This is really fantastic, whenever an old dogma is broken is worth highlighting it as one of the key papers of the year :)!
Congratulations, I have been following this article since it was posted on biorxiv, very huge contribution to the metabolism field 💪

🎉 Our discovery opens up exciting new research avenues for supporting healthy brain aging, and treating other metabolic brain disorders. 3/3 #raredisease #mitochondria #neuronalenergy #fattyacids #beta-oxidation #HSP #SPG #metabolism #lipids

💊 Loss of DDHD2-fatty acid pathway causes hereditary spastic paraplegia (HSP54), a childhood-onset neurodegenerative disorder. Excitingly, we found that a combination of activated fatty acids restored neuronal energy and function in HSP54-model neurons, identifying a potential therapy for HSP54. 2/3