Lucas Sullivan
@lucasbsullivan.bsky.social
Associate Professor @ Fred Hutch
Studying metabolic constraints of cancer cell proliferation
https://research.fredhutch.org/sullivan/en.html
On a mote of dust suspended in a sunbeam
Studying metabolic constraints of cancer cell proliferation
https://research.fredhutch.org/sullivan/en.html
On a mote of dust suspended in a sunbeam
Pinned
Our work detailing the metabolic roles of serum for cancer cell proliferation is now out at JBC, @asbmbjournals.bsky.social!
Congrats to Oliver and Eric and many thanks to the editor and reviewers for a thoughtful and efficient review process.
See here:
www.sciencedirect.com/science/arti...
Congrats to Oliver and Eric and many thanks to the editor and reviewers for a thoughtful and efficient review process.
See here:
www.sciencedirect.com/science/arti...
Our work detailing the metabolic roles of serum for cancer cell proliferation is now out at JBC, @asbmbjournals.bsky.social!
Congrats to Oliver and Eric and many thanks to the editor and reviewers for a thoughtful and efficient review process.
See here:
www.sciencedirect.com/science/arti...
Congrats to Oliver and Eric and many thanks to the editor and reviewers for a thoughtful and efficient review process.
See here:
www.sciencedirect.com/science/arti...
October 13, 2025 at 8:47 PM
Our work detailing the metabolic roles of serum for cancer cell proliferation is now out at JBC, @asbmbjournals.bsky.social!
Congrats to Oliver and Eric and many thanks to the editor and reviewers for a thoughtful and efficient review process.
See here:
www.sciencedirect.com/science/arti...
Congrats to Oliver and Eric and many thanks to the editor and reviewers for a thoughtful and efficient review process.
See here:
www.sciencedirect.com/science/arti...
Check out this great interview with a true rising star in metabolism research (and lab alumni)! 🙌
#MetabolismMondays
Meet Anna Vigil, #PhD student in @justinmcrocker.bsky.social lab @embl.org @embldbunit.bsky.social, discussing her work on how #metabolism impacts cell fate, development & #evolution #Drosophila.
#theNodeCorrespondents #ecr @the-node.bsky.social #DevBio
Meet Anna Vigil, #PhD student in @justinmcrocker.bsky.social lab @embl.org @embldbunit.bsky.social, discussing her work on how #metabolism impacts cell fate, development & #evolution #Drosophila.
#theNodeCorrespondents #ecr @the-node.bsky.social #DevBio
Currents of Change: Metabolism shaping cell fate and evolution #MetabolismMondays - the Node
All the world's a metabolic dance, early career scientists are leading the way! Emerging perspectives in metabolism Anna-Lena Brigitte Gunda VigilPhD
thenode.biologists.com
July 15, 2025 at 4:14 AM
Check out this great interview with a true rising star in metabolism research (and lab alumni)! 🙌
Reposted by Lucas Sullivan
Our paper on regulation of BCAA catabolism by mitochondrial calcium signaling is out!
Mitochondrial calcium signaling regulates branched-chain amino acid catabolism in fibrolamellar carcinoma | Science Advances www.science.org/doi/10.1126/...
Mitochondrial calcium signaling regulates branched-chain amino acid catabolism in fibrolamellar carcinoma | Science Advances www.science.org/doi/10.1126/...
Mitochondrial calcium signaling regulates branched-chain amino acid catabolism in fibrolamellar carcinoma
Mitochondrial Ca2+ signaling regulates branched-chain amino acid catabolism in an adolescent liver cancer.
www.science.org
May 31, 2025 at 6:24 AM
Our paper on regulation of BCAA catabolism by mitochondrial calcium signaling is out!
Mitochondrial calcium signaling regulates branched-chain amino acid catabolism in fibrolamellar carcinoma | Science Advances www.science.org/doi/10.1126/...
Mitochondrial calcium signaling regulates branched-chain amino acid catabolism in fibrolamellar carcinoma | Science Advances www.science.org/doi/10.1126/...
Reposted by Lucas Sullivan
![[Person with ponytail wearing lab coat hands balloon to another person in front of a springboard, a magnet hanging from above, and then a target] PERSON WITH PONYTAIL to Person 2: Rub this balloon against your head, then go jump past that magnet toward the target on the wall. [caption] Before the bathroom scale was invented, the only way to weigh people was mass spectrometry.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:cz73r7iyiqn26upot4jtjdhk/bafkreid7lnvd7afmasx3nxi6anxmyhbatpaw54za3kiw3eaoclrf722faq@jpeg)
Reposted by Lucas Sullivan
Niemi lab graduate student Hannah Pletcher recently joined @prelights.bsky.social and wrote nice highlight of recent work from @lucasbsullivan.bsky.social - check it out here!
Succinate Dehydrogenase loss causes cascading metabolic effects that impair pyrimidine biosynthesis - preLights
Not all aspartate limitation is created equal: An aspartate biosensor reveals that inhibiting succinate dehydrogenase results in defects in pyrimidine synthesis and replication stress, unique from oth...
bit.ly
May 26, 2025 at 4:10 PM
Niemi lab graduate student Hannah Pletcher recently joined @prelights.bsky.social and wrote nice highlight of recent work from @lucasbsullivan.bsky.social - check it out here!
Reposted by Lucas Sullivan
Our latest, in Science Advances: In vivo CRISPR screen revealed sgRNAs that switch chemosensitive SCLC PDXs to become resistant.We validated KEAP1 as key hit and found KEAP1 alterations in IMpower133 trial, where active NRF2 links to reduced survival in chemo arm www.science.org/doi/10.1126/... 1/2
April 29, 2025 at 10:10 PM
Our latest, in Science Advances: In vivo CRISPR screen revealed sgRNAs that switch chemosensitive SCLC PDXs to become resistant.We validated KEAP1 as key hit and found KEAP1 alterations in IMpower133 trial, where active NRF2 links to reduced survival in chemo arm www.science.org/doi/10.1126/... 1/2
Reposted by Lucas Sullivan
Overjoyed to have the opportunity to present my work orally at the Cancer Metabolism Showcase! Hope to see you there virtually!
Less than two weeks until the 2025 Cancer Metabolism Showcase and Workshops!
Speaker lineup now online! Register today!
www.cancermetabolismshowcase.org
Speaker lineup now online! Register today!
www.cancermetabolismshowcase.org
9:30 AM - 3 PM EST, May 5th and 6th, 2025
www.cancermetabolismshowcase.org
April 25, 2025 at 3:15 AM
Overjoyed to have the opportunity to present my work orally at the Cancer Metabolism Showcase! Hope to see you there virtually!
Reposted by Lucas Sullivan
From Nobel prize winning cancer researcher Bill Kaelin
Killing the Science Golden Goose - The American Journal of Medicine www.amjmed.com/article/S000...
Killing the Science Golden Goose - The American Journal of Medicine www.amjmed.com/article/S000...
Killing the Science Golden Goose
In the 1970’s I was probably one of the last American high school students who was
told that if you wanted to go to medical school, you should learn to speak German.
This was because in the late 19th ...
www.amjmed.com
April 18, 2025 at 10:54 AM
From Nobel prize winning cancer researcher Bill Kaelin
Killing the Science Golden Goose - The American Journal of Medicine www.amjmed.com/article/S000...
Killing the Science Golden Goose - The American Journal of Medicine www.amjmed.com/article/S000...
Reposted by Lucas Sullivan
Obliteride registeration opens today!!! Join the @lucasbsullivan.bsky.social team and help to CURE CANCER FASTER! See you August 9th at the starting line!! @obliteride.bsky.social #Obliteride #Obliteride2025 secure.fredhutch.org/goto/sulliva...
April 3, 2025 at 4:26 PM
Obliteride registeration opens today!!! Join the @lucasbsullivan.bsky.social team and help to CURE CANCER FASTER! See you August 9th at the starting line!! @obliteride.bsky.social #Obliteride #Obliteride2025 secure.fredhutch.org/goto/sulliva...
Reposted by Lucas Sullivan
Poster is printed! Looking forward to going to the Keystone Tumor Metabolism meeting next week in Vancouver. Come talk to me about NRF2, cysteine, and novel metabolite discovery! #KSTumorMetab25 #cancermetabolism #keystonesymposia
March 13, 2025 at 9:27 PM
Poster is printed! Looking forward to going to the Keystone Tumor Metabolism meeting next week in Vancouver. Come talk to me about NRF2, cysteine, and novel metabolite discovery! #KSTumorMetab25 #cancermetabolism #keystonesymposia
Reposted by Lucas Sullivan
happy to share our forum now online @Cell_Metabolism! fun for us (Guy & myself) to collaborate with @dfazakerley.bsky.social, Joycelyn, & Sam in putting together what we hope will be a useful piece for the broad metabolism community re: in vitro modeling! www.cell.com/cell-metabol...
Seeing the world through the eyes of cultured cells
The metabolic environment experienced by cultured cells often differs from physiological
conditions. Here, we highlight the effects that the microenvironment can have on cultured
cell behavior and adv...
www.cell.com
March 12, 2025 at 3:54 PM
happy to share our forum now online @Cell_Metabolism! fun for us (Guy & myself) to collaborate with @dfazakerley.bsky.social, Joycelyn, & Sam in putting together what we hope will be a useful piece for the broad metabolism community re: in vitro modeling! www.cell.com/cell-metabol...
Reposted by Lucas Sullivan
We were delighted to have @king5news.com.web.brid.gy visit us in the Termini Lab to discuss how NIH funding cuts could affect cancer research:
m.youtube.com/watch?v=Szo9...
We NEED indirect costs to provide funding needed complete research studies that will lead to life saving discoveries.
m.youtube.com/watch?v=Szo9...
We NEED indirect costs to provide funding needed complete research studies that will lead to life saving discoveries.
Potential NIH funding cuts could affect local cancer research
YouTube video by KING 5 Seattle
m.youtube.com
March 7, 2025 at 3:07 AM
We were delighted to have @king5news.com.web.brid.gy visit us in the Termini Lab to discuss how NIH funding cuts could affect cancer research:
m.youtube.com/watch?v=Szo9...
We NEED indirect costs to provide funding needed complete research studies that will lead to life saving discoveries.
m.youtube.com/watch?v=Szo9...
We NEED indirect costs to provide funding needed complete research studies that will lead to life saving discoveries.
Next, our 2nd preprint of the week (!), this one driven by @madelouhart.bsky.social
Previously: Mitochondrial inhibition impairs cell proliferation by constraining aspartate (ASP) availability.
Here: we investigate the kinetics of ASP depletion/ proliferation impairments and...surprises ensue!
Previously: Mitochondrial inhibition impairs cell proliferation by constraining aspartate (ASP) availability.
Here: we investigate the kinetics of ASP depletion/ proliferation impairments and...surprises ensue!
Succinate Dehydrogenase loss causes cascading metabolic effects that impair pyrimidine biosynthesis https://www.biorxiv.org/content/10.1101/2025.02.18.638948v1
February 20, 2025 at 10:25 PM
Next, our 2nd preprint of the week (!), this one driven by @madelouhart.bsky.social
Previously: Mitochondrial inhibition impairs cell proliferation by constraining aspartate (ASP) availability.
Here: we investigate the kinetics of ASP depletion/ proliferation impairments and...surprises ensue!
Previously: Mitochondrial inhibition impairs cell proliferation by constraining aspartate (ASP) availability.
Here: we investigate the kinetics of ASP depletion/ proliferation impairments and...surprises ensue!
Excited to share a recent preprint by Oliver Newsom, where we evaluate the functional contributions of serum for cancer cell proliferation. Inside:
A broadly applicable serum-free media,
Quantitative lipid uptake characterization,
Evidence lipid scavenging > synthesis for cancer cell proliferation.
A broadly applicable serum-free media,
Quantitative lipid uptake characterization,
Evidence lipid scavenging > synthesis for cancer cell proliferation.
Defined media reveals the essential role of lipid scavenging to support cancer cell proliferation https://www.biorxiv.org/content/10.1101/2025.02.12.637975v1
February 20, 2025 at 2:43 AM
Excited to share a recent preprint by Oliver Newsom, where we evaluate the functional contributions of serum for cancer cell proliferation. Inside:
A broadly applicable serum-free media,
Quantitative lipid uptake characterization,
Evidence lipid scavenging > synthesis for cancer cell proliferation.
A broadly applicable serum-free media,
Quantitative lipid uptake characterization,
Evidence lipid scavenging > synthesis for cancer cell proliferation.
Reposted by Lucas Sullivan
See you next week for Oliver Newsom’s dissertation defense!
Title: No Fat Chance: albumin-associated lipids are critical for culture success
Lab: Sullivan Lab, FH (@lucasbsullivan.bsky.social
When: Thurs, Feb. 13, 1:30pm PDT
Where: FH Sze Suites, Thomas Building & Zoom (email mcb@uw.edu for link)
Title: No Fat Chance: albumin-associated lipids are critical for culture success
Lab: Sullivan Lab, FH (@lucasbsullivan.bsky.social
When: Thurs, Feb. 13, 1:30pm PDT
Where: FH Sze Suites, Thomas Building & Zoom (email mcb@uw.edu for link)
February 6, 2025 at 9:30 PM
See you next week for Oliver Newsom’s dissertation defense!
Title: No Fat Chance: albumin-associated lipids are critical for culture success
Lab: Sullivan Lab, FH (@lucasbsullivan.bsky.social
When: Thurs, Feb. 13, 1:30pm PDT
Where: FH Sze Suites, Thomas Building & Zoom (email mcb@uw.edu for link)
Title: No Fat Chance: albumin-associated lipids are critical for culture success
Lab: Sullivan Lab, FH (@lucasbsullivan.bsky.social
When: Thurs, Feb. 13, 1:30pm PDT
Where: FH Sze Suites, Thomas Building & Zoom (email mcb@uw.edu for link)
Reposted by Lucas Sullivan
I’m really proud to announce the 2025 Cancer Metabolism Showcase and Workshop, May 5th and 6th, 9:30 AM - 3 PM EST. This year, our Keynote Speaker is Dr. Jeffrey Rathmell from VUMC.
I'm excited to come together, talk science, and support researchers in our field.
www.cancermetabolismshowcase.org
I'm excited to come together, talk science, and support researchers in our field.
www.cancermetabolismshowcase.org
9:30 AM - 3 PM EST, May 5th and 6th, 2025
www.cancermetabolismshowcase.org
January 23, 2025 at 2:05 PM
I’m really proud to announce the 2025 Cancer Metabolism Showcase and Workshop, May 5th and 6th, 9:30 AM - 3 PM EST. This year, our Keynote Speaker is Dr. Jeffrey Rathmell from VUMC.
I'm excited to come together, talk science, and support researchers in our field.
www.cancermetabolismshowcase.org
I'm excited to come together, talk science, and support researchers in our field.
www.cancermetabolismshowcase.org
Reposted by Lucas Sullivan
But…..ok, ok, I’m convinced. Elegant and definitive.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Metformin targets mitochondrial complex I to lower blood glucose levels
Acute oral metformin administration lowers blood glucose levels by targeting mitochondrial complex I.
www.science.org
December 23, 2024 at 2:36 PM
But…..ok, ok, I’m convinced. Elegant and definitive.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Lucas Sullivan
November 15, 2024 at 12:59 AM
Reposted by Lucas Sullivan
I have curated a second "metabolism" starter pack, as the first quickly got full. Please have a look, and I am happy to add others (sorry for those who may appear in both): go.bsky.app/CH1MctZ
November 27, 2024 at 4:22 PM
I have curated a second "metabolism" starter pack, as the first quickly got full. Please have a look, and I am happy to add others (sorry for those who may appear in both): go.bsky.app/CH1MctZ
Reposted by Lucas Sullivan
November 15, 2024 at 5:50 AM