Lead-DBS
@lead-dbs.org
Open source toolbox to model deep brain stimulation electrodes in the human brain. www.lead-dbs.org - home at the @netstim.org
From Adaptive DBS to Adaptive Circuit Targeting 👇👇
In #DeepBrainStimulation
the two major developments across the last decade have been
1. Adaptive DBS and
2. Connectomic DBS
In a @natrevneurol.nature.com article with @julianneumann.bsky.social, we ask:
Could the two be united into a common framework?
www.nature.com/articles/s41...
A 🧵
the two major developments across the last decade have been
1. Adaptive DBS and
2. Connectomic DBS
In a @natrevneurol.nature.com article with @julianneumann.bsky.social, we ask:
Could the two be united into a common framework?
www.nature.com/articles/s41...
A 🧵
September 3, 2025 at 8:09 PM
From Adaptive DBS to Adaptive Circuit Targeting 👇👇
Reposted by Lead-DBS
Next steps ahead for DBS! 👇👇
In #DeepBrainStimulation
the two major developments across the last decade have been
1. Adaptive DBS and
2. Connectomic DBS
In a @natrevneurol.nature.com article with @julianneumann.bsky.social, we ask:
Could the two be united into a common framework?
www.nature.com/articles/s41...
A 🧵
the two major developments across the last decade have been
1. Adaptive DBS and
2. Connectomic DBS
In a @natrevneurol.nature.com article with @julianneumann.bsky.social, we ask:
Could the two be united into a common framework?
www.nature.com/articles/s41...
A 🧵
September 3, 2025 at 8:08 PM
Next steps ahead for DBS! 👇👇
Reposted by Lead-DBS
Konstantin Butenko compares four methods for mapping structural network activations in deep brain stimulation—two simple, two complex; some deterministic, some probabilistic—into @lead-dbs.org for direct use in the Fiber Filtering Explorer. See the methods paper below 👇👇
How should we best model recruitment of axons by deep brain stimulation?
Various concepts have been introduced and Konstantin Butenko just introduced a few more in a new publication at Brain Communications:
academic.oup.com/braincomms/a...
Various concepts have been introduced and Konstantin Butenko just introduced a few more in a new publication at Brain Communications:
academic.oup.com/braincomms/a...
August 22, 2025 at 8:17 AM
Konstantin Butenko compares four methods for mapping structural network activations in deep brain stimulation—two simple, two complex; some deterministic, some probabilistic—into @lead-dbs.org for direct use in the Fiber Filtering Explorer. See the methods paper below 👇👇
Reposted by Lead-DBS
New Institute paper out 👇👇
How should we best model recruitment of axons by deep brain stimulation?
Various concepts have been introduced and Konstantin Butenko just introduced a few more in a new publication at Brain Communications:
academic.oup.com/braincomms/a...
Various concepts have been introduced and Konstantin Butenko just introduced a few more in a new publication at Brain Communications:
academic.oup.com/braincomms/a...
August 22, 2025 at 8:19 AM
New Institute paper out 👇👇
How should we best model recruitment of axons by deep brain stimulation?
Various concepts have been introduced and Konstantin Butenko just introduced a few more in a new publication at Brain Communications:
academic.oup.com/braincomms/a...
Various concepts have been introduced and Konstantin Butenko just introduced a few more in a new publication at Brain Communications:
academic.oup.com/braincomms/a...
August 22, 2025 at 8:15 AM
How should we best model recruitment of axons by deep brain stimulation?
Various concepts have been introduced and Konstantin Butenko just introduced a few more in a new publication at Brain Communications:
academic.oup.com/braincomms/a...
Various concepts have been introduced and Konstantin Butenko just introduced a few more in a new publication at Brain Communications:
academic.oup.com/braincomms/a...
Reposted by Lead-DBS
Super excited for Ningfei Li to receive the highly prestigious NSFC Excellent Young Scientists Fund – as of yesterday, Ningfei is Full Professor at the Xian University and has joined a new AI institute! We are both excited to continue our collaboration on @lead-dbs.org and connectomic DBS!
August 18, 2025 at 9:25 AM
Super excited for Ningfei Li to receive the highly prestigious NSFC Excellent Young Scientists Fund – as of yesterday, Ningfei is Full Professor at the Xian University and has joined a new AI institute! We are both excited to continue our collaboration on @lead-dbs.org and connectomic DBS!
Reposted by Lead-DBS
We had a wonderful time talking to @rolstonjohn.bsky.social, the Director of Epilepsy Surgery at Brigham & Women's Hospital. We talk about RNS for epilepsy, DBS for coma, traveling waves in the brain, stem cell therapy, closed loop DBS & more! Tune in 👇
stimulatingbrains.org/72-john-rols...
stimulatingbrains.org/72-john-rols...
August 1, 2025 at 8:25 PM
We had a wonderful time talking to @rolstonjohn.bsky.social, the Director of Epilepsy Surgery at Brigham & Women's Hospital. We talk about RNS for epilepsy, DBS for coma, traveling waves in the brain, stem cell therapy, closed loop DBS & more! Tune in 👇
stimulatingbrains.org/72-john-rols...
stimulatingbrains.org/72-john-rols...
Reposted by Lead-DBS
How may traveling waves in the brain impact seizure focus detection in functional neurosurgery?
How does RNS for epilepsy really work?
Are we ready for stem cell therapy in PD?
DBS for disorders of consciousness?
Find out in a conversation with the one and only @rolstonjohn.bsky.social 👇👇
How does RNS for epilepsy really work?
Are we ready for stem cell therapy in PD?
DBS for disorders of consciousness?
Find out in a conversation with the one and only @rolstonjohn.bsky.social 👇👇
We had a wonderful time talking to @rolstonjohn.bsky.social, the Director of Epilepsy Surgery at Brigham & Women's Hospital. We talk about RNS for epilepsy, DBS for coma, traveling waves in the brain, stem cell therapy, closed loop DBS & more! Tune in 👇
stimulatingbrains.org/72-john-rols...
stimulatingbrains.org/72-john-rols...
August 1, 2025 at 8:26 PM
How may traveling waves in the brain impact seizure focus detection in functional neurosurgery?
How does RNS for epilepsy really work?
Are we ready for stem cell therapy in PD?
DBS for disorders of consciousness?
Find out in a conversation with the one and only @rolstonjohn.bsky.social 👇👇
How does RNS for epilepsy really work?
Are we ready for stem cell therapy in PD?
DBS for disorders of consciousness?
Find out in a conversation with the one and only @rolstonjohn.bsky.social 👇👇
Reposted by Lead-DBS
Massive, Herculanean work by @laurenahart.bsky.social and Garance Meyer to compile and integrate findings from DBS for epilepsy (20 targets!) including meta-analytical evidence for optimal stimulation sites for the two main targets (ANT & CM). Preprint out now 👇👇
🧠 ⚡️ Preprint alert ⚡️ 🧠
I️n the most comprehensive review of DBS in epilepsy, with 124 studies, 1,210 patients, and 20 anatomical targets we map where stimulation works best and why.
Deep Brain Stimulation for Epilepsy: Optimal Targeting and Clinical Outcomes
www.researchgate.net/publication/...
I️n the most comprehensive review of DBS in epilepsy, with 124 studies, 1,210 patients, and 20 anatomical targets we map where stimulation works best and why.
Deep Brain Stimulation for Epilepsy: Optimal Targeting and Clinical Outcomes
www.researchgate.net/publication/...
June 24, 2025 at 7:33 PM
Massive, Herculanean work by @laurenahart.bsky.social and Garance Meyer to compile and integrate findings from DBS for epilepsy (20 targets!) including meta-analytical evidence for optimal stimulation sites for the two main targets (ANT & CM). Preprint out now 👇👇
Reposted by Lead-DBS
🧠 ⚡️ Preprint alert ⚡️ 🧠
I️n the most comprehensive review of DBS in epilepsy, with 124 studies, 1,210 patients, and 20 anatomical targets we map where stimulation works best and why.
Deep Brain Stimulation for Epilepsy: Optimal Targeting and Clinical Outcomes
www.researchgate.net/publication/...
I️n the most comprehensive review of DBS in epilepsy, with 124 studies, 1,210 patients, and 20 anatomical targets we map where stimulation works best and why.
Deep Brain Stimulation for Epilepsy: Optimal Targeting and Clinical Outcomes
www.researchgate.net/publication/...
June 24, 2025 at 7:24 PM
🧠 ⚡️ Preprint alert ⚡️ 🧠
I️n the most comprehensive review of DBS in epilepsy, with 124 studies, 1,210 patients, and 20 anatomical targets we map where stimulation works best and why.
Deep Brain Stimulation for Epilepsy: Optimal Targeting and Clinical Outcomes
www.researchgate.net/publication/...
I️n the most comprehensive review of DBS in epilepsy, with 124 studies, 1,210 patients, and 20 anatomical targets we map where stimulation works best and why.
Deep Brain Stimulation for Epilepsy: Optimal Targeting and Clinical Outcomes
www.researchgate.net/publication/...
Reposted by Lead-DBS
We are actively looking for an administrative position to help lead the newly founded @netstim.org at the University of Cologne – please spread the word and/or let us know if you know somebody that could be interested!
lnkd.in/eEbnXByJ
lnkd.in/eEbnXByJ
June 20, 2025 at 7:52 AM
We are actively looking for an administrative position to help lead the newly founded @netstim.org at the University of Cologne – please spread the word and/or let us know if you know somebody that could be interested!
lnkd.in/eEbnXByJ
lnkd.in/eEbnXByJ
Reposted by Lead-DBS
@foxmdphd.bsky.social's legendary anticorrelation paper has now been cited over 10.000 times and this was reason for a dedicated PNAS cake. Congratulations again, Mike, for this unbelievable pioneering effort that opened up the then novel field of resting-state fMRI!
@braincircuits.bsky.social
@braincircuits.bsky.social
June 2, 2025 at 9:49 AM
@foxmdphd.bsky.social's legendary anticorrelation paper has now been cited over 10.000 times and this was reason for a dedicated PNAS cake. Congratulations again, Mike, for this unbelievable pioneering effort that opened up the then novel field of resting-state fMRI!
@braincircuits.bsky.social
@braincircuits.bsky.social
Reposted by Lead-DBS
Hard to keep track about all the great things our labmembers have achieved recently:
May 29, 2025 at 4:16 PM
Hard to keep track about all the great things our labmembers have achieved recently:
Reposted by Lead-DBS
Happening today! We have two amazing speakers, Nicole Provenza and Martijn Figee who will share their thoughts on engineering for Neuromodulation and circuit based DBS for OCD respectively.
Be sure to tune in on May 29th, 12 noon EST/6:00 PM CET
Register here: partners.zoom.us/webinar/regi...
Be sure to tune in on May 29th, 12 noon EST/6:00 PM CET
Register here: partners.zoom.us/webinar/regi...
May 29, 2025 at 6:27 AM
Happening today! We have two amazing speakers, Nicole Provenza and Martijn Figee who will share their thoughts on engineering for Neuromodulation and circuit based DBS for OCD respectively.
Be sure to tune in on May 29th, 12 noon EST/6:00 PM CET
Register here: partners.zoom.us/webinar/regi...
Be sure to tune in on May 29th, 12 noon EST/6:00 PM CET
Register here: partners.zoom.us/webinar/regi...
Reposted by Lead-DBS
Are we on the cusp of moving beyond the levodopa challenge test to predict the best candidates and response to DBS in Parkinson's disease? We’ve long relied on the levodopa challenge to decide who’s a good candidate for deep brain stimulation but what if that test is only part of the story?
May 24, 2025 at 1:09 PM
Are we on the cusp of moving beyond the levodopa challenge test to predict the best candidates and response to DBS in Parkinson's disease? We’ve long relied on the levodopa challenge to decide who’s a good candidate for deep brain stimulation but what if that test is only part of the story?
Reposted by Lead-DBS
Can brain injury cause the loss of visual imagination?
We studied #aphantasia due to brain injury. Lesions were in many different regions but 100% were connected to the fusiform imagery node - a region active during visual mental imagery @braincircuits.bsky.social
www.medrxiv.org/content/10.1...
We studied #aphantasia due to brain injury. Lesions were in many different regions but 100% were connected to the fusiform imagery node - a region active during visual mental imagery @braincircuits.bsky.social
www.medrxiv.org/content/10.1...
May 23, 2025 at 10:02 PM
Can brain injury cause the loss of visual imagination?
We studied #aphantasia due to brain injury. Lesions were in many different regions but 100% were connected to the fusiform imagery node - a region active during visual mental imagery @braincircuits.bsky.social
www.medrxiv.org/content/10.1...
We studied #aphantasia due to brain injury. Lesions were in many different regions but 100% were connected to the fusiform imagery node - a region active during visual mental imagery @braincircuits.bsky.social
www.medrxiv.org/content/10.1...
Reposted by Lead-DBS
Is there a shared brain circuit target for tremor that transcends diagnosis and DBS site? New work by @lukasgoede.bsky.social @andreashorn.org @braincircuits.bsky.social says YES
Tremor is a common symptom across many neurological disorders.
But is there a shared tremor circuit across disorders - one that could guide treatment, regardless of diagnosis?
We think: yes.
Our study is out now in @natcomms.nature.com:
🔗 www.nature.com/articles/s41...
🧵 A thread.
But is there a shared tremor circuit across disorders - one that could guide treatment, regardless of diagnosis?
We think: yes.
Our study is out now in @natcomms.nature.com:
🔗 www.nature.com/articles/s41...
🧵 A thread.
May 24, 2025 at 2:30 PM
Is there a shared brain circuit target for tremor that transcends diagnosis and DBS site? New work by @lukasgoede.bsky.social @andreashorn.org @braincircuits.bsky.social says YES
Reposted by Lead-DBS
New research from @lukasgoede.bsky.social @andreashorn.org & colleagues provides a robust, cross-condition tremor network that may guide both invasive & noninvasive neuromodulation strategies for #Parkinsons & essential tremor
www.nature.com/articles/s41...
www.nature.com/articles/s41...
May 23, 2025 at 8:32 AM
New research from @lukasgoede.bsky.social @andreashorn.org & colleagues provides a robust, cross-condition tremor network that may guide both invasive & noninvasive neuromodulation strategies for #Parkinsons & essential tremor
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Lead-DBS
Tremor is a common symptom across many neurological disorders.
But is there a shared tremor circuit across disorders - one that could guide treatment, regardless of diagnosis?
We think: yes.
Our study is out now in @natcomms.nature.com:
🔗 www.nature.com/articles/s41...
🧵 A thread.
But is there a shared tremor circuit across disorders - one that could guide treatment, regardless of diagnosis?
We think: yes.
Our study is out now in @natcomms.nature.com:
🔗 www.nature.com/articles/s41...
🧵 A thread.
May 22, 2025 at 8:41 PM
Tremor is a common symptom across many neurological disorders.
But is there a shared tremor circuit across disorders - one that could guide treatment, regardless of diagnosis?
We think: yes.
Our study is out now in @natcomms.nature.com:
🔗 www.nature.com/articles/s41...
🧵 A thread.
But is there a shared tremor circuit across disorders - one that could guide treatment, regardless of diagnosis?
We think: yes.
Our study is out now in @natcomms.nature.com:
🔗 www.nature.com/articles/s41...
🧵 A thread.
Reposted by Lead-DBS
Curious in an update on networks involved in treating tremor using neuromodulation? New study from the lab spearheaded by the one and only @lukasgoede.bsky.social out now at nature comms - nice summary thread below 👇👇
Tremor is a common symptom across many neurological disorders.
But is there a shared tremor circuit across disorders - one that could guide treatment, regardless of diagnosis?
We think: yes.
Our study is out now in @natcomms.nature.com:
🔗 www.nature.com/articles/s41...
🧵 A thread.
But is there a shared tremor circuit across disorders - one that could guide treatment, regardless of diagnosis?
We think: yes.
Our study is out now in @natcomms.nature.com:
🔗 www.nature.com/articles/s41...
🧵 A thread.
May 23, 2025 at 1:04 PM
Curious in an update on networks involved in treating tremor using neuromodulation? New study from the lab spearheaded by the one and only @lukasgoede.bsky.social out now at nature comms - nice summary thread below 👇👇
Reposted by Lead-DBS
Patient selection for Deep Brain Stimulation (DBS) is crucial.
Are there ways to improve it?
In our new study, we found hints that non-invasive brain stimulation might enhance the levodopa response
- and serve as an additional marker for DBS outcomes.
doi.org/10.1002/acn3...
A thread. 🧵
Are there ways to improve it?
In our new study, we found hints that non-invasive brain stimulation might enhance the levodopa response
- and serve as an additional marker for DBS outcomes.
doi.org/10.1002/acn3...
A thread. 🧵
Patient Selection in Deep Brain Stimulation: A Role for Transcranial Direct Current Stimulation to Enhance the Levodopa Challenge?
Dopaminergic medication and deep brain stimulation (DBS) improve motor symptoms in Parkinson's disease (PD), but levodopa response alone may not predict DBS outcomes. We retrospectively analyzed 19 P...
doi.org
May 19, 2025 at 7:14 PM
Patient selection for Deep Brain Stimulation (DBS) is crucial.
Are there ways to improve it?
In our new study, we found hints that non-invasive brain stimulation might enhance the levodopa response
- and serve as an additional marker for DBS outcomes.
doi.org/10.1002/acn3...
A thread. 🧵
Are there ways to improve it?
In our new study, we found hints that non-invasive brain stimulation might enhance the levodopa response
- and serve as an additional marker for DBS outcomes.
doi.org/10.1002/acn3...
A thread. 🧵
Reposted by Lead-DBS
Is there a role for noninvasive "network" stimulation (multifocal tDCS) to evaluate candidates for deep brain stimulation?
@lukasgoede.bsky.social says yes – new study here:
onlinelibrary.wiley.com/doi/10.1002/...
A 🧵
@netstim.org @braincircuits.bsky.social @lead-dbs.org
@lukasgoede.bsky.social says yes – new study here:
onlinelibrary.wiley.com/doi/10.1002/...
A 🧵
@netstim.org @braincircuits.bsky.social @lead-dbs.org
May 19, 2025 at 7:13 PM
Is there a role for noninvasive "network" stimulation (multifocal tDCS) to evaluate candidates for deep brain stimulation?
@lukasgoede.bsky.social says yes – new study here:
onlinelibrary.wiley.com/doi/10.1002/...
A 🧵
@netstim.org @braincircuits.bsky.social @lead-dbs.org
@lukasgoede.bsky.social says yes – new study here:
onlinelibrary.wiley.com/doi/10.1002/...
A 🧵
@netstim.org @braincircuits.bsky.social @lead-dbs.org
First Fiber Filtering study using MRgFUS lesions (instead of DBS Stimulation Volumes)! 👇👇
MR guided focused ultrasound surgery is an effective and uprising treatment option for Essential tremor. But where is the optimal site to sonicate? Which spots to avoid due to side-effects?
@science.org @braincircuits.bsky.social @netstim.org
– a thread🧵!
www.science.org/doi/10.1126/...
@science.org @braincircuits.bsky.social @netstim.org
– a thread🧵!
www.science.org/doi/10.1126/...
May 14, 2025 at 7:33 PM
First Fiber Filtering study using MRgFUS lesions (instead of DBS Stimulation Volumes)! 👇👇
Reposted by Lead-DBS
When modeling volumes of tissue activated in subthalamic DBS for clinical outcomes, does it matter whether we process data in native or template space? Julianna Pijar and Clemens Neudorfer say No in the Brain Stimulation Journal:
doi.org/10.1016/j.br...
doi.org/10.1016/j.br...
May 12, 2025 at 11:18 AM
When modeling volumes of tissue activated in subthalamic DBS for clinical outcomes, does it matter whether we process data in native or template space? Julianna Pijar and Clemens Neudorfer say No in the Brain Stimulation Journal:
doi.org/10.1016/j.br...
doi.org/10.1016/j.br...
Reposted by Lead-DBS
Tune in here for a fantastic primer on ECT – and so much more!
Thank you Dr. Sackeim for joining me on @stimulatingbrains.org!
Thank you Dr. Sackeim for joining me on @stimulatingbrains.org!
It was a great honor to talk with the founding editor of Brain Stimulation, Dr. Harold Sackeim!
Beyond the past, present and future of ECT, we covered the entire field of neuromodulation.
Priceless insights from a key leader in the field!
Tune in here 👇
stimulatingbrains.org/71-harold-sa...
Beyond the past, present and future of ECT, we covered the entire field of neuromodulation.
Priceless insights from a key leader in the field!
Tune in here 👇
stimulatingbrains.org/71-harold-sa...
April 25, 2025 at 2:13 AM
Tune in here for a fantastic primer on ECT – and so much more!
Thank you Dr. Sackeim for joining me on @stimulatingbrains.org!
Thank you Dr. Sackeim for joining me on @stimulatingbrains.org!