Madhur Bain Singh
@madhurbsingh.bsky.social
Studying genes, brain and psychiatry at Social, Genetic & Dev Psychiatry Centre, IoPPN, King's College London.
Alum of Virginia Institute for Psychiatric & Behavioral Genetics, Virginia Commonwealth Univ.
Alum of Virginia Institute for Psychiatric & Behavioral Genetics, Virginia Commonwealth Univ.
Reposted by Madhur Bain Singh
First time on Bsky and first big announcement!
I am excited to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature.
Our manuscript is here: www.nature.com/articles/s41....
I am excited to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature.
Our manuscript is here: www.nature.com/articles/s41....
Estimation and mapping of the missing heritability of human phenotypes - Nature
WGS data were used from 347,630 individuals with European ancestry in the UK Biobank to obtain high-precision estimates of coding and non-coding rare variant heritability for 34 co...
www.nature.com
November 12, 2025 at 5:57 PM
First time on Bsky and first big announcement!
I am excited to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature.
Our manuscript is here: www.nature.com/articles/s41....
I am excited to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature.
Our manuscript is here: www.nature.com/articles/s41....
Reposted by Madhur Bain Singh
🚨 New paper out! In a collaboration across MVP, FinnGen & UK Biobank, we conducted a phenome-wide study of sex chromosome trisomies (SCT) in 1.5M participants. Findings reveal shared disease risks across SCT. 🔗 www.sciencedirect.com/science/arti...
August 26, 2025 at 4:36 PM
🚨 New paper out! In a collaboration across MVP, FinnGen & UK Biobank, we conducted a phenome-wide study of sex chromosome trisomies (SCT) in 1.5M participants. Findings reveal shared disease risks across SCT. 🔗 www.sciencedirect.com/science/arti...
Reposted by Madhur Bain Singh
“What an odd thing“ wrote Oliver Sacks “to see an entire species playing with listening to meaningless tonal patterns, preoccupied for much of their time by what they call ‘music’...“. Our new paper, led by ace student @giacomobignardi.bsky.social, unpacks this puzzle from a genetic perspective. 🧪
Twin modelling reveals partly distinct genetic pathways to music enjoyment - Nature Communications
Here, Bignardi et al. report on a study of over 9,000 Swedish twins that indicates the ability to enjoy music is influenced by multiple partly distinct genetic factors.
www.nature.com
March 25, 2025 at 10:07 PM
“What an odd thing“ wrote Oliver Sacks “to see an entire species playing with listening to meaningless tonal patterns, preoccupied for much of their time by what they call ‘music’...“. Our new paper, led by ace student @giacomobignardi.bsky.social, unpacks this puzzle from a genetic perspective. 🧪
Reposted by Madhur Bain Singh
Out today, our method for comparing multivariate genetic architecture across groups of people, called Genomic Structural Invariance: www.nature.com/articles/s41...
(feat: @tuckerdrob.bsky.social @michelnivard.bsky.social @andrewgrotzinger.bsky.social @mijke.bsky.social @jorsmo.bsky.social et al.)
(feat: @tuckerdrob.bsky.social @michelnivard.bsky.social @andrewgrotzinger.bsky.social @mijke.bsky.social @jorsmo.bsky.social et al.)
Comparison of the multivariate genetic architecture of eight major psychiatric disorders across sex - Nature Genetics
Genomic structural invariance, an extension of genomic structural equation modeling, identifies similarities and differences between males and females in the genetic architectures of eight psychiatric...
www.nature.com
March 7, 2025 at 3:21 PM
Out today, our method for comparing multivariate genetic architecture across groups of people, called Genomic Structural Invariance: www.nature.com/articles/s41...
(feat: @tuckerdrob.bsky.social @michelnivard.bsky.social @andrewgrotzinger.bsky.social @mijke.bsky.social @jorsmo.bsky.social et al.)
(feat: @tuckerdrob.bsky.social @michelnivard.bsky.social @andrewgrotzinger.bsky.social @mijke.bsky.social @jorsmo.bsky.social et al.)
Reposted by Madhur Bain Singh
New preprint🌍 Our trans-ancestry GWAS in UK Biobank uncovers novel risk loci for major depression, improving genetic insights across populations. 🔗: www.medrxiv.org/content/10.1... @madhurbsingh.bsky.social @gentyae.bsky.social @pbb319.bsky.social timbigdeli.bsky.social @roseannpeterson.bsky.social
February 28, 2025 at 6:19 PM
New preprint🌍 Our trans-ancestry GWAS in UK Biobank uncovers novel risk loci for major depression, improving genetic insights across populations. 🔗: www.medrxiv.org/content/10.1... @madhurbsingh.bsky.social @gentyae.bsky.social @pbb319.bsky.social timbigdeli.bsky.social @roseannpeterson.bsky.social
Reposted by Madhur Bain Singh
Many thanks to all of the collaborators and funders (esp
@wellcometrust.bsky.social & @ukri.org) who made this DNA methylome-wide study of antidepressant exposure possible www.nature.com/articles/s41...
@wellcometrust.bsky.social & @ukri.org) who made this DNA methylome-wide study of antidepressant exposure possible www.nature.com/articles/s41...
Insights from a methylome-wide association study of antidepressant exposure - Nature Communications
The mechanism of currently prescribed antidepressants is incompletely understood. Here, the study identifies associations between antidepressant use and DNA methylation, highlighting shared signals ac...
www.nature.com
February 24, 2025 at 3:19 PM
Many thanks to all of the collaborators and funders (esp
@wellcometrust.bsky.social & @ukri.org) who made this DNA methylome-wide study of antidepressant exposure possible www.nature.com/articles/s41...
@wellcometrust.bsky.social & @ukri.org) who made this DNA methylome-wide study of antidepressant exposure possible www.nature.com/articles/s41...
Reposted by Madhur Bain Singh
Excited to share a couple of new items (links below):
1. Our work on gene-environment interactions in the UKBiobank is up at the American Journal of Human Genetics
2. Our work on modeling ancient human population size history is up at Molecular Biology and Evolution
1. Our work on gene-environment interactions in the UKBiobank is up at the American Journal of Human Genetics
2. Our work on modeling ancient human population size history is up at Molecular Biology and Evolution
February 17, 2025 at 4:56 PM
Excited to share a couple of new items (links below):
1. Our work on gene-environment interactions in the UKBiobank is up at the American Journal of Human Genetics
2. Our work on modeling ancient human population size history is up at Molecular Biology and Evolution
1. Our work on gene-environment interactions in the UKBiobank is up at the American Journal of Human Genetics
2. Our work on modeling ancient human population size history is up at Molecular Biology and Evolution
Reposted by Madhur Bain Singh
🚨NEW PAPER! Together with Wuno Akingbuwa (@wonuola.bsky.social) we developed a way to estimate non-linear genetic correlations. It didnt sit well with us that known non-linear relations (e.g. BMI and MDD with a famous U shaped ) are poorly captured in statistical genetics. 🧵
www.biorxiv.org
February 14, 2025 at 1:30 PM
🚨NEW PAPER! Together with Wuno Akingbuwa (@wonuola.bsky.social) we developed a way to estimate non-linear genetic correlations. It didnt sit well with us that known non-linear relations (e.g. BMI and MDD with a famous U shaped ) are poorly captured in statistical genetics. 🧵
Reposted by Madhur Bain Singh
Incredibly proud to see our latest work out in Nature Genetics: www.nature.com/articles/s41...
Here we share our FLAMES framework, which predicts the effector genes in GWAS loci with state-of-the-art precision🔥
Special thanks to @daniposthu.bsky.social
A full thread describing findings below!
Here we share our FLAMES framework, which predicts the effector genes in GWAS loci with state-of-the-art precision🔥
Special thanks to @daniposthu.bsky.social
A full thread describing findings below!
Prioritizing effector genes at trait-associated loci using multimodal evidence
Nature Genetics - FLAMES is a machine learning approach combining variant fine-mapping, SNP-to-gene annotations and convergence-based gene prioritization scores to identify candidate effector genes...
rdcu.be
February 11, 2025 at 9:58 AM
Incredibly proud to see our latest work out in Nature Genetics: www.nature.com/articles/s41...
Here we share our FLAMES framework, which predicts the effector genes in GWAS loci with state-of-the-art precision🔥
Special thanks to @daniposthu.bsky.social
A full thread describing findings below!
Here we share our FLAMES framework, which predicts the effector genes in GWAS loci with state-of-the-art precision🔥
Special thanks to @daniposthu.bsky.social
A full thread describing findings below!
Reposted by Madhur Bain Singh
New paper! Led by Kirsten J. M. van Hooijdonk & Jacqueline Vink, this study finds no bidirectional causal link between diet/physical activity & depression/anxiety using triangulation. No strong causal evidence! @zoereed.bsky.social @madhurbsingh.bsky.social
📖 doi.org/10.1017/S003...
📖 doi.org/10.1017/S003...
February 6, 2025 at 3:29 PM
New paper! Led by Kirsten J. M. van Hooijdonk & Jacqueline Vink, this study finds no bidirectional causal link between diet/physical activity & depression/anxiety using triangulation. No strong causal evidence! @zoereed.bsky.social @madhurbsingh.bsky.social
📖 doi.org/10.1017/S003...
📖 doi.org/10.1017/S003...
Reposted by Madhur Bain Singh
Nice paper showing ~1/540 people have a sex chromosome trisomy from 3 large biobanks (UKB, FinnGen, MVP) comprising 1.5 million individuals along with their phenotypic impact.
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
February 5, 2025 at 7:03 PM
Nice paper showing ~1/540 people have a sex chromosome trisomy from 3 large biobanks (UKB, FinnGen, MVP) comprising 1.5 million individuals along with their phenotypic impact.
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Reposted by Madhur Bain Singh
Are mental disorders extreme manifestations of continuous traits or genetically distinct entities? We present Genomic Taxometric Analysis of Continuous and Case-Control data (GTACCC) for evaluating genetic continuity and differentiation of traits across the severity spectrum. Tweetorial coming soon.
February 5, 2025 at 1:15 AM
Are mental disorders extreme manifestations of continuous traits or genetically distinct entities? We present Genomic Taxometric Analysis of Continuous and Case-Control data (GTACCC) for evaluating genetic continuity and differentiation of traits across the severity spectrum. Tweetorial coming soon.
Reposted by Madhur Bain Singh
Modern GWAS can identify 1000s of significant hits but it can be hard to turn this into biological insight. What key cellular functions link genetic variation to disease?
I'm very excited to present our new work combining associations and Perturb-seq to build interpretable causal graphs! A 🧵
I'm very excited to present our new work combining associations and Perturb-seq to build interpretable causal graphs! A 🧵
January 26, 2025 at 12:13 AM
Modern GWAS can identify 1000s of significant hits but it can be hard to turn this into biological insight. What key cellular functions link genetic variation to disease?
I'm very excited to present our new work combining associations and Perturb-seq to build interpretable causal graphs! A 🧵
I'm very excited to present our new work combining associations and Perturb-seq to build interpretable causal graphs! A 🧵
Reposted by Madhur Bain Singh
King's College London launches the Atlas of Longitudinal Datasets, in partnership with @wellcometrust.bsky.social / @mqmentalhealth.bsky.social, a free platform with over 1,600 datasets, to support mental health research worldwide. 🌍
Read more and learn how to access: www.kcl.ac.uk/news/kings-l...
Read more and learn how to access: www.kcl.ac.uk/news/kings-l...
King's launches the Atlas of Longitudinal Datasets to support mental health research
Researchers at the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King’s College London have launched a new free platform to allow people to discover hundreds of longitudinal mental hea...
www.kcl.ac.uk
January 23, 2025 at 2:27 PM
King's College London launches the Atlas of Longitudinal Datasets, in partnership with @wellcometrust.bsky.social / @mqmentalhealth.bsky.social, a free platform with over 1,600 datasets, to support mental health research worldwide. 🌍
Read more and learn how to access: www.kcl.ac.uk/news/kings-l...
Read more and learn how to access: www.kcl.ac.uk/news/kings-l...
Reposted by Madhur Bain Singh
🚀 New paper by @madhurbsingh.bsky.social on smoking & DNA methylation via twin-based MR using @ntrbiopsy.bsky.social data! Supervised by Mike Neale, @jennyvandongen.bsky.social, & Conor Dolan. Co-authors: @dlapato.bsky.social, @charlesbreeze.bsky.social. 🔗 doi.org/10.1007/s106...
January 16, 2025 at 9:54 PM
🚀 New paper by @madhurbsingh.bsky.social on smoking & DNA methylation via twin-based MR using @ntrbiopsy.bsky.social data! Supervised by Mike Neale, @jennyvandongen.bsky.social, & Conor Dolan. Co-authors: @dlapato.bsky.social, @charlesbreeze.bsky.social. 🔗 doi.org/10.1007/s106...
Reposted by Madhur Bain Singh
Thrilled to share some amazing news— @madhurbsingh.bsky.social, supervised by Roseann Peterson, PhD, and Michael C. Neale, PhD, has been awarded VCU VIPBG's Kenneth S. Kendler Award for Excellence in Predoctoral Research!
January 16, 2025 at 9:46 PM
Thrilled to share some amazing news— @madhurbsingh.bsky.social, supervised by Roseann Peterson, PhD, and Michael C. Neale, PhD, has been awarded VCU VIPBG's Kenneth S. Kendler Award for Excellence in Predoctoral Research!
Reposted by Madhur Bain Singh
1/n Our multi-ancestry #GWAS meta-analysis of major depression is now published in @cellpress.bsky.social.
www.cell.com/cell/fulltex...
A thread 🧵:
www.cell.com/cell/fulltex...
A thread 🧵:
January 14, 2025 at 5:31 PM
1/n Our multi-ancestry #GWAS meta-analysis of major depression is now published in @cellpress.bsky.social.
www.cell.com/cell/fulltex...
A thread 🧵:
www.cell.com/cell/fulltex...
A thread 🧵:
Reposted by Madhur Bain Singh
🚨 This will become a curated list of awesome tools for complex trait genetics, **add yours**! it may become a review in which case those who contribute are invited as co-authors.
GitHub - MichelNivard/awesome-complex-trait-genetics: A list of awesome tools for complex trait genetics.
A list of awesome tools for complex trait genetics. - MichelNivard/awesome-complex-trait-genetics
github.com
November 28, 2024 at 9:21 AM
🚨 This will become a curated list of awesome tools for complex trait genetics, **add yours**! it may become a review in which case those who contribute are invited as co-authors.
Reposted by Madhur Bain Singh
Tidyplots empowers life scientists with easy code-based data visualization https://www.biorxiv.org/content/10.1101/2024.11.08.621836v1 #rstats
November 21, 2024 at 4:30 PM
Tidyplots empowers life scientists with easy code-based data visualization https://www.biorxiv.org/content/10.1101/2024.11.08.621836v1 #rstats
Reposted by Madhur Bain Singh
New here? or logged back in recently? Find your old friends in statistical and psychiatric genetics in this starter pack, ill try to update frequently, let me know if you want to be added: go.bsky.app/9643dwo
November 7, 2024 at 10:09 AM
New here? or logged back in recently? Find your old friends in statistical and psychiatric genetics in this starter pack, ill try to update frequently, let me know if you want to be added: go.bsky.app/9643dwo
Reposted by Madhur Bain Singh
@ent3c.bsky.social suggested we need a behaviour genetics starter pack, let me know who to add!
November 13, 2024 at 12:58 PM
@ent3c.bsky.social suggested we need a behaviour genetics starter pack, let me know who to add!
Reposted by Madhur Bain Singh
I couldn't spot a starter pack for rare disease / clinical genomics, so I started one: go.bsky.app/SUWZ9Hw
Very much a work in progress, and biased by who I have already found here, so please suggest people to add! Self-nominations encouraged.
#ClinicalInformatics #genomics #bioinformatics 🖥️🧬
Very much a work in progress, and biased by who I have already found here, so please suggest people to add! Self-nominations encouraged.
#ClinicalInformatics #genomics #bioinformatics 🖥️🧬
November 15, 2024 at 10:30 AM
I couldn't spot a starter pack for rare disease / clinical genomics, so I started one: go.bsky.app/SUWZ9Hw
Very much a work in progress, and biased by who I have already found here, so please suggest people to add! Self-nominations encouraged.
#ClinicalInformatics #genomics #bioinformatics 🖥️🧬
Very much a work in progress, and biased by who I have already found here, so please suggest people to add! Self-nominations encouraged.
#ClinicalInformatics #genomics #bioinformatics 🖥️🧬
Excited about this work from my PhD being presented by my advisor, Roseann Peterson, at #WCP2024 in MEX🇲🇽
“Empowering Genomic Discovery for Major Depression: A GWAS Workflow Across Ancestries”! 🌎🧬🧠
11/17, 12-1 PM, Station 1.
Advancing trans-ancestry GWAS for genetic insights!💡 #Genetics #Psychiatry
“Empowering Genomic Discovery for Major Depression: A GWAS Workflow Across Ancestries”! 🌎🧬🧠
11/17, 12-1 PM, Station 1.
Advancing trans-ancestry GWAS for genetic insights!💡 #Genetics #Psychiatry
November 15, 2024 at 2:40 AM
Excited about this work from my PhD being presented by my advisor, Roseann Peterson, at #WCP2024 in MEX🇲🇽
“Empowering Genomic Discovery for Major Depression: A GWAS Workflow Across Ancestries”! 🌎🧬🧠
11/17, 12-1 PM, Station 1.
Advancing trans-ancestry GWAS for genetic insights!💡 #Genetics #Psychiatry
“Empowering Genomic Discovery for Major Depression: A GWAS Workflow Across Ancestries”! 🌎🧬🧠
11/17, 12-1 PM, Station 1.
Advancing trans-ancestry GWAS for genetic insights!💡 #Genetics #Psychiatry
Reposted by Madhur Bain Singh
Don’t miss our poster at #WCP2024! 📊 Dive into “Exploring Depression Phenotypes Across Latin American Genomes” with the LAGC-MDD Working Group 🌎 on 11/16, 12-1 PM at Station 03. Join us to explore GWAS insights on MDD in Latin America! #Genomics #Psychiatry
November 15, 2024 at 12:18 AM
Don’t miss our poster at #WCP2024! 📊 Dive into “Exploring Depression Phenotypes Across Latin American Genomes” with the LAGC-MDD Working Group 🌎 on 11/16, 12-1 PM at Station 03. Join us to explore GWAS insights on MDD in Latin America! #Genomics #Psychiatry