP54. 2/3
October 1, 2025 at 4:11 AM
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🌟 Thrilled to share that my lab’s first publication is now out in @natmetabolism.nature.com. Congrats to the team 🎉

🧠 We discovered that neurons use endogenous fatty acids as an energy fuel, challenging long-standing models of sugars being the exclusive energy source for neurons. 1/3
October 1, 2025 at 4:11 AM
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👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻 #neuron #energy #metabolism #fattyacid #raredisease #HSP #mitochondria #betaoxidation #brain #health #neurodegeneration Read more here: rdcu.be/eIQA0 🧠 🔬
October 3, 2025 at 2:41 AM
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Want to hear a mid-career PI pontificate about science, career and cooking? Today's your lucky day thanks to The Microscopists podcast! Thanks Peter @yorkbioimaging.bsky.social for having me 🎙️🎧
themicroscopists.bitesizebio.com/episodes/chr...
The Microscopists | Christophe Leterrier (CNRS & Aix-Marseille Université)
This time on The Microscopists, we're joined by Christophe Leterrier, team leader at NeuroCyto in Marseille and director of a Nikon Center of Excellence for super-resolution microscopy.Christophe r...
themicroscopists.bitesizebio.com
October 3, 2025 at 12:40 PM
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Feeding Frenzy: Protein syntaxin-2 regulates phagocytosis (gobbling up & ingesting waste material) by macrophages

📷 Suman Samanta et al, Indian Institute of Science Education and Research Kolkata in
@jcellsci.bsky.social

➡️ bpod.org.uk/archive/2025... with Lux Fatimathas
September 8, 2025 at 7:58 AM
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Journal of Cell Science is published by a not-for-profit charitable organisation (@biologists.bsky.social)
that exists to benefit science, not shareholders. We provide Travelling Fellowships, Training Grants, support for ECRs and more.
For details, visit: journals.biologists.com/jcs/pages/re...
July 9, 2025 at 3:25 PM
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🧪 Job alert 🔊 we are hiring a Research Assistant - join the Simões Group at DPAG-IDRM @ox.ac.uk supporting #cardiovascular development and regeneration research, working with #zebrafish and #human stem cell systems: my.corehr.com/pls/uoxrecru... @oxforddpag.bsky.social @idrm.ox.ac.uk (1/4)
Job Details
my.corehr.com
July 7, 2025 at 2:43 PM
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Previous preprint is now published in RSC Chemical Biology.
If you are interested in plasma membrane labeling, see the paper! 👇
pubs.rsc.org/en/content/a...
September 8, 2025 at 8:02 AM
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Chicken balancing for #3DThursday!🐔 These utricle hair cells sense gravity & straight-line motion. We segmented them with #CellposeSAM in #syGlass.

🥼: Stefan Heller Group
🏛️: Stanford @stanfordmedicine.bsky.social
🎬: syGlass.io v2.4.0, out now!

#Neuroanatomy #Microscopy #3DVisualization #SciComm
August 28, 2025 at 3:54 PM
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Yesterday I collected some samples from a local Texas pond and was happy to see a bunch of Nauptili. I thought y'all might appreciate this video of one of them -- apologies for a messy condenser --- that gets cleaned this weekend!

#microscope #Iteachbiology #edusky #nature #microscopy #Science
August 29, 2025 at 4:45 PM
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Trying the @zeiss-microscopy.bsky.social LSM 980 with lightfield at my core. I’m very curious about the performance of the lightfield 👀

#microscopy #bioimaging
September 2, 2025 at 5:40 PM