Elliot Tucker-Drob
@tuckerdrob.bsky.social
Reposted by Elliot Tucker-Drob
Our multi-ancestry GWAS of EXTernalizing conditions (ADHD, substance use...) in ~4M people reveals neurodevelopmental risk, drug-repurposing targets, and yields one of the strongest psychiatric polygenic indices yet! 🧬🎉 doi.org/10.64898/202...
Genomic insights into substance use and disinhibitory disorders
Externalizing spectrum disorders- spanning attention-deficit/hyperactivity disorder, conduct disorder, substance use disorders, and other disorders characterized by disinhibition - frequently co-occur...
doi.org
February 11, 2026 at 10:33 AM
Our multi-ancestry GWAS of EXTernalizing conditions (ADHD, substance use...) in ~4M people reveals neurodevelopmental risk, drug-repurposing targets, and yields one of the strongest psychiatric polygenic indices yet! 🧬🎉 doi.org/10.64898/202...
Reposted by Elliot Tucker-Drob
I wrote about the bizarre case of Herasight, the embryo selection company going all in on eugenics.
Embryo selection company Herasight goes all in on eugenics
...
open.substack.com
December 13, 2025 at 8:16 PM
I wrote about the bizarre case of Herasight, the embryo selection company going all in on eugenics.
Reposted by Elliot Tucker-Drob
For more context, see also the @nature.com News & Views article about this work, where I unpack what it means when genetic risk for psychiatric disorders overlaps with normal-range traits, including some positive associations with education-related outcomes: rdcu.be/eT4U7
December 10, 2025 at 5:42 PM
For more context, see also the @nature.com News & Views article about this work, where I unpack what it means when genetic risk for psychiatric disorders overlaps with normal-range traits, including some positive associations with education-related outcomes: rdcu.be/eT4U7
Reposted by Elliot Tucker-Drob
1/4 Thrilled to be sharing new work published today in Nature describing the third wave of results from the PGC Cross-Disorder Group. This reflects a massive group effort to examine shared and unique genetic signal across >1 million cases for 14 psychiatric disorders. www.nature.com/articles/s41...
Mapping the genetic landscape across 14 psychiatric disorders - Nature
Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders...
www.nature.com
December 10, 2025 at 4:22 PM
1/4 Thrilled to be sharing new work published today in Nature describing the third wave of results from the PGC Cross-Disorder Group. This reflects a massive group effort to examine shared and unique genetic signal across >1 million cases for 14 psychiatric disorders. www.nature.com/articles/s41...
Reposted by Elliot Tucker-Drob
I wrote about missing heritability, "missing environmentality," and why I still think twin studies are interesting and valuable: kathrynpaigeharden.substack.com/p/twins-are-...
Twins Are So Much More Interesting Than Heritability Estimates
On starting places, "missing environmentality," and the Waddington landscape of life
kathrynpaigeharden.substack.com
December 4, 2025 at 7:08 PM
I wrote about missing heritability, "missing environmentality," and why I still think twin studies are interesting and valuable: kathrynpaigeharden.substack.com/p/twins-are-...
Reposted by Elliot Tucker-Drob
1/ 🚨New paper in Nature Genetics
Genetic factors are associated with the educational fields people study, from arts to engineering.
Article: www.nature.com/articles/s41...
FAQ: www.thehastingscenter.org/genomic-find...
Genetic factors are associated with the educational fields people study, from arts to engineering.
Article: www.nature.com/articles/s41...
FAQ: www.thehastingscenter.org/genomic-find...
Genetic associations with educational fields - Nature Genetics
Genome-wide analyses of 10 educational fields identify 17 associated loci. Analysis of genetic clustering across specializations identifies two key dimensions that show genetic overlap with personalit...
www.nature.com
November 4, 2025 at 10:23 AM
1/ 🚨New paper in Nature Genetics
Genetic factors are associated with the educational fields people study, from arts to engineering.
Article: www.nature.com/articles/s41...
FAQ: www.thehastingscenter.org/genomic-find...
Genetic factors are associated with the educational fields people study, from arts to engineering.
Article: www.nature.com/articles/s41...
FAQ: www.thehastingscenter.org/genomic-find...
Non-paywalled link to my commentary on @vw1234.bsky.social and colleagues new paper in @nature.com rdcu.be/eI2NG
October 1, 2025 at 6:17 PM
Non-paywalled link to my commentary on @vw1234.bsky.social and colleagues new paper in @nature.com rdcu.be/eI2NG
Reposted by Elliot Tucker-Drob
This was a fantastic collaboration with lots of people including @hilarycmartin.bsky.social @jakobgrove.bsky.social, Experts by Experience, and several others who I can't seem to find on this app.
Article: www.nature.com/articles/s41...
Article: www.nature.com/articles/s41...
Polygenic and developmental profiles of autism differ by age at diagnosis - Nature
A study of several longitudinal birth cohorts and cross-sectional cohorts finds only moderate overlap in genetic variants between autism that is diagnosed earlier and that diagnosed later, so they may represent aetiologically different conditions.
www.nature.com
October 1, 2025 at 4:05 PM
This was a fantastic collaboration with lots of people including @hilarycmartin.bsky.social @jakobgrove.bsky.social, Experts by Experience, and several others who I can't seem to find on this app.
Article: www.nature.com/articles/s41...
Article: www.nature.com/articles/s41...
Reposted by Elliot Tucker-Drob
And a very helpful and informative commentary on the paper by @tuckerdrob.bsky.social www.nature.com/articles/d41...
Early- and late-diagnosed autism are genetically distinct
Analyses of symptoms and genomic data indicate that autism that manifests in early childhood is distinct from autism that is diagnosed later in development.
www.nature.com
October 1, 2025 at 4:05 PM
And a very helpful and informative commentary on the paper by @tuckerdrob.bsky.social www.nature.com/articles/d41...
Reposted by Elliot Tucker-Drob
Keynote speakers: @tuckerdrob.bsky.social @foswald.bsky.social Ellen Hamaker
Hands-on workshops by:
@tedmond.bsky.social & @ukuvainik.bsky.social (genomic analyses)
@dirkwulff.bsky.social (LLMs in personality research)
www.ecp22edinburgh.org/programme
Hands-on workshops by:
@tedmond.bsky.social & @ukuvainik.bsky.social (genomic analyses)
@dirkwulff.bsky.social (LLMs in personality research)
www.ecp22edinburgh.org/programme
September 18, 2025 at 3:21 PM
Keynote speakers: @tuckerdrob.bsky.social @foswald.bsky.social Ellen Hamaker
Hands-on workshops by:
@tedmond.bsky.social & @ukuvainik.bsky.social (genomic analyses)
@dirkwulff.bsky.social (LLMs in personality research)
www.ecp22edinburgh.org/programme
Hands-on workshops by:
@tedmond.bsky.social & @ukuvainik.bsky.social (genomic analyses)
@dirkwulff.bsky.social (LLMs in personality research)
www.ecp22edinburgh.org/programme
A deep and thought-provoking lecture that is definitely worth watching all the way through.
My Dobzhansky lecture at BGA: "Theodosius Dobzhansky and the Origins of Radical Behavior Genetics" is publicly available. I talk about the tensions introduced into the field at the difficult border between science using model organisms and human beings. Thanks to BGA for the opportunity.
Sat_208_Dobzhansky_Lecture
Dobzhansky Lecture by Eric Turkheimer
vimeo.com
August 19, 2025 at 12:16 AM
A deep and thought-provoking lecture that is definitely worth watching all the way through.
Let’s not “memory hole” the Flynn Effect, whereby objective cognitive measures show large mean cohort trends that are not plausibly reflective of any sort of general aspect of intelligence, but the individual correlates are largely invariant across generations.
August 18, 2025 at 12:46 PM
Let’s not “memory hole” the Flynn Effect, whereby objective cognitive measures show large mean cohort trends that are not plausibly reflective of any sort of general aspect of intelligence, but the individual correlates are largely invariant across generations.
But what is messy? What is late? Still subject to frame of reference.
August 18, 2025 at 12:27 PM
But what is messy? What is late? Still subject to frame of reference.
Perhaps not peer comparison but shifting frame-of-reference, concept of normative or ideal, use of language… what @michelnivard.bsky.social likens to a vowel shift. Not necessarily the case, but important to consider, rather than trusting mean trends in self-report as veridical without question.
August 18, 2025 at 12:26 PM
Perhaps not peer comparison but shifting frame-of-reference, concept of normative or ideal, use of language… what @michelnivard.bsky.social likens to a vowel shift. Not necessarily the case, but important to consider, rather than trusting mean trends in self-report as veridical without question.
The interpretation is that the charter schools increase conscientiousness, self control, & grit... but also make students more self-critical with respect to those skills (perhaps they are cured of a Dunning-Krueger effect), such that self reports of those skills go down while the skills improve. 5/5
August 18, 2025 at 12:46 AM
The interpretation is that the charter schools increase conscientiousness, self control, & grit... but also make students more self-critical with respect to those skills (perhaps they are cured of a Dunning-Krueger effect), such that self reports of those skills go down while the skills improve. 5/5
One of the coolest examples of this is a natural experiment (lottery study) for oversubscribed charter schools (doi.org/10.3102/0162...). The charter schools increased student achievement but reduced self-reported noncognitive skills that are known to relate to achievement. 4/
Promise and Paradox - Martin R. West, Matthew A. Kraft, Amy S. Finn, Rebecca E. Martin, Angela L. Duckworth, Christopher F. O. Gabrieli, John D. E. Gabrieli, 2016
We used self-report surveys to gather information on a broad set of non-cognitive skills from 1,368 eighth graders. At the student level, scales measuring consc...
doi.org
August 18, 2025 at 12:44 AM
One of the coolest examples of this is a natural experiment (lottery study) for oversubscribed charter schools (doi.org/10.3102/0162...). The charter schools increased student achievement but reduced self-reported noncognitive skills that are known to relate to achievement. 4/
they may be misleading when comparing across cultures, cohorts, or possibly developmental periods due to different ways that people interpret the questions and use the likert scales, reference bias, etc... 3/
August 18, 2025 at 12:42 AM
they may be misleading when comparing across cultures, cohorts, or possibly developmental periods due to different ways that people interpret the questions and use the likert scales, reference bias, etc... 3/
Unfortunately, "objective" observation- and task-based methods for measuring personality have much weaker construct validity and criterion validity. While self-reports are a great way to measure individual differences in personality among people matched on culture and context... 2/
August 18, 2025 at 12:42 AM
Unfortunately, "objective" observation- and task-based methods for measuring personality have much weaker construct validity and criterion validity. While self-reports are a great way to measure individual differences in personality among people matched on culture and context... 2/
A few related conversations have been converging on the question of when various trends and observations with respect to personality are genuine. This is a complex issue without a simple answer... A key issue is that personality is best measured using self- or informant ratings... 1/
While I am not entirely convinced this is “real” and not some psychometric equivalent of a vowel shift (and PRS could help find out a bit I think) this it is relevant:
August 18, 2025 at 12:40 AM
A few related conversations have been converging on the question of when various trends and observations with respect to personality are genuine. This is a complex issue without a simple answer... A key issue is that personality is best measured using self- or informant ratings... 1/
The twin/family studies were not clear whether it was dominance vs. epistasis vs. some other sort of nonadditivity. Dominance was just the easiest to model. We can now estimate dominance SNP h2 but can’t obtain an estimate of epistatic SNP h2. Assimilation/contrast effects may also be at play.
August 18, 2025 at 12:26 AM
The twin/family studies were not clear whether it was dominance vs. epistasis vs. some other sort of nonadditivity. Dominance was just the easiest to model. We can now estimate dominance SNP h2 but can’t obtain an estimate of epistatic SNP h2. Assimilation/contrast effects may also be at play.
To close the loop on this, this is what we wrote in the review (originally posted on the other platform).
August 18, 2025 at 12:19 AM
To close the loop on this, this is what we wrote in the review (originally posted on the other platform).
Reposted by Elliot Tucker-Drob
Psychiatric Genetics Beyond Heritability: Q&A with Michel Nivard ( @michelnivard.bsky.social )
“We look for genes as a means to an end—biology, epidemiology, and etiology of complex human outcomes.”
www.psychiatrymargins.com/p/psychiatri...
“We look for genes as a means to an end—biology, epidemiology, and etiology of complex human outcomes.”
www.psychiatrymargins.com/p/psychiatri...
Psychiatric Genetics Beyond Heritability: Q&A with Michel Nivard
We look for genes as a means to an end—biology, epidemiology, and etiology of complex human outcomes.
www.psychiatrymargins.com
July 19, 2025 at 1:14 PM
Psychiatric Genetics Beyond Heritability: Q&A with Michel Nivard ( @michelnivard.bsky.social )
“We look for genes as a means to an end—biology, epidemiology, and etiology of complex human outcomes.”
www.psychiatrymargins.com/p/psychiatri...
“We look for genes as a means to an end—biology, epidemiology, and etiology of complex human outcomes.”
www.psychiatrymargins.com/p/psychiatri...
Reposted by Elliot Tucker-Drob
Humbled to receive the BGA's early career award ☺️ Thank you to my brilliant team #MPRGBiosocial, the @maxplanck.de for investing in early career researchers, @mpib-berlin.bsky.social for the excellent environment, and my many mentors incl @kph3k.bsky.social @tuckerdrob.bsky.social #ScienceTeamSport
🏆 @laraffington.bsky.social won the early career award, and Paul Liechtenstein won the Dobzhansky award
July 3, 2025 at 6:20 AM
Humbled to receive the BGA's early career award ☺️ Thank you to my brilliant team #MPRGBiosocial, the @maxplanck.de for investing in early career researchers, @mpib-berlin.bsky.social for the excellent environment, and my many mentors incl @kph3k.bsky.social @tuckerdrob.bsky.social #ScienceTeamSport
Omg 😂. Well played @michelnivard.bsky.social
O, right I promissed JUICE! Not everyone believes in this work, one of the "haters" was very early... In fact @ent3c.bsky.social practically leant over this papers' crib and said: "well that's not going to be a looker."... Someone just as petty as me, but far more organized, kept the receipts 👇
May 20, 2025 at 5:30 PM
Omg 😂. Well played @michelnivard.bsky.social
Reposted by Elliot Tucker-Drob
O, right I promissed JUICE! Not everyone believes in this work, one of the "haters" was very early... In fact @ent3c.bsky.social practically leant over this papers' crib and said: "well that's not going to be a looker."... Someone just as petty as me, but far more organized, kept the receipts 👇
May 20, 2025 at 5:18 PM
O, right I promissed JUICE! Not everyone believes in this work, one of the "haters" was very early... In fact @ent3c.bsky.social practically leant over this papers' crib and said: "well that's not going to be a looker."... Someone just as petty as me, but far more organized, kept the receipts 👇