Adrian Valente
@loradrian.bsky.social
RE at Instadeep, PhD in computational neuroscience, MSc in CS, interested in ML for life sciences.
Reposted by Adrian Valente
I am super happy to share that our project on training biophysical models with Jaxley is now published in Nature Methods: www.nature.com/articles/s41...
Jaxley: differentiable simulation enables large-scale training of detailed biophysical models of neural dynamics - Nature Methods
Jaxley is a versatile platform for biophysical modeling in neuroscience. It allows efficiently simulating large-scale biophysical models on CPUs, GPUs and TPUs. Model parameters can be optimized with ...
www.nature.com
November 13, 2025 at 12:38 PM
I am super happy to share that our project on training biophysical models with Jaxley is now published in Nature Methods: www.nature.com/articles/s41...
Reposted by Adrian Valente
New preprint:
Neural manifolds that orchestrate walking and stopping
Here we develop a new theory for neural generation of walking and how it can stop- Next we test the theory using Neuropixels probes in the lumber spinal cord of freely moving rats. See more:
www.biorxiv.org/content/10.1...
Neural manifolds that orchestrate walking and stopping
Here we develop a new theory for neural generation of walking and how it can stop- Next we test the theory using Neuropixels probes in the lumber spinal cord of freely moving rats. See more:
www.biorxiv.org/content/10.1...
November 9, 2025 at 9:33 PM
New preprint:
Neural manifolds that orchestrate walking and stopping
Here we develop a new theory for neural generation of walking and how it can stop- Next we test the theory using Neuropixels probes in the lumber spinal cord of freely moving rats. See more:
www.biorxiv.org/content/10.1...
Neural manifolds that orchestrate walking and stopping
Here we develop a new theory for neural generation of walking and how it can stop- Next we test the theory using Neuropixels probes in the lumber spinal cord of freely moving rats. See more:
www.biorxiv.org/content/10.1...
Reposted by Adrian Valente
5,290 papers will be published at NeurIPS this year. If you could still get the proceedings in a book, it would be like 50,000 pages long. That’s 14.5 papers a day to read each and every day until the next NeurIPS
September 18, 2025 at 7:06 PM
5,290 papers will be published at NeurIPS this year. If you could still get the proceedings in a book, it would be like 50,000 pages long. That’s 14.5 papers a day to read each and every day until the next NeurIPS
Reposted by Adrian Valente
This site would probably benefit a good deal from community notes. That's maybe the only great twitter feature
August 25, 2025 at 3:24 PM
This site would probably benefit a good deal from community notes. That's maybe the only great twitter feature
Reposted by Adrian Valente
Check out our new review/perspective (w/ @juangallego.bsky.social & Devika Narain) on neural manifolds in the brain! It was a lot of fun to think through these ideas over the past couple of years, and I'm excited it's finally out in the world!
🔗: www.nature.com/articles/s41...
📄: rdcu.be/ex8hW
🔗: www.nature.com/articles/s41...
📄: rdcu.be/ex8hW
A neural manifold view of the brain - Nature Neuroscience
Recent advances in neuroscience have revealed how neural population activity underlying behavior can be well described by topological objects called neural manifolds. Understanding how nature, nurture...
www.nature.com
July 29, 2025 at 7:06 PM
Check out our new review/perspective (w/ @juangallego.bsky.social & Devika Narain) on neural manifolds in the brain! It was a lot of fun to think through these ideas over the past couple of years, and I'm excited it's finally out in the world!
🔗: www.nature.com/articles/s41...
📄: rdcu.be/ex8hW
🔗: www.nature.com/articles/s41...
📄: rdcu.be/ex8hW
Reposted by Adrian Valente
We finally made it to Bluesky—just a few billion years after the Big Bang, and only slightly late to the party ✨🌌
We’re sharing some of our best stories from the year so far to kick off our Bluesky journey!
We’re sharing some of our best stories from the year so far to kick off our Bluesky journey!
What is Scientific American?
YouTube video by Scientific American
www.youtube.com
July 14, 2025 at 4:09 PM
We finally made it to Bluesky—just a few billion years after the Big Bang, and only slightly late to the party ✨🌌
We’re sharing some of our best stories from the year so far to kick off our Bluesky journey!
We’re sharing some of our best stories from the year so far to kick off our Bluesky journey!
Reposted by Adrian Valente
Interesting overview of the limitations of AlphaFold. As with all AI tools, try not to get hit by the hype-train. open.substack.com/pub/clauswil... (h/t @steveroyle.bsky.social)
No, AlphaFold has not completely solved protein folding
Biology is hard. Yes, even for AI.
open.substack.com
July 14, 2025 at 1:43 PM
Interesting overview of the limitations of AlphaFold. As with all AI tools, try not to get hit by the hype-train. open.substack.com/pub/clauswil... (h/t @steveroyle.bsky.social)
Reposted by Adrian Valente
Pytrees for Scientific Python
PyTrees enables you to flatten nested tree into a flat collection of leaves and a “blueprint” of the tree structure, and then being able to unflatten them back into the original PyTree.
blog.scientific-python.org/pytrees/
PyTrees enables you to flatten nested tree into a flat collection of leaves and a “blueprint” of the tree structure, and then being able to unflatten them back into the original PyTree.
blog.scientific-python.org/pytrees/
Pytrees for Scientific Python
Introducing PyTrees for Scientific Python. We discuss what PyTrees are, how they're useful in the realm of scientific Python, and how to work _efficiently_ with them.
blog.scientific-python.org
July 13, 2025 at 1:39 PM
Pytrees for Scientific Python
PyTrees enables you to flatten nested tree into a flat collection of leaves and a “blueprint” of the tree structure, and then being able to unflatten them back into the original PyTree.
blog.scientific-python.org/pytrees/
PyTrees enables you to flatten nested tree into a flat collection of leaves and a “blueprint” of the tree structure, and then being able to unflatten them back into the original PyTree.
blog.scientific-python.org/pytrees/
Reposted by Adrian Valente
Thrilled to see our TinyRNN paper in @nature! We show how tiny RNNs predict choices of individual subjects accurately while staying fully interpretable. This approach can transform how we model cognitive processes in both healthy and disordered decisions. doi.org/10.1038/s415...
Discovering cognitive strategies with tiny recurrent neural networks - Nature
Modelling biological decision-making with tiny recurrent neural networks enables more accurate predictions of animal choices than classical cognitive models and offers insights into the underlying cog...
doi.org
July 2, 2025 at 7:03 PM
Thrilled to see our TinyRNN paper in @nature! We show how tiny RNNs predict choices of individual subjects accurately while staying fully interpretable. This approach can transform how we model cognitive processes in both healthy and disordered decisions. doi.org/10.1038/s415...
Reposted by Adrian Valente
After all these reports of authors adding language instructions for LLM reviews in their papers I wanted to check this myself and I downloaded the .tex source from one of these papers.
Here is an example.
(I will not share the identity of the paper)
Here is an example.
(I will not share the identity of the paper)
July 5, 2025 at 5:12 PM
After all these reports of authors adding language instructions for LLM reviews in their papers I wanted to check this myself and I downloaded the .tex source from one of these papers.
Here is an example.
(I will not share the identity of the paper)
Here is an example.
(I will not share the identity of the paper)
Reposted by Adrian Valente
Dance like ̶n̶o̶b̶o̶d̶y̶ ̶i̶s̶ ̶w̶a̶t̶c̶h̶i̶n̶g̶ you will be part of the training set
Meta announces Oakley smart glasses
Meta announces Oakley smart glasses
The limited-edition gold pair costs $499 and shoots 3K video.
buff.ly
June 21, 2025 at 3:55 PM
Dance like ̶n̶o̶b̶o̶d̶y̶ ̶i̶s̶ ̶w̶a̶t̶c̶h̶i̶n̶g̶ you will be part of the training set
Reposted by Adrian Valente
I don't know why people think picking a model on ChatGPT is so complicated.
May 14, 2025 at 1:36 AM
I don't know why people think picking a model on ChatGPT is so complicated.
Reposted by Adrian Valente
On vient littéralement de tailler de plusieurs centaines de millions dans le budget de la recherche.
Emmanuel Macron annonce un nouvel investissement de 100 millions d’euros pour séduire les chercheurs étrangers
Emmanuel Macron annonce un nouvel investissement de 100 millions d’euros pour séduire les chercheurs étrangers
Ursula von der Leyen va, de son côté, proposer une nouvelle enveloppe de 500 millions d’euros pour « faire de l’Europe un pôle d’attraction ». L’événement, qui a réuni des universités, des commissaires européens et des ministres de la recherche, s’adressait particulièrement aux chercheurs américains.
www.lemonde.fr
May 5, 2025 at 5:37 PM
On vient littéralement de tailler de plusieurs centaines de millions dans le budget de la recherche.
Reposted by Adrian Valente
More from Peter Marks on RFK Jr and the FDA
This extends beyond anti-vax to unproven use of stem cells
Gift link
www.wsj.com/health/healt...
This extends beyond anti-vax to unproven use of stem cells
Gift link
www.wsj.com/health/healt...
Exclusive | Ousted Vaccine Chief Says RFK Jr.’s Team Sought Data to Justify Anti-Science Stance
Peter Marks says the new health secretary’s team wants to show vaccines aren’t safe while promoting dangerous and unproven treatments.
www.wsj.com
April 4, 2025 at 6:26 PM
More from Peter Marks on RFK Jr and the FDA
This extends beyond anti-vax to unproven use of stem cells
Gift link
www.wsj.com/health/healt...
This extends beyond anti-vax to unproven use of stem cells
Gift link
www.wsj.com/health/healt...
Reposted by Adrian Valente
The crush of new grant cancellations hasn't let up.
If your grant was terminated (or your app was pulled) please use this Google Form👇 to submit details for tracking purposes.
Multiple advocacy efforts are moving forward, but we must must must know more about what grants were cancelled and why.
If your grant was terminated (or your app was pulled) please use this Google Form👇 to submit details for tracking purposes.
Multiple advocacy efforts are moving forward, but we must must must know more about what grants were cancelled and why.
Cancelled NIH grant information submission form
Please use this form to submit information identifying specific NIH grants that have been cancelled for any reason after January 20, 2025.
Data from this form will be used to update the Rescinded NIH...
forms.gle
March 21, 2025 at 3:32 AM
The crush of new grant cancellations hasn't let up.
If your grant was terminated (or your app was pulled) please use this Google Form👇 to submit details for tracking purposes.
Multiple advocacy efforts are moving forward, but we must must must know more about what grants were cancelled and why.
If your grant was terminated (or your app was pulled) please use this Google Form👇 to submit details for tracking purposes.
Multiple advocacy efforts are moving forward, but we must must must know more about what grants were cancelled and why.
Reposted by Adrian Valente
Scientists have just cured pancreatic cancer in some patients with personalized mRNA vaccines. Pancreatic cancer. And this Trump administration wants to throw it all away.
They’re throwing away a cure for cancer.
They’re throwing away a cure for cancer.
Exclusive: NIH officials have advised scientists to remove reference to mRNA vaccines from their grant applications, in expectation the Trump administration intends to abandon most research in the field.
By @arthurallen202.bsky.social
kffhealthnews.org/news/article...
By @arthurallen202.bsky.social
kffhealthnews.org/news/article...
Scientists Say NIH Officials Told Them To Scrub mRNA References on Grants - KFF Health News
Two senior scientists say National Institutes of Health officials advised them to remove references to mRNA vaccines in grant applications, and they fear the Trump administration will abandon a promis...
kffhealthnews.org
March 17, 2025 at 1:16 AM
Scientists have just cured pancreatic cancer in some patients with personalized mRNA vaccines. Pancreatic cancer. And this Trump administration wants to throw it all away.
They’re throwing away a cure for cancer.
They’re throwing away a cure for cancer.
Reposted by Adrian Valente
A key set of problems AI can’t yet solve in education is that learning requires mental work & that we are bad at assessing whether we are learning. Many people have a subject in which they are intrinsically motivated to learn, but we generally seek short cuts that ultimately hurt our learning.
March 17, 2025 at 3:30 PM
A key set of problems AI can’t yet solve in education is that learning requires mental work & that we are bad at assessing whether we are learning. Many people have a subject in which they are intrinsically motivated to learn, but we generally seek short cuts that ultimately hurt our learning.
Reposted by Adrian Valente
Please repost to get the word out! @nkgarg.bsky.social and I are excited to present a personalized feed for academics! It shows posts about papers from accounts you’re following bsky.app/profile/pape...
March 10, 2025 at 3:12 PM
Please repost to get the word out! @nkgarg.bsky.social and I are excited to present a personalized feed for academics! It shows posts about papers from accounts you’re following bsky.app/profile/pape...
Reposted by Adrian Valente
New preprint w/ @jennhu.bsky.social @kmahowald.bsky.social : Can LLMs introspect about their knowledge of language?
Across models and domains, we did not find evidence that LLMs have privileged access to their own predictions. 🧵(1/8)
Across models and domains, we did not find evidence that LLMs have privileged access to their own predictions. 🧵(1/8)
March 12, 2025 at 2:31 PM
New preprint w/ @jennhu.bsky.social @kmahowald.bsky.social : Can LLMs introspect about their knowledge of language?
Across models and domains, we did not find evidence that LLMs have privileged access to their own predictions. 🧵(1/8)
Across models and domains, we did not find evidence that LLMs have privileged access to their own predictions. 🧵(1/8)
Reposted by Adrian Valente
🖊️AI for health: the impossible necessity of unbiased data
Is unbiased data important to build health AI? Yes!
Can there be unbiased data? No!
Building health on biased data discriminates
The notion of bias depends on the intended use:
gael-varoquaux.info/science/ai-f...
Is unbiased data important to build health AI? Yes!
Can there be unbiased data? No!
Building health on biased data discriminates
The notion of bias depends on the intended use:
gael-varoquaux.info/science/ai-f...
February 14, 2025 at 8:30 AM
🖊️AI for health: the impossible necessity of unbiased data
Is unbiased data important to build health AI? Yes!
Can there be unbiased data? No!
Building health on biased data discriminates
The notion of bias depends on the intended use:
gael-varoquaux.info/science/ai-f...
Is unbiased data important to build health AI? Yes!
Can there be unbiased data? No!
Building health on biased data discriminates
The notion of bias depends on the intended use:
gael-varoquaux.info/science/ai-f...
Reposted by Adrian Valente
Great interview with @jascha.sohldickstein.com about diffusion models! This is the first in a series: similar interviews with Yang Song and yours truly will follow soon.
(One of these is not like the others -- both of them basically invented the field, and I occasionally write a blog post 🥲)
(One of these is not like the others -- both of them basically invented the field, and I occasionally write a blog post 🥲)
History of Diffusion - Jascha Sohl-Dickstein
YouTube video by Bain Capital Ventures
www.youtube.com
February 10, 2025 at 10:28 PM
Great interview with @jascha.sohldickstein.com about diffusion models! This is the first in a series: similar interviews with Yang Song and yours truly will follow soon.
(One of these is not like the others -- both of them basically invented the field, and I occasionally write a blog post 🥲)
(One of these is not like the others -- both of them basically invented the field, and I occasionally write a blog post 🥲)
Reposted by Adrian Valente
s1: The $6 R1 Competitor?
This isn't a R1 replication, it's a brilliant breakthrough in data reduction, and just plain dumb engineering ingenuity. I considered not writing this up, but I don't think it's obvious why it's so important. Enjoy!
timkellogg.me/blog/2025/02...
This isn't a R1 replication, it's a brilliant breakthrough in data reduction, and just plain dumb engineering ingenuity. I considered not writing this up, but I don't think it's obvious why it's so important. Enjoy!
timkellogg.me/blog/2025/02...
February 4, 2025 at 4:39 PM
s1: The $6 R1 Competitor?
This isn't a R1 replication, it's a brilliant breakthrough in data reduction, and just plain dumb engineering ingenuity. I considered not writing this up, but I don't think it's obvious why it's so important. Enjoy!
timkellogg.me/blog/2025/02...
This isn't a R1 replication, it's a brilliant breakthrough in data reduction, and just plain dumb engineering ingenuity. I considered not writing this up, but I don't think it's obvious why it's so important. Enjoy!
timkellogg.me/blog/2025/02...
Reposted by Adrian Valente
CDC Data Are Disappearing
The agency has already removed scientific data from public view. More could follow.
ignorance is strength
www.theatlantic.com/...
1/6
The agency has already removed scientific data from public view. More could follow.
ignorance is strength
www.theatlantic.com/...
1/6
The CDC Is Altering Data to Follow Trump’s DEI Order - The Atlantic
The agency has already removed scientific data from public view. More could follow.
www.theatlantic.com
February 1, 2025 at 9:54 PM
CDC Data Are Disappearing
The agency has already removed scientific data from public view. More could follow.
ignorance is strength
www.theatlantic.com/...
1/6
The agency has already removed scientific data from public view. More could follow.
ignorance is strength
www.theatlantic.com/...
1/6
Reposted by Adrian Valente
American science and medicine has been thrown into chaos and uncertainty over the past week. Here are some stories to get up to speed. 1/12
January 28, 2025 at 3:58 AM
American science and medicine has been thrown into chaos and uncertainty over the past week. Here are some stories to get up to speed. 1/12
Reposted by Adrian Valente
Us: "Hey we wrote a spirited defense of basic science funding, showing how it drives startup creation and ultimately GDP. Would you like to publish it as an OpEd?"
Major Media Outlets: "No."
Major Media Outlets: "No."
December 12, 2024 at 1:54 PM
Us: "Hey we wrote a spirited defense of basic science funding, showing how it drives startup creation and ultimately GDP. Would you like to publish it as an OpEd?"
Major Media Outlets: "No."
Major Media Outlets: "No."