Liliana M. Vargas
@lmvargas.bsky.social
Veritas filia temporis.
Computational Biology and Drug Design Research Unit @UIBCDF, Federico Gomez Children's Hospital, Mexico City.
Computational Biology and Drug Design Research Unit @UIBCDF, Federico Gomez Children's Hospital, Mexico City.
Reposted by Liliana M. Vargas
All nursing home residents tested in Chicago carried Candida auris and at least one #AMR ESKAPE pathogen. Nursing homes serve as breeding grounds for AMR #infectiousdisease exacerbated by staffing shortages and inadequate resources for decolonization efforts.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Clonal Candida auris and ESKAPE pathogens on the skin of residents of nursing homes - Nature
Analyses of strain-resolved metagenomics with isolate sequencing data of skin samples from residents at nursing homes suggest that skin is a reservoir for Candida auris and other multidrug-resistant b...
www.nature.com
March 5, 2025 at 6:46 PM
All nursing home residents tested in Chicago carried Candida auris and at least one #AMR ESKAPE pathogen. Nursing homes serve as breeding grounds for AMR #infectiousdisease exacerbated by staffing shortages and inadequate resources for decolonization efforts.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Liliana M. Vargas
Prime Minister Justin Trudeau on Donald Trump's looming 25% tariffs on Canada tomorrow:
"If the president does choose to implement any tariffs against Canada, we're ready with a response. A purposeful, forceful but reasonable, immediate response."
"If the president does choose to implement any tariffs against Canada, we're ready with a response. A purposeful, forceful but reasonable, immediate response."
January 31, 2025 at 8:37 PM
Prime Minister Justin Trudeau on Donald Trump's looming 25% tariffs on Canada tomorrow:
"If the president does choose to implement any tariffs against Canada, we're ready with a response. A purposeful, forceful but reasonable, immediate response."
"If the president does choose to implement any tariffs against Canada, we're ready with a response. A purposeful, forceful but reasonable, immediate response."
Reposted by Liliana M. Vargas
Very detailed thread on our latest Review article by @mvanins.bsky.social 👇
Several new technologies have enabled translation profiling in single cells. In our article in @natrevmcb.bsky.social, Alexander and I discuss these single-cell methods for measuring ribosome profiles, ribosome-associated transcripts, and spatial translation 🧵 www.nature.com/articles/s41...
Sequencing technologies to measure translation in single cells - Nature Reviews Molecular Cell Biology
Recent sequencing-based methods, including novel ribosome profiling, ribosome affinity purification and spatial translation methods, have enabled the measurement of translation at single-cell resoluti...
www.nature.com
January 24, 2025 at 8:52 AM
Very detailed thread on our latest Review article by @mvanins.bsky.social 👇
Reposted by Liliana M. Vargas
Machine Learning in Drug Discovery Resources page updated for 2025. github.com/PatWalters/r...
GitHub - PatWalters/resources_2025: Machine Learning in Drug Discovery Resources 2024
Machine Learning in Drug Discovery Resources 2024. Contribute to PatWalters/resources_2025 development by creating an account on GitHub.
github.com
January 23, 2025 at 2:12 PM
Machine Learning in Drug Discovery Resources page updated for 2025. github.com/PatWalters/r...
Reposted by Liliana M. Vargas
This discovery provides new insights into bacterial gene regulation and offers potential targets for new therapies to fight AMR. In short, KorB acts as a "moving clamp" on DNA, while KorA "locks it in place" to turn off gene expression.
Impressive work!
www.nature.com/articles/s41...
Impressive work!
www.nature.com/articles/s41...
KorB switching from DNA-sliding clamp to repressor mediates long-range gene silencing in a multi-drug resistance plasmid - Nature Microbiology
Structural and single-molecule analyses show the CTPase, KorB, is a sliding DNA clamp that interacts with a clamp-locking protein KorA to inhibit gene expression over distances of more than 1 kb in th...
www.nature.com
January 23, 2025 at 11:05 AM
This discovery provides new insights into bacterial gene regulation and offers potential targets for new therapies to fight AMR. In short, KorB acts as a "moving clamp" on DNA, while KorA "locks it in place" to turn off gene expression.
Impressive work!
www.nature.com/articles/s41...
Impressive work!
www.nature.com/articles/s41...
Reposted by Liliana M. Vargas
🛡️ Corporate Intimidation in Health
Industries like tobacco, alcohol, and ultra-processed food use legal threats, surveillance, and discrediting to silence health advocates and researchers.
Cross-sector collaboration could counter these tactics.
🔗 doi.org/10.1093/heap...
#Health #SciComm 🧪
Industries like tobacco, alcohol, and ultra-processed food use legal threats, surveillance, and discrediting to silence health advocates and researchers.
Cross-sector collaboration could counter these tactics.
🔗 doi.org/10.1093/heap...
#Health #SciComm 🧪
Intimidation against advocates and researchers in the tobacco, alcohol and ultra-processed food spaces: a review
Abstract. Unhealthy commodity industries (UCIs) engage in corporate political activity, using diverse practices, including intimidatory tactics, to thwart,
doi.org
January 16, 2025 at 5:59 AM
🛡️ Corporate Intimidation in Health
Industries like tobacco, alcohol, and ultra-processed food use legal threats, surveillance, and discrediting to silence health advocates and researchers.
Cross-sector collaboration could counter these tactics.
🔗 doi.org/10.1093/heap...
#Health #SciComm 🧪
Industries like tobacco, alcohol, and ultra-processed food use legal threats, surveillance, and discrediting to silence health advocates and researchers.
Cross-sector collaboration could counter these tactics.
🔗 doi.org/10.1093/heap...
#Health #SciComm 🧪
Reposted by Liliana M. Vargas
📆 Save the Date! 🧬 We are delighted to announce the upcoming #7thJointDZGSymposium Dresden on March 27, 2025, 1:00-5:15 pm. 🌐 Dive into the world of translational research in diabetes, cancer, neurodegenerative as well as child & adolescents´ diseases conducted in #Dresden.🦠🧠👦
More about to come!
More about to come!
January 9, 2025 at 11:07 AM
📆 Save the Date! 🧬 We are delighted to announce the upcoming #7thJointDZGSymposium Dresden on March 27, 2025, 1:00-5:15 pm. 🌐 Dive into the world of translational research in diabetes, cancer, neurodegenerative as well as child & adolescents´ diseases conducted in #Dresden.🦠🧠👦
More about to come!
More about to come!
Reposted by Liliana M. Vargas
Global Commission on Clinical Obesity proses a major revision of the diagnosis of #obesity. The new approach goes beyond body mass index (BMI) + includes additional measurements of body fat as well as objective symptoms at the individual level.
Read more @thelancet.bsky.social ⬇️⬇️
Read more @thelancet.bsky.social ⬇️⬇️
🆕 Global Commission proposes overhaul of obesity diagnosis – going beyond BMI to define when obesity is a disease.
Find out more: hubs.li/Q030v_j_0
Find out more: hubs.li/Q030v_j_0
January 15, 2025 at 8:12 AM
Global Commission on Clinical Obesity proses a major revision of the diagnosis of #obesity. The new approach goes beyond body mass index (BMI) + includes additional measurements of body fat as well as objective symptoms at the individual level.
Read more @thelancet.bsky.social ⬇️⬇️
Read more @thelancet.bsky.social ⬇️⬇️
Reposted by Liliana M. Vargas
Weekly recap, Jan 2025 part 1: Directed evolution by a protein language model, AI learning to run transcript assemblers, a review/introduction to pangenomics, Alphafold2 refinement for protein design, metagenomic binning, new Python & #RStats pkgs... doi.org/10.59350/2zj... 🧬🖥️🧪
Weekly Recap (Jan 2025, part 1)
Directed evolution by a protein language model, AI learning to run transcript assemblers, a review/introduction to pangenomics, Alphafold2 refinement for proteindesign, metagenomic binning...
doi.org
January 3, 2025 at 4:14 PM
Weekly recap, Jan 2025 part 1: Directed evolution by a protein language model, AI learning to run transcript assemblers, a review/introduction to pangenomics, Alphafold2 refinement for protein design, metagenomic binning, new Python & #RStats pkgs... doi.org/10.59350/2zj... 🧬🖥️🧪
Reposted by Liliana M. Vargas
Protein folding: a 50-year puzzle. Levinthal’s Paradox shows why—a single protein can fold into ~10³⁰⁰ shapes, yet nature does it in milliseconds. Insights from Demis Hassabis at Nobel Prize Week highlight the complexity AI like AlphaFold is helping solve. (Slide source: DeepMind)
January 7, 2025 at 6:37 PM
Protein folding: a 50-year puzzle. Levinthal’s Paradox shows why—a single protein can fold into ~10³⁰⁰ shapes, yet nature does it in milliseconds. Insights from Demis Hassabis at Nobel Prize Week highlight the complexity AI like AlphaFold is helping solve. (Slide source: DeepMind)
Reposted by Liliana M. Vargas
Decades of data from the Protein Data Bank (~170,000 structures) provided the foundation for AlphaFold’s training. Achieving predictions accurate to less than an atom’s width has set a new gold standard in computational biology.
(Slide source: Demis Hassabis, DeepMind)
(Slide source: Demis Hassabis, DeepMind)
January 7, 2025 at 7:28 PM
Decades of data from the Protein Data Bank (~170,000 structures) provided the foundation for AlphaFold’s training. Achieving predictions accurate to less than an atom’s width has set a new gold standard in computational biology.
(Slide source: Demis Hassabis, DeepMind)
(Slide source: Demis Hassabis, DeepMind)
Reposted by Liliana M. Vargas
AlphaFold has folded 200M+ proteins, freely accessible via EMBL-EBI. Accessed by 2M+ scientists in 190 countries and cited 30,000+ times, developed with input from 30+ biosecurity and bioethics experts for safe and impactful use in scientific discovery. (Slide source: Demis Hassabis, DeepMind)
January 9, 2025 at 4:38 PM
AlphaFold has folded 200M+ proteins, freely accessible via EMBL-EBI. Accessed by 2M+ scientists in 190 countries and cited 30,000+ times, developed with input from 30+ biosecurity and bioethics experts for safe and impactful use in scientific discovery. (Slide source: Demis Hassabis, DeepMind)
Reposted by Liliana M. Vargas
New method to help with protein function prediction when mining proteomes with AlphaFold
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Functional protein mining with conformal guarantees - Nature Communications
This study presents a protein search framework with conformal prediction, enabling statistically reliable annotation of protein function. The method improves homology search, enzyme classification, an...
www.nature.com
January 11, 2025 at 8:25 AM
New method to help with protein function prediction when mining proteomes with AlphaFold
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Liliana M. Vargas
The findings offer a detailed view of the circumstances aside from misconduct that lead to retractions, and the emotional toll that the process has on researchers
https://go.nature.com/4fSp1ao
https://go.nature.com/4fSp1ao
Retractions caused by honest mistakes are extremely stressful, say researchers
A survey highlights the emotional toll of retractions for authors and what could be done differently.
go.nature.com
January 14, 2025 at 3:20 PM
The findings offer a detailed view of the circumstances aside from misconduct that lead to retractions, and the emotional toll that the process has on researchers
https://go.nature.com/4fSp1ao
https://go.nature.com/4fSp1ao
Reposted by Liliana M. Vargas
The research community has flocked to the social-media platform Bluesky.
Tell us about your experience
https://go.nature.com/42fihQG
Tell us about your experience
https://go.nature.com/42fihQG
Has Bluesky replaced X for scientists? Take Nature’s poll
The research community has flocked to the social-media platform Bluesky. Tell us about your experience.
go.nature.com
January 14, 2025 at 4:56 PM
The research community has flocked to the social-media platform Bluesky.
Tell us about your experience
https://go.nature.com/42fihQG
Tell us about your experience
https://go.nature.com/42fihQG