David MacPherson Lab
@davidmacphersonlab.bsky.social
Cancer Biologist at Fred Hutchinson Cancer Center. Our lab studies the biology of small cell lung cancer.
Pinned
Hello Bluesky! I’m a Professor at Fred Hutch and our lab studies the biology of small cell lung cancer. Using mouse and PDX models, cell-based and in vivo genetic screens, and genomic approaches, we seek to understand biologically distinct subsets of SCLC and their therapeutic vulnerabilities.
Reposted by David MacPherson Lab
In work published in Science Advances, researchers in the @davidmacphersonlab.bsky.social used #CRISPRCas9 on #SCLC tumor cells to better model how tumors that initially respond to chemotherapy become resistant. www.fredhutch.org/en/news/cent...
Fred Hutch study finds genetic driver of drug resistance in small cell lung cancer
A study of human tumor cells implanted in mice from the MacPherson Lab at Fred Hutch describes a new way to screen for the genes that matter in chemotherapy resistance in small cell lung cancer.
www.fredhutch.org
May 15, 2025 at 6:06 PM
In work published in Science Advances, researchers in the @davidmacphersonlab.bsky.social used #CRISPRCas9 on #SCLC tumor cells to better model how tumors that initially respond to chemotherapy become resistant. www.fredhutch.org/en/news/cent...
Our latest, in Science Advances: In vivo CRISPR screen revealed sgRNAs that switch chemosensitive SCLC PDXs to become resistant.We validated KEAP1 as key hit and found KEAP1 alterations in IMpower133 trial, where active NRF2 links to reduced survival in chemo arm www.science.org/doi/10.1126/... 1/2
April 29, 2025 at 10:10 PM
Our latest, in Science Advances: In vivo CRISPR screen revealed sgRNAs that switch chemosensitive SCLC PDXs to become resistant.We validated KEAP1 as key hit and found KEAP1 alterations in IMpower133 trial, where active NRF2 links to reduced survival in chemo arm www.science.org/doi/10.1126/... 1/2
The MacPherson lab at Fred Hutch is hiring a postdoc to study the biology of small cell lung cancer. We employ in vivo models, genetic screens and genomic approaches to understand + therapeutically target subsets of SCLC. $78K salary ⬆️ to >$90K after 2 yrs
careers-fhcrc.icims.com/jobs/28757/p...
careers-fhcrc.icims.com/jobs/28757/p...
Fred Hutchinson Cancer Center
Fred Hutch is dedicated to the elimination of cancer and related diseases as causes of human suffering and death.
careers-fhcrc.icims.com
December 3, 2024 at 11:55 PM
The MacPherson lab at Fred Hutch is hiring a postdoc to study the biology of small cell lung cancer. We employ in vivo models, genetic screens and genomic approaches to understand + therapeutically target subsets of SCLC. $78K salary ⬆️ to >$90K after 2 yrs
careers-fhcrc.icims.com/jobs/28757/p...
careers-fhcrc.icims.com/jobs/28757/p...
Hello Bluesky! I’m a Professor at Fred Hutch and our lab studies the biology of small cell lung cancer. Using mouse and PDX models, cell-based and in vivo genetic screens, and genomic approaches, we seek to understand biologically distinct subsets of SCLC and their therapeutic vulnerabilities.
November 17, 2024 at 7:04 PM
Hello Bluesky! I’m a Professor at Fred Hutch and our lab studies the biology of small cell lung cancer. Using mouse and PDX models, cell-based and in vivo genetic screens, and genomic approaches, we seek to understand biologically distinct subsets of SCLC and their therapeutic vulnerabilities.
Reposted by David MacPherson Lab
Starting a list of oncology related peopl. Please tell me more to add. Or any similar listd go.bsky.app/GKXp9Fy @n8pennell.bsky.social
November 10, 2024 at 9:54 PM
Starting a list of oncology related peopl. Please tell me more to add. Or any similar listd go.bsky.app/GKXp9Fy @n8pennell.bsky.social
Reposted by David MacPherson Lab
November 9, 2024 at 5:07 PM