Laura de Rooij
@lderooij.bsky.social
Principal Investigator at CeMM | Vascular Aging, Endothelial Cell heterogeneity & Single Cell Omics https://derooijlab.org/
Pinned
Laura de Rooij
@lderooij.bsky.social
· Aug 19
| bioRxiv
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
🚨Preprint alert!🚨What happens to our blood vessels as we age? To begin answering this at the transcriptome level, we built the Human Aging Endothelial Cell Atlas (HAECA), profiling >375,000 endothelial cells from 12 tissues across adulthood. www.biorxiv.org/content/10.1... (1/9)
Reposted by Laura de Rooij
Uncovering the transcriptional hallmarks of endothelial cell aging via integrated single-cell analysis
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Uncovering the transcriptional hallmarks of endothelial cell aging via integrated single-cell analysis
Endothelial cells (ECs) are critical regulators of vascular function and exhibit specialized, organ-specific roles across tissues. During aging, these cells become dysfunctional, resulting in increase...
www.biorxiv.org
August 23, 2025 at 11:57 AM
Uncovering the transcriptional hallmarks of endothelial cell aging via integrated single-cell analysis
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
🚨Preprint alert!🚨What happens to our blood vessels as we age? To begin answering this at the transcriptome level, we built the Human Aging Endothelial Cell Atlas (HAECA), profiling >375,000 endothelial cells from 12 tissues across adulthood. www.biorxiv.org/content/10.1... (1/9)
| bioRxiv
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
August 19, 2025 at 3:22 PM
🚨Preprint alert!🚨What happens to our blood vessels as we age? To begin answering this at the transcriptome level, we built the Human Aging Endothelial Cell Atlas (HAECA), profiling >375,000 endothelial cells from 12 tissues across adulthood. www.biorxiv.org/content/10.1... (1/9)
Reposted by Laura de Rooij
Reposted by Laura de Rooij
"our results indicate that academia pays a price by focusing attention and resources on superstars"
Nice to see this supported by data analysis, now.
H/T: @cxdig.bsky.social
www.nature.com/articles/s41...
Nice to see this supported by data analysis, now.
H/T: @cxdig.bsky.social
www.nature.com/articles/s41...
The innovation trade-off: how following superstars shapes academic novelty - Humanities and Social Sciences Communications
Humanities and Social Sciences Communications - The innovation trade-off: how following superstars shapes academic novelty
www.nature.com
July 19, 2025 at 12:05 PM
"our results indicate that academia pays a price by focusing attention and resources on superstars"
Nice to see this supported by data analysis, now.
H/T: @cxdig.bsky.social
www.nature.com/articles/s41...
Nice to see this supported by data analysis, now.
H/T: @cxdig.bsky.social
www.nature.com/articles/s41...
Reposted by Laura de Rooij
🔬 As we near the end of #EquationsForLife, today we spotlight @ar-abdelfattah.bsky.social's Group!
They use the #ReactionDiffussion equation to characterize the process of tissue organization and maintenance in physiology, and how disease disrupts it.
🔎 bit.ly/4ef2Pbe
They use the #ReactionDiffussion equation to characterize the process of tissue organization and maintenance in physiology, and how disease disrupts it.
🔎 bit.ly/4ef2Pbe
June 24, 2025 at 6:30 AM
🔬 As we near the end of #EquationsForLife, today we spotlight @ar-abdelfattah.bsky.social's Group!
They use the #ReactionDiffussion equation to characterize the process of tissue organization and maintenance in physiology, and how disease disrupts it.
🔎 bit.ly/4ef2Pbe
They use the #ReactionDiffussion equation to characterize the process of tissue organization and maintenance in physiology, and how disease disrupts it.
🔎 bit.ly/4ef2Pbe
Reposted by Laura de Rooij
We kicked off the week with Roger Kamm (@mitdeptofbe.bsky.social) for a #CeMMinar on brain neurovascular models & its applications to modeling drug & toxin transport. Thanks to Roger for the great insights & hosts @lderooij.bsky.social & @ar-abdelfattah.bsky.social
June 16, 2025 at 1:38 PM
We kicked off the week with Roger Kamm (@mitdeptofbe.bsky.social) for a #CeMMinar on brain neurovascular models & its applications to modeling drug & toxin transport. Thanks to Roger for the great insights & hosts @lderooij.bsky.social & @ar-abdelfattah.bsky.social
Reposted by Laura de Rooij
A very insightful Impromptu Seminar today at #CeMM by Kumar Sharma (@uthealthsa.bsky.social), hosted by our PI @ar-abdelfattah.bsky.social! His talk on spatial mass spectrometry & precision therapeutics offered powerful insights into disease mechanisms and inter-organ crosstalk. Thank you, Kumar!
June 5, 2025 at 3:12 PM
A very insightful Impromptu Seminar today at #CeMM by Kumar Sharma (@uthealthsa.bsky.social), hosted by our PI @ar-abdelfattah.bsky.social! His talk on spatial mass spectrometry & precision therapeutics offered powerful insights into disease mechanisms and inter-organ crosstalk. Thank you, Kumar!
Reposted by Laura de Rooij
🌐 Introducing MOTION WorkPackage 2 by @reibergerthomas.bsky.social 🌐
In this particular WP the team is focusing on decompensated cirrhosis..
#liver #PortalHypertension #clinicaltrails #dACLD
🔽 Find out more in the video below 📷🔽
In this particular WP the team is focusing on decompensated cirrhosis..
#liver #PortalHypertension #clinicaltrails #dACLD
🔽 Find out more in the video below 📷🔽
May 16, 2025 at 9:28 AM
🌐 Introducing MOTION WorkPackage 2 by @reibergerthomas.bsky.social 🌐
In this particular WP the team is focusing on decompensated cirrhosis..
#liver #PortalHypertension #clinicaltrails #dACLD
🔽 Find out more in the video below 📷🔽
In this particular WP the team is focusing on decompensated cirrhosis..
#liver #PortalHypertension #clinicaltrails #dACLD
🔽 Find out more in the video below 📷🔽
Reposted by Laura de Rooij
Let’s kick off the week with #EquationsForLife! @lderooij.bsky.social’s group studies how #aging affects endothelial cells in blood vessels. Using #MurraysLaw & 3D “vessel-on-a-chip” models, they aim to decode & combat cardiovascular aging.
🔍 tinyurl.com/CeMMRR2024-d...
#CeMMResearchReport2024
🔍 tinyurl.com/CeMMRR2024-d...
#CeMMResearchReport2024
May 5, 2025 at 7:07 AM
Let’s kick off the week with #EquationsForLife! @lderooij.bsky.social’s group studies how #aging affects endothelial cells in blood vessels. Using #MurraysLaw & 3D “vessel-on-a-chip” models, they aim to decode & combat cardiovascular aging.
🔍 tinyurl.com/CeMMRR2024-d...
#CeMMResearchReport2024
🔍 tinyurl.com/CeMMRR2024-d...
#CeMMResearchReport2024
🚨 Exciting Opportunity! 🚨
Join us on June 9th in Brussels for a satellite conference to the 4th MPS World Summit, where we will address advancements & challenges in #aging research using #microphysiological systems and #organoids.
Sign up here: lnkd.in/dCu_yCBr
Join us on June 9th in Brussels for a satellite conference to the 4th MPS World Summit, where we will address advancements & challenges in #aging research using #microphysiological systems and #organoids.
Sign up here: lnkd.in/dCu_yCBr
April 23, 2025 at 5:02 PM
🚨 Exciting Opportunity! 🚨
Join us on June 9th in Brussels for a satellite conference to the 4th MPS World Summit, where we will address advancements & challenges in #aging research using #microphysiological systems and #organoids.
Sign up here: lnkd.in/dCu_yCBr
Join us on June 9th in Brussels for a satellite conference to the 4th MPS World Summit, where we will address advancements & challenges in #aging research using #microphysiological systems and #organoids.
Sign up here: lnkd.in/dCu_yCBr
🚨Job alert🚨! We are looking for a highly motivated research technician to join us in our quest to dissect the transcriptomic make-up and function of endothelial cells across the human body, using cutting-edge omics technologies, clinical samples, and vessel-on-chip models. Please share & apply! 👇
CeMM hiring Laboratory Technician in Vascular Heterogeneity (m/f/d) in Vienna, Austria | LinkedIn
Posted 11:40:28 AM. The laboratory of Laura de Rooij at CeMM, the Research Center for Molecular Medicine of the…See this and similar jobs on LinkedIn.
lnkd.in
February 23, 2025 at 3:56 PM
🚨Job alert🚨! We are looking for a highly motivated research technician to join us in our quest to dissect the transcriptomic make-up and function of endothelial cells across the human body, using cutting-edge omics technologies, clinical samples, and vessel-on-chip models. Please share & apply! 👇
Only two weeks left to apply, don't miss out!! 👇
Looking for a fully funded PhD position in wonderful Vienna? The CeMM PhD program is now open for applications! 🎓 🥼 🧫
We are seeking passionate and driven students interested in helping us understand #endothelial cell heterogeneity in both healthy and pathological #aging. See below for more info 👇
We are seeking passionate and driven students interested in helping us understand #endothelial cell heterogeneity in both healthy and pathological #aging. See below for more info 👇
January 6, 2025 at 7:18 PM
Only two weeks left to apply, don't miss out!! 👇
Reposted by Laura de Rooij
Excited to share our single-cell study on aging mouse brain! We found 2,449 cell-type specific age-DE genes, and an aging hotspot in specific hypothalamic cell types involved in energy homeostasis, which show both decreased neuronal function and increased immune response. doi.org/10.1038/s415...
January 2, 2025 at 3:56 AM
Excited to share our single-cell study on aging mouse brain! We found 2,449 cell-type specific age-DE genes, and an aging hotspot in specific hypothalamic cell types involved in energy homeostasis, which show both decreased neuronal function and increased immune response. doi.org/10.1038/s415...
Looking for a fully funded PhD position in wonderful Vienna? The CeMM PhD program is now open for applications! 🎓 🥼 🧫
We are seeking passionate and driven students interested in helping us understand #endothelial cell heterogeneity in both healthy and pathological #aging. See below for more info 👇
We are seeking passionate and driven students interested in helping us understand #endothelial cell heterogeneity in both healthy and pathological #aging. See below for more info 👇
December 19, 2024 at 2:43 PM
Looking for a fully funded PhD position in wonderful Vienna? The CeMM PhD program is now open for applications! 🎓 🥼 🧫
We are seeking passionate and driven students interested in helping us understand #endothelial cell heterogeneity in both healthy and pathological #aging. See below for more info 👇
We are seeking passionate and driven students interested in helping us understand #endothelial cell heterogeneity in both healthy and pathological #aging. See below for more info 👇
Reposted by Laura de Rooij
Is anyone else just *not interested* in using AI for their writing? All accuracy and morality aside, I just don't want to. I want every last word I put on a page to have flowed out from my own body. Maybe I'm romanticizing it, but I just can't see it any other way.
December 10, 2024 at 3:52 PM
Is anyone else just *not interested* in using AI for their writing? All accuracy and morality aside, I just don't want to. I want every last word I put on a page to have flowed out from my own body. Maybe I'm romanticizing it, but I just can't see it any other way.
Reposted by Laura de Rooij
Our #TBI project got funded! Driven by what happens when forces are too much to handle, we will engineer tools to traumatize organoids and focus on #ECMatrix dynamics, #mechanobiology, and molecular-to-multicellular tissue organization. Happy to collaborate! Happening @ CeMM
December 7, 2024 at 12:59 PM
Our #TBI project got funded! Driven by what happens when forces are too much to handle, we will engineer tools to traumatize organoids and focus on #ECMatrix dynamics, #mechanobiology, and molecular-to-multicellular tissue organization. Happy to collaborate! Happening @ CeMM
Reposted by Laura de Rooij
Not checking nuclear markers like MALAT1 or intronic reads in your scRNA-seq data?🚨
We show their power to flag low-quality cells—even in top public datasets. It’s time to prioritize better QC for cleaner, more reliable genomics research!
Read more: bmcgenomics.biomedcentral.com/articles/10....
1/8
High content of nuclei-free low-quality cells in reference single-cell atlases: a call for more stringent quality control using nuclear fraction - BMC Genomics
The advent of droplet-based single-cell RNA-sequencing (scRNA-seq) has dramatically increased data throughput, enabling the release of a diverse array of tissue cell atlases to the public. However, we...
bmcgenomics.biomedcentral.com
December 3, 2024 at 8:38 AM
Not checking nuclear markers like MALAT1 or intronic reads in your scRNA-seq data?🚨
We show their power to flag low-quality cells—even in top public datasets. It’s time to prioritize better QC for cleaner, more reliable genomics research!
Read more: bmcgenomics.biomedcentral.com/articles/10....
1/8
The complications of SARS-CoV-2 infection highlight the key role of #endothelial functions in health and disease. Great perspective in light of acute and Long Covid, and strongly in line with what we previously speculated: doi.org/10.1161/CIRC...
November 29, 2024 at 3:30 PM
The complications of SARS-CoV-2 infection highlight the key role of #endothelial functions in health and disease. Great perspective in light of acute and Long Covid, and strongly in line with what we previously speculated: doi.org/10.1161/CIRC...
Reposted by Laura de Rooij
Blood vessel wall (endothelial) inflammation as a key to multi-organ complications of Covid and #LongCovid
@science.org
science.org/doi/10.1126/...
@science.org
science.org/doi/10.1126/...
Endothelial inflammation in COVID-19
Disrupted endothelial function underlies the multiorgan complications of COVID-19
science.org
November 28, 2024 at 8:33 PM
Blood vessel wall (endothelial) inflammation as a key to multi-organ complications of Covid and #LongCovid
@science.org
science.org/doi/10.1126/...
@science.org
science.org/doi/10.1126/...
Reposted by Laura de Rooij
The strain on scientific publishing: we set out to characterise the remarkable growth of the scientific literature in the last few years, in spite of declining growth in total scientists. What is going on?
direct.mit.edu/qss/article/...
A 🧵 1/n
#AcademicSky #PhDchat #ScientificPublishing #SciPub
direct.mit.edu/qss/article/...
A 🧵 1/n
#AcademicSky #PhDchat #ScientificPublishing #SciPub
November 19, 2024 at 12:27 PM
The strain on scientific publishing: we set out to characterise the remarkable growth of the scientific literature in the last few years, in spite of declining growth in total scientists. What is going on?
direct.mit.edu/qss/article/...
A 🧵 1/n
#AcademicSky #PhDchat #ScientificPublishing #SciPub
direct.mit.edu/qss/article/...
A 🧵 1/n
#AcademicSky #PhDchat #ScientificPublishing #SciPub
Reposted by Laura de Rooij
Atlas of the plasma proteome in health and disease in 53,026 adults. #Cell #medBsky #SciBsky #scisky #proteome
These results provide an open-access comprehensive proteome-phenome resource (proteome-phenome-atlas.com).
Open Access
www.cell.com/cell/fulltex...
These results provide an open-access comprehensive proteome-phenome resource (proteome-phenome-atlas.com).
Open Access
www.cell.com/cell/fulltex...
November 25, 2024 at 12:56 AM
Atlas of the plasma proteome in health and disease in 53,026 adults. #Cell #medBsky #SciBsky #scisky #proteome
These results provide an open-access comprehensive proteome-phenome resource (proteome-phenome-atlas.com).
Open Access
www.cell.com/cell/fulltex...
These results provide an open-access comprehensive proteome-phenome resource (proteome-phenome-atlas.com).
Open Access
www.cell.com/cell/fulltex...
Reposted by Laura de Rooij
@bioeng-talk.bsky.social is posting here as well! Speaking of moving to new places (🦋), in this episode, a bunch of us discuss why we moved to Europe to continue our academic careers. Tune in to hear about our experiences and what motivated us to make the leap.
For our first post here 🦋, we discuss why some of us changed environments to pursue science, focusing on career moves that brought us to Europe. Are you planning to move for your next position? Hear us about our experiences, motivations, and the hurdles we faced.
t.co/5gRHhw2eef
t.co/5gRHhw2eef
https://spotifycreators-web.app.link/e/6hFYUzm3MOb
t.co
November 24, 2024 at 5:10 PM
@bioeng-talk.bsky.social is posting here as well! Speaking of moving to new places (🦋), in this episode, a bunch of us discuss why we moved to Europe to continue our academic careers. Tune in to hear about our experiences and what motivated us to make the leap.
Reposted by Laura de Rooij
Updated Aging Starter Pack!! People and labs interested in aging 😀 Let me know if you'd like to be added!
go.bsky.app/5UXXaDA
go.bsky.app/5UXXaDA
November 23, 2024 at 4:15 PM
Updated Aging Starter Pack!! People and labs interested in aging 😀 Let me know if you'd like to be added!
go.bsky.app/5UXXaDA
go.bsky.app/5UXXaDA
Reposted by Laura de Rooij
Let the first post be about our lab website! Happy to announce it's up and running. Our vision of controlling tissue organization and probing its mechanics is rather magnetic 🧲⚙️🧫🧬! #mechanobiology
👉 www.abdelfattahlab.org
👉 www.abdelfattahlab.org
Abdel Fattah Lab
www.abdelfattahlab.org
November 23, 2024 at 2:25 PM
Let the first post be about our lab website! Happy to announce it's up and running. Our vision of controlling tissue organization and probing its mechanics is rather magnetic 🧲⚙️🧫🧬! #mechanobiology
👉 www.abdelfattahlab.org
👉 www.abdelfattahlab.org
Excited to join the 🦋 community, and even more excited to share that the lab has its very own logo & website! 🖥️🔎 Visit us at derooijlab.org to explore our work, stay updated on ongoing projects, papers, and more!
November 23, 2024 at 7:00 PM
Excited to join the 🦋 community, and even more excited to share that the lab has its very own logo & website! 🖥️🔎 Visit us at derooijlab.org to explore our work, stay updated on ongoing projects, papers, and more!